The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of use.LGBs are guided by semi-active laser ground-seek-ing technology,which means that atmospheri...The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of use.LGBs are guided by semi-active laser ground-seek-ing technology,which means that atmospheric conditions can affect their accuracy.The spatial release region(SRR)of LGBs is difficult to calculate precisely,especially when there is a poor field of view.This can result in a lower real hit probability.To increase the hit probability of LGBs in tough atmospheric situa-tions,a novel method for calculating the SRR has been pro-posed.This method is based on the transmittance model of the 1.06μm laser in atmospheric species and the laser diffuse reflection model of the target surface to determine the capture target time of the laser seeker.Then,it calculates the boundary ballistic space starting position by ballistic model and gets the spatial scope of the spatial release region.This method can determine the release region of LGBs based on flight test data such as instantaneous velocity,altitude,off-axis angle,and atmospheric visibility.By more effectively employing aircraft release conditions,atmospheric visibility and other factors,the SRR calculation method can improve LGB hit probabi-lity by 9.2%.展开更多
The buried village is Vinh Moc where more than 1200 Vietnamese, including soldiers, who lived underground during the Vietnam War (1965 to 1972) were hand dug into red basalt bedrock. The Vinh Moc Village was strategic...The buried village is Vinh Moc where more than 1200 Vietnamese, including soldiers, who lived underground during the Vietnam War (1965 to 1972) were hand dug into red basalt bedrock. The Vinh Moc Village was strategically located on the border of North Vietnam and South Vietnam approximately 14 km north of the DMZ and along the shoreline of the South China Sea. During the Vietnam War, the US Air Force heavily bombed Vinh Moc. The North Vietnamese Army (NVA) had an important military base on nearby Con Co Island. Brave civil volunteers from Vinh Moc would make the 28 km dangerous journey to the island, disguised as fishermen, to deliver supplies to the soldiers stationed there. The people who remained at Vinh Moc dug tunnels into red basalt hills in order to survive this onslaught. The American forces assessed the villagers of Vinh Moc were supplying food and armaments to the NVA garrison on the island of Con Co, which was in turn hindering the American bombers on their way to bomb Hanoi. The US military objective was to force the villagers of Vinh Moc to leave the area. The villagers initially dug the tunnels to a 10 m depth but the American forces designed bombs that burrowed down 10 m before exploding. The soil tunnels were then deepened to 30 m to provide safety for the soldiers and civilians working there during the intense US Air Force bombing. The primary objective of the research study was to determine how the soils and parent material of Vinh Moc Village, protected their villagers from the United States Air Force bombardment during the Vietnam War. In addition, the natural parent material at both the Vinh Moc and Cu Chi were assessed to determine why the tunnels were so resilient. The Cu Chi and Iron Triangle soil tunnels were dug by hand in the Old Alluvium soils and parent material where iron in solution precipitated and became the soil binding material. The Vinh Moc tunnels were hand dug in porous, red basalt (bedrock) hills where the consolidated rock structure itself provided the required binding material. Neither site needed support beams to hold up the ceilings.展开更多
BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH...BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH pathway,mind bomb 1(MIB1)is upregulated in various tumors and has been reported to promote cell metastasis and invasion.However,studies on the role of MIB1 in STAD are limited.Here,we evaluated the prognostic value of MIB1 in STAD and its association with immune infiltration and copy number variation.AIM To elucidate the relationship between MIB1 gene and gastric cancer(GC)and provide a new idea for the treatment of GC.METHODS We identified mutations in the MIB1 gene by searching the cBioPortal database and then analyzed their relationship with the overall survival rate and diseasefree survival rate using the Kaplan-Meier method.The Cancer Genome Atlas(TCGA)database provided transcript levels for MIB1 in STADs and normal tissues.As a method of distinguishing the STAD tissues from adjacent normal tissues,a receiver operating characteristic(ROC)curve was generated.Kaplan-Meier plotter was used to determine the effect of MIB1 expression on survival.Based on the LinkedOmics database,we were able to identify the coexpressed genes of the MIB1 gene,the top 50 positively correlated genes,and the top 50 negatively correlated genes.STRING was used to construct protein-protein interaction networks related to the MIB1 gene.An analysis of functional enrichment was carried out using the R package“Cluster Profiler”.The relationships between mRNA expression of MIB1 and immune infiltrates were assessed by Tumor IMmune Estimation Resource(TIMER)and the“GSVA package”in R.RESULTS According to the cBioPortal database,the MIB1 mutation rate in 287 patients in the TCGA dataset was approximately 6%.Kaplan-Meier survival analysis showed that patients with STAD in the mutated group had a worse prognosis than those in the unmutated group(P=0.0156).There was a significant upregulation of MIB1 expression in STAD tissues compared to adjacent normal tissues.A high T stage was associated with increased MIB1 mRNA expression.The ROC curve analysis revealed 59.4%sensitivity and 85.6%specificity of MIB1 for differentiating STAD tissues from adjacent normal tissues at a truncation level of 2.248.Kaplan-Meier plotter indicated that patients with higher MIB1 levels had a worse prognosis than those with lower levels(26.4 mo vs 56.2 mo,P=0.0330).A correlation analysis demonstrated an association between immune infiltrates and MIB1 mRNA expression.CONCLUSION Upregulation of MIB1 expression is significantly associated with poor survival rate and immune infiltration in gastric adenocarcinoma.MIB1 may be a biomarker for the poor prognosis of STAD patients and a potential immunotherapeutic target.展开更多
BACKGROUND: Bombing is a unique incident which produces unique patterns, multiple and occult injuries. Death often is a result of combined blast, ballistic and thermal effect injuries. Various natures of injury, self ...BACKGROUND: Bombing is a unique incident which produces unique patterns, multiple and occult injuries. Death often is a result of combined blast, ballistic and thermal effect injuries. Various natures of injury, self referrals and arrival by private transportation may lead to "wrong triage" in the emergency department. In India there has been an increase in incidence of bombing in the last 15 years. There is no documented triage tool from the National Disaster Management Authority of India for Bombings. We have tried to develop an ideal bombing specific triage tool which will guide the right patients to the right place at the right time and save more lives.METHODS: There are three methods of studying the triage tool: 1) real disaster; 2) mock drill; 3) table top exercise. In this study, a table top exercise method was selected. There are two groups, each consisting of an emergency physician, a nurse and a paramedic.RESULTS: By using the proportion test, we found that correct triaging was significantly different(P=0.005) in proportion between the two groups: group B(80%) with triage tool performed better in triaging the bomb blast victims than group A(50%) without the bombing specific triage tool performed.CONCLUSION: Development of bombing specific triage tool can reduce under triaging.展开更多
The sequential dispersing results of aerial cluster bomb are discussed. The ballistic model and the mod- el for impact point distribution of bullets are established. The main factors influencing impact point distribut...The sequential dispersing results of aerial cluster bomb are discussed. The ballistic model and the mod- el for impact point distribution of bullets are established. The main factors influencing impact point distribution are analyzed by numerical simulation. And the feasibility of improving distribution effect through sequential dis- persing is validated. Sequential dispersion and optimized airdrop parameters can help to achieve better battle effec- tiveness.展开更多
An upsurge of terrorist activity has occurred in the past two decades. As part of this, explosive devices continue to be extensively deployed against civilians in wide-ranging environments. Bombings remain the leading...An upsurge of terrorist activity has occurred in the past two decades. As part of this, explosive devices continue to be extensively deployed against civilians in wide-ranging environments. Bombings remain the leading worldwide cause of civilian fatalities due to terrorism. This demands an understanding of modern terrorist bombing trends to inform mitigation strategy. The objective of this study was to identify the occurrence and severity of bombings against civilian targets in diverse attack settings, and to establish corresponding blast injury profiles. Data was obtained from analysis of the Global Terrorism Database(GTD) and a meta-analysis of blast injury data derived from the PubMed database. Closed environment explosions were associated with significantly greater(p<0.05) mortality than in open spaces. The injury profiles were found to be influenced by attack setting, with higher rates of primary injury on trains and buses, and secondary injury in open space.展开更多
Background:Since the 1970 s,terrorist bombings in subways have been frequently occurring worldwide.To cope with this threat and to provide medical response countermeasures,we analyzed the characteristics of subway bom...Background:Since the 1970 s,terrorist bombings in subways have been frequently occurring worldwide.To cope with this threat and to provide medical response countermeasures,we analyzed the characteristics of subway bombing terrorist attacks and used the Haddon matrix to explore medical response strategies.Methods:First,we analyzed 111 subway bombings from 1970 to 2017 recorded in the Global Terrorism Database to provide a reference for the strategy exploration.Then,we convened an expert panel to use the Haddon matrix to explore the medical response strategies to subway bombings.Results:In recent decades,at least one bombing attack occurs every 3 years.Summarized by the Haddon matrix,the influencing factors of medical responses to conventional subway bombings include the adequacy of first-aid kits and the medical evacuation equipment,the traffic conditions affecting the evacuation,the continuity and stability of communication,as well as the factors exclusively attributed to dirty bomb attacks in subways,such as ionizing radiation protection capabilities,the structure of the radiation sickness treatment network based on the subway lines,and the disposal of radioactive sewage.These factors form the basis of the strategy discussion.Conclusions:Since subway bombings are long-term threats,it is necessary to have proper medical response preparation.Based on the Haddon matrix,we explored the medical response strategies for terrorist subway bombings,especially dirty bomb attacks.Haddon matrix can help policymakers systematically find the most important factors,which makes the preparations of the response more efficient.展开更多
PIT tests are usually performed when a mass distribution of High Explosive(H.E) projectile fragments is required. This paper shows the underwater detonation effects of 60 mm, M90 H.E. mortar bomb filled with Comp. B o...PIT tests are usually performed when a mass distribution of High Explosive(H.E) projectile fragments is required. This paper shows the underwater detonation effects of 60 mm, M90 H.E. mortar bomb filled with Comp. B on cylindrical concrete structure(concrete pipe closed at one end-similar to a PIT test)which is 2 m high(inner height) with inner diameter of also 2 m. Thickness of both wall and bottom of a pipe is 0.35 m. Detailed characteristics of concrete which is used for manufacturing of a pipe are specified. Mortar bomb is submerged directly in to the water(no free airspace around the bomb) with the nose pointing to the bottom of a pipe. Number and mass of fragments after detonation are presented by table and photographs. Fragments of dummy fuze, through which blasting cap was protruded, are collected and reassembled to form a shape of a fuze after detonation where expanding of fuze material due to a detonation products is visualized. After underwater detonation, detonation of the same mortar bomb is performed in an empty pipe and the effects of this kind of detonation are observed. Distance at which fragments generated from submerged mortar bomb will not reach concrete pipes wall is also determined.展开更多
When considering the bomb explosion damage effect,the air shock wave and high-speed fragments of the bomb case are two major threats.In experiments,the air shock wave was studied by the bare explosives superseding the...When considering the bomb explosion damage effect,the air shock wave and high-speed fragments of the bomb case are two major threats.In experiments,the air shock wave was studied by the bare explosives superseding the real cased bomb;in contrast,the bomb case influence was ignored to reduce risk.The air explosion simulations of the MK84 warhead with and without the case were conducted.The numerical simulation results showed that the bomb case significantly influenced the shock wave generated by the bomb:the spatial distribution of shock wave in the near field changed,and the peak value of shock wave was reduced.Breakage of the case and kinetic energy of the fragmentation consumed 3 and 38% of the explosion energy,respectively.The increasing factors of the peak overpressure induced by the bare explosive on the ground and in the air were 1.43-3.04 and 1.37-1.57,respectively.Four typical stages of case breakage were defined.The mass distribution of the fragments follows the Mott distribution.The initial velocity distribution of the fragments agreed well with the Gurney equation.展开更多
Background: In radiological emergencies with radionuclide incorporation, decorporation treatment is particularly effective if started early. Treating all people potentially contaminated("urgent treatment") m...Background: In radiological emergencies with radionuclide incorporation, decorporation treatment is particularly effective if started early. Treating all people potentially contaminated("urgent treatment") may require large antidote stockpiles. An efficacious way to reduce antidote requirements is by using radioactivity screening equipment. We analyzed the suitability of such equipment for triage purposes and determined the most efficient mix of screening units and antidote daily doses.Methods: The committed effective doses corresponding to activities within the detection limits of monitoring portals and mobile whole-body counters were used to assess their usefulness as triage tools. To determine the optimal resource mix, we departed from a large-scale scenario(60,000 victims) and based on purchase prices of antidotes and screening equipment in Germany, we calculated efficiencies of different combinations of medical countermeasure resources by data envelopment analysis. Cost-effectiveness was expressed as the costs per life year saved and compared to risk reduction opportunities in other sectors of society as well as the values of a statistical life.Results: Monitoring portals are adequate instruments for a sensitive triage after cesium-137 exposure with a high screening throughput. For the detection of americium-241 whole-body counters with a lower daily screening capacity per unit are needed. Assuming that 1% of the potentially contaminated patients actually need decorporation treatment, an efficient resource mix includes 6 monitoring portals and 25 mobile whole-body counters. The optimum mix depends on price discounts and in particular the fraction of victims actually needing treatment. The costeffectiveness of preparedness for a "dirty bomb" attack is less than for common health care, but costs for a life year saved are less than for many risk-reduction interventions in the environmental sector.Conclusion: To achieve economic efficiency a high daily screening capacity is of major importance to substantially decrease the required amount of antidote doses. Among the determinants of the number of equipment units needed, the fraction of the potentially contaminated victims that actually needs treatment is the most difficult to assess. Judging cost-effectiveness of the preparedness for "dirty bomb" attacks is an issue of principle that must be dealt with by political leaders.展开更多
In the case of a terrorist attack by a“dirty bomb”,blast injuries,external irradiation and the incorporation of radioactivity are to be expected.Departing from information about the radiological attack scenario with...In the case of a terrorist attack by a“dirty bomb”,blast injuries,external irradiation and the incorporation of radioactivity are to be expected.Departing from information about the radiological attack scenario with cesium-137 in the U.S.National Scenario Planning Guide,we estimated the radiological doses absorbed.Similar calculations were performed for a smaller plume size and a detonation in a subway.For conditions as described in the U.S.scenario,the committed effective dose amounted to a maximum of 848 mSv,even for very unfavorable conditions.Red bone marrow equivalent doses are insufcient to induce acute radiation sickness(ARS).In the case of a smaller plume size,the ARS threshold may be exceeded in some cases.In a subway bombing,doses are much higher and the occurrence of ARS should be expected.The health hazards from a dirty bomb attack will depend on the location and the explosive device.The derived Haddon matrix indicates that preparing for such an event includes education of all the medical staff about radiation effects,the time lines of radiation damages and the treatment priorities.Further determinants of the outcome include rapid evacuation even from difficult locations,the availability of a specific triage tool to rapidly identify victims at risk for ARS,the availability of an antidote stockpile and dedicated hospital beds to treat seriously irradiated victims.展开更多
The military situation of the thirteenth century required that the Song and the Mongols construct a great number of defensive works,relying on the mountains or facing the rivers,in the mountainous Sichuan Province and...The military situation of the thirteenth century required that the Song and the Mongols construct a great number of defensive works,relying on the mountains or facing the rivers,in the mountainous Sichuan Province and Chongqing.In recent years,a special kind of explosive firearms,huolei火雷(bombs),was unearthed in the large-scale excavations of the site of Diaoyu Fortress钓鱼城in Hechuan District合川and the Baidicheng白帝城in Fengjie County奉节,both of which were defensive works constructed in this mountainous area during the Southern Song dynasty.In addition,the ruins of kilns and the clay molds that were relevant to the casting of iron huolei have been discovered at the site of Baidicheng,indicating that these huolei might have been produced locally.The Southern Song iron huolei unearthed in Chongqing are the most direct evidence of the evolvement of gunpowder and firearms,and are of great significance to the history of science and technology,in particular the history of military technology.展开更多
The world’s earliest bomb with an iron casing,the iron huopao鐵火砲(cast-iron bomb,also referred to as zhentian lei震天雷,literally“thunder-crash bomb”),is one of the most important inventions of ancient China rela...The world’s earliest bomb with an iron casing,the iron huopao鐵火砲(cast-iron bomb,also referred to as zhentian lei震天雷,literally“thunder-crash bomb”),is one of the most important inventions of ancient China relating to gunpowder and firearms.Until recently,however,academics were not able to conduct substantial research on the topic,as no actual remains of a huopao had yet been found.Since 2013,in the excavation of two sites of Southern Song ancient cities(Diaoyu Fortress and Baidicheng)in Chongqing,archaeologists from the Chongqing Cultural Heritage Research Institute have discovered a number of iron huopao of the Southern Song dynasty.This finding not only provides first-hand material for research on the history of the invention of gunpowder and firearms,which has always been lacking,but also offers new physical evidence for an exploration of the history of war and the military history of the thirteenth century(in particular the Mongol-Song war),and is thus historically significant.展开更多
A wide spectrum of scenarios may lead to radiation incidents and the liberation of radioactive material. In the case of a terrorist attack by a "dirty bomb", there is a risk of mechanical and thermal trauma,...A wide spectrum of scenarios may lead to radiation incidents and the liberation of radioactive material. In the case of a terrorist attack by a "dirty bomb", there is a risk of mechanical and thermal trauma, external irradiation, superficial contamination and incorporation of radioactive material. The first treatment priority must be given to the care of trauma patients with life-threatening injuries, as the health effects of radiation occur with latency. Radionuclide incorporation will lead to a longer-lasting irradiation from inside the body, associated with a higher risk of stochastic radiation effects(e.g., occurrence of tumors) in the long run. It must be expected that victims with potentially incorporated radionuclides will far outnumber trauma patients. The elimination of radionuclides can be enhanced by the administration of decorporation agents such as(Ca) Diethylenetriaminepentaacetic acid(DTPA) or Prussian blue,reducing the radiological burden of the body. There is still no consensus whether decorporation treatment should be started immediately based only on a suspicion of radionuclide incorporation("urgent approach") or if the results of internal dosimetry confirming the necessity of a treatment should be awaited, accepting the delay caused by the measurements and computations("precautionary approach"). As the therapeutic effectiveness may be substantially decreased if treatment initiation is delayed only by several days, depending on the radionuclide, the physicochemical properties of the compounds involved and the route of absorption, we favor an "urgent approach" from a medical point of view. In doubt, it seems justified to treat victims by precaution, as the adverse effects of the medication seem minimal. However, in the case of a high number of victims, an "urgent treatment approach" may require a large number of daily doses of antidotes, and therefore, adequate investments in preparedness and antidote stockpiling are necessary.展开更多
The data of M≥5 earthquakes occurred in one year before and after 4 deep penetrating bombs in the region within 500 km and 1 000 km from the shooting site are presented. The 4 bombs are those happened in 1999 Kosovo ...The data of M≥5 earthquakes occurred in one year before and after 4 deep penetrating bombs in the region within 500 km and 1 000 km from the shooting site are presented. The 4 bombs are those happened in 1999 Kosovo of Yugoslavia, the 1991 Baghdad of Iraq, the 2001 Tora Bora of Afghanistan, and the 2003 Kirkuk of Iraq, respec-tively. The data indicate that the deep penetrating bombs may have remotely triggered some earthquakes. The deep penetrating bombs in seismically active regions should be forbidden.展开更多
Blast wall can prevent vehicles from approaching the protective building and can reduce the destructive power of shock wave to a certain extent.However,majority of studies on blast walls have some shortcomings.The exp...Blast wall can prevent vehicles from approaching the protective building and can reduce the destructive power of shock wave to a certain extent.However,majority of studies on blast walls have some shortcomings.The explosion test data are few.Most exsiting studies focus on the propagation of shock wave and the influence of blast wall on the propagation of shock wave.Discussion on the main parameters of blast wall design is meagre,such as the design of safety distance,the distance from the blast wall to the protective building,height and width of the blast wall.This paper uses the finite element programme LS-DYNA to design the blast wall.To analyze the convergence of the finite element model and to determine the mesh size of the model,this paper establishes several finite element models with different sizes of meshes to verify the model.Then,the overpressure distribution of the shock wave on the protective building is simulated to implement the blast wall design.The geometric parameters of the blast wall are preliminarily determined.And the influence of the safety distance on the overpressure of the building surface is mainly discussed,so as to determine the final design parameters.When the overpressure is less than 2 kPa,it is considered that there will be no damage to people caused by flying fragments.Eventually,the blast wall height is 3 m,the thickness is 1 m,and the safety distance is 35 m.The proposed method is used to demonstrate the design method,and the final design parameters of the blast wall can thus be used for reference.展开更多
Although terrorist bombings have tormented the world for a long time, currently they have reached unprecedented levels and become a continuous threat without borders, race or age. Almost all of them are caused by impr...Although terrorist bombings have tormented the world for a long time, currently they have reached unprecedented levels and become a continuous threat without borders, race or age. Almost all of them are caused by improvised explosive devices. The unpredictability of the terrorist bombings, leading to simultaneous generation of a large number of casualties and severe "multidimensional" blast trauma require a constant vigilance and preparedness of every hospital worldwide. Approximately 1.0%-2.6% of all trauma patients and 7% of the combat casualties require a massive blood transfusion. Coagulopathy is presented in 65% of them with mortality exceeding 50%. Damage control resuscitation is a novel approach, developed in the military practice for treatment of this subgroup of trauma patients. The comparison with the conventional approach revealed mortality reduction with 40%-74%, lower frequency of abdominal compartment syndrome(8% vs 16%), sepsis(9% vs 20%), multiorgan failure(16% vs 37%) and a significant reduction of resuscitation volumes, both crystalloids and blood products. Damage control surgery(DCS) and damage control resuscitation(DCR) are promising new approaches, contributing for the mortality reduction among the most severely wounded patients. Despite the lack of consensus about the optimal ratio of the blood products and the possible influence of the survival bias, we think that DCR carries survival benefit and recommend it in trauma patients with exsanguinating bleeding.展开更多
This study proposes an architecture for the prediction of extremist human behaviour from projected suicide bombings.By linking‘dots’of police data comprising scattered information of people,groups,logistics,location...This study proposes an architecture for the prediction of extremist human behaviour from projected suicide bombings.By linking‘dots’of police data comprising scattered information of people,groups,logistics,locations,communication,and spatiotemporal characters on different social media groups,the proposed architecture will spawn beneficial information.This useful information will,in turn,help the police both in predicting potential terrorist events and in investigating previous events.Furthermore,this architecture will aid in the identification of criminals and their associates and handlers.Terrorism is psychological warfare,which,in the broadest sense,can be defined as the utilisation of deliberate violence for economic,political or religious purposes.In this study,a supervised learning-based approach was adopted to develop the proposed architecture.The dataset was prepared from the suicide bomb blast data of Pakistan obtained from the South Asia Terrorism Portal(SATP).As the proposed architecture was simulated,the supervised learning-based classifiers na飗e Bayes and Hoeffding Tree reached 72.17%accuracy.One of the additional benefits this study offers is the ability to predict the target audience of potential suicide bomb blasts,which may be used to eliminate future threats or,at least,minimise the number of casualties and other property losses.展开更多
After World War II,the choice of the plutonium bomb as the technology roadmap for the first French atomic bomb was not a military issue,but rather one guided by civilian nuclear technology policy.After consideration o...After World War II,the choice of the plutonium bomb as the technology roadmap for the first French atomic bomb was not a military issue,but rather one guided by civilian nuclear technology policy.After consideration of the amount of uranium to be mined,technical reserves,and the financial situation,the civilian nuclear energy project of the Commissariatàl’énergie Atomique(CEA)was based on plutonium and natural uranium as the fissile materials,which indirectly provided enough plutonium for the future development of a nuclear weapon.When the Fourth Republic decided to develop the atomic bomb,a“Common Core”was established with the CEA,a public institution,as the lead,assisted by the military.Faced by the US embargo of nuclear weapons technology,the co-existence of civilian and military branches and their collaboration to some degree in the CEA not only made it a civilian-military complex,but also facilitated breakthroughs in the core technologies of implosion,the plutonium core,the tamper,and the neutron source.The success of the first French nuclear weapons test on February 13,1960,announced that France was on its way to becoming self-reliant in the military use of nuclear science.展开更多
An“explosive extratropical cyclone”is an atmospheric phenomenon that occurs when there is a very rapid drop in central atmospheric pressure.This phenomenon,with its characteristic of rapidly lowering the pressure in...An“explosive extratropical cyclone”is an atmospheric phenomenon that occurs when there is a very rapid drop in central atmospheric pressure.This phenomenon,with its characteristic of rapidly lowering the pressure in its interior,generates very intense winds and for this reason it is called explosive cyclone,bomb cyclone.With gusts recorded of 116 km/h,atmospheric phenomenon-“cyclone bomb”(CB)hit southern Brazil on June 30,the beginning of winter 2020,causing destruction in its influence over.One of the cities most affected was Chapecó,west of the state of Santa Catarina.The satellite images show that the CB generated a low pressure(976 mbar)inside it,generating two atmospheric currents that moved at high speed.In a northwest-southeast direction,Bolivia and Paraguay,crossing the states of Parana and Santa Catarina,and this draft that hit the south of Brazil,which caused the destruction of the affected states.Another moving to Argentina,southwest-northeast direction,due to high area of high pressure(1022 mbar).Both enhanced the phenomenon.展开更多
基金This work was supported by the major research projects within the military-international class(JY2021B077).
文摘The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of use.LGBs are guided by semi-active laser ground-seek-ing technology,which means that atmospheric conditions can affect their accuracy.The spatial release region(SRR)of LGBs is difficult to calculate precisely,especially when there is a poor field of view.This can result in a lower real hit probability.To increase the hit probability of LGBs in tough atmospheric situa-tions,a novel method for calculating the SRR has been pro-posed.This method is based on the transmittance model of the 1.06μm laser in atmospheric species and the laser diffuse reflection model of the target surface to determine the capture target time of the laser seeker.Then,it calculates the boundary ballistic space starting position by ballistic model and gets the spatial scope of the spatial release region.This method can determine the release region of LGBs based on flight test data such as instantaneous velocity,altitude,off-axis angle,and atmospheric visibility.By more effectively employing aircraft release conditions,atmospheric visibility and other factors,the SRR calculation method can improve LGB hit probabi-lity by 9.2%.
文摘The buried village is Vinh Moc where more than 1200 Vietnamese, including soldiers, who lived underground during the Vietnam War (1965 to 1972) were hand dug into red basalt bedrock. The Vinh Moc Village was strategically located on the border of North Vietnam and South Vietnam approximately 14 km north of the DMZ and along the shoreline of the South China Sea. During the Vietnam War, the US Air Force heavily bombed Vinh Moc. The North Vietnamese Army (NVA) had an important military base on nearby Con Co Island. Brave civil volunteers from Vinh Moc would make the 28 km dangerous journey to the island, disguised as fishermen, to deliver supplies to the soldiers stationed there. The people who remained at Vinh Moc dug tunnels into red basalt hills in order to survive this onslaught. The American forces assessed the villagers of Vinh Moc were supplying food and armaments to the NVA garrison on the island of Con Co, which was in turn hindering the American bombers on their way to bomb Hanoi. The US military objective was to force the villagers of Vinh Moc to leave the area. The villagers initially dug the tunnels to a 10 m depth but the American forces designed bombs that burrowed down 10 m before exploding. The soil tunnels were then deepened to 30 m to provide safety for the soldiers and civilians working there during the intense US Air Force bombing. The primary objective of the research study was to determine how the soils and parent material of Vinh Moc Village, protected their villagers from the United States Air Force bombardment during the Vietnam War. In addition, the natural parent material at both the Vinh Moc and Cu Chi were assessed to determine why the tunnels were so resilient. The Cu Chi and Iron Triangle soil tunnels were dug by hand in the Old Alluvium soils and parent material where iron in solution precipitated and became the soil binding material. The Vinh Moc tunnels were hand dug in porous, red basalt (bedrock) hills where the consolidated rock structure itself provided the required binding material. Neither site needed support beams to hold up the ceilings.
基金Supported by the Science and Technology Program of Liaoning Province,No.2021-MS-040.
文摘BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH pathway,mind bomb 1(MIB1)is upregulated in various tumors and has been reported to promote cell metastasis and invasion.However,studies on the role of MIB1 in STAD are limited.Here,we evaluated the prognostic value of MIB1 in STAD and its association with immune infiltration and copy number variation.AIM To elucidate the relationship between MIB1 gene and gastric cancer(GC)and provide a new idea for the treatment of GC.METHODS We identified mutations in the MIB1 gene by searching the cBioPortal database and then analyzed their relationship with the overall survival rate and diseasefree survival rate using the Kaplan-Meier method.The Cancer Genome Atlas(TCGA)database provided transcript levels for MIB1 in STADs and normal tissues.As a method of distinguishing the STAD tissues from adjacent normal tissues,a receiver operating characteristic(ROC)curve was generated.Kaplan-Meier plotter was used to determine the effect of MIB1 expression on survival.Based on the LinkedOmics database,we were able to identify the coexpressed genes of the MIB1 gene,the top 50 positively correlated genes,and the top 50 negatively correlated genes.STRING was used to construct protein-protein interaction networks related to the MIB1 gene.An analysis of functional enrichment was carried out using the R package“Cluster Profiler”.The relationships between mRNA expression of MIB1 and immune infiltrates were assessed by Tumor IMmune Estimation Resource(TIMER)and the“GSVA package”in R.RESULTS According to the cBioPortal database,the MIB1 mutation rate in 287 patients in the TCGA dataset was approximately 6%.Kaplan-Meier survival analysis showed that patients with STAD in the mutated group had a worse prognosis than those in the unmutated group(P=0.0156).There was a significant upregulation of MIB1 expression in STAD tissues compared to adjacent normal tissues.A high T stage was associated with increased MIB1 mRNA expression.The ROC curve analysis revealed 59.4%sensitivity and 85.6%specificity of MIB1 for differentiating STAD tissues from adjacent normal tissues at a truncation level of 2.248.Kaplan-Meier plotter indicated that patients with higher MIB1 levels had a worse prognosis than those with lower levels(26.4 mo vs 56.2 mo,P=0.0330).A correlation analysis demonstrated an association between immune infiltrates and MIB1 mRNA expression.CONCLUSION Upregulation of MIB1 expression is significantly associated with poor survival rate and immune infiltration in gastric adenocarcinoma.MIB1 may be a biomarker for the poor prognosis of STAD patients and a potential immunotherapeutic target.
文摘BACKGROUND: Bombing is a unique incident which produces unique patterns, multiple and occult injuries. Death often is a result of combined blast, ballistic and thermal effect injuries. Various natures of injury, self referrals and arrival by private transportation may lead to "wrong triage" in the emergency department. In India there has been an increase in incidence of bombing in the last 15 years. There is no documented triage tool from the National Disaster Management Authority of India for Bombings. We have tried to develop an ideal bombing specific triage tool which will guide the right patients to the right place at the right time and save more lives.METHODS: There are three methods of studying the triage tool: 1) real disaster; 2) mock drill; 3) table top exercise. In this study, a table top exercise method was selected. There are two groups, each consisting of an emergency physician, a nurse and a paramedic.RESULTS: By using the proportion test, we found that correct triaging was significantly different(P=0.005) in proportion between the two groups: group B(80%) with triage tool performed better in triaging the bomb blast victims than group A(50%) without the bombing specific triage tool performed.CONCLUSION: Development of bombing specific triage tool can reduce under triaging.
基金Supported by the Independent Scientific Research of Nanjing University of Science and Technology(2011YBXM110)~~
文摘The sequential dispersing results of aerial cluster bomb are discussed. The ballistic model and the mod- el for impact point distribution of bullets are established. The main factors influencing impact point distribution are analyzed by numerical simulation. And the feasibility of improving distribution effect through sequential dis- persing is validated. Sequential dispersion and optimized airdrop parameters can help to achieve better battle effec- tiveness.
基金support of the Institute for Security Science and TechnologyThe Royal British Legion Centre for Blast Injury Studies at Imperial College LondonThe Institute of Shock Physics also acknowledges the support of Imperial College London
文摘An upsurge of terrorist activity has occurred in the past two decades. As part of this, explosive devices continue to be extensively deployed against civilians in wide-ranging environments. Bombings remain the leading worldwide cause of civilian fatalities due to terrorism. This demands an understanding of modern terrorist bombing trends to inform mitigation strategy. The objective of this study was to identify the occurrence and severity of bombings against civilian targets in diverse attack settings, and to establish corresponding blast injury profiles. Data was obtained from analysis of the Global Terrorism Database(GTD) and a meta-analysis of blast injury data derived from the PubMed database. Closed environment explosions were associated with significantly greater(p<0.05) mortality than in open spaces. The injury profiles were found to be influenced by attack setting, with higher rates of primary injury on trains and buses, and secondary injury in open space.
文摘Background:Since the 1970 s,terrorist bombings in subways have been frequently occurring worldwide.To cope with this threat and to provide medical response countermeasures,we analyzed the characteristics of subway bombing terrorist attacks and used the Haddon matrix to explore medical response strategies.Methods:First,we analyzed 111 subway bombings from 1970 to 2017 recorded in the Global Terrorism Database to provide a reference for the strategy exploration.Then,we convened an expert panel to use the Haddon matrix to explore the medical response strategies to subway bombings.Results:In recent decades,at least one bombing attack occurs every 3 years.Summarized by the Haddon matrix,the influencing factors of medical responses to conventional subway bombings include the adequacy of first-aid kits and the medical evacuation equipment,the traffic conditions affecting the evacuation,the continuity and stability of communication,as well as the factors exclusively attributed to dirty bomb attacks in subways,such as ionizing radiation protection capabilities,the structure of the radiation sickness treatment network based on the subway lines,and the disposal of radioactive sewage.These factors form the basis of the strategy discussion.Conclusions:Since subway bombings are long-term threats,it is necessary to have proper medical response preparation.Based on the Haddon matrix,we explored the medical response strategies for terrorist subway bombings,especially dirty bomb attacks.Haddon matrix can help policymakers systematically find the most important factors,which makes the preparations of the response more efficient.
文摘PIT tests are usually performed when a mass distribution of High Explosive(H.E) projectile fragments is required. This paper shows the underwater detonation effects of 60 mm, M90 H.E. mortar bomb filled with Comp. B on cylindrical concrete structure(concrete pipe closed at one end-similar to a PIT test)which is 2 m high(inner height) with inner diameter of also 2 m. Thickness of both wall and bottom of a pipe is 0.35 m. Detailed characteristics of concrete which is used for manufacturing of a pipe are specified. Mortar bomb is submerged directly in to the water(no free airspace around the bomb) with the nose pointing to the bottom of a pipe. Number and mass of fragments after detonation are presented by table and photographs. Fragments of dummy fuze, through which blasting cap was protruded, are collected and reassembled to form a shape of a fuze after detonation where expanding of fuze material due to a detonation products is visualized. After underwater detonation, detonation of the same mortar bomb is performed in an empty pipe and the effects of this kind of detonation are observed. Distance at which fragments generated from submerged mortar bomb will not reach concrete pipes wall is also determined.
文摘When considering the bomb explosion damage effect,the air shock wave and high-speed fragments of the bomb case are two major threats.In experiments,the air shock wave was studied by the bare explosives superseding the real cased bomb;in contrast,the bomb case influence was ignored to reduce risk.The air explosion simulations of the MK84 warhead with and without the case were conducted.The numerical simulation results showed that the bomb case significantly influenced the shock wave generated by the bomb:the spatial distribution of shock wave in the near field changed,and the peak value of shock wave was reduced.Breakage of the case and kinetic energy of the fragmentation consumed 3 and 38% of the explosion energy,respectively.The increasing factors of the peak overpressure induced by the bare explosive on the ground and in the air were 1.43-3.04 and 1.37-1.57,respectively.Four typical stages of case breakage were defined.The mass distribution of the fragments follows the Mott distribution.The initial velocity distribution of the fragments agreed well with the Gurney equation.
文摘Background: In radiological emergencies with radionuclide incorporation, decorporation treatment is particularly effective if started early. Treating all people potentially contaminated("urgent treatment") may require large antidote stockpiles. An efficacious way to reduce antidote requirements is by using radioactivity screening equipment. We analyzed the suitability of such equipment for triage purposes and determined the most efficient mix of screening units and antidote daily doses.Methods: The committed effective doses corresponding to activities within the detection limits of monitoring portals and mobile whole-body counters were used to assess their usefulness as triage tools. To determine the optimal resource mix, we departed from a large-scale scenario(60,000 victims) and based on purchase prices of antidotes and screening equipment in Germany, we calculated efficiencies of different combinations of medical countermeasure resources by data envelopment analysis. Cost-effectiveness was expressed as the costs per life year saved and compared to risk reduction opportunities in other sectors of society as well as the values of a statistical life.Results: Monitoring portals are adequate instruments for a sensitive triage after cesium-137 exposure with a high screening throughput. For the detection of americium-241 whole-body counters with a lower daily screening capacity per unit are needed. Assuming that 1% of the potentially contaminated patients actually need decorporation treatment, an efficient resource mix includes 6 monitoring portals and 25 mobile whole-body counters. The optimum mix depends on price discounts and in particular the fraction of victims actually needing treatment. The costeffectiveness of preparedness for a "dirty bomb" attack is less than for common health care, but costs for a life year saved are less than for many risk-reduction interventions in the environmental sector.Conclusion: To achieve economic efficiency a high daily screening capacity is of major importance to substantially decrease the required amount of antidote doses. Among the determinants of the number of equipment units needed, the fraction of the potentially contaminated victims that actually needs treatment is the most difficult to assess. Judging cost-effectiveness of the preparedness for "dirty bomb" attacks is an issue of principle that must be dealt with by political leaders.
基金Bundeswehr Institute of Radiobiology,Neuherberg Str.1180937 Munich,Germany。
文摘In the case of a terrorist attack by a“dirty bomb”,blast injuries,external irradiation and the incorporation of radioactivity are to be expected.Departing from information about the radiological attack scenario with cesium-137 in the U.S.National Scenario Planning Guide,we estimated the radiological doses absorbed.Similar calculations were performed for a smaller plume size and a detonation in a subway.For conditions as described in the U.S.scenario,the committed effective dose amounted to a maximum of 848 mSv,even for very unfavorable conditions.Red bone marrow equivalent doses are insufcient to induce acute radiation sickness(ARS).In the case of a smaller plume size,the ARS threshold may be exceeded in some cases.In a subway bombing,doses are much higher and the occurrence of ARS should be expected.The health hazards from a dirty bomb attack will depend on the location and the explosive device.The derived Haddon matrix indicates that preparing for such an event includes education of all the medical staff about radiation effects,the time lines of radiation damages and the treatment priorities.Further determinants of the outcome include rapid evacuation even from difficult locations,the availability of a specific triage tool to rapidly identify victims at risk for ARS,the availability of an antidote stockpile and dedicated hospital beds to treat seriously irradiated victims.
文摘The military situation of the thirteenth century required that the Song and the Mongols construct a great number of defensive works,relying on the mountains or facing the rivers,in the mountainous Sichuan Province and Chongqing.In recent years,a special kind of explosive firearms,huolei火雷(bombs),was unearthed in the large-scale excavations of the site of Diaoyu Fortress钓鱼城in Hechuan District合川and the Baidicheng白帝城in Fengjie County奉节,both of which were defensive works constructed in this mountainous area during the Southern Song dynasty.In addition,the ruins of kilns and the clay molds that were relevant to the casting of iron huolei have been discovered at the site of Baidicheng,indicating that these huolei might have been produced locally.The Southern Song iron huolei unearthed in Chongqing are the most direct evidence of the evolvement of gunpowder and firearms,and are of great significance to the history of science and technology,in particular the history of military technology.
文摘The world’s earliest bomb with an iron casing,the iron huopao鐵火砲(cast-iron bomb,also referred to as zhentian lei震天雷,literally“thunder-crash bomb”),is one of the most important inventions of ancient China relating to gunpowder and firearms.Until recently,however,academics were not able to conduct substantial research on the topic,as no actual remains of a huopao had yet been found.Since 2013,in the excavation of two sites of Southern Song ancient cities(Diaoyu Fortress and Baidicheng)in Chongqing,archaeologists from the Chongqing Cultural Heritage Research Institute have discovered a number of iron huopao of the Southern Song dynasty.This finding not only provides first-hand material for research on the history of the invention of gunpowder and firearms,which has always been lacking,but also offers new physical evidence for an exploration of the history of war and the military history of the thirteenth century(in particular the Mongol-Song war),and is thus historically significant.
文摘A wide spectrum of scenarios may lead to radiation incidents and the liberation of radioactive material. In the case of a terrorist attack by a "dirty bomb", there is a risk of mechanical and thermal trauma, external irradiation, superficial contamination and incorporation of radioactive material. The first treatment priority must be given to the care of trauma patients with life-threatening injuries, as the health effects of radiation occur with latency. Radionuclide incorporation will lead to a longer-lasting irradiation from inside the body, associated with a higher risk of stochastic radiation effects(e.g., occurrence of tumors) in the long run. It must be expected that victims with potentially incorporated radionuclides will far outnumber trauma patients. The elimination of radionuclides can be enhanced by the administration of decorporation agents such as(Ca) Diethylenetriaminepentaacetic acid(DTPA) or Prussian blue,reducing the radiological burden of the body. There is still no consensus whether decorporation treatment should be started immediately based only on a suspicion of radionuclide incorporation("urgent approach") or if the results of internal dosimetry confirming the necessity of a treatment should be awaited, accepting the delay caused by the measurements and computations("precautionary approach"). As the therapeutic effectiveness may be substantially decreased if treatment initiation is delayed only by several days, depending on the radionuclide, the physicochemical properties of the compounds involved and the route of absorption, we favor an "urgent approach" from a medical point of view. In doubt, it seems justified to treat victims by precaution, as the adverse effects of the medication seem minimal. However, in the case of a high number of victims, an "urgent treatment approach" may require a large number of daily doses of antidotes, and therefore, adequate investments in preparedness and antidote stockpiling are necessary.
文摘The data of M≥5 earthquakes occurred in one year before and after 4 deep penetrating bombs in the region within 500 km and 1 000 km from the shooting site are presented. The 4 bombs are those happened in 1999 Kosovo of Yugoslavia, the 1991 Baghdad of Iraq, the 2001 Tora Bora of Afghanistan, and the 2003 Kirkuk of Iraq, respec-tively. The data indicate that the deep penetrating bombs may have remotely triggered some earthquakes. The deep penetrating bombs in seismically active regions should be forbidden.
基金This work was supported by the National Natural Science Foundation of China(No.51878507).
文摘Blast wall can prevent vehicles from approaching the protective building and can reduce the destructive power of shock wave to a certain extent.However,majority of studies on blast walls have some shortcomings.The explosion test data are few.Most exsiting studies focus on the propagation of shock wave and the influence of blast wall on the propagation of shock wave.Discussion on the main parameters of blast wall design is meagre,such as the design of safety distance,the distance from the blast wall to the protective building,height and width of the blast wall.This paper uses the finite element programme LS-DYNA to design the blast wall.To analyze the convergence of the finite element model and to determine the mesh size of the model,this paper establishes several finite element models with different sizes of meshes to verify the model.Then,the overpressure distribution of the shock wave on the protective building is simulated to implement the blast wall design.The geometric parameters of the blast wall are preliminarily determined.And the influence of the safety distance on the overpressure of the building surface is mainly discussed,so as to determine the final design parameters.When the overpressure is less than 2 kPa,it is considered that there will be no damage to people caused by flying fragments.Eventually,the blast wall height is 3 m,the thickness is 1 m,and the safety distance is 35 m.The proposed method is used to demonstrate the design method,and the final design parameters of the blast wall can thus be used for reference.
文摘Although terrorist bombings have tormented the world for a long time, currently they have reached unprecedented levels and become a continuous threat without borders, race or age. Almost all of them are caused by improvised explosive devices. The unpredictability of the terrorist bombings, leading to simultaneous generation of a large number of casualties and severe "multidimensional" blast trauma require a constant vigilance and preparedness of every hospital worldwide. Approximately 1.0%-2.6% of all trauma patients and 7% of the combat casualties require a massive blood transfusion. Coagulopathy is presented in 65% of them with mortality exceeding 50%. Damage control resuscitation is a novel approach, developed in the military practice for treatment of this subgroup of trauma patients. The comparison with the conventional approach revealed mortality reduction with 40%-74%, lower frequency of abdominal compartment syndrome(8% vs 16%), sepsis(9% vs 20%), multiorgan failure(16% vs 37%) and a significant reduction of resuscitation volumes, both crystalloids and blood products. Damage control surgery(DCS) and damage control resuscitation(DCR) are promising new approaches, contributing for the mortality reduction among the most severely wounded patients. Despite the lack of consensus about the optimal ratio of the blood products and the possible influence of the survival bias, we think that DCR carries survival benefit and recommend it in trauma patients with exsanguinating bleeding.
文摘This study proposes an architecture for the prediction of extremist human behaviour from projected suicide bombings.By linking‘dots’of police data comprising scattered information of people,groups,logistics,locations,communication,and spatiotemporal characters on different social media groups,the proposed architecture will spawn beneficial information.This useful information will,in turn,help the police both in predicting potential terrorist events and in investigating previous events.Furthermore,this architecture will aid in the identification of criminals and their associates and handlers.Terrorism is psychological warfare,which,in the broadest sense,can be defined as the utilisation of deliberate violence for economic,political or religious purposes.In this study,a supervised learning-based approach was adopted to develop the proposed architecture.The dataset was prepared from the suicide bomb blast data of Pakistan obtained from the South Asia Terrorism Portal(SATP).As the proposed architecture was simulated,the supervised learning-based classifiers na飗e Bayes and Hoeffding Tree reached 72.17%accuracy.One of the additional benefits this study offers is the ability to predict the target audience of potential suicide bomb blasts,which may be used to eliminate future threats or,at least,minimise the number of casualties and other property losses.
基金a phase study of a key project of the Fourteenth Five-Year Plan of the Institute for the History of Natural Sciences,Chinese Academy of Sciences:“A Comparative Study of the Sino-Foreign History of Scientific and Technological Innovation:The Road to Scientific and Technological Self-Reliance and Self-Improvement”(中外科技创新史比较研究——科技自立自强之路)(E2291J01)
文摘After World War II,the choice of the plutonium bomb as the technology roadmap for the first French atomic bomb was not a military issue,but rather one guided by civilian nuclear technology policy.After consideration of the amount of uranium to be mined,technical reserves,and the financial situation,the civilian nuclear energy project of the Commissariatàl’énergie Atomique(CEA)was based on plutonium and natural uranium as the fissile materials,which indirectly provided enough plutonium for the future development of a nuclear weapon.When the Fourth Republic decided to develop the atomic bomb,a“Common Core”was established with the CEA,a public institution,as the lead,assisted by the military.Faced by the US embargo of nuclear weapons technology,the co-existence of civilian and military branches and their collaboration to some degree in the CEA not only made it a civilian-military complex,but also facilitated breakthroughs in the core technologies of implosion,the plutonium core,the tamper,and the neutron source.The success of the first French nuclear weapons test on February 13,1960,announced that France was on its way to becoming self-reliant in the military use of nuclear science.
文摘An“explosive extratropical cyclone”is an atmospheric phenomenon that occurs when there is a very rapid drop in central atmospheric pressure.This phenomenon,with its characteristic of rapidly lowering the pressure in its interior,generates very intense winds and for this reason it is called explosive cyclone,bomb cyclone.With gusts recorded of 116 km/h,atmospheric phenomenon-“cyclone bomb”(CB)hit southern Brazil on June 30,the beginning of winter 2020,causing destruction in its influence over.One of the cities most affected was Chapecó,west of the state of Santa Catarina.The satellite images show that the CB generated a low pressure(976 mbar)inside it,generating two atmospheric currents that moved at high speed.In a northwest-southeast direction,Bolivia and Paraguay,crossing the states of Parana and Santa Catarina,and this draft that hit the south of Brazil,which caused the destruction of the affected states.Another moving to Argentina,southwest-northeast direction,due to high area of high pressure(1022 mbar).Both enhanced the phenomenon.