Introduction: Human immunodeficiency virus infec- tion is associated with several different types of peripheral neuropathy: distal predominantly sensory axonal polyneuropathy, like Guillain Barre syndrome. Case presen...Introduction: Human immunodeficiency virus infec- tion is associated with several different types of peripheral neuropathy: distal predominantly sensory axonal polyneuropathy, like Guillain Barre syndrome. Case presentation: A 55-year-old Caucasian woman with Human immunodeficiency virus infection, diag- nosed with Guillain Barre syndrome was studied. Serum and CSF immunoglobulin G and Albumin levels were quantified by using an immunodiffusion technique. She had preceding viral symptoms. The clinical diagnosis of the illness in this patient was pa-resthesias or sensory loss, tendon reflexes. It was also observed cranial nerves abnormalities, acute mo- tor and sensory axonal neuropathy and ophthalmoplegia. The mean CD4 count was 367/mm3, CSF white blood cell 25 wbc/mm3. The serum sodium concentration was significantly low (133 mmol/L). She had a respiratory compromise as a result of their neuropa- thy and developed congestive heart failure and hy- potension and died of a cardiac arrest. The neuro-immunological response described by our patient was a blood/CSF barrier dysfunction without IgG intra-thecal synthesis. Conclusion: There is no doubt that this study is of great importance because will help clinicians increase their knowledge of the immune response in patients with this autoimmune disorder on the basis of this case report, in which, for first time, could be seen the neuroimmunological response through the reibergram in a patient with HIV- asso-ciated Guillain-Barre syndrome.展开更多
To determine whether genetic factors may work in concert with autoimmune factors in the pathogenesis of Guillain Barre syndrome (GBS) Methods We determined the differences in the distribution of HLA alleles between...To determine whether genetic factors may work in concert with autoimmune factors in the pathogenesis of Guillain Barre syndrome (GBS) Methods We determined the differences in the distribution of HLA alleles between GBS patients and normal controls HLA DQA, DQB and DRB alleles were typed by the sequence specific primer polymerase chain reaction (PCR SSP) methods in 47 GBS, 7 patients with Campylobacter jejuni (CJ) enteritis and 50 normal controls Results There were no differences in the frequency of HLA DQA, DQB and DRB among GBS group, CJ group, normal controls and GBS subgroups with respect to recent CJ infection, GM1 IgG and GM1 IgM antibodies ( P >0 05) There was an increasing tendency of DQA1*0301 ( P =0 056, RR =2 991) in the subgroup with GM1 IgG antibodies and DQA1 *0302 ( P =0 087, RR =3 587) in the subgroup with recent CJ infection No difference was found among GBS, CJ enteritis patients and normal controls Conclusions The increasing tendency of the two alleles suggests that there may be some relation between genetic factors and immunological factors, but a definite conclusion waits for more cases展开更多
Objective To investigate the relationship between the pathogenesis of Guillain Barre syndrome (GBS) and Campylobacter jejuni (C jejuni) in China Methods C jejuni strains were isolated from fresh stools...Objective To investigate the relationship between the pathogenesis of Guillain Barre syndrome (GBS) and Campylobacter jejuni (C jejuni) in China Methods C jejuni strains were isolated from fresh stools of 47 GBS patients in Beijing area from 1995 to 1997 by modified Skirrow’s method Serotyping of C jejuni was performed with Penner’s method in 47 GBS patients and 171 patients with C jejuni enteritis in our hospital during the same period The stools from which no C jejuni strains could be isolated were typed by PCR RFLP (restriction fragment length polymorphism) method Results Six C jejuni strains were isolated by Skirrow’s method, including 3 strains of Penner serotype 2, 1 Penner serotype 4, 1 Penner serotype 19 and 1 Penner serotype 26 Three strains of DNA Ⅰ, which was equal to the same type of Penner serotype 19, were found by PCR RFLP method Conclusion C jejuni isolated from Beijing area are similar to those reported in literature, which once more confirms the molecular mimicry pathogenetic theory of GBS caused by C jejuni infection in China The similarities of serotypes between C jejuni strains from GBS patients and those from C jejuni enteritis patients may explain the high incidence of GBS following C jejuni infection in China展开更多
Strongyloidiasis stercoralis can cause disease when larvae invade the human body through the skin or mucosa and can also infect a host when the host ingests its eggs.[1]Strongyloidiasis lacks characteristic manifestat...Strongyloidiasis stercoralis can cause disease when larvae invade the human body through the skin or mucosa and can also infect a host when the host ingests its eggs.[1]Strongyloidiasis lacks characteristic manifestations,and its clinical symptoms are related to the immune response of the host and the degree of infection.Immunodefi cient patients with underlying disease or who are receiving long-term corticosteroid treatment are more prone to developing severe disease.[2]The present study reports a case of Strongyloides stercoralis-induced sepsis and acute respiratory distress syndrome(ARDS)in a patient with Guillain-Barrésyndrome.展开更多
文摘Introduction: Human immunodeficiency virus infec- tion is associated with several different types of peripheral neuropathy: distal predominantly sensory axonal polyneuropathy, like Guillain Barre syndrome. Case presentation: A 55-year-old Caucasian woman with Human immunodeficiency virus infection, diag- nosed with Guillain Barre syndrome was studied. Serum and CSF immunoglobulin G and Albumin levels were quantified by using an immunodiffusion technique. She had preceding viral symptoms. The clinical diagnosis of the illness in this patient was pa-resthesias or sensory loss, tendon reflexes. It was also observed cranial nerves abnormalities, acute mo- tor and sensory axonal neuropathy and ophthalmoplegia. The mean CD4 count was 367/mm3, CSF white blood cell 25 wbc/mm3. The serum sodium concentration was significantly low (133 mmol/L). She had a respiratory compromise as a result of their neuropa- thy and developed congestive heart failure and hy- potension and died of a cardiac arrest. The neuro-immunological response described by our patient was a blood/CSF barrier dysfunction without IgG intra-thecal synthesis. Conclusion: There is no doubt that this study is of great importance because will help clinicians increase their knowledge of the immune response in patients with this autoimmune disorder on the basis of this case report, in which, for first time, could be seen the neuroimmunological response through the reibergram in a patient with HIV- asso-ciated Guillain-Barre syndrome.
文摘To determine whether genetic factors may work in concert with autoimmune factors in the pathogenesis of Guillain Barre syndrome (GBS) Methods We determined the differences in the distribution of HLA alleles between GBS patients and normal controls HLA DQA, DQB and DRB alleles were typed by the sequence specific primer polymerase chain reaction (PCR SSP) methods in 47 GBS, 7 patients with Campylobacter jejuni (CJ) enteritis and 50 normal controls Results There were no differences in the frequency of HLA DQA, DQB and DRB among GBS group, CJ group, normal controls and GBS subgroups with respect to recent CJ infection, GM1 IgG and GM1 IgM antibodies ( P >0 05) There was an increasing tendency of DQA1*0301 ( P =0 056, RR =2 991) in the subgroup with GM1 IgG antibodies and DQA1 *0302 ( P =0 087, RR =3 587) in the subgroup with recent CJ infection No difference was found among GBS, CJ enteritis patients and normal controls Conclusions The increasing tendency of the two alleles suggests that there may be some relation between genetic factors and immunological factors, but a definite conclusion waits for more cases
文摘Objective To investigate the relationship between the pathogenesis of Guillain Barre syndrome (GBS) and Campylobacter jejuni (C jejuni) in China Methods C jejuni strains were isolated from fresh stools of 47 GBS patients in Beijing area from 1995 to 1997 by modified Skirrow’s method Serotyping of C jejuni was performed with Penner’s method in 47 GBS patients and 171 patients with C jejuni enteritis in our hospital during the same period The stools from which no C jejuni strains could be isolated were typed by PCR RFLP (restriction fragment length polymorphism) method Results Six C jejuni strains were isolated by Skirrow’s method, including 3 strains of Penner serotype 2, 1 Penner serotype 4, 1 Penner serotype 19 and 1 Penner serotype 26 Three strains of DNA Ⅰ, which was equal to the same type of Penner serotype 19, were found by PCR RFLP method Conclusion C jejuni isolated from Beijing area are similar to those reported in literature, which once more confirms the molecular mimicry pathogenetic theory of GBS caused by C jejuni infection in China The similarities of serotypes between C jejuni strains from GBS patients and those from C jejuni enteritis patients may explain the high incidence of GBS following C jejuni infection in China
基金supported by the Medical Scientific Research Foundation of Guangdong Province(A2022506)Natural Science Foundation of Guangdong Province(2023A1515010267)Cerebrovascular Disease Youth Innovation(Z-2016-20-2201).
文摘Strongyloidiasis stercoralis can cause disease when larvae invade the human body through the skin or mucosa and can also infect a host when the host ingests its eggs.[1]Strongyloidiasis lacks characteristic manifestations,and its clinical symptoms are related to the immune response of the host and the degree of infection.Immunodefi cient patients with underlying disease or who are receiving long-term corticosteroid treatment are more prone to developing severe disease.[2]The present study reports a case of Strongyloides stercoralis-induced sepsis and acute respiratory distress syndrome(ARDS)in a patient with Guillain-Barrésyndrome.
