Composites consisting of carbopol (CP) and ceramic titanium dioxide nanoparticles, TiO2 have been investigated. The CP-TiO2, organic-inorganic hybrid composites have been prepared in DMF by heating the mixture with a ...Composites consisting of carbopol (CP) and ceramic titanium dioxide nanoparticles, TiO2 have been investigated. The CP-TiO2, organic-inorganic hybrid composites have been prepared in DMF by heating the mixture with a constant rate of 1。C/min, up to 30。C, 45。C, 60。C, 80。C, 100。C and 120。C. Proprieties such as absorption, structure and external aspect of the obtained materials were investigated by Uv-vis, FTIR, DRX and SEM analyses. The X-ray diffraction patterns confirmed that the TiO2 nanoparticles maintained their original tetragonal anatase-type crystalline structure in the composites. The chemical structure of the obtained materials was determined by ATR-FTIR spectroscopy. The influence of TiO2 nanoparticles on the thermal proprieties of carbopol matrix was investigated using thermo-gravimetric analysis and differential scanning calorimetry. The glass transition temperature (Tg) of the carbopol matrix was considerably increased by the presence of ceramic feller nanoparticles and its thermal stability was significantly improved. Furthermore the water loss which represents 7.56% of the weight loss in pure CP at 100。C was avoided in the CP-TiO2 nanocomposites at this same temperature. This important finding revealed that ceramic fellers blocked the water loss in the modified carbopol nanocomposites, which stayed stable till 200。C.展开更多
Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced psoriasis.Methods:Imiquimod was used to induce psoriasis in rats.Body weight,skin thickness,erythema,scaling,spleen wei...Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced psoriasis.Methods:Imiquimod was used to induce psoriasis in rats.Body weight,skin thickness,erythema,scaling,spleen weight,and histological alternations were measured to assess the effect of Coleus forskohlii.Furthermore,an emulgel formulation containing Coleus forskohlii 10%was prepared and characterized along with its ex vivo permeation studies.Results:The emulgel formulation containing Coleus forskohlii 10%had a pH of 5.40±0.36,with optimum spreadability of(31.67±2.08)g/(cm·s)and viscosity of(15966.67±1274.10)cps,and enhanced both the rate and the extent of drug permeation through psoriatic skin.In an ex vivo study,the quantity of drug permeated(19.18%),deposited(52.38%),and drug remaining in the donor compartments(28.31%)was satisfactory.Coleus forskohlii significantly alleviated imiquimod-induced psoriasis by increasing glutathione and superoxide dismutase activity,decreasing malondialdehyde and nitric oxide levels,and alleviating histological alternations in rat skin.Conclusions:Coleus forskohlii can alleviate imiquimod-induced psoriasis,which may be used as a therapeutic candidate for the treatment of psoriasis.展开更多
文摘Composites consisting of carbopol (CP) and ceramic titanium dioxide nanoparticles, TiO2 have been investigated. The CP-TiO2, organic-inorganic hybrid composites have been prepared in DMF by heating the mixture with a constant rate of 1。C/min, up to 30。C, 45。C, 60。C, 80。C, 100。C and 120。C. Proprieties such as absorption, structure and external aspect of the obtained materials were investigated by Uv-vis, FTIR, DRX and SEM analyses. The X-ray diffraction patterns confirmed that the TiO2 nanoparticles maintained their original tetragonal anatase-type crystalline structure in the composites. The chemical structure of the obtained materials was determined by ATR-FTIR spectroscopy. The influence of TiO2 nanoparticles on the thermal proprieties of carbopol matrix was investigated using thermo-gravimetric analysis and differential scanning calorimetry. The glass transition temperature (Tg) of the carbopol matrix was considerably increased by the presence of ceramic feller nanoparticles and its thermal stability was significantly improved. Furthermore the water loss which represents 7.56% of the weight loss in pure CP at 100。C was avoided in the CP-TiO2 nanocomposites at this same temperature. This important finding revealed that ceramic fellers blocked the water loss in the modified carbopol nanocomposites, which stayed stable till 200。C.
基金supported by Researchers Supporting Project number(RSPD2024R734)King Saud University,Riyadh,Saudi Arabia.
文摘Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced psoriasis.Methods:Imiquimod was used to induce psoriasis in rats.Body weight,skin thickness,erythema,scaling,spleen weight,and histological alternations were measured to assess the effect of Coleus forskohlii.Furthermore,an emulgel formulation containing Coleus forskohlii 10%was prepared and characterized along with its ex vivo permeation studies.Results:The emulgel formulation containing Coleus forskohlii 10%had a pH of 5.40±0.36,with optimum spreadability of(31.67±2.08)g/(cm·s)and viscosity of(15966.67±1274.10)cps,and enhanced both the rate and the extent of drug permeation through psoriatic skin.In an ex vivo study,the quantity of drug permeated(19.18%),deposited(52.38%),and drug remaining in the donor compartments(28.31%)was satisfactory.Coleus forskohlii significantly alleviated imiquimod-induced psoriasis by increasing glutathione and superoxide dismutase activity,decreasing malondialdehyde and nitric oxide levels,and alleviating histological alternations in rat skin.Conclusions:Coleus forskohlii can alleviate imiquimod-induced psoriasis,which may be used as a therapeutic candidate for the treatment of psoriasis.
