To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VB...To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VBIV were randomly divided into two groups; 45 patients （the treated group） were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients （control group） were treated with Xueshuantong （血栓通） and BHI intravenous dripping, once daily for 14 days. The clinical syndromes and the index of the transcranial Doppler （TCD） and hemorheology were observed. Results： The total effective rate was 100% in the treated group, which was better than that in the control group 90.5%, （P〈0. 05）. The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, （P〈0.01）. Conclusion： YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.展开更多
Betahistine drugs are widely used in vestibular compensation process. For theunderstanding of drugs＇ structural feature, two betahistine drugs＇ （betahistine hydrochloride andbetahistine methanesulfonate） structure...Betahistine drugs are widely used in vestibular compensation process. For theunderstanding of drugs＇ structural feature, two betahistine drugs＇ （betahistine hydrochloride andbetahistine methanesulfonate） structure and vibrational spectra were calculated within densityfunctional theory （DFT） method and comparisons have been made with histamine. The drugs＇interactions with the receptors were revealed by using the molecular docking methods. The resultsshow that the discrepancies of pharmacodynamic property would be resulted from minor molecularstructure difference, and the vibrational spectra can be used for monitoring the drugs＇metabolization. Generally, betahistine drugs have better performance in the docking patterns withreceptors, like stronger interactions, forming more hydrogen bonds with receptors than histamine,and the betahistine methanesulfonate is found out to be the best for body recovery as it did inclinical presentation.展开更多
文摘To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VBIV were randomly divided into two groups; 45 patients （the treated group） were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients （control group） were treated with Xueshuantong （血栓通） and BHI intravenous dripping, once daily for 14 days. The clinical syndromes and the index of the transcranial Doppler （TCD） and hemorheology were observed. Results： The total effective rate was 100% in the treated group, which was better than that in the control group 90.5%, （P〈0. 05）. The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, （P〈0.01）. Conclusion： YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.
基金financially supported by the Natural Science Foundation of Fujian Province(2017Y0040)New Century Excellent Talent Project in University of Fujian Province,Educational Department of Fujian Province(JAT170151)+2 种基金Fujian Province University Key Laboratory of Green Energy and Environment Catalysis(FJ-GEEC201703)Research Fund for Industry-university Cooperation of Fujian Province(2014H6003)Beijing National Laboratory for Molecular Sciences(BNLMS20160101)
文摘Betahistine drugs are widely used in vestibular compensation process. For theunderstanding of drugs＇ structural feature, two betahistine drugs＇ （betahistine hydrochloride andbetahistine methanesulfonate） structure and vibrational spectra were calculated within densityfunctional theory （DFT） method and comparisons have been made with histamine. The drugs＇interactions with the receptors were revealed by using the molecular docking methods. The resultsshow that the discrepancies of pharmacodynamic property would be resulted from minor molecularstructure difference, and the vibrational spectra can be used for monitoring the drugs＇metabolization. Generally, betahistine drugs have better performance in the docking patterns withreceptors, like stronger interactions, forming more hydrogen bonds with receptors than histamine,and the betahistine methanesulfonate is found out to be the best for body recovery as it did inclinical presentation.
