Objective:To investgate the forced degradation study for the determination of degradation of the drug substance.Methods:Paracetamol was exposed to different conditions according to International Conference on Harmoniz...Objective:To investgate the forced degradation study for the determination of degradation of the drug substance.Methods:Paracetamol was exposed to different conditions according to International Conference on Harmonization guideline.The amount of degradation product can be calculated with the help of UV spectrophotometer.The official test limits according to British Pharmacopoeia/United States Pharmacopoeia should not less than and should not more than lapelled amount.Forced degradation of drug substance was exposed to acidic and basic medium of panadol.Forced degradation of drug substance of panadol,disprol and calpol were also observed negligible difference in availability on exposure to UV and heat.This method can be used successfully for studying the stress degradation factors.Because this method is less time consuming and simple and cost effective also.Results:The brands i.e.calpol,panadol and disprol,when they come in contact with different degradation parameters(before,acid,base,heat and UV treatments)according to statistical analysis,the result showed significant values(P<0.05)which indicated that there was no degradation in any of the brand.Conclusions:The result indicated there is no degradation found in these brands.展开更多
The kinetics of ultrasonic degradation of aqueous solution of polyacrylamide（PAM）and poly（ethyleneoxide）（PEO）as well as ultrasonic block copolymerization of aqueous solution of the mixture of PAM/PEOwere studied...The kinetics of ultrasonic degradation of aqueous solution of polyacrylamide（PAM）and poly（ethyleneoxide）（PEO）as well as ultrasonic block copolymerization of aqueous solution of the mixture of PAM/PEOwere studied respectively.The degradation reaction of PEO follows a linear relationship between（P1-P∞）-1and irradiation time,while that of PAM follows a linear relationship between（P1-P∞）-1/2and irradiation time.The structure of the copolymer was identified by IR,NMR and DTA,and the copolymer prepared is a blockone.The copolymer formed by irradiating 1% aqueous solution of PEO/PAM mixture（1:1）for a period of40min.at 18.2 kHz with a sonic intensity corresponding to 2.OA input current on the reversed main circuitamounts to 61.8%.展开更多
Degradation reaction of doxycycline or methacycline was carried out in KOH solution and intense fluorescence was obtained.A degradation mechanism of doxycycline or methacycline was suggested.
Pramipexole belongs to a class of nonergot dopamine agonist recently approved for the treatment of early and advanced Parkinson＇s disease.A validated specific stability indicating reversed-phase liquid chromatographi...Pramipexole belongs to a class of nonergot dopamine agonist recently approved for the treatment of early and advanced Parkinson＇s disease.A validated specific stability indicating reversed-phase liquid chromatographic method has been developed for the quantitative determination of pramipexole in bulk as well as in pharmaceutical dosage forms in the presence of degradation products.Forced degradation studies were performed by exposition of drug to hydrolytic（acidic and basic）,oxidative and photolytic stress conditions,as defined under ICH guideline Q1A（R2）.Significant degradation was observed under hydrolytic,oxidative and photolytic conditions and the degradation products formed were identified by LC-MS.展开更多
文摘Objective:To investgate the forced degradation study for the determination of degradation of the drug substance.Methods:Paracetamol was exposed to different conditions according to International Conference on Harmonization guideline.The amount of degradation product can be calculated with the help of UV spectrophotometer.The official test limits according to British Pharmacopoeia/United States Pharmacopoeia should not less than and should not more than lapelled amount.Forced degradation of drug substance was exposed to acidic and basic medium of panadol.Forced degradation of drug substance of panadol,disprol and calpol were also observed negligible difference in availability on exposure to UV and heat.This method can be used successfully for studying the stress degradation factors.Because this method is less time consuming and simple and cost effective also.Results:The brands i.e.calpol,panadol and disprol,when they come in contact with different degradation parameters(before,acid,base,heat and UV treatments)according to statistical analysis,the result showed significant values(P<0.05)which indicated that there was no degradation in any of the brand.Conclusions:The result indicated there is no degradation found in these brands.
文摘The kinetics of ultrasonic degradation of aqueous solution of polyacrylamide（PAM）and poly（ethyleneoxide）（PEO）as well as ultrasonic block copolymerization of aqueous solution of the mixture of PAM/PEOwere studied respectively.The degradation reaction of PEO follows a linear relationship between（P1-P∞）-1and irradiation time,while that of PAM follows a linear relationship between（P1-P∞）-1/2and irradiation time.The structure of the copolymer was identified by IR,NMR and DTA,and the copolymer prepared is a blockone.The copolymer formed by irradiating 1% aqueous solution of PEO/PAM mixture（1:1）for a period of40min.at 18.2 kHz with a sonic intensity corresponding to 2.OA input current on the reversed main circuitamounts to 61.8%.
文摘Degradation reaction of doxycycline or methacycline was carried out in KOH solution and intense fluorescence was obtained.A degradation mechanism of doxycycline or methacycline was suggested.
文摘Pramipexole belongs to a class of nonergot dopamine agonist recently approved for the treatment of early and advanced Parkinson＇s disease.A validated specific stability indicating reversed-phase liquid chromatographic method has been developed for the quantitative determination of pramipexole in bulk as well as in pharmaceutical dosage forms in the presence of degradation products.Forced degradation studies were performed by exposition of drug to hydrolytic（acidic and basic）,oxidative and photolytic stress conditions,as defined under ICH guideline Q1A（R2）.Significant degradation was observed under hydrolytic,oxidative and photolytic conditions and the degradation products formed were identified by LC-MS.
