Continuous Wear of Hydrogel Contact Lenses for Therapeutic Use

Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired.

A survey of corneal changes caused by daily wear silicone hydrogel contact lenses

The examination of the effects of second generation lotra filcon B silicone hydrogel(SiH)lenses on the cornea when worn for three years of daily wear.Material and Methods:55 healthy patients were divided into two groups:current hydrogel contact lens wearers refitted with lotrafilcon B lenses(Group 1;28 patients)and neophyte contact lens wearers(Group 2;27 patients).Each patient's subjective eye comfort was measured with a self-administered questionnaire.The corneas were analyzed using contact specular microscope to measure corneal thickness and the endothelium before the SiH lenses werefitted after four weeks,one month,six months,one year,two years,and three years of lens wear.Results:Subjective complaints of patients in Group 1 were reduced;however patients in Group 2 experienced discomfort during the first two to four weeks of use.In Group 1,objective examinations identified a decrease in endothelial cell density.In Group 2,the endothelial cell density increased slightly in the first two years but decreased after three years.The results indicate that lotra filcon B slows down the deleterious effects of contact lenses.The coe±cient of variation significantly decreased after six months in Group 1(0.47 vs 0.44;p?0:049),whereas,in Group 2,the hexagonal cells improved significantly after one month(27.78 vs 28.25;p=0.025).Conclusion:Based on the subjects involved and the period of time under examination,it can be concluded that high-Dk SiH lenses support the physiological metabolism and functions of the cornea by improving oxygen provision.

Cytotoxicity of Contact Lens Care Solution to Human Corneal Epithelium in Vitro

Purpose: To investigate the cytotoxicity of soft contact lens multi-purpose care solutions which are now in common use in China.Methods: The cell culture method was used. Cytotoxicity was indicated by significant increases in the number of dead cells relative to controls.Results: Cells were exposed to soft contact lens care solutions for 15 min. They were irregular in shape and variable in size. The intercellular space increased and variable in size.The in-tercelluar space increased and the cells became scrunken. With the time of exposure elongated , damage of cells became more severe.Conclusions: Four kinds of soft contact lens multi-purpose care solutions may have harmful effects on the culture of human corneal epithelial cells. Soaked lenses should be rinsed with saline before being placed in the eyes in order to reduce the potential toxicity of contact lens care solutions. Eye science 1998; 14 :45 - 47.

Clinic study on silicone hydrogel contact lenses used as bandage contact lenses after LASEK surgery

AIM: To compare the clinical performance of two types of silicon hydrogel contact lenses used as bandage lenses after LASEK surgery. METHODS: A prospective, double-masked study was conducted on 42 eyes of 21 patients who received binocular LASEK surgeries. The interocular difference in spherical equivalent power was less than -1.50D. Patients were randomly assigned to wear Galyfilcon A (Lens A) bandage contact lens in one eye and Balafilcon A (Lens B) in the fellow eye after the surgery. The responses to a subjective questionnaire on comfort of wearing, corneal epithelial status, conjunctival hyperemia, limbal neovascularization, lens fitting and contact lens debris were assessed 1 and 5 days postoperatively. Corneal endothelium was assessed before and 5 days after the surgery upon bandage lens removal. RESULTS: There was no difference between the two groups in terms of conjunctival hyperemia, limbal neovascularization, contact lens fitting, corneal epithelial status, corneal endothelium cell density (CD) and endothelium cell size (CS) at any postoperative visit. Complaints of discomfort, including foreign body sensation, pain and intolerance were statistically more among Lens B wearers at any postoperative visit (P < 0.05). Lens B appeared to attract much more debris than Lens A at the 5-day post-operative follow-up visit (P < 0.01). CONCLUSION: The two types of silicon hydrogel lenses investigated in this study demonstrated similar clinical performance in terms of corneal responses and lens fitting. However, Lens A showed a better performance in terms of comfort of wearing and deposit resistance.

Effects of rigid gas permeable contact lens on morphological parameters and vision-related quality of life in keratoconus patients

AIM: To evaluate the effect of rigid gas permeable contact lens(RGP-CL) on corneal morphological parameters and vision-related quality of life in keratoconus(KC) patients.METHODS: Totally 57 eyes of 30 KC patients who were followed-up for more than two years, including 17 RGP wearers(32 eyes) and 13 non-wearers(25 eyes) were retrospectively analyzed. Initial medical history and corneal topography were collected at baseline. Corneal topography, corneal aberration, optical coherence tomography, and vision-related quality of life questionnaires were performed at the last follow-up.RESULTS: According to corneal topography, increase of the flattest keratometric values was higher in RGP wearers than in non-wearers(P=0.038). The morphological parameters, including symmetry index of front corneal curvature(P=0.004) and Baiocchi-Calossi-Versaci index front(P=0.047), were lower in RGP wearers than in nonwearers. Vertical coma was smaller in RGP wearers than non-wearers in 3.0, 5.0, 6.0, and 7.0 mm pupil diameters, respectively(P<0.05). The environmental triggering domain of ocular surface disease index was worse in RGP wearers as compared to non-wearers(P=0.003). At the last followup, there were no significant differences in constituent ratios of KC progression, corneal thickness topography, epithelial thickness topography, morphological parameters of corneal topography, and other questionnaire scores between the two groups(all P>0.05).CONCLUSION: Long-term use of RGP does not worsen KC but may cause corneal epithelial remodeling to increase symmetry of corneal anterior surface, reduce corneal vertical coma and improve visual quality. However, RGP wearing causes a slight decrease in vision-related quality of life. The occurrence of ocular surface symptoms is mainly associated with environmental triggering factors.

EFFECT OF SHORT-TERM SOFT CONTACT LENS WEAR ON HUMAN OCULAR ABERRATIONS

Objective To evaluate the effect of short-term soft contact lens （SCLs） wearing on human ocular aberrations （ HOA ）. Methods This prospective study included 50 eyes of 50 young volunteers wearing SCLs for 1 month. The ocular aberrations were measured by Allegretto Wavefront Analyzer. The root-mean-square （RMS） values of the general （RMSG） , higher-order （RMSH） , first to sixth order （ RMS1 to RMS6） and aberration coefficients were analyzed. Results There were no significant differences in the mean values of RMSG, RMSH, RMS1 to RMS6 （ P 〉 0. 05 ） and changes of absolute values of aberration coefficients between baseline and various visits after SCLs discontinuation. However, at d I after the discontinuation of SCLs, changes in coefficient values of the third-order aberrations （ C6 to C9 ） were slightly higher than others, and C7 was the highest. The increase factors of RMS values were higher at 1 week and lower at the 2 week visit after SCLs discontinuation. The uniformity of dominating type in HOA and the corneal topography form was both about 60% after discontinuation of SCLs. The corneal thickness increased after SCLs wear and gradually decreased to baseline until 1 month discontinuation of SCLs. Conclusion The effect of short-term SCLs wear on human ocular aberrations is slight but profound. A month or more wait should be allowed before the short-term SCLs wearers are scheduled for wavefronted-guided LASIK.

Orthokeratology lens related infections

Orthokeratology is a reversible technique that temporarily changes the curvature of the cornea with the aim of addressing refractive errors. The United States Food and Drug Administration(FDA) granted approval for using reverse geometry contact lenses to correct myopia without any age restriction. Information from the pre-market applications to the FDA was rated as level Ⅱ evidence. Another unapproved use of overnight orthokeratology is for the prevention of myopic progression. Although orthokeratology is advocated to reduce myopic progression, there are limited long-term studies with substantial evidence of its benefits. Much of this evidence comes from non-robust experimental studies using historical or self-selected controls with relative high dropout rates. Although some positive results have been published in temporarily reducing the myopic refractive error and its progression, the use of these lenses can be associated with serious complications such as microbial keratitis. Microbial keratitis is a potentially vision-threatening adverse response associated with contact lens wear. In fact, contact lens wearhas been shown to be the predominant risk factor of microbial keratitis in some developed countries. Most of the published cases on overnight orthokeratology related microbial keratitis occurred in children or adolescents. Parents considering orthokeratology must make an informed decision about its temporary benefit and its potential for permanent loss of vision. The ophthalmic community should be reminded of the potential complications of orthokeratology.

Reversible grafting of antibiotics onto contact lens mediated by labile chemical bonds for smart prevention and treatment of corneal bacterial infections

Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate(GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADAGS/PEI(polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release.

Management of corneal ulceration with a moisture chamber due to temporary lagophthalmos in a brain injury patient:A case report

BACKGROUND This study describes the use of a moisture chamber to treat corneal ulceration due to temporary lagophthalmos in a critically ill patient.CASE SUMMARY A 46-year-old woman was admitted to the intensive care unit after a car accident.She suffered multiple injuries that included brain injury and presented with moderately decreased consciousness and lagophthalmos in her right eye.Within 6 d,her consciousness improved considerably;at which time,exposure keratopathy occurred and worsened to corneal ulceration.Lubricating gel,antibiotic ointment,and bandage contact lens were all ineffective in preventing or treating the exposure keratopathy.Instead of tarsorrhaphy,a moisture chamber was applied which successfully controlled the corneal ulceration.The moisture chamber was discontinued when complete eyelid closure recovered a week later.CONCLUSION A moisture chamber may be an effective,noninvasive alternative to tarsorrhaphy for treating severe exposure keratopathy due to temporary lagophthalmos.

Effects of Contact Lens Wear on the Corneal Endotnelium and Sensitivity

The corneal endothelium of 38 contact lens wearers(74 eyes) and 74 normal eyes for control was photographed and analyzed with specular microscopy and the graphic processing system.The central corneal sensitivity and thickness were also measured.The results showed that the frequency

巩膜镜矫正屈光不正的安全性

目的 探讨硬性巩膜接触镜在矫正屈光不正方面的安全性。方法 前瞻性研究,选取96例(192眼)近视患者(度数-20.00~0 D,散光度数0~3.50 D)为研究对象,分为试验组(配戴硬性巩膜接触镜)和对照组[配戴硬性角膜接触镜(RGP)],每组48例,分别于戴镜前、戴镜当天、戴镜后1周、戴镜后1个月及戴镜后3个月时检测并比较两组患者眼部相关参数指标[最佳矫正视力、角膜内皮细胞密度、六角形细胞比率、泪膜破裂时间(BUT)、眼压、角膜荧光素染色评分、结膜充血及睫状充血评分],观察是否出现眼部异常改变。结果 戴镜前至戴镜3个月期间,两组患者最佳矫正视力均≥1.00;戴镜后3个月时,与戴镜前比较,试验组患者角膜内皮细胞密度轻微下降,六角形细胞比率轻微上升,但差异均无统计学意义(均为P>0.05);戴镜前及戴镜后3个月时,试验组角膜内皮细胞密度及六角形比率均较对照组稍高,但差异均无统计学意义(均为P>0.05)。戴镜前、戴镜当天、戴镜后1周、戴镜后1个月及戴镜后3个月时,试验组与对照组患者BUT比较,差异均无统计学意义(均为P>0.05)。戴镜前、戴镜当天、戴镜后1周、戴镜后1个月及戴镜后3个月试验组与对照组患者眼压比较,差异均无统计学意义(均为P>0.05)。戴镜前及戴镜后3个月时,两组患者角膜荧光染色评级、结膜充血及睫状充血评级比较,差异均无统计学意义(均为P>0.05)。戴镜后3个月时,试验组患者均未出现结膜及角膜水肿等异常改变。结论 硬性巩膜接触镜与RGP具有一致的安全性与矫正屈光不正的有效性,值得推广及应用。

眼科药械组合产品国内外现状及质量评价

眼科药械组合产品是当下眼部疾病治疗的一种新型手段,有着生物利用度高、靶向性强、依从性好的特点。然而,人眼生理结构的复杂性、药与器械的相互作用等因素给相关产品的研发和监管带来诸多困难。本文从眼科药械组合产品的相关法规、产品研究现状、质量评价等方面进行分析讨论,为保证产品研发与管理过程中的安全性和有效性提供参考依据。

接触镜在圆锥角膜中的临床应用及并发症研究进展

圆锥角膜是一种不断进展的致盲性眼病,其特征是角膜变薄和突起,伴有不规则散光和视力下降。早期圆锥角膜的不规则散光可通过框架眼镜矫正,对于中重度圆锥角膜的不规则散光,框架眼镜不再适用,接触镜成为患者矫正视力的最佳选择。接触镜种类繁多,在接触镜的选择上难以抉择,如长时间试戴镜片会增加患者的不适,影响整体感受,也大大增加了医生的工作量。因此,本文对接触镜的分类、接触镜在不同圆锥角膜类型中的应用、接触镜配戴中的并发症及其未来展望等方面予以汇总和讨论,以期了解接触镜在圆锥角膜中的临床应用与管理,有助于进一步发挥接触镜在圆锥角膜中的应用价值。

Influence of overnight orthokeratology lens fitting decentration on corneal topography reshaping

Background:This retrospective study was designed to investigate the sole influence of orthokeratology(OK)lens fitting decentration on the Zernike coefficients of the reshaped anterior corneal surface.Methods:This study comprised a review of 106 right eyes and measurements of corneal topography both before OK and at 1-month follow-up visit.A routine was designed to calculate local corneal surface astigmatism and assist the determination of OK lens fitting decentration from pupil center.The pupil-centered corneal Zernike coefficients of baseline(PCCB)and post-treatment(PCCP)were calculated.Meanwhile,the OK-lens-centered corneal Zernike coefficients of post-treatment(OCCP)were also calculated and considered as the presumptive ideal fitting group without decentration.Relationships between lens fitting decentration and the change of Zernike coefficients including(PCCP−PCCB)and(PCCP−OCCP)were analyzed.Results:Patients with a mean age of 11±2.36 years old had an average spherical equivalent refractive error of−3.52±1.06 D before OK.One month after treatment,OK lens fitting decentration from pupil center was 0.68±0.35 mm.RMS of 3rd-order(P<0.05),RMS of 4th-order(P<0.001)and RMS of total high order(P<0.001)corneal Zernike coefficients were increased in PCCP by comparing with OCCP,which was solely caused by lens fitting decentration.Nevertheless,no significant difference was observed in C^(0)_(2)(P>0.05).For the high order corneal Zernike coefficients in(PCCP–OCCP),radial distance of decentration was correlated with C^(−1)_(3)(r=−0.296,P<0.05),C^(1)_(3)(r=−0.396,P<0.001),and C^(0)_(4)(r=0.449,P<0.001),horizontal decentration was significantly correlated with C^(1)_(3)(r=0.901,P<0.001)and C^(1)_(5)(r=0.340,P<0.001),and vertical decentration was significantly correlated with C^(−1)_(3)(r=0.904,P<0.001).Conclusions:OK lens fitting decentration within 1.5 mm hardly influenced the change of corneal spherical power for myopia correction,but significantly induced additional corneal high order Zernike coefficients including C^(−1)_(3),C^(1)_(3),C^(0)_(4),and C^(1)_(5).

ICL植入术治疗高度近视术后早期眼前节形态的变化分析

目的探讨有晶体状眼后房型人工晶状体(ICL)植入术治疗高度近视术后早期眼前节形态的变化情况。方法选取60例(113眼)高度近视患者,均接受ICL植入术治疗。对比患者治疗前后裸眼视力、最佳矫正视力变化情况,眼前节形态变化情况[角膜厚度(CCT)、角膜曲率(K值)、中央前房深度(ACD)],角膜像差变化情况[角膜高阶像差(CHOA)、角膜低阶像差(CLOA)、角膜总像差(CTA)]。结果治疗后30 d、90 d、半年的裸眼视力、最佳矫正视力均优于治疗前(P<0.05)。治疗前及治疗后30 d、90 d、半年,角膜厚度分别为(532.50±25.40)、(532.54±23.17)、(534.64±22.55)、(532.97±24.10)μm,角膜曲率分别为(43.80±0.89)、(43.55±0.92)、(43.55±0.97)、(43.43±1.03)D,中央前房深度分别为(3.22±0.14)、(3.06±0.17)、(3.06±0.14)、(3.09±0.11)mm。与治疗前对比,治疗后30 d、90 d、半年的角膜曲率、中央前房深度均有所减小(P<0.05);治疗前后各个阶段,角膜厚度对比均无明显差异(P>0.05)。治疗后30 d、90 d、半年的CHOA均大于治疗前(P<0.05);治疗后30 d、90 d、半年的CLOA、CTA与治疗前对比均无明显差异(P>0.05)。结论高度近视患者应用ICL植入术治疗,患者的最佳矫正视力、裸眼视力均有所改善,角膜曲率变小、中央前房深度变浅、前房角变窄,患者术后早期眼前节形态良好,且较小影响角膜,安全性较高,可促进患者术后早日康复。

角巩膜镜对圆锥角膜患者视力和角膜参数的影响

目的:探讨配戴角巩膜接触镜对圆锥角膜患者视力和角膜参数的影响。方法:前瞻性研究。共纳入43例(83眼)圆锥角膜患者。配戴角巩膜接触镜,并分别在戴镜前、戴镜3、6 mo后行裂隙灯检查、客观验光和主观验光、裸眼视力(UCVA)和最佳矫正视力(BCVA)、角膜曲率(Kmax、K1和K2)、中央角膜厚度和内皮细胞计数检查。结果:配戴6 mo框架眼镜后平均BCVA(LogMAR)为0.34±0.23,角巩膜接触镜为0.03±0.05(P<0.001)。戴镜6 mo后,Kmax由52.80±5.93 D变为51.51±5.64 D(P<0.001),角膜中央厚度由483.84±34.69μm变为476.28±35.38μm(P<0.001),角膜中央细胞计数由2559.18±275.7 cells/mm^(2)变为2572.73±274.3 cells/mm^(2)(P<0.001)。结论:临床中角膜参数未发生明显变化,角巩膜镜可显著提高视力,且可安全用于圆锥角膜患者。

角膜接触镜在翼状胬肉切除手术后应用对视觉质量的影响

目的探讨与分析角膜接触镜在翼状胬肉切除手术后应用对视觉质量的影响。方法选择2019年9月—2022年12月在岐山县中医医院进行诊治的翼状胬肉患者88例作为研究对象,根据随机数表法将其分为角膜接触镜组与对照组,每组44例。两组都给予翼状胬肉切除手术治疗,对照组给予术后常规治疗,角膜接触镜组给予佩戴角膜接触镜治疗,观察与记录患者的视觉质量变化情况。结果两组患者术后4周的最佳裸眼视力明显高于术前1 d,且角膜接触镜组术后4周的最佳裸眼视力也明显高于对照组,差异有统计学意义(P<0.05)。角膜接触镜组术后4周的角膜水肿、结膜下出血、延迟性出血、高眼压等并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。两组术后4周的角膜散光值均低于术前1 d,且角膜接触镜组术后4周的角膜散光值与对照组相比也显著降低,差异有统计学意义(P<0.05)。两组术后4周的眼部症状评分明显低于术前1 d,且角膜接触镜组术后4周的眼部症状评分也明显低于对照组,差异有统计学意义(P<0.05)。结论角膜接触镜在翼状胬肉切除手术后的应用能改善患者的最佳裸眼视力,降低患者的并发症发生率,降低患者的角膜散光值,改善患者的眼部症状。

儿童长期佩戴角膜塑形镜的角膜内皮状态评估

背景配戴角膜塑形镜可通过非手术方式治疗和延缓近视儿童屈光度的进展，但长期佩戴对角膜组织的影响值得研究。目的观察儿童长期佩戴角膜塑形镜对角膜内皮的影响。方法纳入2009年12月至2011年12月在同济大学附属第十人民医院眼科配戴角膜塑形镜的近视儿童76例150眼，近视儿童每日夜间佩戴角膜塑形镜8～10h，分别于配戴前，配戴后3、6、12、24个月用角膜内皮细胞显微镜测量戴镜者的角膜内皮细胞平均面积、角膜内皮细胞密度、角膜内皮细胞面积变异系数和角膜内皮六角形细胞密度，采用SPSS13．0统计学软件对儿童配戴角膜塑形镜前后的上述各指标变化进行重复测量单因素方差分析。结果近视儿童配戴前与配戴后各时间点间角膜内皮细胞平均面积、角膜内皮细胞密度的变化差异均无统计学意义（F=11．34、7．16，均P〉0．05）。配戴前与配戴后3、6、12、24个月近视儿童角膜内皮细胞面积变异系数的总体差异有统计学意义（F=12．70，P=0．02），其中配戴后24个月近视儿童的角膜内皮细胞面积变异系数值为0．36~0．02，明显高于配戴前的0．28±0．05，差异有统计学意义（P〈0．05）。近视儿童配戴前及配戴后不同时间点间角膜内皮六角形细胞比例的总体差异有统计学意义（F=13．40，P=0．04），其中配戴后12个月、24个月的角膜内皮六角形细胞比例分别为（62~12）％和（60~14）％，明显低于配戴前的（69~12）％，差异均有统计学意义（P〈0．05）。结论角膜塑形镜长期佩戴可使角膜内皮六角形细胞的比例下降及角膜细胞面积变异系数增加。

PV角膜接触镜的治疗应用观察

目的:评估连续过夜配戴博士伦PV接触镜的治疗应用的指征与疗效。方法:非随机选用中山眼科中心的门诊与住院病例29例31只眼,包括需要缓解疼痛与刺激症,保护角膜和促进角膜创面愈合等病例。采用PV镜片连续过夜配戴治疗的同时,根据眼病性质、局部适当给予抗生素或人工泪液,定期检查或询问疼痛缓解情况、眼部改变、镜片的配适状态、镜片沉淀物以及眼部并发症。结果:病例共29例(31只眼),观察时间3～57d。平均20.9d,眼病包括大泡性角膜病变(6例6只眼),角膜炎合并小穿孔或后弹力层膨出5例(5只眼),化学烧伤上皮缺损6例(7只眼),角膜移植术或创伤缝线刺激3例(3只眼),丝状角膜炎3例(3只眼),角膜上皮糜烂2例(3只眼),反复性角膜上皮剥脱症1例(1只眼),角膜板层裂伤与上皮缺损1例(1只眼),外伤性白内障摘除术后持续上皮溃疡1例(1只眼),角膜缘移植联合羊膜移植术后1例(1只眼)。用于缓解疼痛与刺激症为目的者21例(22只眼),疼痛完全缓解或部分缓解达100%。促进角膜愈合者20例(22只眼);完全治愈15例(16只眼)占72.7%,部分改善者4例(5只眼)占22.7%。绷带保护角膜21例(23只眼),其中20例22只眼(95.7%)均有满意的保护作用,仅1例因配适不良无效。结论:PV角膜接触镜对于多种角膜病、眼表病、及角膜术后角膜保护、促进角膜愈合和缓解疼痛刺激等有显著疗效;镜片具有高透氧性能及抗沉淀性好,可大大减少眼部合并症发生的危险,这种新型的镜片可作为理想的首选的治疗性应用镜片。

夜戴型角膜塑形镜对角膜形态及泪液的影响

目的：探讨夜戴型角膜塑形镜对角膜形态及泪液的影响。方法：连续配戴角膜塑形镜1a以上的青少年近视患者40例80眼,平均年龄13.68±2.32岁,戴镜前平均等效球镜-3.61±1.48D,夜间戴镜8~10h,观察戴镜前和戴镜后1wk;1,3,6,12mo的屈光度、角膜曲率、角膜表面规则指数（SRI）、泪膜破裂时间（BUT）、泪液基础分泌量、角膜上皮荧光素染色的情况。结果：戴镜后12mo与戴镜前相比,屈光度明显降低,平均等效球镜从-3.61±1.48D下降为-1.39±1.31D,差异有显著统计学意义（P〈0.01）;角膜曲率明显变平坦,平均K值从42.29±1.55D下降为40.13±1.41D,差异有显著统计学意义（P〈0.01）;SRI升高,从0.34±0.01增加到0.37±0.01,差异有显著统计学意义（P〈0.01）;BUT减少,从10.39±2.25s下降到7.26±1.77s,差异有显著统计学意义（P〈0.01）;以上指标均在戴镜1wk后趋于稳定,戴镜后1,3,6,12mo各指标与戴镜后1wk相比,差异均无统计学意义（P〉0.05）。泪液基础分泌量戴镜前后各时间点比较,差异均无统计学意义（P〉0.05）。戴镜后角膜上皮染色病例数增加,以Ⅰ级为主,戴镜后1wk;1,3,6,12mo角膜染色Ⅰ级分别为15眼（18.8%）,9眼（11.3%）,13眼（16.3%）,9眼（11.3%）,12眼（15.0%）。戴镜后各时间点,角膜荧光素染色Ⅰ级者的BUT均比0级者显著降低（P〈0.05）。结论：夜戴型角膜塑形镜可使近视度下降,角膜变平坦,不影响泪液的基础分泌,但泪膜稳定性下降,应注意定期随访。