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A Study to Determine the Impact of Movies on Travel Intention: Anime Movies and Japan Sample
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作者 Hacl Mehmet Yildirim Pinar Yalcinkaya +2 位作者 Oyku Coker Abdurrahman Kucuk Nedim Gorman 《Journal of Tourism and Hospitality Management》 2017年第5期201-213,共13页
The link between film/drama-induced tourism and the Internet to promote the destination apart from purchase intention has been studied for a long while. By using cinema hall and television, cost-efficient promotion to... The link between film/drama-induced tourism and the Internet to promote the destination apart from purchase intention has been studied for a long while. By using cinema hall and television, cost-efficient promotion tools were shaped. Anime consisting of digital drawing techniques has been one of the most remarkable examples in terms of promotion of destination and culture as well. In this paper, to evaluate the travel intention of watchers in Turkish anime forums to Japan, open ended questions based on the model of purchase intention were presented to members and followers in two popular anime forums via the Internet. The responses of 31 participants were analyzed. The results demonstrated that participants' purchase intention has been enhanced as the consequence of watching anime series. 展开更多
关键词 film tourism anime tourism travel intention
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The Anime Subculture and Socialist Core Value System
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作者 Lihua Wang 《International English Education Research》 2014年第10期31-33,共3页
The rise of the anirne subculture assembles the huge youth groups in the construction of the socialist core value system, and provides a new carrier and injected into the innovative dynamic. At the same time, their pe... The rise of the anirne subculture assembles the huge youth groups in the construction of the socialist core value system, and provides a new carrier and injected into the innovative dynamic. At the same time, their perverse behavior and exaggerated style of dress and the strange language constitute the alienation and challenges of a core value system. It should strengthen the ideological review and classification management, with the criticism of the mainstream media to enhance the vigilance of the community, as well as through commercial activities to digest rebel style, which is the effective way to promote the core value system. 展开更多
关键词 anime Subculture Socialist Core Value System STYLE Subcultural Capital Incorporated
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Zoom In ANIME SEASON
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《音乐世界》 2009年第20期93-103,共11页
ANIME SEASON,最不缺的是人气,每部大作都请来当红明星,“献声”演绎,就怕你光顾着动画,忘记了到底那是谁的声音,所以最后要记得check华丽的配音名单。
关键词 anime SEASON 动画片 配音 阿童木
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The Conflict of Realism and Surrealism in Anime Movies - Taking the Works of Hayao Miyazaki as Examples
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作者 Xianfeng Gong Bin Li 《Journal of Contemporary Educational Research》 2021年第12期104-108,共5页
Anime movie is a branch of cinematics.Unlike traditional movies,anime movies stand out with special characteristics in terms of how they shape the personality of the characters and how they portray the inner world of ... Anime movie is a branch of cinematics.Unlike traditional movies,anime movies stand out with special characteristics in terms of how they shape the personality of the characters and how they portray the inner world of those characters.“Realism”and“surrealism”are important elements in anime movies to portray the stories.In this article,the special aesthetic of anime movies is analyzed using the works produced by Hayao Miyazaki.The internal conflict between“realism”and“surrealism”is analyzed in order to understand the character image and story theme in an in-depth manner. 展开更多
关键词 anime movie REALISM SURREALISM Hayao Miyazaki
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AnimeNet: A Deep Learning Approach for Detecting Violence and Eroticism in Animated Content
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作者 Yixin Tang 《Computers, Materials & Continua》 SCIE EI 2023年第10期867-891,共25页
Cartoons serve as significant sources of entertainment for children and adolescents.However,numerous animated videos contain unsuitable content,such as violence,eroticism,abuse,and vehicular accidents.Current content ... Cartoons serve as significant sources of entertainment for children and adolescents.However,numerous animated videos contain unsuitable content,such as violence,eroticism,abuse,and vehicular accidents.Current content detection methods rely on manual inspection,which is resource-intensive,time-consuming,and not always reliable.Therefore,more efficient detection methods are necessary to safeguard young viewers.This paper addresses this significant problem by proposing a novel deep learning-based system,AnimeNet,designed to detect varying degrees of violent and erotic content in videos.AnimeNet utilizes a novel Convolutional Neural Network(CNN)model to extract image features effectively,classifying violent and erotic scenes in videos and images.The novelty of the work lies in the introduction of a novel channel-spatial attention module,enhancing the feature extraction performance of the CNN model,an advancement over previous efforts in the literature.To validate the approach,I compared AnimeNet with state-of-the-art classification methods,including ResNet,RegNet,ConvNext,ViT,and MobileNet.These were used to identify violent and erotic scenes within specific video frames.The results showed that AnimeNet outperformed these models,proving it to be well-suited for real-time applications in videos or images.This work presents a significant leap forward in automatic content detection in animation,offering a high-accuracy solution that is less resource-intensive and more reliable than current methods.The proposed approach enables it possible to better protect young audiences from exposure to unsuitable content,underlining its importance and potential for broad social impact. 展开更多
关键词 Computer vision ANIMATION deep learning classification attention mechanism
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Continual few-shot patch-based learning for anime-style colorization
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作者 Akinobu Maejima Seitaro Shinagawa +4 位作者 Hiroyuki Kubo Takuya Funatomi Tatsuo Yotsukura Satoshi Nakamura Yasuhiro Mukaigawa 《Computational Visual Media》 SCIE EI CSCD 2024年第4期705-723,共19页
The automatic colorization of anime line drawings is a challenging problem in production pipelines.Recent advances in deep neural networks have addressed this problem;however,collectingmany images of colorization targ... The automatic colorization of anime line drawings is a challenging problem in production pipelines.Recent advances in deep neural networks have addressed this problem;however,collectingmany images of colorization targets in novel anime work before the colorization process starts leads to chicken-and-egg problems and has become an obstacle to using them in production pipelines.To overcome this obstacle,we propose a new patch-based learning method for few-shot anime-style colorization.The learning method adopts an efficient patch sampling technique with position embedding according to the characteristics of anime line drawings.We also present a continuous learning strategy that continuously updates our colorization model using new samples colorized by human artists.The advantage of our method is that it can learn our colorization model from scratch or pre-trained weights using only a few pre-and post-colorized line drawings that are created by artists in their usual colorization work.Therefore,our method can be easily incorporated within existing production pipelines.We quantitatively demonstrate that our colorizationmethod outperforms state-of-the-art methods. 展开更多
关键词 anime COLORIZATION few-shot learning continuous learning strategy
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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics
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作者 Pieter-Jan Serneels Julie D.De Schutter +2 位作者 Lies De Groef Lieve Moons Steven Bergmans 《Neural Regeneration Research》 SCIE CAS 2025年第11期3179-3192,共14页
Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and oligodendrocytes.However,recent studies employing single-cell RNA sequencing techniques have ... Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and oligodendrocytes.However,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing terminology.Going forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature oligodendrocytes.This new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological contexts.Adopting this uniform terminology will facilitate comparison and integration of data across studies.This,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating diseases.Additionally,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination failure.Thus,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction. 展开更多
关键词 animal models DEMYELINATION fish MAMMALS multiple sclerosis MYELIN neurodegeneration OLIGODENDROCYTES oligodendroglial lineage REMYELINATION
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Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration
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作者 Prajakta Deshpande Anuradha Venkatakrishnan Chimata Amit Singh 《Neural Regeneration Research》 SCIE CAS 2025年第10期2862-2871,共10页
Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivo... Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration. 展开更多
关键词 acetyl-coenzyme A Alzheimer’s disease animal models cell death DROSOPHILA eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 NEURODEGENERATION
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Anime4K算法在广电超分辨率中的应用分析
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作者 张华权 张林 《市场周刊·理论版》 2019年第49期131-132,共2页
本文通过介绍Anime4K算法的基本特性,通过新闻、体育赛事、动漫等特定图像场景下,Anime4K超分算法与人工智能AI传统图像超分的性能对比分析,得出适用于广电前端的应用场景。
关键词 超分辨率 人工智能 anime4K算法
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Jungle Animals
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作者 Rhonda Telfer 《空中英语教室(初级版.大家说英语)》 2025年第1期40-43,55,56,共6页
A jungle is full of life.You can sometimes see exhibits of jungle animals and learn about them.Monkeys play in jungle trees.Colorful parrots fly and call to one another.Black and orange tigers hunt under the trees.
关键词 ORANGE SOMETIMES ANIMALS
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Animated by Anime
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作者 Li Xiaoyang 《Beijing Review》 2023年第31期42-43,共2页
How the animation industry has boosted Xiamen City Animated movie Ne Zha rocked the Chinese box office in 2019.Based on the Chinese mythical figure of the same name,the main character,shaped as an antihero,soon attrac... How the animation industry has boosted Xiamen City Animated movie Ne Zha rocked the Chinese box office in 2019.Based on the Chinese mythical figure of the same name,the main character,shaped as an antihero,soon attracted many Chinese and even overseas fans.At the climax of the story,Ne Zha uses his superpowers to hold and melt a huge block of ice to save people from being crushed by it. 展开更多
关键词 XIAMEN SHAPED Animate
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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis 被引量:4
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作者 Jong Mi Park Masoud Rahmati +2 位作者 Sang Chul Lee Jae Il Shin Yong Wook Kim 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1584-1592,共9页
Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse ... Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols. 展开更多
关键词 ANIMAL animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation
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Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations 被引量:5
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作者 Shun Wang Peng Zhang +12 位作者 Fan Fei Tianyang Tong Xiujuan Zhou Yajie Zhou Jing Zhang Mengke Wei Yanqi Zhang Lei Zhang Yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie 《Zoological Research》 SCIE CSCD 2024年第1期69-78,共10页
Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity i... Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions. 展开更多
关键词 Homing and migration Animal navigation Magnetoreceptor(MagR) Diverse navigation pattern Conserved protein
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Cell reprogramming therapy for Parkinson’s disease 被引量:6
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作者 Wenjing Dong Shuyi Liu +1 位作者 Shangang Li Zhengbo Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第11期2444-2455,共12页
Parkinson’s disease is typically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta.Many studies have been performed based on the supplementation of lost dopaminergic ... Parkinson’s disease is typically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta.Many studies have been performed based on the supplementation of lost dopaminergic neurons to treat Parkinson’s disease.The initial strategy for cell replacement therapy used human fetal ventral midbrain and human embryonic stem cells to treat Parkinson’s disease,which could substantially alleviate the symptoms of Parkinson’s disease in clinical practice.However,ethical issues and tumor formation were limitations of its clinical application.Induced pluripotent stem cells can be acquired without sacrificing human embryos,which eliminates the huge ethical barriers of human stem cell therapy.Another widely considered neuronal regeneration strategy is to directly reprogram fibroblasts and astrocytes into neurons,without the need for intermediate proliferation states,thus avoiding issues of immune rejection and tumor formation.Both induced pluripotent stem cells and direct reprogramming of lineage cells have shown promising results in the treatment of Parkinson’s disease.However,there are also ethical concerns and the risk of tumor formation that need to be addressed.This review highlights the current application status of cell reprogramming in the treatment of Parkinson’s disease,focusing on the use of induced pluripotent stem cells in cell replacement therapy,including preclinical animal models and progress in clinical research.The review also discusses the advancements in direct reprogramming of lineage cells in the treatment of Parkinson’s disease,as well as the controversy surrounding in vivo reprogramming.These findings suggest that cell reprogramming may hold great promise as a potential strategy for treating Parkinson’s disease. 展开更多
关键词 animal models ASTROCYTES AUTOLOGOUS cell reprogramming cell therapy direct lineage reprogramming dopaminergic neurons induced pluripotent stem cells non-human primates Parkinson’s disease
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Genetically modified non-human primate models for research on neurodegenerative diseases 被引量:2
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作者 Ming-Tian Pan Han Zhang +1 位作者 Xiao-Jiang Li Xiang-Yu Guo 《Zoological Research》 SCIE CSCD 2024年第2期263-274,共12页
Neurodegenerative diseases(NDs)are a group of debilitating neurological disorders that primarily affect elderly populations and include Alzheimer's disease(AD),Parkinson's disease(PD),Huntington's disease(... Neurodegenerative diseases(NDs)are a group of debilitating neurological disorders that primarily affect elderly populations and include Alzheimer's disease(AD),Parkinson's disease(PD),Huntington's disease(HD),and amyotrophic lateral sclerosis(ALS).Currently,there are no therapies available that can delay,stop,or reverse the pathological progression of NDs in clinical settings.As the population ages,NDs are imposing a huge burden on public health systems and affected families.Animal models are important tools for preclinical investigations to understand disease pathogenesis and test potential treatments.While numerous rodent models of NDs have been developed to enhance our understanding of disease mechanisms,the limited success of translating findings from animal models to clinical practice suggests that there is still a need to bridge this translation gap.Old World nonhuman primates(NHPs),such as rhesus,cynomolgus,and vervet monkeys,are phylogenetically,physiologically,biochemically,and behaviorally most relevant to humans.This is particularly evident in the similarity of the structure and function of their central nervous systems,rendering such species uniquely valuable for neuroscience research.Recently,the development of several genetically modified NHP models of NDs has successfully recapitulated key pathologies and revealed novel mechanisms.This review focuses on the efficacy of NHPs in modeling NDs and the novel pathological insights gained,as well as the challenges associated with the generation of such models and the complexities involved in their subsequent analysis. 展开更多
关键词 NEURODEGENERATION Non-human primate Macaque monkey Animal model Gene modification
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Knee osteoarthritis:A review of animal models and intervention of traditional Chinese medicine 被引量:2
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作者 Xuyu Song Ying Liu +5 位作者 Siyi Chen Lei Zhang Huijie Zhang Xianhui Shen Hang Du Rong Sun 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第2期114-126,共13页
Background:Knee osteoarthritis(KOA)characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults.The pathophysiology of KOA remains poo... Background:Knee osteoarthritis(KOA)characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults.The pathophysiology of KOA remains poorly understood,as it involves complex mechanisms that result in the same outcome.Consequently,researchers are interested in studying KOA and require appropriate animal models for basic research.Chinese herbal compounds,which consist of multiple herbs with diverse pharmacological properties,possess characteristics such as multicomponent,multipathway,and multitarget effects.The potential benefits in the treatment of KOA continue to attract attention.Purpose:This study aims to provide a comprehensive overview of the advantages,limitations,and specific considerations in selecting different species and methods for KOA animal models.This will help researchers make informed decisions when choosing an animal model.Methods:Online academic databases(e.g.,PubMed,Google Scholar,Web of Science,and CNKI)were searched using the search terms“knee osteoarthritis,”“animal models,”“traditional Chinese medicine,”and their combinations,primarily including KOA studies published from 2010 to 2023.Results:Based on literature retrieval,this review provides a comprehensive overview of the methods of establishing KOA animal models;introduces the current status of advantages and disadvantages of various animal models,including mice,rats,rabbits,dogs,and sheep/goats;and presents the current status of methods used to establish KOA animal models.Conclusion:This study provides a review of the animal models used in recent KOA research,discusses the common modeling methods,and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA. 展开更多
关键词 animal models knee osteoarthritis system review traditional Chinese medicine
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The application of omics technologies for understanding tropical plants-based bioactive compounds in ruminants:a review 被引量:1
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作者 Metha Wanapat Gamonmas Dagaew +5 位作者 Sukruthai Sommai Maharach Matra Chaichana Suriyapha Rittikeard Prachumchai Uswatun Muslykhah Srisan Phupaboon 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第4期1376-1390,共15页
Finding out how diet impacts health and metabolism while concentrating on the functional qualities and bioactive components of food is the crucial scientific objective of nutritional research. The complex relationship... Finding out how diet impacts health and metabolism while concentrating on the functional qualities and bioactive components of food is the crucial scientific objective of nutritional research. The complex relationship between metabolism and nutrition could be investigated with cutting-edge "omics" and bioinformatics techniques. This review paper provides an overview of the use of omics technologies in nutritional research, with a particular emphasis on the new applications of transcriptomics, proteomics, metabolomics, and genomes in functional and biological activity research on ruminant livestock and products in the tropical regions. A wealth of knowledge has been uncovered regarding the regulation and use of numerous physiological and pathological processes by gene, m RNA, protein, and metabolite expressions under various physiological situations and guidelines. In particular, the components of meat and milk were assessed using omics research utilizing the various methods of transcriptomics, proteomics, metabolomics, and genomes. The goal of this review is to use omics technologies—which have been steadily gaining popularity as technological tools—to develop new nutritional, genetic, and leadership strategies to improve animal products and their quality control. We also present an overview of the new applications of omics technologies in cattle production and employ nutriomics and foodomics technologies to investigate the microbes in the rumen ecology. Thus, the application of state-of-the-art omics technology may aid in our understanding of how species and/or breeds adapt, and the sustainability of tropical animal production, in the long run, is becoming increasingly important as a means of mitigating the consequences of climate change. 展开更多
关键词 Animal nutrition Animal production Cutting-edge Molecular markers RUMINANTS
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Occurrence of microcystins in water,sediment,and aquatic animals in Dau Tieng Reservoir,Vietnam 被引量:1
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作者 Thanh Luu PHAM Manh Ha BUI +1 位作者 Tan Duc NGUYEN Thanh Son DAO 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第6期1751-1763,共13页
This study investigates the variations of microcystins(MCs)in water,cyanobacterial blooms,sediment,and aquatic organisms collected from the Dau Tieng Reservoir(DTR).Vietnam.Highperformance liquid chromatography(HPLC)w... This study investigates the variations of microcystins(MCs)in water,cyanobacterial blooms,sediment,and aquatic organisms collected from the Dau Tieng Reservoir(DTR).Vietnam.Highperformance liquid chromatography(HPLC)was employed to measure MC concentrations in various target samples.Results indicate that Microcystis spp.dominates as the primary MC producer in the DTR.The average concentrations of analyzed MCs in surface water ranged from 1.10 to 5.54μg/L,temporally and spatially.In sediment,average concentrations varied from 0.15 to 1.13μg/g wet weight(WW)temporally and from 0.41 to 0.72μg/g WW spatially.MCs were detected in different organs of fish species(Oreochromis sp.and Labiobarbus sp.)and in the entire soft tissues of bivalve(Corbicula sp.)and gastropod(Assiminea sp.).The highest observed MC concentration in July was 0.83±0.22μg/g WW in the intestines of fish Oreochromis sp.The presence of MCs in grass shrimp Palaemonetes sp.was observed solely in June,reaching a concentration of 0.28±0.19μg/g WW.This is the first report of MC accumulation in the grass shrimp Palaemonetes sp.during field collection.For the bivalve Corbicula sp.,the presence of analyzed MCs was consistent throughout the study period,except for March and September,with the highest concentrations in July at 0.77±0.1μg/g WW.Pearson correlation analysis revealed significant positive correlations between MCs in water and sediment with MC concentrations in aquatic animals,indicating the potential transfer of MCs across different trophic levels.The estimated daily intake values for analyzed MCs indicate that fish collected from the DTR are considered safe for consumption,as long as only the edible organs,such as the muscle,are consumed.However,bivalves or gastropods collected from the DTR are not safe for human consumption.This study underscored the importance of monitoring MC accumulation in aquatic animals used as food to mitigate adverse effects on human health. 展开更多
关键词 aquatic animal BIOACCUMULATION CYANOTOXIN health risk toxic cyanobacteria
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Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review 被引量:1
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作者 Bo Han Weishi Liang +4 位作者 Yong Hai Duan Sun Hongtao Ding Yihan Yang Peng Yin 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期563-570,共8页
Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the i... Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and behavior.Very few studies have been published on the specific characteristics of distraction spinal cord injury.In this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this disease.In addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury.We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease. 展开更多
关键词 animal models behavior DISTRACTION heterogeneity HISTOLOGY mechanism NEUROPHYSIOLOGY spinal cord injury systematic review tension
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Decoding the Molecular Mechanisms of BRAFV600E-Induced Nevi Formation 被引量:1
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作者 Weizheng Liang Yuxuan Liu +2 位作者 Dandan Xu Wenjie Jiang Rensen Ran 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第7期774-784,共11页
Melanocytes derived from neural crest cells harbor the BRAFV600E mutation,which is the predominant driver of nevus formation in humans.This mutation leads to malignant cell proliferation and subsequent cell cycle arre... Melanocytes derived from neural crest cells harbor the BRAFV600E mutation,which is the predominant driver of nevus formation in humans.This mutation leads to malignant cell proliferation and subsequent cell cycle arrest,culminating in oncogene-induced senescence and nevus development.Nevertheless,emerging evidence has highlighted the heterogeneity of cellular senescence markers in BRAFV600E-induced senescent melanocytes.Moreover,the capacity of melanocytes within nevi to regain their proliferative ability raises questions about the molecular mechanisms by which BRAFV600E,via the mitogen-activated protein kinase signaling pathway,triggers nevus formation.This study provides an overview and discussion of the molecular mechanisms underpinning BRAFV600E-induced melanocyte nevus formation and the relevant animal models employed for their elucidation.It also highlights the significance of elucidating dynamic changes in cytoplasmic and nuclear substrates that interact with phosphorylated extracellular signal-regulated protein kinases 1 and 2 and underscores the value of using targeted BRAFV600E animal models created through gene editing technologies. 展开更多
关键词 BRAFV600E MELANOCYTES NEVI Oncogene-induced senescence Animal models
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