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Tackling application limitations of high-safetyγ-butyrolactone electrolytes:Exploring mechanisms and proposing solutions
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作者 Haojun Wu Zhangyating Xie +9 位作者 Guanjie Li Lei Zheng Zhiwei Zhao Jiarong He Yanbin Shen Jiahao Hu Zhangquan Peng Guiming Zhong Lidan Xing Weishan Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期193-201,I0005,共10页
Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Bu... Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its incompatibility with graphite anode has hindered its application.This limitation necessitates a comprehensive investigation into the underlying mechanisms and potential solutions.In this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function calculations.Our findings reveal that,even at high salt concentrations,GBL consistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL decomposition and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)layer.Contrary to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite anode.This approach effectively inhibits GBL decomposition and significantly enhances the battery's lifespan.This study provides the first reported intrinsic understanding of the unique GBLgraphite incompatibility and offers valuable insights for the development of wide-temperature and high-safety LIBs. 展开更多
关键词 γ-butyrolactone/Graphite incompatibility Unique solvation structure SEI film Lithium-ion batteries
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Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries 被引量:1
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作者 JiaChengNING ShuMAO YeDiGUAN 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第1期17-19,共3页
Eleven (S)-(-)-bishydrocarbyl-(1-alkanoylpyrrolidin-2-yl)-methanol derivatives of three types were synthesized from L-proline, asymmtrically selective alkylation products were obtained by LDA treatment and alkylatio... Eleven (S)-(-)-bishydrocarbyl-(1-alkanoylpyrrolidin-2-yl)-methanol derivatives of three types were synthesized from L-proline, asymmtrically selective alkylation products were obtained by LDA treatment and alkylation using methyl 2-bromoethyl ether, and three types of chiral α-substituted-γ-butyrolactones were obtained by hydrolyzing the alkylation products, with %e.e. being up to 89 percent. 展开更多
关键词 Asymmetric synthesis α-substituted-γ-butyrolactone.
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Promotional Effect of CoO(OH) on Selective Hydrogenation of Maleic Anhydride to γ-Butyrolactone over Supported Ruthenium Catalyst 被引量:1
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作者 Zhou Yafen Wang Qing +3 位作者 Wang Manman Yang Wenjuan Zhou Limei Ma Xiaoyan 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2015年第4期96-101,共6页
A decorated ruthenium catalyst was prepared by the coprecipitation method and used for the selective hydrogenation of maleic anhydride(MA) to γ-butyrolactone(GBL). The as-prepared catalyst was characterized by XRD, T... A decorated ruthenium catalyst was prepared by the coprecipitation method and used for the selective hydrogenation of maleic anhydride(MA) to γ-butyrolactone(GBL). The as-prepared catalyst was characterized by XRD, TGDTG and N2 adsorption techniques. The characterization tests revealed that the catalyst carrier was composed of monoclinic zirconia(m-ZrO2) and hydroxyl cobalt oxide(CoO(OH)). The hydrogenation results showed that the content of CoO(OH), the reaction temperature, the hydrogen pressure and the reaction time significantly affected the catalytic selectivity to GBL. The promotional effect of CoO(OH) was remarkable, which led to an obvious increase in GBL selectivity. An 100% MA conversion and 92.0% selectivity to GBL were achieved over the Ru/ZrO2-CoO(OH)(35%) catalyst in water solvent under the conditions involving a reaction temperature of 180 ℃, a hydrogen pressure of 3.0 MPa, and a reaction time of 6 h. 展开更多
关键词 ruthenium catalyst hydrogenation maleic anhydride γ-butyrolactone
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An Efficient Method for α-Alkylation of γ-Butyrolactone
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作者 YuanRuMENG YeDiGUAN 《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第11期1039-1042,共4页
This paper provides a simple, convenient and mild condition method for -alkylation of g-butyrolactone. Three types of (E)-a-alkenyl-g-butyrolactone compounds were synthesized by condensation of corresponding aldehyd... This paper provides a simple, convenient and mild condition method for -alkylation of g-butyrolactone. Three types of (E)-a-alkenyl-g-butyrolactone compounds were synthesized by condensation of corresponding aldehydes and g-butyrolactone, using MeONa and EtONa as base. Then the a-alkyl-g-butyrolactones were gained by reducing the former alkenyl compounds through catalytic transfer hydrogenation under Pd/C catalyst with sodium hypophosphite at room temperature. 展开更多
关键词 Alkylation of -butyrolactone CONDENSATION catalytic transfer hydrogenation Pd / C-sodium hypophosphite.
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The stable planar conformation of the γ-butyrolactone ring in solution
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作者 Zhi Qiang Feng Cheng Lie Yin 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第2期187-190,共4页
The conformations ofγ-butyrolactone ring in solution were deduced on the basis of ~1H NMR spectra of geminal protons of the butyrolactone ring.A series of optically pure(Z)-(-)-4-(1 -alkoxyl-1 -carbalkoxy-methylene)-... The conformations ofγ-butyrolactone ring in solution were deduced on the basis of ~1H NMR spectra of geminal protons of the butyrolactone ring.A series of optically pure(Z)-(-)-4-(1 -alkoxyl-1 -carbalkoxy-methylene)-5(R)[(1R)-menthyloxy]-γ-butyr-olactones with a stable planar conformation of γ-butyrolactone ring were found. 展开更多
关键词 β-Methylene-γ-butyrolactone Planar conformation Envelope conformation
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Highly Branched Poly(α-Methylene-γ-Butyrolactone) from Ring-Opening Homopolymerization
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作者 Pascal Binda Zakiya Barnes +1 位作者 Dechristian Guthrie Rasaan Ford 《Open Journal of Polymer Chemistry》 2017年第4期76-91,共16页
New heteroleptic lanthanide complex [L1ILaN{Si(CH3)2}] (1) containing tridentate [ONO] ancillary ligand was synthesized from an acid-base ligand exchange reaction with ligands H2L1 and corresponding homoleptic lanthan... New heteroleptic lanthanide complex [L1ILaN{Si(CH3)2}] (1) containing tridentate [ONO] ancillary ligand was synthesized from an acid-base ligand exchange reaction with ligands H2L1 and corresponding homoleptic lanthanide compound La[N{Si(CH3)3}2]3. Meanwhile, dimeric complexes [L1LaCl] (2) and [L1ILaCl] (3) were prepared from salt metathesis reaction between one equivalent of ligands H2LI,II, three equivalent of NaN{Si(CH3)3}2, and one equivalent of LaCl3. These compounds were characterized by nuclear magnetic resonance (300 MHz) and elemental analysis. These complexes were used as catalysts in the ring-opening homopolymerization of α-methylene-γ-butyrolactone. While compound 1 did not show any significant reactivity, compounds 2 and 3 gave significant amount of highly branched poly(α-methylene-γ-butyrolactone) as confirmed by 1H NMR spectroscopy and Malvern’s triple detector GPCMax analysis in DMSO with molecular weights of over 500,000 Dalton. The glass-transition temperatures of the branched polymer samples were determined using a Dynamic Mechanical Analyzer, DMA Q800. 展开更多
关键词 LANTHANIDE α-Methylene-γ-butyrolactone Polyesters RING-OPENING POLYMERIZATION
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Continuous-flow synthesis of polysubstituted γ-butyrolactones via enzymatic cascade catalysis
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作者 Liliang Chu Xiaoyan Zhang +6 位作者 Jianing Li Xuelei Deng Miao Wu Ya Cheng Weiping Zhu Xuhong Qian Yunpeng Bai 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第4期404-408,共5页
Polysubstituted chiral γ-butyrolactones are the core structural units of many natural products and high value-added flavors and fragrances used in the food and cosmetic industry. Current enzymatic cascade synthesis o... Polysubstituted chiral γ-butyrolactones are the core structural units of many natural products and high value-added flavors and fragrances used in the food and cosmetic industry. Current enzymatic cascade synthesis of these molecules faces the problems of low enzyme activity and phase separation in batch reaction, resulting in low productivity. Herein, we report a new continuous-flow process to synthesize the optically pure Nicotiana tabacum lactone(3S,4S)-4a and whisky lactone(3R,4S)-4b from α,β-unsaturatedγ-ketoesters. A new ene reductase(ER) from Swingsia samuiensi(Ss ER) and a carbonyl reductase(Ss CR)were engineered by directed evolution to improve their activity and thermostability. The continuous-flow preparative reactions were performed in two 3D microfluidic reactors, generating(3S,4S)-4a(99% ee and87% de) and(3R,4S)-4b(99% ee and 98% de) with space-time yields 3 and 7.4 times higher than those of the batch reactions. The significant enhancement in the productivity of enzyme cascade catalysis brought by cutting-edge continuous microfluidic technology will benefit the general multi-enzyme catalytic systems in the future. 展开更多
关键词 Enzyme catalysis Cascade catalysis Directed evolution CONTINUOUS-FLOW γ-butyrolactones
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Stereodivergent synthesis ofα-fluoroα-azaarylγ-butyrolactones via cooperative copper and iridium catalysis
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作者 Kui Tian Xin Chang +2 位作者 Lu Xiao Xiu-Qin Dong Chun-Jiang Wang 《Fundamental Research》 CAS CSCD 2024年第1期77-85,共9页
The development of stereodivergent synthetic methods to access all four stereoisomers of biologically importantα-fluoroγ-butyrolactones containing vicinal stereocenters is of great importance and poses a formidable ... The development of stereodivergent synthetic methods to access all four stereoisomers of biologically importantα-fluoroγ-butyrolactones containing vicinal stereocenters is of great importance and poses a formidable challenge owing to ring strain and steric hindrance.Herein,a novel asymmetric[3+2]annulation ofα-fluoroα-azaaryl acetates with vinylethylene carbonate was successfully developed through Cu/Ir-catalyzed cascade allylic alkylation/lactonization,affording a variety of enantioenrichedα-fluoroγ-butyrolactones bearing vicinal stereogenic centers with high reaction efficiency and excellent levels of both stereoselectivity and regioselectivity(up to 98%yield,generally>20:1 dr and>99%ee).Notably,all four stereoisomers of these pharmaceutically valuable molecules could be accessed individually via simple permutations of two enantiomeric catalysts.In addition,other azaaryl acetates bearingα-methyl,α-chlorine orα-phenyl group were tolerated well in this transformation.Reaction mechanistic investigations were conducted to explore the process of this bimetallic catalysis based on the results of reaction intermediates,isotopic labelling experiments,and kinetic studies. 展开更多
关键词 Asymmetric catalysis α-Fluoroγ-butyrolactones Synergistic catalysis Cascade reaction Stereodivergent synthesis
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A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules 被引量:2
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作者 Xiang Liu Wenxi Wang +3 位作者 Junyue Li Yue Li Jihui Zhang Huarong Tan 《Science China(Life Sciences)》 SCIE CAS CSCD 2021年第10期1575-1589,共15页
Cell-cell communication is critical for bacterial survival in natural habitats,in which miscellaneous regulatory networks are encompassed.However,elucidating the interaction networks of a microbial community has been ... Cell-cell communication is critical for bacterial survival in natural habitats,in which miscellaneous regulatory networks are encompassed.However,elucidating the interaction networks of a microbial community has been hindered by the population complexity.This study reveals thatγ-butyrolactone(GBL)molecules from Streptomyces species,the major antibiotic producers,can directly bind to the acyl-homoserine lactone(AHL)receptor of Chromobacterium violaceum and influence violacein production controlled by the quorum sensing(QS)system.Subsequently,the widespread responses of more Gram-negative bacterial AHL receptors to Gram-positive Streptomyces signaling molecules are unveiled.Based on the cross-talk between GBL and AHL signaling systems,combinatorial regulatory circuits(CRC)are designed and proved to be workable in Escherichia coli(E.coli).It is significant that the QS systems of Gram-positive and Gram-negative bacteria can be bridged via native Streptomyces signaling molecules.These findings pave a new path for unlocking the comprehensive cell-cell communications in microbial communities and facilitate the exploitation of innovative regulatory elements for synthetic biology. 展开更多
关键词 signaling communication CROSS-TALK Gram-positive bacteria STREPTOMYCES Γ-butyrolactone Gram-negative bacteria acyl-homoserine lactone synthetic biology combinatorial regulatory circuit
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A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena 被引量:2
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作者 SUN Jing HUO Hui-Xia +3 位作者 HUANG Zheng ZHANG Jing LI Jun TU Peng-Fei 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2015年第9期699-703,共5页
A new γ-alkylated-γ-butyrolactone, named melongenolide A(1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A(1),(+)-syringar... A new γ-alkylated-γ-butyrolactone, named melongenolide A(1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A(1),(+)-syringaresinol(2),(+)- lyoniresinol(3), 5,5′-dimethoxy lariciresinol(4),(+)-(7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneoligna-7, 9-diol-7′- aldehyde(5), kaempferol-3-O-(2′′,6′′-di-O-p-trans-coumaroyl)-β-glucoside(6), arjunolic acid(7), vanillic acid(8), scoparone(9), and β-sitosterol(10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L-1, respectively. 展开更多
关键词 Solanaceae Solanum melongena γ-Alkylated-γ-butyrolactone Melongenolide A Anti-inflammation
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Fully Chemical Recyclable Poly(γ-butyrolactone)-based Copolymers with Tunable Structures and Properties
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作者 Yi-Huan Liu Xin Yuan +4 位作者 Jia-Qi Wu Ming-Xuan Luo Xin Hu Ning Zhu Kai Guo 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2022年第5期456-461,共6页
The emerging chemical recyclable polymers,such as poly(γ-butyrolactone)(PGBL)and poly((R)-3,4-trans six-membered ring-fused GBL)(P((R)-M)),provide a good solution to the plastic pollution.However,these homopolymers s... The emerging chemical recyclable polymers,such as poly(γ-butyrolactone)(PGBL)and poly((R)-3,4-trans six-membered ring-fused GBL)(P((R)-M)),provide a good solution to the plastic pollution.However,these homopolymers suffer from limited structures and properties.Herein,we reported a fully chemical recyclable copolymer P(GBL-co-((R)-M))through ring-opening copolymerization(ROCOP)of GBL and(R)-M.By employing organomagnesium as the catalyst and regulating the reaction conditions,the chemical structures of copolymers were wellcontrolled(GBL content=13%-78%,Mn=6560-15600 g/mol,DM=1.08-1.59).The resultant P(GBL-co-((R)-M))exhibited fully chemical recyclability,which rapidly and quantitatively depolymerized into initial GBL and(R)-M monomer through chemolysis.By varying GBL content,tunable thermal properties were achieved for P(GBL-co-((R)-M)).The onset decomposition temperatures of copolymers varied from 193°C to 234°C.A linear evolution of glass transition temperature(T_(g))of P(GBL-co-((R)-M))versus GBL content was obtained as following equation of Tg=-1.06×GBL mol%×100+39.6.We hope that the reported fully chemical recyclable copolymers with tunable structures and properties would serve as the candidate material for sustainable applications. 展开更多
关键词 Poly(γ-butyrolactone)-based copolymers Ring-opening copolymerization Chemical recyclability Organomagnesium
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Samarium diiodide induced asymmetric synthesis of γ-butyrolactone using chiral auxiliaries derived from isosorbide and isomannide
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作者 徐明华 林国强 夏立钧 《Chinese Journal of Chemistry》 SCIE CAS CSCD 1998年第6期561-564,共0页
The asymmetric reductive coupling reaction of various acrylates derived from D-isosorbide and D-isomannide with acetophenone mediated by samarium diiodide to give both enantiomers of the optically active γ-butyrolact... The asymmetric reductive coupling reaction of various acrylates derived from D-isosorbide and D-isomannide with acetophenone mediated by samarium diiodide to give both enantiomers of the optically active γ-butyrolactone was described. The best enantiomeric excess of the products was 60%. 展开更多
关键词 Asymmetry Γ-butyrolactone ISOSORBIDE ISOMANNIDE samarium diiodide
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IONIC CONDUCTIVITY OF POLY (β-ALKOXYCARBONYLETHYLMETHYLSILOXANE)-LiClO_4 CROSSLINKED FILMS
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作者 李永军 吴留仁 +1 位作者 方世璧 江英彦 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1990年第2期127-132,共6页
Poly (β-carboxyethylmethylsiloxane)-LiClO_4 and poly (β-alkoxylethylmethylsiloxane)-LiClO_4 crosslinked fllms have been prepared. The ionic conductivity of the films depends on the polymer species, concentration of ... Poly (β-carboxyethylmethylsiloxane)-LiClO_4 and poly (β-alkoxylethylmethylsiloxane)-LiClO_4 crosslinked fllms have been prepared. The ionic conductivity of the films depends on the polymer species, concentration of lithium perchlorate, temperature and content of crosslinking agent. The effect of high polar organic solvent 1, 4-butyrolactone on the ionic conductivity and mechanical properties of poly (β-carhoxyethylmethylsiloxane )-LiClO_4 system was also investignied. 展开更多
关键词 Ionic conductivity: Poly(β-alkoxycarbonylethylmethylsiloxane)- Lithium Complex 1 4-butyrolactone Crosslinked film.
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Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases 被引量:8
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作者 Haowen Xu Jiahao Chen +7 位作者 Pan Chen Weifeng Li Jingjing Shao Shanshan Hong Yi Wang Lingfeng Chen Wu Luo Guang Liang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第2期678-693,共16页
The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussu... The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain unclear.Here,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 inflammasome.We declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation.We also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation.Taken together,NLRP3 is identified as a direct target of COS for its anti-inflammasome activity.COS,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound. 展开更多
关键词 COSTUNOLIDE NLRP3 inflammasome Inflammation Molecular target NACHT domain α-Methylene-γ-butyrolactone Gouty arthritis Ulcerative colitis
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Organocatalytic enantioselective construction of bicyclic γ-butrolactones
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作者 Qiang Zhang Jingxiang Pang +7 位作者 Tian-Zhang Wang Feng Chen Minghao Shen Tianyu Li Yongshuai Chai Yu-Feng Liang Jie Sun Zhushuang Bai 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第7期122-126,共5页
An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been established herein, which provides an efficient access to chiral bicyclic γ-butyrolactones in good yields, enantiosel... An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been established herein, which provides an efficient access to chiral bicyclic γ-butyrolactones in good yields, enantioselectivities and diastereoselectivities. Further transformations of product are demonstrated. A diamine mediated catalytic cycle is proposed. 展开更多
关键词 ORGANOCATALYST Asymmetric synthesis Bicyclicγ-butyrolactone DIAMINE CYCLIZATION
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Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387 被引量:7
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作者 Xiangxi Meng Wenzhao Wang +9 位作者 Zhoujie Xie Pengwei Li Yue Li Zhengyan Guo Yingjian Lu Jie Yang Kaile Guan Zhaoxin Lu Huarong Tan Yihua Chen 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第9期980-991,共12页
Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural applications.To elucidate the regulatory mechanism of neomycin biosynthesis,we completed draft genome sequencing of a neomycin pr... Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural applications.To elucidate the regulatory mechanism of neomycin biosynthesis,we completed draft genome sequencing of a neomycin producer Streptomyces fradiae CGMCC 4.7387 from marine sediments,and the neomycin biosynthesis gene cluster was identified.Inactivation of the afsA-g gene encoding a γ-butyrolactone(GBL) synthase in S.fradiae CGMCC 4.7387 resulted in a significant decrease of neomycin production.Quantitative RT-PCR analysis revealed that the transcriptional level of neoR and the aphA-neoGH operon were reduced in the afsA-g::aac(3)Ⅳ mutant.Interestingly,a conserved binding site of AdpA,a key activator in the GBL regulatory cascade,was discovered upstream of neoR,a putative regulatory gene encoding a protein with an ATPase domain and a tetratricopeptide repeat domain.When neoR was inactivated,the neomycin production was reduced about 40%in comparison with the WT strain.Quantitative RT-PCR analysis revealed that the transcriptional levels of genes in the aphA-neoGH operon were reduced clearly in the neoR::aac(3)Ⅳ mutant.Finally,the titers of neomycin were improved considerably by overexpression of qfsA-gand neoR in S.fradiae CGMCC 4.7387. 展开更多
关键词 NEOMYCIN REGULATION Γ-butyrolactone STREPTOMYCES
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Tautomerizations and intramolecular hydrogen bondings of the chiral α-nitroester, α-nitrosoester and α-ketoester
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作者 Fu’an Kang Chenglie Yin 《Chinese Science Bulletin》 SCIE EI CAS 1998年第18期1531-1536,共0页
Interesting and diverse tautomerizations and intramolecular hydrogen bondings of the chiral α-nitroester, α-nitrosoester and α-ketoester are described and rationally interpreted.
关键词 TAUTOMERIZATION INTRAMOLECULAR hydrogen BONDING α-ketoester γ-butyrolactone.
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Synthesis of Optically Active β-Alkyl-α-methylene-γ-butyro- lactones from Enantioselective Biotransformation of Nitriles, an Unusual Inversion of Enantioselectivity
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作者 赵生敏 王梅祥 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2002年第11期1291-1299,1129,共10页
A new approach to optically active β-alkyl-α-methylene-γ-butyrolactone derivatives was reported from the Rhodococcus sp. AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of th... A new approach to optically active β-alkyl-α-methylene-γ-butyrolactone derivatives was reported from the Rhodococcus sp. AJ270-catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced into the hydroxy group of the parent substrate. 展开更多
关键词 BIOTRANSFORMATION nitrile hydratase AMIDASE optically active β-alkyl-α-methylene-γ-butyrolactone inversion of enantioselectivity
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