Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(over...Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and breccias.This particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore minerals.Electron probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and pyrite.Fluid inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 m.This particular character has not been previously recorded for other sectors of the eastern north Patagonian region.展开更多
An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elonga...An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elongated to form tetra-and hexasaccharides followed by the introduction of anomeric groups via glycosylation couplings. A number of CS-E tetra-and hexasaccharide precursors were prepared in high yields.展开更多
目的观察BAPTA-AM对胞外酸化诱导大鼠关节软骨细胞自噬作用的影响,探讨其可能的作用机制。方法体外使用胰酶-Ⅱ型胶原酶消化法分离提取大鼠关节软骨细胞,分为正常组(p H 7.4)、酸化组(p H 6.0)、以及分别经BAPTA-AM处理的正常组和酸化组...目的观察BAPTA-AM对胞外酸化诱导大鼠关节软骨细胞自噬作用的影响,探讨其可能的作用机制。方法体外使用胰酶-Ⅱ型胶原酶消化法分离提取大鼠关节软骨细胞,分为正常组(p H 7.4)、酸化组(p H 6.0)、以及分别经BAPTA-AM处理的正常组和酸化组,激光共聚焦技术检测软骨细胞胞内钙离子变化,实时荧光定量PCR法检测细胞自噬基因Beclin-1、ULK1 mRNA的表达,Western blot法检测自噬蛋白LC3的表达,吖啶橙染色分析细胞自噬溶酶体形成情况。结果与p H 7.4正常组比较,p H 6.0酸化刺激明显增加大鼠关节软骨细胞内Ca2+的浓度,且自噬标志物Beclin-1、ULK1 mRNA及LC3Ⅱ蛋白表达均明显升高,酸性自噬溶酶体形成增多,同时酸化刺激能引起Ca MKKβ及pAMPK蛋白表达水平增高,磷酸化蛋白p-m TOR水平明显降低。BAPTA-AM酸化组自噬水平和Ca MKKβ及p-AMPK表达明显降低,p-m TOR表达明显升高。结论 BAPTA-AM能明显减弱胞外酸化诱导软骨细胞自噬作用,其机制可能与抑制胞内Ca2+有关。展开更多
At the beginning of 2004, the Chinese government decided to introduce the System of Social Support for Some Rural Families Practicing Family Planning ("social support system"). The General Office of the Stat...At the beginning of 2004, the Chinese government decided to introduce the System of Social Support for Some Rural Families Practicing Family Planning ("social support system"). The General Office of the State Council introduced the proposed program of the National Population and Family Planning Commission (NPFPC) and Ministry of Finance (MOF) on implementing the pilot project of the social support system ("Pilot展开更多
High mountain areas provide water resources for a large share of the world＇s population. The ongoing deglaciation of these areas is resulting in great instability of mountainous headwater regions, which could signifi...High mountain areas provide water resources for a large share of the world＇s population. The ongoing deglaciation of these areas is resulting in great instability of mountainous headwater regions, which could significantly affect water supply and intensify dangerous hydrological processes. The hydrological processes in mountains are still poorly understood due to the complexity of the natural conditions, great spatial variation and a lack of observation. A knowledge of flow-forming processes in alpine areas is essential to predict future possible trends in hydrological conditions and to calculate river runoff characteristics. The goal of this study is to gain detailed field data on various components of natural hydrological processes in the alpine areas of the North Caucasus and Central Tien Shan, and to investigate the possibility that the isotopic method can reveal important regularities of river flow formation in these regions. The study is based on field observations in representative alpine river basins in the North Caucasus （the Dzhankuat river basin） and the Central Tien Shan （the Chon-Kyzyl-Suu river basin） during 2013-2015. A mixing-model approach was used to conduct river hydrograph separation. Isotope methods were used to estimate the contribution of different nourishment sources in total runoff and its regime. ~80, ~D and mineralization were used as indicators. Two equation systems for the study sites were derived： in terms of water routing and runoff genesis. The Dzhankuat and Chon-Kyzyl-Suu river hydrographs were separated into 4 components： liquid precipitation/meltwaters, surface routed/subsurface routed waters.展开更多
文摘Arroyo Verde epithermal deposit,in the North Patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and breccias.This particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore minerals.Electron probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and pyrite.Fluid inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 m.This particular character has not been previously recorded for other sectors of the eastern north Patagonian region.
基金supported by the CAMS Innovation Fund for Medical Sciences(Nos.CIFMS 2016-I2M-3-009 and CIFMS 2017I2M-3-011)
文摘An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elongated to form tetra-and hexasaccharides followed by the introduction of anomeric groups via glycosylation couplings. A number of CS-E tetra-and hexasaccharide precursors were prepared in high yields.
文摘目的观察BAPTA-AM对胞外酸化诱导大鼠关节软骨细胞自噬作用的影响,探讨其可能的作用机制。方法体外使用胰酶-Ⅱ型胶原酶消化法分离提取大鼠关节软骨细胞,分为正常组(p H 7.4)、酸化组(p H 6.0)、以及分别经BAPTA-AM处理的正常组和酸化组,激光共聚焦技术检测软骨细胞胞内钙离子变化,实时荧光定量PCR法检测细胞自噬基因Beclin-1、ULK1 mRNA的表达,Western blot法检测自噬蛋白LC3的表达,吖啶橙染色分析细胞自噬溶酶体形成情况。结果与p H 7.4正常组比较,p H 6.0酸化刺激明显增加大鼠关节软骨细胞内Ca2+的浓度,且自噬标志物Beclin-1、ULK1 mRNA及LC3Ⅱ蛋白表达均明显升高,酸性自噬溶酶体形成增多,同时酸化刺激能引起Ca MKKβ及pAMPK蛋白表达水平增高,磷酸化蛋白p-m TOR水平明显降低。BAPTA-AM酸化组自噬水平和Ca MKKβ及p-AMPK表达明显降低,p-m TOR表达明显升高。结论 BAPTA-AM能明显减弱胞外酸化诱导软骨细胞自噬作用,其机制可能与抑制胞内Ca2+有关。
文摘At the beginning of 2004, the Chinese government decided to introduce the System of Social Support for Some Rural Families Practicing Family Planning ("social support system"). The General Office of the State Council introduced the proposed program of the National Population and Family Planning Commission (NPFPC) and Ministry of Finance (MOF) on implementing the pilot project of the social support system ("Pilot
基金Acknowledgements This work was supported by the Russian Foundation for Basic Research （project No. 16-35-60042 methodology of the study, equipment and calculations, project No. 15-05-00599a field observations, equipment）, Russian Science Foundation （project No. 14-17-00155 hydrochemical analysis and sensitivity tests）.
文摘High mountain areas provide water resources for a large share of the world＇s population. The ongoing deglaciation of these areas is resulting in great instability of mountainous headwater regions, which could significantly affect water supply and intensify dangerous hydrological processes. The hydrological processes in mountains are still poorly understood due to the complexity of the natural conditions, great spatial variation and a lack of observation. A knowledge of flow-forming processes in alpine areas is essential to predict future possible trends in hydrological conditions and to calculate river runoff characteristics. The goal of this study is to gain detailed field data on various components of natural hydrological processes in the alpine areas of the North Caucasus and Central Tien Shan, and to investigate the possibility that the isotopic method can reveal important regularities of river flow formation in these regions. The study is based on field observations in representative alpine river basins in the North Caucasus （the Dzhankuat river basin） and the Central Tien Shan （the Chon-Kyzyl-Suu river basin） during 2013-2015. A mixing-model approach was used to conduct river hydrograph separation. Isotope methods were used to estimate the contribution of different nourishment sources in total runoff and its regime. ~80, ~D and mineralization were used as indicators. Two equation systems for the study sites were derived： in terms of water routing and runoff genesis. The Dzhankuat and Chon-Kyzyl-Suu river hydrographs were separated into 4 components： liquid precipitation/meltwaters, surface routed/subsurface routed waters.
文摘The 2010 Friendship Competition among Ambassadors and their wives on Knowing Chinese Culture sponsored by the CPAFFC started on March 29 and ended on
