Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering emulsions.However,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly sparse.This gap in knowledge holds significant potential for enhancing vaccine efficacy.This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue.The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study.Various factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion itself.The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency.Additionally,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel.This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions.Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery.Importantly,the desired transport efficiency varies depending on the specific application.For instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

Simulation of nanofluid natural convection based on single-particle hydrodynamics in energy-conserving dissipative particle dynamics(eDPD)

In the present study,the nanofliud natural convection is investigated by the energy-conserving dissipative particle dynamics(eDPD)method,where the nanoparticles are considered at the single-particle level.The thermal expansion coefficientβand the viscosityμof the simulated system containing nanoparticles are calculated and found to be in close alignment with the previous simulation results.The single-particle hydrodynamics in e DPD enables simulations of nanofluid natural convection with higher Rayleigh numbers and greater nanoparticle volume fractions.Additionally,this approach is utilized to simulate the nanoparticle distribution during the enhanced heat transfer process in the nanofluid natural convection.The localized aggregation of nanoparticles enhances the heat transfer performance of the nanofluid under specific Rayleigh numbers and nanoparticles volume fractions.

Nonlinearly induced entanglement in dissipatively coupled optomechanical system

Nonlinearly induced steady-state photon–phonon entanglement of a dissipative coupled system is studied in the bistable regime. Quantum dynamical characteristics are analysed by solving the mean-field and fluctuation equations of the system. It is shown that dissipative coupling can induce bistable behaviour for the effective dissipation of the system.Under suitable parameters, one of the steady states significantly reduces the dissipative effect of the system. Consequently,a larger steady-state entanglement can be achieved compared to linear dynamics. Furthermore, the experimental feasibility of the parameters is analysed. Our results provide a new perspective for the implementation of steady-state optomechanical entanglement.

The Paraffin Crystallization in Emulsified Waxy Crude Oil by Dissipative Particle Dynamics

With the advancement of oilfield extraction technology,since oil-water emulsions in waxy crude oil are prone to be deposited on the pipe wall,increasing the difficulty of crude oil extraction.In this paper,the mesoscopic dissipative particle dynamics method is used to study themechanism of the crystallization and deposition adsorbed on thewall.The results show that in the absence of water molecules,the paraffin molecules near the substrate are deposited on themetallic surface with a horizontalmorphology,while the paraffin molecules close to the fluid side are arranged in a vertical column morphology.In the emulsified system,more water molecules will be absorbed on the metallic substrate than paraffin molecules,which obstructed the direct interaction between paraffin molecules and solid surface.Therefore,the addition of watermolecules hinders the crystallization of wax near the substrate.Perversely,on the fluid side,water molecules promote the formation of paraffin crystallization.The research in this paper reveals the crystallization mechanism of paraffin wax in oil-water emulsions in the pipeline from the microscopic scale,which provides theoretical support for improving the recovery of wax-containing crude oil and enhancing the transport efficiency.

Microphase Separation of Star-diblock Copolymer Films： a Dissipative Particle Dynamics Simulation

The microphase-separating behaviors of two types of star-diblock copolymers （Ax）4（By）4 and （A^Bg）4 in thin films are studied using the simulation technique of dissipative particle dynamics. A variety of ordered mesostructures have been observed and the simulated phase diagrams show obvious symmetries for the （Ax）4（By）a films and asymmetries for the （AxBy）4 films, besides, it is easier for the （Ax）4（By）4 than for the （A^By）4 to carry out microphase separation under the same conditions, which has been recognized in bulk and can be ascribed to the structural difference between the two types of star copolymers. There are some correspondences between the mesostructures formed in the film and those formed in bulk at the same composition fraction. Decreasing the thickness of film and strengthening the A-B repulsion both help the mesostructures enhance the degree of order. Composition fraction dependences of the mean-square radius of gyration in the two types of star copolymer films are almost contrary, which can be attributed to the differences in their respective structures. These findings can provide a guide to designing novel microstructures involving star-diblock copolymers via geometrical confinement.

Dissipative Particle Dynamics Simulation of Microscopic Properties in Diblock Copolymer Films

Mean-square bond length, root-mean-square end-to-end distance and gyration radius in diblock copolymer films have been studied by dissipative particle dynamics simulations. Results show evident linear trends of any property separately with the thickness of film, the interaction between particles of different types, the repulsion between particle and boundary, except for the dependence of the variations of mean-square bond length on the thickness of film, which exhibits as a wave trend. What＇s more, the varying trends of mean-square bond length and root-mean-square end-to-end distance can correspond to each other. The density distribution of either component in diblock copolymer film can be controlled and adjusted effectively through its interaction with boundary.

Dynamics of high-frequency modulated waves in a nonlinear dissipative continuous bi-inductance network

This paper presents intensive investigation of dynamics of high frequency nonlinear modulated excitations in a damped bimodal lattice. The effects of the dissipation are considered through a linear dissipation coefficient whose evolution in terms of the carrier wave frequency is checked. There appears that the dissipation coefficient increases with the carrier wave frequency. In the linear limit and for high frequency waves, study of the asymptotic behavior of plane waves reveals the existence of two additional regions in the dispersion curve where the modulational phenomenon is observed compared to the lossless line. Based on the multiple scales method exploited in the continuum approximation using an appropriate decoupling ansatz for the voltage of the two different cells, it appears that the motion of modulated waves is described by a dissipative complex Ginzburg–Landau equation instead of a Korteweg–de Vries equation. We also show that this amplitude wave equation admits envelope and hole solitons in the high frequency mode. From basic sources, we design a programmable electronic generator of complex signals with desired characteristics, which delivers signals exploited as input waves for all our numerical simulations. These simulations are performed in the LTspice software that uses realistic components and give the results that corroborate perfectly our analytical predictions.

ROBUST DISSIPATIVE CONTROL FOR STATE-DELAYED SYSTEMS WITH DISSIPATIVE UNCERTAINTY

This paper focused on a class of linear state-delayed systems with or without uncertainty. As for uncertain systems, dissipative uncertainty description contains norm-bounded and positive real uncertainties as special cases. The paper is concerned with the design of dissipative static state feedback controllers such that the closed-loop system is (robustly) asymptotically stable and strictly (Q,S,R)-dissipative. Sufficient conditions for the existence of the quadratic dissipative state feedback controllers are obtained by using a linear matrix inequality (LMI) approach. It is shown that the solvability of dissipative controller design problem is implied by the feasibility of LMIs. The main results of this paper unify the existing results on H ∞ control and passive control.

Temperature effect on dissipative holographic screening-photovoltaic solitons in a biased dissipative system

In a biased dissipative photovoltaic-photorefractive system, this paper investigates the temperature effect on the evolution and the self-deflection of the dissipative holographic screening-photovoltaic （DHSP） solitons. The results reveal that, the evolution and the self-deflection of the bright and dark DHSP solitons are influenced by the system temperature. At a given temperature, for a stable DHSP soliton originally formed in the dissipative system, it attempts to evolve into another DHSP soliton when the temperature change is appropriately small, whereas it will become unstable or break down if the temperature departure is large enough. Moreover, the self-deflection degree of the solitary beam centre increases as temperature rises in some range, while it is decided by the system parameters and is slight under small-signal condition. The system temperature can be adjusted to change the formation and the self-deflection of the solitary beam in order to gain certain optical ends. In a word, the system temperature plays a role for the DHSP solitons in the dissipative system.

Quantum Squeezing Effects of a Non-dissipative Mesoscopic Circuit with Coupled Inductors and Capacitors

The quantum fluctuations of the charge and current in a non-dissipative mesoscopic circuit with coupled inductors and capacitors are studied for the squeezed vacuum state.The influence of the phase angle upon the quantum fluctuations is discussed in particular.Our results indicate that when the circuit parameters remain constant and the phasesθof the two circuits are equal,the squeezing of the charge or its conjugate variable increases.When the difference of the two phases equalsπ,the squeezing will deteriorate.Therefore,if we want to decrease the quantum noise,we should not only control the amplitude r,but also control the phaseθcarefully.

Quankum Effects of a Dissipative Mesoscopic Circuit with Mutual Inductance

We study the quantum fluctuations of the charge and current of two L-C dissipative mesoscopic circuit with the mutual inductance in the vacuum state.Our results show that the system state will evolve to a squeezed coherent state under the effect of external source.We find that the squeezing amplitude parameter is relative to the parameters of circuit and the mutual-inductance coefficient in the existence of dissipation.When the circuit has no dissipation or there is complete coupling between two meshes,the squeezing amplitude parameter only depends on the capacitance's ratio.

Dissipative particle dynamics simulation of wettability alternation phenomena in the chemical flooding process

Wettability alternation phenomena is considered one of the most important enhanced oil recovery （EOR） mechanisms in the chemical flooding process and induced by the adsorption of surfactant on the rock surface. These phenomena are studied by a mesoscopic method named as dissipative particle dynamics （DPD）. Both the alteration phenomena of water-wet to oil-wet and that of oil-wet to water-wet are simulated based on reasonable definition of interaction parameters between beads. The wetting hysteresis phenomenon and the process of oil-drops detachment from rock surfaces with different wettability are simulated by adding long-range external forces on the fluid particles. The simulation results show that, the oil drop is liable to spread on the oil-wetting surface and move in the form of liquid film flow, whereas it is likely to move as a whole on the waterwetting surface. There are the same phenomena occuring in wettability-alternated cases. The results also show that DPD method provides a feasible approach to the problems of seepage flow with physicochemical phenomena and can be used to study the mechanism of EOR of chemical flooding.

ATTRACTORS FOR FULLY DISCRETE FINITE DIFFERENCE SCHEME OF DISSIPATIVE ZAKHAROV EQUATIONS

A fully discrete finite difference scheme for dissipative Zakharov equations is analyzed. On the basis of a series of the time-uniform priori estimates of the difference solutions, the stability of the difference scheme and the error bounds of optimal order of the difference solutions are obtained in L^2 × H^1 × H^2 over a finite time interval （0, T]. Finally, the existence of a global attractor is proved for a discrete dynamical system associated with the fully discrete finite difference scheme.

ASYMPTOTIC STABILITY OF TRAVELING WAVES FOR A DISSIPATIVE NONLINEAR EVOLUTION SYSTEM

This paper is concerned with the existence and the nonlinear asymptotic stabil- ity of traveling wave solutions to the Cauchy problem for a system of dissipative evolution equations {θt=vζx＋（ζθ）x＋aθxx,ζt=-θx＋βζxx;with initial data and end states （ζθ）（x,0）=（ζ0,θ0）（x）→（ζ±,θ±）as x→∞.We obtain the existence of traveling wave solutions by phase plane analysis and show the asymptotic nonlinear stability of traveling wave solutions without restrictions on the coeffi- cients a and v by the method of energy estimates.

Interaction Time Study of the Dissipative Process in the Reaction ^(19)F+^(45)Sc

Excitation functions have been measured for the dissipative products of 4≤Z≤12 in ^(19)F+^(45)Sc reaction from 102 to ^(108)MeV by a step of 300keV at θl=42°.The energy coherence widths have been extracted and the dinuclear system lifetimes of the order of 10^(-21 ) s have been deduced by analysing the cross section Auctuations.

Diffusion-induced deflection and the effect of two-wave mixing gain on dissipative photovoltaic solitons

In an open-circuit dissipative photovoltaic （PV） crystal, by considering the diffusion effect, the deflection of bright dissipative photovoltaic （DPV） solitons has been investigated by employing numerical technique and perturbational procedure. The relevant results show that the centre of the optical beam moves along a parabolic trajectory, while the central spatial-frequency component shifts linearly with the propagation distance; furthermore, both the spatial deflection and the angular derivation are associated with the photovoltaic field. Such DPV solitons have a fixed deflection degree completely determined by the parameters of the dissipative system. The small bending cannot affect the formation of the DPV soliton via two-wave mixing.

Dynamical Properties of Two Coupled Dissipative QED Cavities Driven by Coherent Fields

When two identical QED cavities driven by the coherent fields are located in a uniform environment, in addition to dissipation, there appears an indirect coupling between the two cavities induced by the background fields. We investigate the effects of the coherent fields, the dissipation as well as the incoherent coupling on the following dynamical properties of the system： photon transfer, reversible decoherence, and quantum state transfer, etc. We find that the photons in the cavities do not leak completely into the environment due to the collective coupling between the cavities and the enviroment, and the photons are transferred irreversibly from the cavity with more photons to the cavity with less ones due to the incoherent coupling so that they are equally distributed among the two cavities. The coherent field pumping on the two cavities increases the mean photons, complements the revived magnitude of the reversible decoherence, but hinders the quantum state transfer between the two cavities. The above phenomena may find applications in quantum communication and other basic fields.

A new finite difference scheme for a dissipative cubic nonlinear Schrdinger equation

This paper considers the one-dimensional dissipative cubic nonlinear SchrSdinger equation with zero Dirichlet boundary conditions on a bounded domain. The equation is discretized in time by a linear implicit three-level central difference scheme, which has analogous discrete conservation laws of charge and energy. The convergence with two orders and the stability of the scheme are analysed using a priori estimates. Numerical tests show that the three-level scheme is more efficient.

Reflection of Plane Waves from a Free Surface of an Initially Stressed Transversely Isotropic Dissipative Medium

The governing equations of a transversely isotropic dissipative medium are solved analytically to obtain the speeds of plane waves. The appropriate solutions satisfy the required boundary conditions at the stress-free surface to obtain the expressions of the reflection coefficients of reflected quasi-P (qP) and quasi-SV (qSV) waves in closed form for the incidence of qP and qSV waves. A particular model is chosen for numerical computation of these reflection coefficients for a certain range of the angle of incidence. The numerical values of these reflection coefficients are shown graphically against the angle of incidence for different values of initial stress parameter. The impact of initial stress parameter on the reflection coefficients is observed significantly.

Traveling Wave Solutions and Kind Wave Excitations for the (2 + 1)-Dimensional Dissipative Zabolotskaya-Khokhlov Equation

In this work, with the help of the symbolic computation system Maple and the Riccati mapping approach and a linear variable separation approach, a new family of traveling wave solutions of the (2 + 1)-dimensional dissipative Zabolotskaya-Khokhlov equation (DZK) is derived. Based on the derived solitary wave solution, some novel kind wave excitations are investigated.