期刊文献+
共找到5,348篇文章
< 1 2 250 >
每页显示 20 50 100
The Influences of the "Eight Sights" Culture on Modern Landscape Design 被引量:1
1
作者 申月华 李硕 李品 《Journal of Landscape Research》 2009年第1期75-78,共4页
The cultural details and characteristics of 'Eight sights',which were existent but ignored,were found out through the introduction of the origin and the development of 'Eight sights'.The influences of ... The cultural details and characteristics of 'Eight sights',which were existent but ignored,were found out through the introduction of the origin and the development of 'Eight sights'.The influences of the 'Eight sights' on modern landscape design were summarized,reflecting the regional and cultural characteristics.The practical significance of re-examining the 'Eight sights' for the development of our garden landscape was pointed out. 展开更多
关键词 eight sights CULTURE REGIONAL CHARACTERISTIC MODERN LANDSCAPE
下载PDF
Exploring Regional Ecological Cultures in the Upper Reaches of the Yellow River in the Ming and Qing Dynasties from the Perspective of "Top Eight Views" 被引量:1
2
作者 冯红英 《Journal of Landscape Research》 2011年第11期36-41,共6页
By studying typical "Top Eight Views" in cities like Xining,Lanzhou and Yinchuan in the upper reaches of the Yellow River,mountain and water landscapes in the study area were analyzed in terms of natural eco... By studying typical "Top Eight Views" in cities like Xining,Lanzhou and Yinchuan in the upper reaches of the Yellow River,mountain and water landscapes in the study area were analyzed in terms of natural ecology;bridges,canals,ferries,pavilions,mansions,towers,temples,historical sites,production and living landscapes were analyzed in terms of humanistic ecology.On this basis,"Top Eight Views" in the upper reaches of the Yellow River were compared and the following conclusions obtained:mountain landscapes were distributed in the whole region,waterscapes unevenly valued in different cities,bridges,canals and ferries mostly located in Ningxia,temples commonly found in all cities,garden arts introduced into cities,traditional cultures carried forward by historical relics.Then the relationship between "Top Eight Views" and regional eco-cultures was analyzed,and it was proposed that humanistic and cultural connotations of these "Top Eight Views" contributed a lot to beautifying urban environment,satisfying needs of the locals' spiritual life,carrying forward local history and culture,enriching urban cultural connotations,expanding living spaces of local residents and improving integrated functions of cities."Top Eight Views" culture complied with the construction gist of urban ecological cultures,and was of great referential value for the construction of urban ecological cultures in the upper reaches of the Yellow River,and also the healthy,scientific and sustainable development of local cities. 展开更多
关键词 "Top eight Views" Urban ECOLOGICAL CULTURES The upper reaches of the YELLOW River
下载PDF
Linkage analysis and integrated software GAPL for pure-line populations derived from four-way and eight-way crosses 被引量:6
3
作者 Luyan Zhang Lei Meng Jiankang Wang 《The Crop Journal》 SCIE CAS CSCD 2019年第3期283-293,共11页
Pure lines derived from multiple parents provide abundant variation for genetic study.However,efficient genetic analysis methods and user-friendly software are still lacking.In this study, we developed linkage analysi... Pure lines derived from multiple parents provide abundant variation for genetic study.However,efficient genetic analysis methods and user-friendly software are still lacking.In this study, we developed linkage analysis methods and integrated analysis software for pure-line populations derived from four-way and eight-way crosses.First, polymorphic markers are classified into different categories according to the number of identifiable alleles in the inbred parents.Expected genotypic probability is then derived for each pair of complete markers, and based on them a maximum likelihood estimate(MLE) of recombination frequency is calculated.An EM algorithm is proposed for calculating recombination frequencies in scenarios that at least one marker is incomplete.A linkage map can thus be constructed using estimated recombination frequencies.We describe a software package called GAPL for recombination frequency estimation and linkage map construction in multi-parental pure-line populations.Both simulation studies and results from a reported four-way cross recombinant inbred line population demonstrate that the proposed method and software can build more accurate linkage maps in shorter times than other published software packages.The GAPL software is freely available from www.isbreeding.net and can also be used for QTL mapping in multi-parental populations. 展开更多
关键词 Pure lines Four-way CROSS eight-way CROSS Recombination frequency estimation Integrated software
下载PDF
Grey Relevancy Degree and Improved Eight-Direction Sobel Operator Edge Detection 被引量:2
4
作者 Yang Yang Lianxin Wei 《Journal of Signal and Information Processing》 2021年第2期43-55,共13页
Edge detection is an important aspect to improve image edge quality in image processing. The purpose of edge detection is to identify the points in digital images with great brightness variation. However, the accuracy... Edge detection is an important aspect to improve image edge quality in image processing. The purpose of edge detection is to identify the points in digital images with great brightness variation. However, the accuracy of traditional edge detection methods in edge extraction is low. For the actual image, the grey edge is sometimes not very clear, the image also contains noise. The detection result of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">traditional Sobel operator is relatively accurate, but the detection result is rough and sensitive to noise. To solve the above problems, this paper proposes an improved eight-direction Sobel operator based on grey relevancy degree, which combines 5</span><span style="font-family:""> </span><span style="font-family:Verdana;">×</span><span style="font-family:""> </span><span style="font-family:Verdana;">5 Sobel operator with </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">grey relational degree and a new eight-direction grey relevancy method. The results show that this method can detect the useful information of edge more accurately and improve the anti-noise performance. However, the drawback is that the algorithm is not automatic. 展开更多
关键词 Edge Detection Grey Relevancy eight Directions Sobel Operator
下载PDF
Acupoint Exploration A PRELIMINARY EXPLORATION OF THE CHARACTERISTICS OF SELECTING ACUPOINTS FOR EIGHT CATEGORIES OF PATTERNS OF IMBALANCE
5
作者 Liu Ligong Huang Xianming Wu Shaode Shanghai Research Institute of Acupuncture and Moxibustion,Shanghai 200030,ChinaZhang Linzheng Gu Jie Shangshai Traditional Chinese Medicine College,Shanghai 200030,China 《World Journal of Acupuncture-Moxibustion》 1993年第2期40-45,共6页
With the help of computers,we have made statistics as to the frequency of se-lecting points for the eight categories of patterns of imbalance.We suggest that for the heat syn-drome,the points in the upper part should ... With the help of computers,we have made statistics as to the frequency of se-lecting points for the eight categories of patterns of imbalance.We suggest that for the heat syn-drome,the points in the upper part should usually be selected,for the cold syndrome,the points inthe lower part should generally be adopted;for the exterior syndrome,the points on the yang surfaceshould mostly be selected,for the interior syndrome,the points on the yin surface should generally beadopted;for the asthenic syndrome,the points in the trunk should mostly be selected,for the sthenicsyndrome,the points at the extremities generally be adopted. 展开更多
关键词 eight principal SYNDROMES Yin and Yang eight diagram Principle of selecting ACUPOINTS
下载PDF
Synthesis and Structure Characterization of a Manganese(Ⅱ) Complex With Eight Coordination Geometry: [Mn(O_2CMe)_2(phen)_2]
6
作者 王梅 马成丙 +2 位作者 王会生 陈昌能 刘秋田 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第7期753-756,共4页
The title compound [Mn(O2CMe)2(phen)2] (phen = 1,10-phenanthroline) 1 has been synthesized and structurally determined by single-crystal X-ray diffraction. The crystal is of orthor- hombic, space group Pbcn, wit... The title compound [Mn(O2CMe)2(phen)2] (phen = 1,10-phenanthroline) 1 has been synthesized and structurally determined by single-crystal X-ray diffraction. The crystal is of orthor- hombic, space group Pbcn, with a = 12.554(4), b = 10.168(3), c = 17.704(5)A, V= 2259.7(12)A^3 Z = 4, C28H22MnN4O4, Mr= 533.44, Dc= 1.568 g]cm^3, F(000) = 1100, Rint = 0.0242, T= 293(2) K and p = 0.631 mm^-1. The final R = 0.0687 and wR = 0.1960 for 2046 observed reflections with I 〉 20(/). The structure of the complex consists of one Mn(II) core coordinated by two bidentate-bound CH3COO^- groups and two η^2-phen groups forming an eight-coordinate geometrical configuration. 展开更多
关键词 MANGANESE crystal structure eight-coordination photosystem
下载PDF
A New Eight-connected Three-dimensional Network Based on a Tetranuclear Zinc Cluster Building Block
7
作者 张鹏 徐敏 +2 位作者 李莹 陈维琳 王恩波 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第6期766-770,共5页
One interesting coordination polymer, [Zn2(1,2,4-BTC)(OH)(H2O)2]2·2H2O 1, has been synthesized from 1,2,4-BTC (1,2,4-BTC = 1,2,4-bentricarboxylate) under hydrothermal conditions and characterized by eleme... One interesting coordination polymer, [Zn2(1,2,4-BTC)(OH)(H2O)2]2·2H2O 1, has been synthesized from 1,2,4-BTC (1,2,4-BTC = 1,2,4-bentricarboxylate) under hydrothermal conditions and characterized by elemental analyses, IR, TG and single-crystal X-ray diffraction. Complex I crystallizes in triclinic, space group P^-1, with a = 6.5200(13), b = 9,0600(18), c = 10.968(2) A^°, α = 111.55(3), β = 92.07(3),γ= 95.03(3)°, C9H10O10Zn2, Mr = 408.91, V= 598.7(2) A^°^3, Dc = 2.268 g/cm^3, F(000) = 408 and Z = 2. X-ray diffraction analysis reveals that complex 1 is a three-dimensional network built from tetranuclear Zn(Ⅱ) building unit. In this complex, the Zn4 unit is an eight-connected knot, while 1,2,4-BTC a four-connected knot. This results in a CaF2 topology. To the best of our knowledge, such Zn4 unit is the first 8-connected building block built from asymmetry ligand. 展开更多
关键词 eight-connected asymmetry ligand three-dimensional network CaF2 topology
下载PDF
Drinfeld twist and the domain wall partition function of the eight-vertex model
8
作者 郝昆 陈曦 +1 位作者 石康杰 杨文力 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第1期110-120,共11页
With the help of the F-basis provided by the Drinfeld twist or factorising F-matrix for the spatial optical soliton model associated with the eight-vertex model, we calculate the partition function for the eight-verte... With the help of the F-basis provided by the Drinfeld twist or factorising F-matrix for the spatial optical soliton model associated with the eight-vertex model, we calculate the partition function for the eight-vertex model on an N ×N square lattice with domain wall boundary condition. 展开更多
关键词 eight-vertex model domain wall boundary condition Drinfeld twist
下载PDF
Numerical study of strained InGaAs quantum well lasers emitting at 2.33 μm using the eight-band model
9
作者 汪明 谷永先 +2 位作者 季海铭 杨涛 王占国 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第7期380-386,共7页
We investigate the band structure of a compressively strained In(Ga)As/In0.53Ga0.47As quantum well (QW) on an InP substrate using the eight-band k.p theory. Aiming at the emission wavelength around 2.33 μm, we di... We investigate the band structure of a compressively strained In(Ga)As/In0.53Ga0.47As quantum well (QW) on an InP substrate using the eight-band k.p theory. Aiming at the emission wavelength around 2.33 μm, we discuss the influences of temperature, strain and well width on the band structure and on the emission wavelength of the QW. The wavelength increases with the increase of temperature, strain and well width. Furthermore, we design an InAs /In0.53Ga0.47As QW with a well width of 4.1 nm emitting at 2.33 μm by optimizing the strain and the well width. 展开更多
关键词 band structure eight-band k.p theory strained quantum well peak emission wavelength
下载PDF
Numerical Computation of Figure-eight Solution for 3-body Problems
10
作者 徐乐顺 冀书关 《Northeastern Mathematical Journal》 CSCD 2007年第3期226-230,共5页
The main goal of this paper is to compute the Figure-eight solutions for the planar Newtonian 3-body problem with equal masses by finding the critical points of the functional associated with the motion equations of 3... The main goal of this paper is to compute the Figure-eight solutions for the planar Newtonian 3-body problem with equal masses by finding the critical points of the functional associated with the motion equations of 3-body in plane R2. The algorithm adopted here is the steepest descent method, which is simple but very valid for our problem. 展开更多
关键词 numerical computation figure-eight solution N-body problem
下载PDF
Homoclinic Bifurcation Properties near Eight-figure Homoclinic Orbit
11
作者 邹永魁 佘彦 《Northeastern Mathematical Journal》 CSCD 2002年第1期79-88,共10页
In this paper we investigate the homoclinic bifurcation properties near an eight-figure homoclinic orbit of co-dimension two of a planar dynamical system. The corresponding local bifurcation diagram is also illustrate... In this paper we investigate the homoclinic bifurcation properties near an eight-figure homoclinic orbit of co-dimension two of a planar dynamical system. The corresponding local bifurcation diagram is also illustrated by numerical computation. 展开更多
关键词 eight figure homoclinic orbit BIFURCATION turning point
下载PDF
Modeling and Robust Backstepping Sliding Mode Control with Adaptive RBFNN for a Novel Coaxial Eight-rotor UAV 被引量:12
12
作者 Cheng Peng Yue Bai +3 位作者 Xun Gong Qingjia Gao Changjun Zhao Yantao Tian 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI 2015年第1期56-64,共9页
This paper focuses on the robust attitude control of a novel coaxial eight-rotor unmanned aerial vehicles (UAV) which has higher drive capability as well as greater robustness against disturbances than quad-rotor UAV.... This paper focuses on the robust attitude control of a novel coaxial eight-rotor unmanned aerial vehicles (UAV) which has higher drive capability as well as greater robustness against disturbances than quad-rotor UAV. The dynamical and kinematical model for the coaxial eight-rotor UAV is developed, which has never been proposed before. A robust backstepping sliding mode controller (BSMC) with adaptive radial basis function neural network (RBFNN) is proposed to control the attitude of the eightrotor UAV in the presence of model uncertainties and external disturbances. The combinative method of backstepping control and sliding mode control has improved robustness and simplified design procedure benefiting from the advantages of both controllers. The adaptive RBFNN as the uncertainty observer can effectively estimate the lumped uncertainties without the knowledge of their bounds for the eight-rotor UAV. Additionally, the adaptive learning algorithm, which can learn the parameters of RBFNN online and compensate the approximation error, is derived using Lyapunov stability theorem. And then the uniformly ultimate stability of the eight-rotor system is proved. Finally, simulation results demonstrate the validity of the proposed robust control method adopted in the novel coaxial eight-rotor UAV in the case of model uncertainties and external disturbances. © 2014 Chinese Association of Automation. 展开更多
关键词 Adaptive control systems Aircraft control Approximation algorithms Attitude control BACKSTEPPING Controllers Functions Learning algorithms Radial basis function networks Robust control Robustness (control systems) Sliding mode control Uncertainty analysis
下载PDF
基于改进RANSAC-EightPoint算法的单目视觉的自动初始化方法
13
作者 何斌 李晓明 《工业控制计算机》 2017年第11期70-71,共2页
为解决利用单目相机估计相机位姿时产生的尺度问题和尺度不统一带来的影响,需通过初始化方法来固定尺度,而初始化方法应无需人为选择两张良好的图片来进行初始化且要有良好的鲁棒性,提出了一种基于改进RANSAC-EightPoint算法的自动初始... 为解决利用单目相机估计相机位姿时产生的尺度问题和尺度不统一带来的影响,需通过初始化方法来固定尺度,而初始化方法应无需人为选择两张良好的图片来进行初始化且要有良好的鲁棒性,提出了一种基于改进RANSAC-EightPoint算法的自动初始化方法 ,可自动选择有显著视差的两张图片进行初始化。通过随机采样一致性(Random Sample Concensus,RANSAC)与八点法(Eight-point-algorithm)结合的改进RANSAC-Eight Point算法来估计两图像间的位姿,使得对带有错误匹配的数据也有较准确的估计值。最后采用标准测试数据集和自己采集数据对该方法进行测试,并比较了利用该初始化方法后获得的轨迹和无初始化方法获得的轨迹与真实轨迹之间的差异。实验结果表明该方法都能对这些数据集完成初始化,通过该方法后所得到的轨迹具有全局一致性。 展开更多
关键词 单目视觉 随机采样一致性 八点法 初始化
下载PDF
Anybody仿真太极不同步法时股骨及下肢骨主要关节的应力特征
14
作者 都志豪 朱宇童 +2 位作者 李浩杰 翟丰 李飞鱼 《中国组织工程研究》 CAS 北大核心 2025年第15期3121-3128,共8页
背景:Anybody骨肌建模系统,使用数学建模技术模拟人体骨骼、肌肉和环境的关系,可对人体的逆向动力学进行研究,得出下肢关节力等指标。目的:分析练习太极拳动作时下肢骨主要关节的应力分布规律,为其科学训练和锻炼价值提供依据。方法:在... 背景:Anybody骨肌建模系统,使用数学建模技术模拟人体骨骼、肌肉和环境的关系,可对人体的逆向动力学进行研究,得出下肢关节力等指标。目的:分析练习太极拳动作时下肢骨主要关节的应力分布规律,为其科学训练和锻炼价值提供依据。方法:在北京体育大学武术学院选取8名太极拳健将级运动员进行7组步法动作和右腿股骨CT的数据采集。使用BTS红外捕捉系统、Kistler三维测力台采集太极(八法五步)7组步法动作的运动和力学数据,利用Anybody 7.2骨肌模型的多体动力学仿真技术计算下肢关节动力学参数,结合Workbench 19.2对股骨进行应力计算分析。结果与结论:①利用Workbench软件分析得出了7组步法动作的股骨应力结果,7组动作的应力峰值由大至小顺序是:退步捋势(22.00 MPa)、退步採势(19.379 MPa)、左右移步挤按(9.35 MPa)、左右移步肘靠(6.30 MPa)、进步掤势(4.68 MPa)、进步挒势(2.57 MPa)、中定独立势(0.31 MPa)。②在7组步法动作中2种向后退步动作股骨应力最大(P<0.05),且在7组动作运动过程中的股骨最大应力位置均不同。③上述结果证实,在太极(八法五步)7种步法动作练习时,股骨应力阈值和最大应力位置会随着5种方向(7组动作)运动不同而变化,通过连续训练能够全面地刺激股骨体,进步动作对于股骨体正面和外侧上端影响较大,退步动作对股骨体后面和内侧影响较大,左右横向步法动作主要是股骨体两侧对称受力。④初学者要根据不同步法动作的受力特点来进行针对训练,进步动作和退步动作训练时要注重太极拳的旋转用力以及左右横移步法动作训练时的内侧对抗用力,根据自身薄弱问题,对太极拳训练步法有所侧重,进而达到更好的锻炼效果。 展开更多
关键词 太极 八法五步 股骨 Anybody骨肌模型 有限元分析 生物力学 关节受力 下肢骨
下载PDF
Development of High Sensitivity Eight-Element Multiplexed Fiber Laser Acoustic Pressure Hydrophone Array and Interrogation System 被引量:6
15
作者 Ming LI Zhihui SUN +8 位作者 Xiaolei ZHANG Shujuan LI Zhiqiang SONG Meng WANG Jian GUO Jiasheng NI Chang WANG Gangding PENG Xiangang XU 《Photonic Sensors》 SCIE EI CAS CSCD 2017年第3期253-260,共8页
Fiber laser hydrophones have got widespread concems due to the unique advantages and broad application prospects. In this paper, the research results of the eight-element multiplexed fiber laser acoustic pressure arra... Fiber laser hydrophones have got widespread concems due to the unique advantages and broad application prospects. In this paper, the research results of the eight-element multiplexed fiber laser acoustic pressure array and the interrogation system are introduced, containing low-noise distributed feedback fiber laser (DFB-FL) fabrication, sensitivity enhancement packaging, and interferometric signal demodulation. The frequency response range of the system is 10Hz-10kHz, the laser frequency acoustic pressure sensitivity reaches 115 dB re Hz/Pa, and the equivalent noise acoustic pressure is less than 60μa/Hz^1/2. The dynamic range of the system is greater than 120 dB. 展开更多
关键词 Fiber laser hydrophone DFB-FL packaging sensitization eight-element multiplex interferometric demodulation
原文传递
Modeling Yin-Yang Balance in Tai-Chi Diagram with a Melting-Freezing Rotating Device Part 3 -The Contemporary Tai-Chi Diagram,the Yuan-Chi Diagram and the Fu Xi's Eight Trigrams 被引量:3
16
作者 Sui Lin Tzu-Fang Chen 《Journal of Thermal Science》 SCIE EI CAS CSCD 2002年第4期296-302,共7页
The physical model describing the Yin-Yang balance in the tai-chi diagram via the melting and freezing processes in a rotating device presented in parts 1 and 2 is further developed for the contemporary tai-chi diagra... The physical model describing the Yin-Yang balance in the tai-chi diagram via the melting and freezing processes in a rotating device presented in parts 1 and 2 is further developed for the contemporary tai-chi diagram and in the yuan-chi diagram. The contemporary tai-chi diagram shown in Fig.1 is a simplification form of the ancient tai-chi diagram presented in Reference [2]. There are two semi-circles forming the interface curve between the yin and yang in the contemporary tai-chi diagram. By knowing the location of the interface between the yin and yang in the contemporary tai-chi diagram, the requirement for the simulation model is to find the condition to match the interface location. The simplification changes not only the structure but also the physical insight of the ancient tai-chi diagram, which will be described in the present study.The yuan-chi diagram shown in Fig.2 is the combination of the Master Chen’s tai-chi diagram presented in References [1,2] and the contemporary tai-chi diagram. 展开更多
关键词 Tai-chi DIAGRAM Yuan-chi DIAGRAM Fu Xi’s eight trigrams.
原文传递
A luminescent metal-organic framework with an open cubic cage and eight-coordinate cadmium nodes 被引量:3
17
作者 WANG ChuanFeng ZHANG ZhengXing +2 位作者 ZHANG LiLi LI FuYou ZHOU XiGeng 《Science China Chemistry》 SCIE EI CAS 2010年第10期2079-2082,共4页
Self-assembly of cadmium ions and the rigid bridging ligand 4,4′-methylenebis(3-hydroxy-2-naphthoic acid) (pamoic acid, H4PA) leads to a one-dimensional metal-organic framework with open cube-like M2(H2PA)2 cages wit... Self-assembly of cadmium ions and the rigid bridging ligand 4,4′-methylenebis(3-hydroxy-2-naphthoic acid) (pamoic acid, H4PA) leads to a one-dimensional metal-organic framework with open cube-like M2(H2PA)2 cages within its backbone, and exhibiting interesting yellow fluorescence. 展开更多
关键词 framework eight-coordinate cadmium cubic cage fluorescence pamoic acid
原文传递
Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia 被引量:4
18
作者 Sai Huang Meng-Meng Jiang +9 位作者 Guo-Feng Chen Kun Qian Hong-Hao Gao Wei Guan Jin-Long Shi An-Qi Liu Jing Liu Bian-Hong Wang Yong-Hui Li Li Yu 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第11期1355-1362,共8页
Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;2 1)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML. By focu... Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;2 1)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML. By focusing on the anti-leukemia effects of eyes absent 4 (EYA4) gene on AML cells, we investigated the biologic and molecular mechanism associated with AML 1 -ETO expressed in t(8;21) AML. Methods: Qualitative polymerase chain reaction (PCR), quantitative reverse transcription PCR (RT-PCR), and Western blotting analysis were used to observe the mRNA and protein expression levels of EYA4 in cell lines. Different plasmids (including mutant plasmids) of dual luciferase reporter vector were built to study the binding status of AML1-ETO to the promoter region of EYA4. Chromatin immunoprecipitation assay was used to study the epigenetic silencing mechanism of EYA4. Bisulfite sequencing was applied to detect the methylation status in EYA4 promoter region. The influence ofEYA4 gene in the cell proliferation, apoptosis, and cell clone-forming ability was detected by the technique of Cell Counting Kit-8, flow cytometry, and clonogenic assay. Results: EYA4 gene was hyperrnethylated in AMLI-ETO+ patients and its expression was down-regulated by 6-fold in Kasumi-1 and SKNO-1 cells, compared to HL-60 and SKNO-1-siA/E cells, respectively. We demonstrated that AML1-ETO triggered the epigenetic silencing of EYA 4 gene by binding at AML 1-binding sites and recruiting histone deacetylase 1 and DNA methyltransferases. Enhanced EYA4 expression levels inhibited cellular proliferation and suppressed cell colony formation in AMLI-ETO cell lines. We also found EYA4 transfection increased apoptosis of Kasumi- 1 and SKNO-1 cells by 1.6-fold and 1.4-fold compared to negative control, respectively. Conclusions: Our study identified EYA4 gene as targets for AML1-ETO and indicated it as a novel tumor suppressor gene. In addition, we provided evidence that EYA4 gene might be a novel therapeutic target and a potential candidate for treating AML 1-ETO+ t (8;21 ) AML. 展开更多
关键词 Acute Myeloid Gene 1-eight-twenty-one Acute Myeloid Leukemia Epigenetics Eyes Absent 4
原文传递
Design of 10 GHz eight-phase voltage controlled oscillator in 90nm CMOS
19
作者 CHEN Ying-mei WANG Hui +2 位作者 YAN Shuang-chao ZHANG Li LI Wei 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2012年第6期113-117,共5页
A novel 10 GHz eight-phase voltage-controlled oscillator (VCO) architecture applied in clock and data recovery (CDR) circuit for 40 Gbit/s optical communications system is proposed. Compared with the traditional e... A novel 10 GHz eight-phase voltage-controlled oscillator (VCO) architecture applied in clock and data recovery (CDR) circuit for 40 Gbit/s optical communications system is proposed. Compared with the traditional eight-phase oscillator, a new ring CL ladder filter structure with four inductors is proposed. The VCO is designed and fabricated in IBM 90 nm complementary metal-oxide-semiconductor transistor (CMOS) technology. Measurement results show the tuning range is 9.2 GHz-11.0 GHz and the phase noise of - 108.85 dBc/Hz at 1 MHz offset from the carrier frequency of 10 GHz. The chip area of VCO is 500 μm × 685 μm and the power dissipation is 17.4 mW with the 1.2 V supply voltage. 展开更多
关键词 VCO eight-phase LC ring oscillator CL ladder filtering
原文传递
Novel single-walled carbon nanotubes periodically embedded with four- and eight-membered rings
20
作者 Xiao-Ning Wang Jun-Zhe Lu +3 位作者 Heng-Jiang Zhu Fang-Fang Li Miao-Miao Ma Gui-Ping Tan 《Frontiers of physics》 SCIE CSCD 2018年第4期175-184,共10页
Based on experimental results, we obtain five types of single-walled carbon nanotube (SWNT) clusters with different chirality indices and diameters using density functional theory (DFT). We then obtain the corresp... Based on experimental results, we obtain five types of single-walled carbon nanotube (SWNT) clusters with different chirality indices and diameters using density functional theory (DFT). We then obtain the corresponding SWNTs by using periodic boundary conditions. Studies of the stability and elec- tronic properties show that the stability of the novel SWNTs is independent of the chirality index and relates only to the tube diameter; larger diameters correspond to more stable SWNTs. The electronic properties all show metallic characteristics independent of the chirality indices and tube diameters, thereby promoting the application of metallic-type SWNTs. 展开更多
关键词 four- and eight-membered rings novel SWNTs stability electronic properties
原文传递
上一页 1 2 250 下一页 到第
使用帮助 返回顶部