AIM： To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B （CHB）. METHODS： A total of 137 consecutive ...AIM： To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B （CHB）. METHODS： A total of 137 consecutive patients with CriB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were divided into two groups according to their aminotransferase （ALT） level. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, the likelihood ratio （LR） of aminotransferase/platelet ratio index （APRI） ≥ 1.5 or 〈 1.5 in combination with different hyaluronic acid （HA） cut-off points were calculated for the presence of moderate to severe fibrosis/cirrhosis （fibrosis stages 2 and 4） and no to mild fibrosis/cirrhosis （fibrosis stages 0 and 1）. RESULTS： The APRI correlated with fibrosis stage in CriB patients. The APRI ≥1.5 in combination with a cut-off HA cut-off point 〉 300 ng/mL could detect moderate to severe fibrosis （stages 2-4） in Crib patients. The PPV was 93.7%, the specificity was 98.9%. The APRI 〈 1.5 in combination with different HA cut-off points could not detect no to mild fibrosis in CHB patients. CONCLUSION： The APRI ≥ 1.5 in combination with a HA cut-off point 〉 300 ng/mL can detect moderate to severe fibrosis （stages 2-4） in Crib patients.展开更多
2-Acrylamido-2-methyl-1-propanesulfonic acid （AMPS）, and maleic acid （MA） copolymerized with different feed ratios using N,N-dimethylformamide as a solvent and benzoyl peroxide （Bz2O2） as an initiator at 70℃. S...2-Acrylamido-2-methyl-1-propanesulfonic acid （AMPS）, and maleic acid （MA） copolymerized with different feed ratios using N,N-dimethylformamide as a solvent and benzoyl peroxide （Bz2O2） as an initiator at 70℃. Structure and composition of copolymers for a wide range of monomer feed were determined by elemental analysis （content of N for AMPS-units）. Monomer reactivity ratios for AMPS （M1）-MA （M2） pair were determined by the application of conventional linearization methods such as Fineman-Ross （F-R）, Kelen-Tudos（KT） and Extended Kelen-Tudos （EKT） and a nonlinear error invariable model method using a computer program RREVM. The characterizations were done by Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC） thermal gravimetry analysis （TGA）, and and X-ray diffraction. The antimicrobial effects of polymers were also tested on various bacteria, and yeast.展开更多
The changes of tissue appearances and structures in the process of UV-induced ＂melting＂ for sea cucumber （Stichopus japonicus） body wall were studied. And the localization and determination of acid phosphatase （...The changes of tissue appearances and structures in the process of UV-induced ＂melting＂ for sea cucumber （Stichopus japonicus） body wall were studied. And the localization and determination of acid phosphatase （ACP）, Cathepsin B and Cathepsin L activities were also investigated. The results show that the connective tissue was damaged with many hollows emerging and the regular collagen bundles were broken apart into irregular fragments. Margination of condensed chromatin at the nuclear membrane was observed. Both Golgi＇s body and endoplasmic reticulure swelled, curled, and eventually double- or multi-lamellar vesicles were formed. A number of autophagic vesicles distributed in all through the whole cytoplasm. ACP becomes more active after UV irradiation. The activities of cathepsin B and cathepsin L increased in UV-treated sea cucumbers and both achieved their maximum under certain conditions, It indicates that autophagy plays a potential role in the ＂melting＂ process for sea cucumber body wall induced by UV irradiation.展开更多
目的探讨血尿酸(UA)、N末端B型利钠肽原(NT-proBNP)、血小板与淋巴细胞比值(PLR)在急性脑梗死(AIS)静脉溶栓中动态变化及意义。方法选取沧州市人民医院105例AIS患者,均行静脉溶栓治疗,根据发病90 d改良Rankin量表评分(mRS)分为预后不良...目的探讨血尿酸(UA)、N末端B型利钠肽原(NT-proBNP)、血小板与淋巴细胞比值(PLR)在急性脑梗死(AIS)静脉溶栓中动态变化及意义。方法选取沧州市人民医院105例AIS患者,均行静脉溶栓治疗,根据发病90 d改良Rankin量表评分(mRS)分为预后不良组(n=26)、良好组(n=79),比较两组溶栓前、溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平及发病90 d mRS评分,分析预后的相关影响因素,并分析溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平与发病90 d mRS评分关系及预测预后不良的价值。结果不良组溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平均高于良好组,差异有统计学意义(P<0.05);不良组发病后90 d mRS评分高于良好组,差异有统计学意义(P<0.05);溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平与发病后90 d mRS评分间存在正相关关系(P<0.05),与AIS患者预后显著相关(P<0.05);溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR预测AIS患者预后不良的曲线下面积(AUC)均>0.7,溶栓后7 d各指标联合预测的AUC最大,为0.953。结论UA、NT-proBNP、PLR水平在脑梗死静脉溶栓中随着病情改善逐渐降低,与患者预后显著相关,可辅助临床预测患者预后转归方向。展开更多
Background: The use of feed grade amino acids can reduce the cost of lactation feed. With changing genetics,increasing feed costs, and higher number of pigs weaned with heavier wean weights further evaluation of highe...Background: The use of feed grade amino acids can reduce the cost of lactation feed. With changing genetics,increasing feed costs, and higher number of pigs weaned with heavier wean weights further evaluation of higher inclusion levels of feed-grade amino acid in lactation diets than previously published is warranted. Two experiments(Exp.) were conducted to determine the optimal inclusion level of L-lysine HCl to be included in swine lactation diets while digestible lysine levels remain constant across dietary treatments and allowing feed grade amino acids to be added to the diet to maintain dietary ratios relative to lysine to maximize litter growth rate and sow reproductive performance. Furthermore, the studies were to evaluate minimal amino acid ratios relative to lysine that allows for optimal litter growth rate and sow reproductive performance.Results: Exp. 1: Increasing L-lysine HCl resulted in similar gilt feed intake, litter, and reproductive performance.Average litter gain from birth to weaning was 2.51, 2.49, 2.59, 2.43, and 2.65 kg/d when gilts were fed 0.00, 0.075,0.150, 0.225, and 0.30% L-lysine HCl, respectively. Exp. 2: The average litter gain from birth to weaning was 2.68,2.73, 2.67, 2.70, and 2.64 kg/d(P < 0.70) when sows were fed 0.1, 0.2, 0.3, 0.4, and 0.4% L-lysine HCl plus valine,respectively. No other differences among dietary treatments were observed.Conclusions: Collectively, these studies demonstrate corn-soybean meal based lactation diets formulated with a constant SID lysine content for all parities containing up to 0.40% L-lysine HCl with only supplemental feed grade threonine and a methionine source have no detrimental effect on litter growth rate and subsequent total born.展开更多
文摘AIM： To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B （CHB）. METHODS： A total of 137 consecutive patients with CriB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were divided into two groups according to their aminotransferase （ALT） level. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, the likelihood ratio （LR） of aminotransferase/platelet ratio index （APRI） ≥ 1.5 or 〈 1.5 in combination with different hyaluronic acid （HA） cut-off points were calculated for the presence of moderate to severe fibrosis/cirrhosis （fibrosis stages 2 and 4） and no to mild fibrosis/cirrhosis （fibrosis stages 0 and 1）. RESULTS： The APRI correlated with fibrosis stage in CriB patients. The APRI ≥1.5 in combination with a cut-off HA cut-off point 〉 300 ng/mL could detect moderate to severe fibrosis （stages 2-4） in Crib patients. The PPV was 93.7%, the specificity was 98.9%. The APRI 〈 1.5 in combination with different HA cut-off points could not detect no to mild fibrosis in CHB patients. CONCLUSION： The APRI ≥ 1.5 in combination with a HA cut-off point 〉 300 ng/mL can detect moderate to severe fibrosis （stages 2-4） in Crib patients.
文摘2-Acrylamido-2-methyl-1-propanesulfonic acid （AMPS）, and maleic acid （MA） copolymerized with different feed ratios using N,N-dimethylformamide as a solvent and benzoyl peroxide （Bz2O2） as an initiator at 70℃. Structure and composition of copolymers for a wide range of monomer feed were determined by elemental analysis （content of N for AMPS-units）. Monomer reactivity ratios for AMPS （M1）-MA （M2） pair were determined by the application of conventional linearization methods such as Fineman-Ross （F-R）, Kelen-Tudos（KT） and Extended Kelen-Tudos （EKT） and a nonlinear error invariable model method using a computer program RREVM. The characterizations were done by Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC） thermal gravimetry analysis （TGA）, and and X-ray diffraction. The antimicrobial effects of polymers were also tested on various bacteria, and yeast.
基金the National Natural Science Foundation of China(30571449)the National Basic Research Program of China (2006CB708210)the Chinese International Corporation Project (2006DFA32580)
文摘The changes of tissue appearances and structures in the process of UV-induced ＂melting＂ for sea cucumber （Stichopus japonicus） body wall were studied. And the localization and determination of acid phosphatase （ACP）, Cathepsin B and Cathepsin L activities were also investigated. The results show that the connective tissue was damaged with many hollows emerging and the regular collagen bundles were broken apart into irregular fragments. Margination of condensed chromatin at the nuclear membrane was observed. Both Golgi＇s body and endoplasmic reticulure swelled, curled, and eventually double- or multi-lamellar vesicles were formed. A number of autophagic vesicles distributed in all through the whole cytoplasm. ACP becomes more active after UV irradiation. The activities of cathepsin B and cathepsin L increased in UV-treated sea cucumbers and both achieved their maximum under certain conditions, It indicates that autophagy plays a potential role in the ＂melting＂ process for sea cucumber body wall induced by UV irradiation.
文摘目的探讨血尿酸(UA)、N末端B型利钠肽原(NT-proBNP)、血小板与淋巴细胞比值(PLR)在急性脑梗死(AIS)静脉溶栓中动态变化及意义。方法选取沧州市人民医院105例AIS患者,均行静脉溶栓治疗,根据发病90 d改良Rankin量表评分(mRS)分为预后不良组(n=26)、良好组(n=79),比较两组溶栓前、溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平及发病90 d mRS评分,分析预后的相关影响因素,并分析溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平与发病90 d mRS评分关系及预测预后不良的价值。结果不良组溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平均高于良好组,差异有统计学意义(P<0.05);不良组发病后90 d mRS评分高于良好组,差异有统计学意义(P<0.05);溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR水平与发病后90 d mRS评分间存在正相关关系(P<0.05),与AIS患者预后显著相关(P<0.05);溶栓后24 h、溶栓后7 d UA、NT-proBNP、PLR预测AIS患者预后不良的曲线下面积(AUC)均>0.7,溶栓后7 d各指标联合预测的AUC最大,为0.953。结论UA、NT-proBNP、PLR水平在脑梗死静脉溶栓中随着病情改善逐渐降低,与患者预后显著相关,可辅助临床预测患者预后转归方向。
基金PICAjinomoto HeartlandNovus International listed in the author section fully financially supported this study
文摘Background: The use of feed grade amino acids can reduce the cost of lactation feed. With changing genetics,increasing feed costs, and higher number of pigs weaned with heavier wean weights further evaluation of higher inclusion levels of feed-grade amino acid in lactation diets than previously published is warranted. Two experiments(Exp.) were conducted to determine the optimal inclusion level of L-lysine HCl to be included in swine lactation diets while digestible lysine levels remain constant across dietary treatments and allowing feed grade amino acids to be added to the diet to maintain dietary ratios relative to lysine to maximize litter growth rate and sow reproductive performance. Furthermore, the studies were to evaluate minimal amino acid ratios relative to lysine that allows for optimal litter growth rate and sow reproductive performance.Results: Exp. 1: Increasing L-lysine HCl resulted in similar gilt feed intake, litter, and reproductive performance.Average litter gain from birth to weaning was 2.51, 2.49, 2.59, 2.43, and 2.65 kg/d when gilts were fed 0.00, 0.075,0.150, 0.225, and 0.30% L-lysine HCl, respectively. Exp. 2: The average litter gain from birth to weaning was 2.68,2.73, 2.67, 2.70, and 2.64 kg/d(P < 0.70) when sows were fed 0.1, 0.2, 0.3, 0.4, and 0.4% L-lysine HCl plus valine,respectively. No other differences among dietary treatments were observed.Conclusions: Collectively, these studies demonstrate corn-soybean meal based lactation diets formulated with a constant SID lysine content for all parities containing up to 0.40% L-lysine HCl with only supplemental feed grade threonine and a methionine source have no detrimental effect on litter growth rate and subsequent total born.
