Exposure in water-damaged buildings (WDB) to airborne bioaerosols including metabolic products of toxigenic fungi, bacteria and actinomycetes;and inflammagens, can lead to a persistent innate immune inflammatory illne...Exposure in water-damaged buildings (WDB) to airborne bioaerosols including metabolic products of toxigenic fungi, bacteria and actinomycetes;and inflammagens, can lead to a persistent innate immune inflammatory illness. This illness, termed a chronic inflammatory response syndrome (CIRS-WDB), is systemic with symptoms acquired from multiple organ systems. Treatment of CIRS-WDB has progressed rapidly as a better understanding of the inflammatory pathophysiology has led to targeted, sequential therapies. The fundamental basis of uncontrolled innate immune responses, the humoral deficiency of regulatory neuropeptides melanocyte stimulating hormone (MSH) or vasoactive intestinal polypeptide (VIP), seen in over 98% of pa tients, has not consistently responded to any treatment modality. Use of replacement VIP has been attempted anecdotally;VIP replacement therapies show promise in short term studies but longer therapies have not been attempted. Here we report an open label trial of 20 patients with refractory CIRS-WDB illness who took replacement VIP in a nasal spray for at least 18 months with confirmation of durable efficacy and absence of significant side effects. These 20 patients were similar in symptoms and lab find- ings to three previously published cohorts in- volving 1829 patients and 169 controls. Dosage of VIP was titrated downwards from four to zero doses a day to determine minimum effective dose, and retitrated upwards for maximum improvement over time. The trial showed that VIP therapy safely 1) reduced refractory symptoms to equal controls;2) corrected inflammatory parameters C4a, TGF beta-1, VEGF, MMP9;3) corrected estradiol, testosterone and 25-OH Vitamin D;4) returned pulmonary artery systolic pressure (PASP) during exercise to normal;and 5) enhanced quality of life in 100% of trial patients. Subsequent identification of correction of T-regulatory cell levels supports the potential role of VIP in both innate and adaptive immune function.展开更多
Channel parameters estimation in an orthogonal for the receiver station is a multi-dimensional （MD） frequency division multiple access （OFDMA） system optimization problem, because every user node has a separate lo...Channel parameters estimation in an orthogonal for the receiver station is a multi-dimensional （MD） frequency division multiple access （OFDMA） system optimization problem, because every user node has a separate local oscillator and every transmitter to receiver link has individual carrier frequency offset （CFO） and channel impulse response （CIR） parameters. In order to reduce the computational complexity for MD optimization, a time domain CFOs and CIRs estimation algorithm over the OFDMA based wireless multimedia sensor networks （WMSN） is proposed in this paper. In this algorithm, the receiver station can decouple the signal from every node by correlation based on specially designed training sequences, so that the MD optimization problem is simplified to an 1-D optimal problem. It is proved that the multiple CFOs can be identified from the correlation result using the phase shift of the consecutive training se- quences. Based on the CFOs estimation result, the CIRs can then he estimated according to the minimum mean square error （MMSE） criterion. The theoretic analysis and simulation results show that the proposed algorithm can effectively decouple the signal from different user nodes and the bit error rate （BER） per- formance curves are close to the ideal estimation when the user number is not large.展开更多
In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environ...In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environments.In the proposed sum-of-sinusoids(SoS)channel model,the waves that emerge from the transmitter undergo line-of-sight(LoS)and non-line-of-sight(NLoS)propagation to the receiver,which makes the model suitable for describing numerous V2X wireless communication scenarios for sixth-generation(6G).We derive expressions for the real and imaginary parts of the complex channel impulse response(CIR),which characterize the physical propagation characteristics of V2X wireless channels.The statistical properties of the real and imaginary parts of the complex CIRs,i.e.,autocorrelation functions(ACFs),Doppler power spectral densities(PSDs),cross-correlation functions(CCFs),and variances of ACFs and CCFs,are derived and discussed.Simulation results are generated and match those predicted by the underlying theory,demonstrating the accuracy of our derivation and analysis.The proposed framework and underlying theory arise as an efficient tool to investigate the statistical properties of 6G MIMO V2X communication systems.展开更多
The effect of a tilted-dipole three-dimensional corotating interaction region(CIR)on the transport and acceleration of solar energetic particles(SEPs)is studied.In this work,we discussed how the particle intensity lon...The effect of a tilted-dipole three-dimensional corotating interaction region(CIR)on the transport and acceleration of solar energetic particles(SEPs)is studied.In this work,we discussed how the particle intensity longitudinal and radial dependence might be influenced by the background structures.Moreover,we investigate how the spectral index distribution is modulated by the CIR structure We use the focused transport equation(FTE)to describe the propagation and acceleration of SEPs in a tilt-dipole 3D CIR,generated by the high-resolution 3D magnetohydrodynamic(MHD)model.The forward stochastic differential method is used to solve the FTE.The protons with theE~(-4.4)spectrum from 0.5 to 15 MeV are injected uniformly at the heliographic equator of 0.15 AU.Physical quantities are extracted along each interplanetary magnetic field(IMF)line to show the results.In the tilted-dipole CIR background,if injected from the solar equator at the inner boundary,particles in the slow flow are transported to higher latitudes due to the extension of the IMF lines to higher latitudes.The longitudinal patterns of the particles are dominated by the density of IMF lines.The focusing effect modulates the longitudinal variation of the particle intensity and gives rise to new longitudinal intensity peaks.The adiabatic effect largely increases the intensity fluctuation along the longitude.The structure of the solar wind can also lead to the difference of the indexαin the empirical functionI_(max)=kR~(-α),describing the radial variation of peak intensity according to our simulation.Under the influence of the CIR structure,the indexαvaries from 1.9 to 3.4 at 0.3-1.0 AU.The variation of the solar wind speed should be considered when estimating the radial dependence of the SEP peak intensity.The spectra indices rise near the CIR boundaries and drop near the stream interface(SI).The adiabatic effect makes the spatial variability of the spectral index larger.The spectral index could be similar at different radial distances in the CIR structure.展开更多
文摘Exposure in water-damaged buildings (WDB) to airborne bioaerosols including metabolic products of toxigenic fungi, bacteria and actinomycetes;and inflammagens, can lead to a persistent innate immune inflammatory illness. This illness, termed a chronic inflammatory response syndrome (CIRS-WDB), is systemic with symptoms acquired from multiple organ systems. Treatment of CIRS-WDB has progressed rapidly as a better understanding of the inflammatory pathophysiology has led to targeted, sequential therapies. The fundamental basis of uncontrolled innate immune responses, the humoral deficiency of regulatory neuropeptides melanocyte stimulating hormone (MSH) or vasoactive intestinal polypeptide (VIP), seen in over 98% of pa tients, has not consistently responded to any treatment modality. Use of replacement VIP has been attempted anecdotally;VIP replacement therapies show promise in short term studies but longer therapies have not been attempted. Here we report an open label trial of 20 patients with refractory CIRS-WDB illness who took replacement VIP in a nasal spray for at least 18 months with confirmation of durable efficacy and absence of significant side effects. These 20 patients were similar in symptoms and lab find- ings to three previously published cohorts in- volving 1829 patients and 169 controls. Dosage of VIP was titrated downwards from four to zero doses a day to determine minimum effective dose, and retitrated upwards for maximum improvement over time. The trial showed that VIP therapy safely 1) reduced refractory symptoms to equal controls;2) corrected inflammatory parameters C4a, TGF beta-1, VEGF, MMP9;3) corrected estradiol, testosterone and 25-OH Vitamin D;4) returned pulmonary artery systolic pressure (PASP) during exercise to normal;and 5) enhanced quality of life in 100% of trial patients. Subsequent identification of correction of T-regulatory cell levels supports the potential role of VIP in both innate and adaptive immune function.
基金supported by the National High Technology Research and Development Programme of China(No.2006AA01Z216)
文摘Channel parameters estimation in an orthogonal for the receiver station is a multi-dimensional （MD） frequency division multiple access （OFDMA） system optimization problem, because every user node has a separate local oscillator and every transmitter to receiver link has individual carrier frequency offset （CFO） and channel impulse response （CIR） parameters. In order to reduce the computational complexity for MD optimization, a time domain CFOs and CIRs estimation algorithm over the OFDMA based wireless multimedia sensor networks （WMSN） is proposed in this paper. In this algorithm, the receiver station can decouple the signal from every node by correlation based on specially designed training sequences, so that the MD optimization problem is simplified to an 1-D optimal problem. It is proved that the multiple CFOs can be identified from the correlation result using the phase shift of the consecutive training se- quences. Based on the CFOs estimation result, the CIRs can then he estimated according to the minimum mean square error （MMSE） criterion. The theoretic analysis and simulation results show that the proposed algorithm can effectively decouple the signal from different user nodes and the bit error rate （BER） per- formance curves are close to the ideal estimation when the user number is not large.
基金supported by National Natural Science Foundation of China(NSFC)(No.62101274 and 62101275)Natural Science Foundation of Jiangsu Province(BK20210640)Open Research Fund of National Mobile Communications Research Laboratory Southeast University under Grant 2021D03。
文摘In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environments.In the proposed sum-of-sinusoids(SoS)channel model,the waves that emerge from the transmitter undergo line-of-sight(LoS)and non-line-of-sight(NLoS)propagation to the receiver,which makes the model suitable for describing numerous V2X wireless communication scenarios for sixth-generation(6G).We derive expressions for the real and imaginary parts of the complex channel impulse response(CIR),which characterize the physical propagation characteristics of V2X wireless channels.The statistical properties of the real and imaginary parts of the complex CIRs,i.e.,autocorrelation functions(ACFs),Doppler power spectral densities(PSDs),cross-correlation functions(CCFs),and variances of ACFs and CCFs,are derived and discussed.Simulation results are generated and match those predicted by the underlying theory,demonstrating the accuracy of our derivation and analysis.The proposed framework and underlying theory arise as an efficient tool to investigate the statistical properties of 6G MIMO V2X communication systems.
基金jointly supported by the National Natural Science Foundation of China(42330210 and 41974202)the National Key R&D Program of China(grant Nos.2022YFF0503800 and2021YFA0718600)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB 41000000)the Specialized Research Fund for State Key Laboratories。
文摘The effect of a tilted-dipole three-dimensional corotating interaction region(CIR)on the transport and acceleration of solar energetic particles(SEPs)is studied.In this work,we discussed how the particle intensity longitudinal and radial dependence might be influenced by the background structures.Moreover,we investigate how the spectral index distribution is modulated by the CIR structure We use the focused transport equation(FTE)to describe the propagation and acceleration of SEPs in a tilt-dipole 3D CIR,generated by the high-resolution 3D magnetohydrodynamic(MHD)model.The forward stochastic differential method is used to solve the FTE.The protons with theE~(-4.4)spectrum from 0.5 to 15 MeV are injected uniformly at the heliographic equator of 0.15 AU.Physical quantities are extracted along each interplanetary magnetic field(IMF)line to show the results.In the tilted-dipole CIR background,if injected from the solar equator at the inner boundary,particles in the slow flow are transported to higher latitudes due to the extension of the IMF lines to higher latitudes.The longitudinal patterns of the particles are dominated by the density of IMF lines.The focusing effect modulates the longitudinal variation of the particle intensity and gives rise to new longitudinal intensity peaks.The adiabatic effect largely increases the intensity fluctuation along the longitude.The structure of the solar wind can also lead to the difference of the indexαin the empirical functionI_(max)=kR~(-α),describing the radial variation of peak intensity according to our simulation.Under the influence of the CIR structure,the indexαvaries from 1.9 to 3.4 at 0.3-1.0 AU.The variation of the solar wind speed should be considered when estimating the radial dependence of the SEP peak intensity.The spectra indices rise near the CIR boundaries and drop near the stream interface(SI).The adiabatic effect makes the spatial variability of the spectral index larger.The spectral index could be similar at different radial distances in the CIR structure.
