A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle cells（VSMC） vegetation activities were evaluated by the 3-（4,5-dimethylthlazol-2-yl）-2,5- dipheny...A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle cells（VSMC） vegetation activities were evaluated by the 3-（4,5-dimethylthlazol-2-yl）-2,5- diphenyltetrazolium bromide（MTT） method with tetrandrine as a positive contrast drug. The structures of the com- pounds were confirmed by 1H NMR, 13C NMR and electrospray ionization mass spectrometry（ESI-MS）. Several new compounds exhibited promising activity against VSMC proliferation and the preliminary structure-activity relation- ships（SAR） were discussed in order to investigate the essential structures required for their bioactivities.展开更多
基金Supported by the National Natural Science Foundation of China(No.81172938)the Program for the Top Science and Technology Innovation Teams of Higher Learning Institutions of Shanxi Province,China+1 种基金the Shanxi Foundation for Overseas Returned,China(No.2008-51)the Program for the Top Young and Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi Province,China
文摘A series of new aurone derivatives was prepared by means of a practical route and their anti-vascular smooth muscle cells（VSMC） vegetation activities were evaluated by the 3-（4,5-dimethylthlazol-2-yl）-2,5- diphenyltetrazolium bromide（MTT） method with tetrandrine as a positive contrast drug. The structures of the com- pounds were confirmed by 1H NMR, 13C NMR and electrospray ionization mass spectrometry（ESI-MS）. Several new compounds exhibited promising activity against VSMC proliferation and the preliminary structure-activity relation- ships（SAR） were discussed in order to investigate the essential structures required for their bioactivities.
