西洋参总皂苷碱降解产物的分离及结构鉴定

从西洋参总皂苷碱降解产物中分离得到了5种化合物,经理化方法鉴定为人参皂苷Rh1(1),人参皂苷Rh2(2),人参皂苷Rk2(3),达玛烷型-20(21),24-二烯-3β,12β-二醇(4),人参皂苷Rg3(5);本研究同时还提供了化合物更多的理化数据.化合物3、4为首次从碱降解物中获得.

甘肃东紫苏的化学成分研究(Ⅰ)

目的研究东紫苏(Elsholtzia bodinieri)全草的化学成分。方法采用硅胶柱色谱及薄层色谱进行分离和纯化,通过理化性质和波谱数据分析鉴定其结构。结果从东紫苏全草的乙醇提取物中分离出6种化合物,分别鉴定为:三达右松脂-15-烯-8β,12β-二醇(1),表没食子儿茶素(2),小麦黄酮(3),金合欢素(4),槲皮素(5)和β-谷甾醇(6)。结论化合物1和2为首次从该属植物中分离得到。

The blood-brain barrier permeability of 20(S) and 20(R)-protopanaxatriol epimers and dammar-20(22)E,24-diene-3β,6α,12β-triol in MDCK-pHa MDR cell monolayer model

The blood-brain barrier permeability of 20（S） and 20（R）-protopanaxatriol epimers and dammar-20（22）E,24-diene- 313,6α,12β-triol were investigated using the MDCK-pHaMDR cell monolayer model. The bidirectional permeability tests were carried out, and the apparent permeability coefficients （Papp） were calculated. The two protopanaxatriol epimers showed good permeability with Papp values of-10^-5 cm/s, whereas dammar-20（22）E,24-diene-3β,6α, 12β-triol showed poor permeability with Papp of 〈1 × 10^-7 cm/s. The three compounds showed differences in intracellular accumulations due to their different structures. Inhibition of P-gp with verapamil showed that the transport mechanisms in MDCK-pHaMDR cell monolayer for compounds 1 and 2 epimers were not only simple passive diffusion but also involving an effiux way mediated by P-gp. These findings provided new basis for the further study of compounds 1 and 2 acting on the brain.

薤白中皂苷类化学成分研究

目的研究薤白Allii Macrostemonis Bulbus的皂苷类化学成分。方法采用正相、反相硅胶柱色谱进行分离纯化,根据理化性质和波谱数据分析鉴定化合物的结构。结果从薤白70%乙醇提取物中分离鉴定了3个皂苷类化合物,分别为5β-螺甾-25(27)-烯-3β,12β-二醇-3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃半乳糖苷(1)、(25R)-5β-螺甾-3β,12β-二醇-3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃半乳糖苷(2)、5β-螺甾-25(27)-烯-2β,3β-二醇-3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃半乳糖苷(3)。结论化合物1为1个新化合物,命名为薤白皂苷S,化合物2为首次从该植物中分离得到。