In this paper,by characterizing Carleson measures,we investigate a class of bounded Toeplitz operator between weighted Bergman spaces with Békolléweights over the half-plane for all index choices.
目的探讨血浆N末端B型钠尿肽前体(N-terminal pro-B-type natriuretic peptide,NTproBNP)在预测中重度支气管肺发育不良(bronchopulmonary dysplasia,BPD)风险中的临床价值。方法采用前瞻观察性研究方法,选择2021年6月—2022年12月福建...目的探讨血浆N末端B型钠尿肽前体(N-terminal pro-B-type natriuretic peptide,NTproBNP)在预测中重度支气管肺发育不良(bronchopulmonary dysplasia,BPD)风险中的临床价值。方法采用前瞻观察性研究方法,选择2021年6月—2022年12月福建省妇幼保健院新生儿科收治的胎龄<30周极/超早产儿95例。分别于出生后第1、7、14、21天检测NTproBNP水平并收集住院期间基本资料,根据美国国家儿童健康与人类发展研究所(National Institute of Child Health and Human Development,NICHD)诊断标准,分为无-轻度BPD组(n=74)和中-重度BPD组(n=21)。比较2组不同时间点NTproBNP水平。结果中-重度BPD组胎龄、出生体质量均低于无-轻度BPD组(P<0.05);中-重度BPD组胎膜早破>18 h、≥3级新生儿呼吸窘迫综合征(respiratory distress syndrome,RDS)、有创机械通气时间>7 d、症状性动脉导管未闭(symptomatic patent ductus arteriosus,sPDA)、晚发型败血症、早产儿视网膜病(retinopathy of prematurity,ROP)的发生率均高于无-轻度BPD组,差异有统计学意义(P<0.05)。无-轻度BPD组NTproBNP水平在出生后第1天最高,中-重度BPD组NTproBNP水平在出生后第7天最高,随后逐渐降低。中-重度BPD组各时间点NTproBNP水平均高于无-轻度BPD组,差异有统计学意义(P<0.05)。出生后第1天NTproBNP水平为5631.52 pg/mL,是中重度BPD最佳预测参考值,受试者工作特征(receiver operating characteristic,ROC)曲线下面积为0.89(95%CI0.83~0.95),诊断准确性为85.71%。结论出生后第1天NTproBNP水平有助于早期预测中重度BPD发病风险,动态监测NTproBNP趋势可能对疾病防治提供一定参考价值。展开更多
AIM:To investigate the use of multi-b-value diffusionweighted imaging in diagnosing pancreatic cancer.METHODS:We retrospectively analyzed 33 cases of pancreatic cancer and 12 cases of benign pancreatic tumors at the S...AIM:To investigate the use of multi-b-value diffusionweighted imaging in diagnosing pancreatic cancer.METHODS:We retrospectively analyzed 33 cases of pancreatic cancer and 12 cases of benign pancreatic tumors at the Second Affiliated Hospital of Kunming Medical University from December 2008 to January2011.The demographic characteristics,clinical presentation,routine magnetic resonance imaging and diffusion weighted imaging(DWI)features with different b values were reviewed.Continuous data were expressed as mean±SD.Comparisons between pancreatic cancer and benign pancreatic tumors were performed using the Student’s t test.A probability of P<0.05 was considered statistically significant.RESULTS:Thirty-three patients with pancreatic cancer were identified.The mean age at diagnosis was 60±5.6 years.The male:female ratio was 21:12.Twenty cases were confirmed by surgical resection and 13 by biopsy of metastases.T1 weighted images demonstrated a pancreatic head mass in 16 patients,a pancreatic body mass in 10 cases,and a pancreatic tail mass with pancreatic atrophy in 7 cases.Eight patients had hepatic metastases,13 had invasion or envelopment of mesenteric vessels,4 had bone metastases,and 8had lymph node metastases.DWI demonstrated an irregular intense mass with unclear margins.Necrotic tissue demonstrated an uneven low signal.A b of 1100s/mm2was associated with a high intensity signal with poor anatomical delineation.A b of 700 s/mm2was associated with apparent diffusion coefficients(ADCs)that were useful in distinguishing benign and malignant pancreatic tumors(P<0.05).b values of 50,350,400,450 and 1100 s/mm2were associated with ADCs that did not differentiate the two tumors.CONCLUSION:Low b value images demonstrated superior anatomical details when compared to high b value images.Tumor tissue definition was high and contrast with the surrounding tissues was good.DWI was useful in diagnosing pancreatic cancer.展开更多
Background:Although concomitant nonalcoholic steatohepatitis(NASH)is common in chronic hepatitis B(CHB),the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear.We aimed...Background:Although concomitant nonalcoholic steatohepatitis(NASH)is common in chronic hepatitis B(CHB),the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear.We aimed to investigate the outcomes of NASH in CHB patients receiving antiviral treatment.Methods:In the post-hoc analysis of a multicenter trial,na?ve CHB patients receiving 72-week entecavir treatment were enrolled.We evaluated the biochemical,viral and histopathological responses of these patients.The histopathological features of NASH were also evaluated,using paired liver biopsies at baseline and week 72.Results:A total of 1000 CHB patients were finally enrolled for analysis,with 18.2%of whom fulfilling the criteria of NASH.A total of 727 patients completed entecavir antiviral treatment and received the second biopsy.Serum HBe Ag loss,HBe Ag seroconversion and HBV-DNA undetectable rates were similar between patients with or without NASH(P>0.05).Among patients with NASH,the hepatic steatosis,ballooning,lobular inflammation scores and fibrosis stages all improved during follow-up(all P<0.001),46%(63/136)achieved NASH resolution.Patients with baseline body mass index(BMI)≥23 kg/m2(Asian criteria)[odds ratio(OR):0.414;95%confidence interval(95%CI):0.190-0.899;P=0.012]and weight gain(OR:0.187;95%CI:0.050-0.693;P=0.026)were less likely to have NASH resolution.Among patients without NASH at baseline,22(3.7%)developed NASH.Baseline BMI≥23 kg/m2(OR:12.506;95%CI:2.813-55.606;P=0.001)and weight gain(OR:5.126;95%CI:1.674-15.694;P=0.005)were predictors of incident NASH.Conclusions:Lower BMI and weight reduction but not virologic factors determine NASH resolution in CHB.The value of weight management in CHB patients during antiviral treatment deserves further evaluation.展开更多
Satellite-based precipitation products have been widely used to estimate precipitation, especially over regions with sparse rain gauge networks. However, the low spatial resolution of these products has limited their ...Satellite-based precipitation products have been widely used to estimate precipitation, especially over regions with sparse rain gauge networks. However, the low spatial resolution of these products has limited their application in localized regions and watersheds.This study investigated a spatial downscaling approach, Geographically Weighted Regression Kriging(GWRK), to downscale the Tropical Rainfall Measuring Mission(TRMM) 3 B43 Version 7 over the Lancang River Basin(LRB) for 2001–2015. Downscaling was performed based on the relationships between the TRMM precipitation and the Normalized Difference Vegetation Index(NDVI), the Land Surface Temperature(LST), and the Digital Elevation Model(DEM). Geographical ratio analysis(GRA) was used to calibrate the annual downscaled precipitation data, and the monthly fractions derived from the original TRMM data were used to disaggregate annual downscaled and calibrated precipitation to monthly precipitation at 1 km resolution. The final downscaled precipitation datasets were validated against station-based observed precipitation in 2001–2015. Results showed that: 1) The TRMM 3 B43 precipitation was highly accurate with slight overestimation at the basin scale(i.e., CC(correlation coefficient) = 0.91, Bias = 13.3%). Spatially, the accuracies of the upstream and downstream regions were higher than that of the midstream region. 2) The annual downscaled TRMM precipitation data at 1 km spatial resolution obtained by GWRK effectively captured the high spatial variability of precipitation over the LRB. 3) The annual downscaled TRMM precipitation with GRA calibration gave better accuracy compared with the original TRMM dataset. 4) The final downscaled and calibrated precipitation had significantly improved spatial resolution, and agreed well with data from the validated rain gauge stations, i.e., CC = 0.75, RMSE(root mean square error) = 182 mm, MAE(mean absolute error) = 142 mm, and Bias = 0.78%for annual precipitation and CC = 0.95, RMSE = 25 mm, MAE = 16 mm, and Bias = 0.67% for monthly precipitation.展开更多
B vitamins are enzyme cofactors that play an important role in energy metabolism.The aim of this study was to elucidate whether B vitamin administration can reduce body weight(BW)gain by improving energy metabolism-re...B vitamins are enzyme cofactors that play an important role in energy metabolism.The aim of this study was to elucidate whether B vitamin administration can reduce body weight(BW)gain by improving energy metabolism-related enzyme activities in rats fed on a highfat diet.Fifty rats were randomly assigned to one of the following five groups:control group(C),including rats fed on standard rat chow;four treatment groups(H0,H1,H2,and H3),in which rats were fed on a high-fat diet.Rats in the H1 group were treated daily with 100 mg/kg BW thiamine(VB1),100 mg/kg BW riboflavin(VB2),and 250 mg/kg BW niacin(VPP);rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine(VB6),100 mg/kg BW cobalamin(VB12),and 5 mg/kg BW folate(FA);and rats in the H3 group were treated daily with all of the B vitamins administered to the H1 and H2 groups.After 12 weeks,the BW gains from the initial value were 154.5±58.4 g and 159.1±53.0 g in the H1 and C groups,respectively,which were significantly less than the changes in the H0 group(285.2±14.8 g,P〈0.05).In the H0 group,the plasma total cholesterol(CHO)and triglyceride(TG)levels were 1.59±0.30 mmol/L and 1.55±0.40 mmol/L,respectively,which were significantly greater than those in the H1 group(1.19±0.18 mmol/L and 0.76±0.34 mmol/L,respectively,P〈0.05).The activities of transketolase(TK),glutathione reductase,and Na^+/K^+adenosine triphosphatase were significantly increased in the B vitamin-treated groups and were significantly greater than those in the H0 group(P〈0.05).Furthermore,the glucose-6-phosphate dehydrogenase,pyruvic acid kinase,and succinate dehydrogenase activities also were increased after treatment with B vitamins.Supplementation with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats,thus possibly providing potential benefits to humans.展开更多
Objective: The aim of this study is to evaluate vitamin B12, folate, and homocysteine status in pregnant women in the third trimester of pregnancy and their relationship to fetal birth weight and their correlation to ...Objective: The aim of this study is to evaluate vitamin B12, folate, and homocysteine status in pregnant women in the third trimester of pregnancy and their relationship to fetal birth weight and their correlation to corresponding neonatal cord blood levels, and in addition, to evaluate the possibility of maternal serum homocysteine level as a predictor of low birth weight infants. Subjects and Methods: In this cross-sectional study, a total of two hundred pregnant women in third trimester (≥28 weeks) were recruited. After a detailed obstetrical and medical history, and clinical assessment, participants were subdivided into two groups: Group (A)—pregnant women who delivered average birth weight (ABW) infants and Group (B) for those who delivered low birth weight (LBW) infants between completed 37 and 42 weeks. Results: Vitamin B12 deficiency was observed in 24.1% of the total cohort. The mean vitamin B12 level was significantly lower in group (B) compared to group (A) (195.2 ± 38.9 vs. 225.9 ± 66.59 respectively P = 0.008). The mean level of homocysteine for women in group (B) was significantly higher than those determined from women in group (A) (9.10 ± 5.9 vs. 7.6 ± 3.83 respectively, P = 0.042). On the other hand, the mean folate levels showed statistically insignificant differences between both groups. The mean cord vitamin B12 level was significantly lower in LBW infants in comparison to ABW infants (277 ± 61.93 vs. 312.03 ± 81.87 respectively, P = 0.015), while the mean level of cord homocysteine for LBW infants was significantly higher than those levels determined from ABW infants (7.9 ± 3.79 vs. 6.6 ± 2.09 respectively P = 0.0049). Conclusion: Maternal micronutrients particularly cobalamin deficiency could be significant risk for LBW infants. Hyperhomocysteinemia has been shown to be a predictor for adverse pregnancy outcomes particularly LBW.展开更多
基金supported by the Natural Science Foundation of China(12271134)the Shanxi Scholarship Council of China(2020–089)the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20200019).
文摘In this paper,by characterizing Carleson measures,we investigate a class of bounded Toeplitz operator between weighted Bergman spaces with Békolléweights over the half-plane for all index choices.
文摘目的探讨血浆N末端B型钠尿肽前体(N-terminal pro-B-type natriuretic peptide,NTproBNP)在预测中重度支气管肺发育不良(bronchopulmonary dysplasia,BPD)风险中的临床价值。方法采用前瞻观察性研究方法,选择2021年6月—2022年12月福建省妇幼保健院新生儿科收治的胎龄<30周极/超早产儿95例。分别于出生后第1、7、14、21天检测NTproBNP水平并收集住院期间基本资料,根据美国国家儿童健康与人类发展研究所(National Institute of Child Health and Human Development,NICHD)诊断标准,分为无-轻度BPD组(n=74)和中-重度BPD组(n=21)。比较2组不同时间点NTproBNP水平。结果中-重度BPD组胎龄、出生体质量均低于无-轻度BPD组(P<0.05);中-重度BPD组胎膜早破>18 h、≥3级新生儿呼吸窘迫综合征(respiratory distress syndrome,RDS)、有创机械通气时间>7 d、症状性动脉导管未闭(symptomatic patent ductus arteriosus,sPDA)、晚发型败血症、早产儿视网膜病(retinopathy of prematurity,ROP)的发生率均高于无-轻度BPD组,差异有统计学意义(P<0.05)。无-轻度BPD组NTproBNP水平在出生后第1天最高,中-重度BPD组NTproBNP水平在出生后第7天最高,随后逐渐降低。中-重度BPD组各时间点NTproBNP水平均高于无-轻度BPD组,差异有统计学意义(P<0.05)。出生后第1天NTproBNP水平为5631.52 pg/mL,是中重度BPD最佳预测参考值,受试者工作特征(receiver operating characteristic,ROC)曲线下面积为0.89(95%CI0.83~0.95),诊断准确性为85.71%。结论出生后第1天NTproBNP水平有助于早期预测中重度BPD发病风险,动态监测NTproBNP趋势可能对疾病防治提供一定参考价值。
文摘AIM:To investigate the use of multi-b-value diffusionweighted imaging in diagnosing pancreatic cancer.METHODS:We retrospectively analyzed 33 cases of pancreatic cancer and 12 cases of benign pancreatic tumors at the Second Affiliated Hospital of Kunming Medical University from December 2008 to January2011.The demographic characteristics,clinical presentation,routine magnetic resonance imaging and diffusion weighted imaging(DWI)features with different b values were reviewed.Continuous data were expressed as mean±SD.Comparisons between pancreatic cancer and benign pancreatic tumors were performed using the Student’s t test.A probability of P<0.05 was considered statistically significant.RESULTS:Thirty-three patients with pancreatic cancer were identified.The mean age at diagnosis was 60±5.6 years.The male:female ratio was 21:12.Twenty cases were confirmed by surgical resection and 13 by biopsy of metastases.T1 weighted images demonstrated a pancreatic head mass in 16 patients,a pancreatic body mass in 10 cases,and a pancreatic tail mass with pancreatic atrophy in 7 cases.Eight patients had hepatic metastases,13 had invasion or envelopment of mesenteric vessels,4 had bone metastases,and 8had lymph node metastases.DWI demonstrated an irregular intense mass with unclear margins.Necrotic tissue demonstrated an uneven low signal.A b of 1100s/mm2was associated with a high intensity signal with poor anatomical delineation.A b of 700 s/mm2was associated with apparent diffusion coefficients(ADCs)that were useful in distinguishing benign and malignant pancreatic tumors(P<0.05).b values of 50,350,400,450 and 1100 s/mm2were associated with ADCs that did not differentiate the two tumors.CONCLUSION:Low b value images demonstrated superior anatomical details when compared to high b value images.Tumor tissue definition was high and contrast with the surrounding tissues was good.DWI was useful in diagnosing pancreatic cancer.
基金supported by grants from the National Major Special Project for the Prevention and Treatment of Major Infectious Diseases:AIDS and viral hepatitis(2013ZX10005002,2018ZX10725506)the National Key Research and Development Program(2017YFC0908903)。
文摘Background:Although concomitant nonalcoholic steatohepatitis(NASH)is common in chronic hepatitis B(CHB),the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear.We aimed to investigate the outcomes of NASH in CHB patients receiving antiviral treatment.Methods:In the post-hoc analysis of a multicenter trial,na?ve CHB patients receiving 72-week entecavir treatment were enrolled.We evaluated the biochemical,viral and histopathological responses of these patients.The histopathological features of NASH were also evaluated,using paired liver biopsies at baseline and week 72.Results:A total of 1000 CHB patients were finally enrolled for analysis,with 18.2%of whom fulfilling the criteria of NASH.A total of 727 patients completed entecavir antiviral treatment and received the second biopsy.Serum HBe Ag loss,HBe Ag seroconversion and HBV-DNA undetectable rates were similar between patients with or without NASH(P>0.05).Among patients with NASH,the hepatic steatosis,ballooning,lobular inflammation scores and fibrosis stages all improved during follow-up(all P<0.001),46%(63/136)achieved NASH resolution.Patients with baseline body mass index(BMI)≥23 kg/m2(Asian criteria)[odds ratio(OR):0.414;95%confidence interval(95%CI):0.190-0.899;P=0.012]and weight gain(OR:0.187;95%CI:0.050-0.693;P=0.026)were less likely to have NASH resolution.Among patients without NASH at baseline,22(3.7%)developed NASH.Baseline BMI≥23 kg/m2(OR:12.506;95%CI:2.813-55.606;P=0.001)and weight gain(OR:5.126;95%CI:1.674-15.694;P=0.005)were predictors of incident NASH.Conclusions:Lower BMI and weight reduction but not virologic factors determine NASH resolution in CHB.The value of weight management in CHB patients during antiviral treatment deserves further evaluation.
基金Under the auspices of the National Natural Science Foundation of China(No.41661099)the National Key Research and Development Program of China(No.Grant 2016YFA0601601)
文摘Satellite-based precipitation products have been widely used to estimate precipitation, especially over regions with sparse rain gauge networks. However, the low spatial resolution of these products has limited their application in localized regions and watersheds.This study investigated a spatial downscaling approach, Geographically Weighted Regression Kriging(GWRK), to downscale the Tropical Rainfall Measuring Mission(TRMM) 3 B43 Version 7 over the Lancang River Basin(LRB) for 2001–2015. Downscaling was performed based on the relationships between the TRMM precipitation and the Normalized Difference Vegetation Index(NDVI), the Land Surface Temperature(LST), and the Digital Elevation Model(DEM). Geographical ratio analysis(GRA) was used to calibrate the annual downscaled precipitation data, and the monthly fractions derived from the original TRMM data were used to disaggregate annual downscaled and calibrated precipitation to monthly precipitation at 1 km resolution. The final downscaled precipitation datasets were validated against station-based observed precipitation in 2001–2015. Results showed that: 1) The TRMM 3 B43 precipitation was highly accurate with slight overestimation at the basin scale(i.e., CC(correlation coefficient) = 0.91, Bias = 13.3%). Spatially, the accuracies of the upstream and downstream regions were higher than that of the midstream region. 2) The annual downscaled TRMM precipitation data at 1 km spatial resolution obtained by GWRK effectively captured the high spatial variability of precipitation over the LRB. 3) The annual downscaled TRMM precipitation with GRA calibration gave better accuracy compared with the original TRMM dataset. 4) The final downscaled and calibrated precipitation had significantly improved spatial resolution, and agreed well with data from the validated rain gauge stations, i.e., CC = 0.75, RMSE(root mean square error) = 182 mm, MAE(mean absolute error) = 142 mm, and Bias = 0.78%for annual precipitation and CC = 0.95, RMSE = 25 mm, MAE = 16 mm, and Bias = 0.67% for monthly precipitation.
文摘B vitamins are enzyme cofactors that play an important role in energy metabolism.The aim of this study was to elucidate whether B vitamin administration can reduce body weight(BW)gain by improving energy metabolism-related enzyme activities in rats fed on a highfat diet.Fifty rats were randomly assigned to one of the following five groups:control group(C),including rats fed on standard rat chow;four treatment groups(H0,H1,H2,and H3),in which rats were fed on a high-fat diet.Rats in the H1 group were treated daily with 100 mg/kg BW thiamine(VB1),100 mg/kg BW riboflavin(VB2),and 250 mg/kg BW niacin(VPP);rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine(VB6),100 mg/kg BW cobalamin(VB12),and 5 mg/kg BW folate(FA);and rats in the H3 group were treated daily with all of the B vitamins administered to the H1 and H2 groups.After 12 weeks,the BW gains from the initial value were 154.5±58.4 g and 159.1±53.0 g in the H1 and C groups,respectively,which were significantly less than the changes in the H0 group(285.2±14.8 g,P〈0.05).In the H0 group,the plasma total cholesterol(CHO)and triglyceride(TG)levels were 1.59±0.30 mmol/L and 1.55±0.40 mmol/L,respectively,which were significantly greater than those in the H1 group(1.19±0.18 mmol/L and 0.76±0.34 mmol/L,respectively,P〈0.05).The activities of transketolase(TK),glutathione reductase,and Na^+/K^+adenosine triphosphatase were significantly increased in the B vitamin-treated groups and were significantly greater than those in the H0 group(P〈0.05).Furthermore,the glucose-6-phosphate dehydrogenase,pyruvic acid kinase,and succinate dehydrogenase activities also were increased after treatment with B vitamins.Supplementation with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats,thus possibly providing potential benefits to humans.
文摘Objective: The aim of this study is to evaluate vitamin B12, folate, and homocysteine status in pregnant women in the third trimester of pregnancy and their relationship to fetal birth weight and their correlation to corresponding neonatal cord blood levels, and in addition, to evaluate the possibility of maternal serum homocysteine level as a predictor of low birth weight infants. Subjects and Methods: In this cross-sectional study, a total of two hundred pregnant women in third trimester (≥28 weeks) were recruited. After a detailed obstetrical and medical history, and clinical assessment, participants were subdivided into two groups: Group (A)—pregnant women who delivered average birth weight (ABW) infants and Group (B) for those who delivered low birth weight (LBW) infants between completed 37 and 42 weeks. Results: Vitamin B12 deficiency was observed in 24.1% of the total cohort. The mean vitamin B12 level was significantly lower in group (B) compared to group (A) (195.2 ± 38.9 vs. 225.9 ± 66.59 respectively P = 0.008). The mean level of homocysteine for women in group (B) was significantly higher than those determined from women in group (A) (9.10 ± 5.9 vs. 7.6 ± 3.83 respectively, P = 0.042). On the other hand, the mean folate levels showed statistically insignificant differences between both groups. The mean cord vitamin B12 level was significantly lower in LBW infants in comparison to ABW infants (277 ± 61.93 vs. 312.03 ± 81.87 respectively, P = 0.015), while the mean level of cord homocysteine for LBW infants was significantly higher than those levels determined from ABW infants (7.9 ± 3.79 vs. 6.6 ± 2.09 respectively P = 0.0049). Conclusion: Maternal micronutrients particularly cobalamin deficiency could be significant risk for LBW infants. Hyperhomocysteinemia has been shown to be a predictor for adverse pregnancy outcomes particularly LBW.
