Serum proteins differentially expressed in gestational diabetes mellitus assessed using isobaric tag for relative and absolute quantitation proteomics

BACKGROUND As a well-known fact to the public,gestational diabetes mellitus(GDM)could bring serious risks for both pregnant women and infants.During this important investigation into the linkage between GDM patients and their altered expression in the serum,proteomics techniques were deployed to detect the differentially expressed proteins(DEPs)of in the serum of GDM patients to further explore its pathogenesis,and find out possible biomarkers to forecast GDM occurrence.METHODS Subjects were divided into GDM and normal control groups according to the IADPSG diagnostic criteria.Serum samples were randomly selected from four cases in each group at 24-28 wk of gestation,and the blood samples were identified by applying iTRAQ technology combined with liquid chromatography-tandem mass spectrometry.Key proteins and signaling pathways associated with GDM were identified by bioinformatics analysis,and the expression of key proteins in serum from 12 wk to 16 wk of gestation was further verified using enzyme-linked immunosorbent assay (ELISA).RESULTS Forty-seven proteins were significantly differentially expressed by analyzing the serum samples between the GDMgravidas as well as the healthy ones. Among them, 31 proteins were found to be upregulated notably and the rest16 proteins were downregulated remarkably. Bioinformatic data report revealed abnormal expression of proteinsassociated with lipid metabolism, coagulation cascade activation, complement system and inflammatory responsein the GDM group. ELISA results showed that the contents of RBP4, as well as ANGPTL8, increased in the serumof GDM gravidas compared with the healthy ones, and this change was found to initiate from 12 wk to 16 wk ofgestation.CONCLUSION GDM symptoms may involve abnormalities in lipid metabolism, coagulation cascade activation, complementsystem and inflammatory response. RBP4 and ANGPTL8 are expected to be early predictors of GDM.

Measurement and Analysis of Vibration Effect of Free-falling Corner Cube Driving Mechanism in Free Fall Absolute Gravimeter

The vibration interference of the reference corner cube runs through the free flight process of the free-falling corner cube,which is superimposed on the whole laser interference fringes.Thus,it is necessary to solve the interference fringes with the entire fringe to analyze the quantitative influence of vibration on gravity measurements.

Euler Product Expressions of Absolute Tensor Products of Dirichlet L-Functions

In this paper, we calculate the absolute tensor square of the Dirichlet L-functions and show that it is expressed as an Euler product over pairs of primes. The method is to construct an equation to link primes to a series which has the factors of the absolute tensor product of the Dirichlet L-functions. This study is a generalization of Akatsuka’s theorem on the Riemann zeta function, and gives a proof of Kurokawa’s prediction proposed in 1992.

A Novel Inverse-Free Neurodynamic Approach for Solving Absolute Value Equations

We propose a novel inverse-free neurodynamic approach (NIFNA) for solving absolute value equations (AVE). The NIFNA guarantees global convergence and notably improves convergence speed by achieving fixed-time convergence. To validate the theoretical findings, numerical simulations are conducted, demonstrating the effectiveness and efficiency of the proposed NIFNA.

Absolute Wall Thickness Measurement of Conducting Plates Using Pulsed Eddy Currents

The method using pulsed eddy currents to determine the thickness of a conduction plate is extended to enable the simultaneous measurement of the plate thickness and material properties. For optimal performance, a probe must be designed depending on the thickness range that should be accessible. The need for a calibration of the material properties of a conducting plate to enable the measurement of its thickness has been removed. All that is needed is a probe with known dimensions and suitable hardware to create a current pulse and measure a transient magnetic induction.

Research of the wave measurement using GPS absolute velocity estimation technology

This paper analyzed the existing methods of wave measurement, and described the advantages of GPS applied in measuring the wave. The equations of absolute velocity estimation were discussed, focusing on two methods with Doppler shill. The error sources and their effect on velocity estimation were analyzed. Then, some tests were carried on to simulate dynamic velocity determination using static data Based on the high-frequency carrier-phase derived Doppler observations, the velocity has been estimated to the precision of 1 cm/s or so, even to the mm/s level. And with the receiver generated Doppler measurements, the precision can reach 3 - 15 cm/s.

New criterion for delay-dependent absolute stability of Lurie system with interval time-varying delay

The delay-dependent absolute stability for a class of Lurie systems with interval time-varying delay is studied. By employing an augmented Lyapunov functional and combining a free-weighting matrix approach and the reciprocal convex technique, an improved stability condition is derived in terms of linear matrix inequalities （LMIs）. By retaining some useful terms that are usually ignored in the derivative of the Lyapunov function, the proposed sufficient condition depends not only on the lower and upper bounds of both the delay and its derivative, but it also depends on their differences, which has wider application fields than those of present results. Moreover, a new type of equality expression is developed to handle the sector bounds of the nonlinear function, which achieves fewer LMIs in the derived condition, compared with those based on the convex representation. Therefore, the proposed method is less conservative than the existing ones. Simulation examples are given to demonstrate the validity of the approach.

First acceptance testing of multiple A10 absolute gravimeters in China and analysis of the comparison results

Three A10 absolute gravimeters(AGs) were first acquired in China by the Hubei Earthquake Agency under the Belt and Road Seismic Monitoring Network Project. Although AG measuring and testing technique is not new, the purchase and simultaneous testing of 3 A10 absolute gravimeters is unprecedented in China. This study conducted the first acceptance testing of the AGs at 3 locations(the Jiufengshan Gravity Observation Station, the Global Navigation Satellite System Observation Station in Wuhan, and the Jiugongshan Observation Station in Xianning). The results were compared using a method based on expert validation, and the acceptance testing scheme was formulated by referring to the Technical Regulations for Tectonic Environment Monitoring Networks in China and Specifications for Gravimetry Control. Based on the repeatability, precision, and consistency of the measured g values, the results from each instrument were evaluated using the air pressure precision test. Comparing the instrument reference values, the final test results can identify the indicator parameters for 3 A10 AGs, the effects of the surrounding environment, and the related parameters on measurement precision. The precision of A10-059, A10-058, and A10-057 exceeded 0.78 μGal, 0.79 μGal, and 0.42 μGal, respectively.This testing scheme can be used as a reference for conducting acceptance testing of AGs in the future and obtaining absolute gravimetric measurements.

MULTIVARIATE ABSOLUTE DEGREE OF GREY INCIDENCE BASED ON DISTRIBUTION CHARACTERISTICS OF POINTS

The analysis result of absolute degree of grey incidence for multivariate time series is often inconsistent with the qualitative analysis. To overcome this shortage, a multivariate absolute degree of grey incidence based on distribution characteristics of points is proposed. Based on the geometric description of multivariate time se- ries, the neighborhood extrema are extracted in the different regions, and a characteristic point set is constructed. Then according to the distribution of the characteristic point set, a characteristic point sequence reflecting the ge- ometric features of multivariate time series is obtained. The incidence analysis between multivariate time series is transformed into the relational analysis between characteristic point sequences, and a grey incidence model is established. The model possesses the properties of translational invariance, transpose and rank transform invari- ance, and satisfies the grey incidence analysis axioms. Finally, two cases are studied and the results prove the ef- fectiveness of the model.

Absolute Exponential Stability of Generalized Dynamical Neural Networks

This paper investigates the absolute exponential stability of generalized neural networks with a general class of partially Lipschitz continuous and monotone increasing activation functions. The main obtained result is that if the interconnection matrix T of the neural system satisfies that - T is an H matrix with nonnegative diagonal elements, then the neural system is absolutely exponentially stable(AEST). The Hopfield network, Cellular neural network and Bidirectional associative memory network are special cases of the network model considered in this paper. So this work gives some improvements to the previous ones.

Empirical Bayes Absolute Error Loss Estimation for Parameter of One-Side Truncation Distribution Families

In this paper we propose an absolute error loss EB estimator for parameter of one-side truncation distribution families. Under some conditions we have proved that the convergence rates of its Bayes risk is o, where 0<λ,r≤1,Mn≤lnln n (for large n),Mn→∞ as n→∞.

极性强化词的语义走向——以absolutely为例

以absolutely为例,结合共时与历时主观化框架,对英语极性强化词的语义演化路径加以追踪,发现abso-lutely的意义体现了客观义<主观义<交互主观义的单向演进趋势。对照汉语对应成分"极",可以发现英汉对应范畴在语义演化路径上存在一定的共通性。

Existing conditions of full bandgaps and absolute negative refraction in metallic-dielectric photonic crystal

This paper has theoretically studied the characteristic frequencies of band structures in two-dimensional metallic- dielectric photonic crystals. It is demonstrated that a large filling fraction benefits the existence of absolute photonic band gap, while a smaller filling fraction benefits an absolute negative refraction band. In addition, it also finds that the relation between the cut-off frequency of E-polarized wave and the filling fraction exceeding 10% is content with a linear increasing function, whose coefficients are exponential to the normalized lattice constant. These investigations have significant implications for tuning the operational frequencies to desired applications and manufacturing photonic crystals.

Absolute Instability in Superlattice Miniband Transport

The possible absolute instability in superlattice miniband transport using the hydrodynamic balance equations for arbitrary energy dispersion is investigated.In contrast to the prediction of the drift-diffusion model that in doped semiconductor superlattices absolute instability occurs closely following the onset of negative differential mobility(NDM),the present analysis shows that a wide-miniband planar superlattice may become absolutely unstable only when it is biased deep in the NDM regime.This result is in agreement with recent experimental findings.

Field measurements of absolute gravity in East Antarctica

This paper reports the results of field-based absolute gravity measurements aimed at detecting gravity change and crustal displacement caused by glacial isostatic adjustment. The project was initiated within the framework of the 53rd Japanese Antarctic Research Expedition （JARE53）. Absolute gravity measurements, together with GPS measurements, were planned at several outcrops along the Prince Olav Coast and S6ya Coast of East Antarctica, including at Syowa Station. Since the icebreaker Shirase （AGB 5003） was unable to moor alongside Syowa Station, operations were somewhat restricted during JARE53. However, despite this setback, we were able to complete measurements at two sites： Syowa Station and Langhovde. The absolute gravity value at the Syowa Station IAGBN （A） site, observed using an FG-5 absolute gravimeter （serial number 210; FG-5 #210）, was 982 524 322.7＋0.1 ktGal, and the gravity change rate at the beginning of 2012 was -0.26 gGal.a-1. An absolute gravity value of 982 535 584.2~0.7 ktGal was obtained using a portable A-10 absolute gravimeter （serial number 017; A-10 #017） at the newly located site AGS01 in Langhovde.

Absolute Velocity and Total Stellar Aberration

It is generally accepted that stellar annual or secular aberration is attributed to the changes in velocity of the detector. We can say it in a slightly different way. By means of the all known experiments, stellar aberration is directly or indirectly detectable and measurable, only if a detector changes its velocity. Our presumption is that stellar aberration is not caused by the changes in the velocity of the detector. It exists due to the movement of the detector regarding to an absolute inertial frame. Therefore it is just the question of how to choose such a frame. In this paper it is proposed a method to detect and measure instantaneous stellar aberration due to absolute velocity. We can call it an “absolute” stellar aberration. Combining an “annual” and an “absolute” we can define a “total” stellar aberration.

Review of low timing jitter mode-locked fiber lasers and applications in dual-comb absolute distance measurement

Passively mode-locked fiber lasers emit femtosecond pulse trains with excellent short-term stability. The quantum-limited timing jitter of a free running femtosecond erbium-doped fiber laser working at room temperature is considerably below one femtosecond at high Fourier frequency. The ultrashort pulse train with ultralow timing jitter enables absolute time-of-flight measurements based on a dual-comb implementation, which is typically composed of a pair of optical frequency combs generated by femtosecond lasers. Dead-zone-free absolute distance measurement with sub-micrometer precision and kHz update rate has been routinely achieved with a dual-comb configuration, which is promising for a number of precision manufacturing applications, from large step-structure measurements prevalent in microelectronic profilometry to three coordinate measurements in large-scale aerospace manufacturing and shipbuilding. In this paper, we first review the sub-femtosecond precision timing jitter characterization methods and approaches for ultralow timing jitter mode-locked fiber laser design. Then, we provide an overview of the state-of-the-art dual-comb absolute ranging technology in terms of working principles, experimental implementations, and measurement precisions. Finally, we discuss the impact of quantum-limited timing jitter on the dual-comb ranging precision at a high update rate. The route to highprecision dual-comb range finder design based on ultralow jitter femtosecond fiber lasers is proposed.

A Mathematical Method for Determination of Absolute Adsorption from Experimental Isotherms of Supercritical Gases

A mathematical method was proposed for the determination of absolute adsorption from experimental isotherms. The method is based on the numerical equality of the absolute and the excess adsorption when either the gas phase density or the amount adsorbed is not quite considerable. The initial part of the experimentalisotherms, which represents the absolute adsorption, became linear with some mathematical manipulations. The linear isotherms were reliably formulated. As consequence, either the volume or the density of the supercritical adsorbate could be determined by a non-empirical way. This method was illustrated by the adsorption data of supercritical hydrogen and methane on a superactivated carbon in large ranges of temperature and pressure.

Axially variable-length solid element of absolute nodal coordinate formulation

An axially variable-length solid element with eight nodes is proposed by integrating the arbitrary Lagrangian-Eulerian (ALE) formulation and the absolute nodal coordinate formulation (ANCF). In addition to the nodal positions and slopes of eight nodes, two material coordinates in the axial direction are used as the generalized coordinates. As a consequence, the nodes in the ALE-ANCF are not associated with any specific material points and the axial length of the solid element can be varied over time. These two material coordinates give rise to a variable mass matrix and an additional inertial force vector. Computationally efficient formulae of the additional inertial forces and elastic forces, as well as their Jacobians, are also derived. The dynamic equation of a flexible multibody system (FMBS) with variable-length bodies is presented. The maximum and minimum lengths of the boundary elements of an FMBS have to be appropriately defined to ensure accuracy and non-singularity when solving the dynamic equation. Three numerical examples of static and dynamic problems are given to validate the variable-length solid elements of ALE-ANCF and show their capability.

Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer

AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers.