The cultural details and characteristics of 'Eight sights',which were existent but ignored,were found out through the introduction of the origin and the development of 'Eight sights'.The influences of ...The cultural details and characteristics of 'Eight sights',which were existent but ignored,were found out through the introduction of the origin and the development of 'Eight sights'.The influences of the 'Eight sights' on modern landscape design were summarized,reflecting the regional and cultural characteristics.The practical significance of re-examining the 'Eight sights' for the development of our garden landscape was pointed out.展开更多
By studying typical "Top Eight Views" in cities like Xining,Lanzhou and Yinchuan in the upper reaches of the Yellow River,mountain and water landscapes in the study area were analyzed in terms of natural eco...By studying typical "Top Eight Views" in cities like Xining,Lanzhou and Yinchuan in the upper reaches of the Yellow River,mountain and water landscapes in the study area were analyzed in terms of natural ecology;bridges,canals,ferries,pavilions,mansions,towers,temples,historical sites,production and living landscapes were analyzed in terms of humanistic ecology.On this basis,"Top Eight Views" in the upper reaches of the Yellow River were compared and the following conclusions obtained:mountain landscapes were distributed in the whole region,waterscapes unevenly valued in different cities,bridges,canals and ferries mostly located in Ningxia,temples commonly found in all cities,garden arts introduced into cities,traditional cultures carried forward by historical relics.Then the relationship between "Top Eight Views" and regional eco-cultures was analyzed,and it was proposed that humanistic and cultural connotations of these "Top Eight Views" contributed a lot to beautifying urban environment,satisfying needs of the locals' spiritual life,carrying forward local history and culture,enriching urban cultural connotations,expanding living spaces of local residents and improving integrated functions of cities."Top Eight Views" culture complied with the construction gist of urban ecological cultures,and was of great referential value for the construction of urban ecological cultures in the upper reaches of the Yellow River,and also the healthy,scientific and sustainable development of local cities.展开更多
Pure lines derived from multiple parents provide abundant variation for genetic study.However,efficient genetic analysis methods and user-friendly software are still lacking.In this study, we developed linkage analysi...Pure lines derived from multiple parents provide abundant variation for genetic study.However,efficient genetic analysis methods and user-friendly software are still lacking.In this study, we developed linkage analysis methods and integrated analysis software for pure-line populations derived from four-way and eight-way crosses.First, polymorphic markers are classified into different categories according to the number of identifiable alleles in the inbred parents.Expected genotypic probability is then derived for each pair of complete markers, and based on them a maximum likelihood estimate(MLE) of recombination frequency is calculated.An EM algorithm is proposed for calculating recombination frequencies in scenarios that at least one marker is incomplete.A linkage map can thus be constructed using estimated recombination frequencies.We describe a software package called GAPL for recombination frequency estimation and linkage map construction in multi-parental pure-line populations.Both simulation studies and results from a reported four-way cross recombinant inbred line population demonstrate that the proposed method and software can build more accurate linkage maps in shorter times than other published software packages.The GAPL software is freely available from www.isbreeding.net and can also be used for QTL mapping in multi-parental populations.展开更多
Edge detection is an important aspect to improve image edge quality in image processing. The purpose of edge detection is to identify the points in digital images with great brightness variation. However, the accuracy...Edge detection is an important aspect to improve image edge quality in image processing. The purpose of edge detection is to identify the points in digital images with great brightness variation. However, the accuracy of traditional edge detection methods in edge extraction is low. For the actual image, the grey edge is sometimes not very clear, the image also contains noise. The detection result of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">traditional Sobel operator is relatively accurate, but the detection result is rough and sensitive to noise. To solve the above problems, this paper proposes an improved eight-direction Sobel operator based on grey relevancy degree, which combines 5</span><span style="font-family:""> </span><span style="font-family:Verdana;">×</span><span style="font-family:""> </span><span style="font-family:Verdana;">5 Sobel operator with </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">grey relational degree and a new eight-direction grey relevancy method. The results show that this method can detect the useful information of edge more accurately and improve the anti-noise performance. However, the drawback is that the algorithm is not automatic.展开更多
With the help of computers,we have made statistics as to the frequency of se-lecting points for the eight categories of patterns of imbalance.We suggest that for the heat syn-drome,the points in the upper part should ...With the help of computers,we have made statistics as to the frequency of se-lecting points for the eight categories of patterns of imbalance.We suggest that for the heat syn-drome,the points in the upper part should usually be selected,for the cold syndrome,the points inthe lower part should generally be adopted;for the exterior syndrome,the points on the yang surfaceshould mostly be selected,for the interior syndrome,the points on the yin surface should generally beadopted;for the asthenic syndrome,the points in the trunk should mostly be selected,for the sthenicsyndrome,the points at the extremities generally be adopted.展开更多
The title compound [Mn(O2CMe)2(phen)2] (phen = 1,10-phenanthroline) 1 has been synthesized and structurally determined by single-crystal X-ray diffraction. The crystal is of orthor- hombic, space group Pbcn, wit...The title compound [Mn(O2CMe)2(phen)2] (phen = 1,10-phenanthroline) 1 has been synthesized and structurally determined by single-crystal X-ray diffraction. The crystal is of orthor- hombic, space group Pbcn, with a = 12.554(4), b = 10.168(3), c = 17.704(5)A, V= 2259.7(12)A^3 Z = 4, C28H22MnN4O4, Mr= 533.44, Dc= 1.568 g]cm^3, F(000) = 1100, Rint = 0.0242, T= 293(2) K and p = 0.631 mm^-1. The final R = 0.0687 and wR = 0.1960 for 2046 observed reflections with I 〉 20(/). The structure of the complex consists of one Mn(II) core coordinated by two bidentate-bound CH3COO^- groups and two η^2-phen groups forming an eight-coordinate geometrical configuration.展开更多
One interesting coordination polymer, [Zn2(1,2,4-BTC)(OH)(H2O)2]2·2H2O 1, has been synthesized from 1,2,4-BTC (1,2,4-BTC = 1,2,4-bentricarboxylate) under hydrothermal conditions and characterized by eleme...One interesting coordination polymer, [Zn2(1,2,4-BTC)(OH)(H2O)2]2·2H2O 1, has been synthesized from 1,2,4-BTC (1,2,4-BTC = 1,2,4-bentricarboxylate) under hydrothermal conditions and characterized by elemental analyses, IR, TG and single-crystal X-ray diffraction. Complex I crystallizes in triclinic, space group P^-1, with a = 6.5200(13), b = 9,0600(18), c = 10.968(2) A^°, α = 111.55(3), β = 92.07(3),γ= 95.03(3)°, C9H10O10Zn2, Mr = 408.91, V= 598.7(2) A^°^3, Dc = 2.268 g/cm^3, F(000) = 408 and Z = 2. X-ray diffraction analysis reveals that complex 1 is a three-dimensional network built from tetranuclear Zn(Ⅱ) building unit. In this complex, the Zn4 unit is an eight-connected knot, while 1,2,4-BTC a four-connected knot. This results in a CaF2 topology. To the best of our knowledge, such Zn4 unit is the first 8-connected building block built from asymmetry ligand.展开更多
With the help of the F-basis provided by the Drinfeld twist or factorising F-matrix for the spatial optical soliton model associated with the eight-vertex model, we calculate the partition function for the eight-verte...With the help of the F-basis provided by the Drinfeld twist or factorising F-matrix for the spatial optical soliton model associated with the eight-vertex model, we calculate the partition function for the eight-vertex model on an N ×N square lattice with domain wall boundary condition.展开更多
We investigate the band structure of a compressively strained In(Ga)As/In0.53Ga0.47As quantum well (QW) on an InP substrate using the eight-band k.p theory. Aiming at the emission wavelength around 2.33 μm, we di...We investigate the band structure of a compressively strained In(Ga)As/In0.53Ga0.47As quantum well (QW) on an InP substrate using the eight-band k.p theory. Aiming at the emission wavelength around 2.33 μm, we discuss the influences of temperature, strain and well width on the band structure and on the emission wavelength of the QW. The wavelength increases with the increase of temperature, strain and well width. Furthermore, we design an InAs /In0.53Ga0.47As QW with a well width of 4.1 nm emitting at 2.33 μm by optimizing the strain and the well width.展开更多
The main goal of this paper is to compute the Figure-eight solutions for the planar Newtonian 3-body problem with equal masses by finding the critical points of the functional associated with the motion equations of 3...The main goal of this paper is to compute the Figure-eight solutions for the planar Newtonian 3-body problem with equal masses by finding the critical points of the functional associated with the motion equations of 3-body in plane R2. The algorithm adopted here is the steepest descent method, which is simple but very valid for our problem.展开更多
In this paper we investigate the homoclinic bifurcation properties near an eight-figure homoclinic orbit of co-dimension two of a planar dynamical system. The corresponding local bifurcation diagram is also illustrate...In this paper we investigate the homoclinic bifurcation properties near an eight-figure homoclinic orbit of co-dimension two of a planar dynamical system. The corresponding local bifurcation diagram is also illustrated by numerical computation.展开更多
Fiber laser hydrophones have got widespread concems due to the unique advantages and broad application prospects. In this paper, the research results of the eight-element multiplexed fiber laser acoustic pressure arra...Fiber laser hydrophones have got widespread concems due to the unique advantages and broad application prospects. In this paper, the research results of the eight-element multiplexed fiber laser acoustic pressure array and the interrogation system are introduced, containing low-noise distributed feedback fiber laser (DFB-FL) fabrication, sensitivity enhancement packaging, and interferometric signal demodulation. The frequency response range of the system is 10Hz-10kHz, the laser frequency acoustic pressure sensitivity reaches 115 dB re Hz/Pa, and the equivalent noise acoustic pressure is less than 60μa/Hz^1/2. The dynamic range of the system is greater than 120 dB.展开更多
The physical model describing the Yin-Yang balance in the tai-chi diagram via the melting and freezing processes in a rotating device presented in parts 1 and 2 is further developed for the contemporary tai-chi diagra...The physical model describing the Yin-Yang balance in the tai-chi diagram via the melting and freezing processes in a rotating device presented in parts 1 and 2 is further developed for the contemporary tai-chi diagram and in the yuan-chi diagram. The contemporary tai-chi diagram shown in Fig.1 is a simplification form of the ancient tai-chi diagram presented in Reference [2]. There are two semi-circles forming the interface curve between the yin and yang in the contemporary tai-chi diagram. By knowing the location of the interface between the yin and yang in the contemporary tai-chi diagram, the requirement for the simulation model is to find the condition to match the interface location. The simplification changes not only the structure but also the physical insight of the ancient tai-chi diagram, which will be described in the present study.The yuan-chi diagram shown in Fig.2 is the combination of the Master Chen’s tai-chi diagram presented in References [1,2] and the contemporary tai-chi diagram.展开更多
Self-assembly of cadmium ions and the rigid bridging ligand 4,4′-methylenebis(3-hydroxy-2-naphthoic acid) (pamoic acid, H4PA) leads to a one-dimensional metal-organic framework with open cube-like M2(H2PA)2 cages wit...Self-assembly of cadmium ions and the rigid bridging ligand 4,4′-methylenebis(3-hydroxy-2-naphthoic acid) (pamoic acid, H4PA) leads to a one-dimensional metal-organic framework with open cube-like M2(H2PA)2 cages within its backbone, and exhibiting interesting yellow fluorescence.展开更多
Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;2 1)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML. By focu...Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;2 1)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML. By focusing on the anti-leukemia effects of eyes absent 4 (EYA4) gene on AML cells, we investigated the biologic and molecular mechanism associated with AML 1 -ETO expressed in t(8;21) AML. Methods: Qualitative polymerase chain reaction (PCR), quantitative reverse transcription PCR (RT-PCR), and Western blotting analysis were used to observe the mRNA and protein expression levels of EYA4 in cell lines. Different plasmids (including mutant plasmids) of dual luciferase reporter vector were built to study the binding status of AML1-ETO to the promoter region of EYA4. Chromatin immunoprecipitation assay was used to study the epigenetic silencing mechanism of EYA4. Bisulfite sequencing was applied to detect the methylation status in EYA4 promoter region. The influence ofEYA4 gene in the cell proliferation, apoptosis, and cell clone-forming ability was detected by the technique of Cell Counting Kit-8, flow cytometry, and clonogenic assay. Results: EYA4 gene was hyperrnethylated in AMLI-ETO+ patients and its expression was down-regulated by 6-fold in Kasumi-1 and SKNO-1 cells, compared to HL-60 and SKNO-1-siA/E cells, respectively. We demonstrated that AML1-ETO triggered the epigenetic silencing of EYA 4 gene by binding at AML 1-binding sites and recruiting histone deacetylase 1 and DNA methyltransferases. Enhanced EYA4 expression levels inhibited cellular proliferation and suppressed cell colony formation in AMLI-ETO cell lines. We also found EYA4 transfection increased apoptosis of Kasumi- 1 and SKNO-1 cells by 1.6-fold and 1.4-fold compared to negative control, respectively. Conclusions: Our study identified EYA4 gene as targets for AML1-ETO and indicated it as a novel tumor suppressor gene. In addition, we provided evidence that EYA4 gene might be a novel therapeutic target and a potential candidate for treating AML 1-ETO+ t (8;21 ) AML.展开更多
A novel 10 GHz eight-phase voltage-controlled oscillator (VCO) architecture applied in clock and data recovery (CDR) circuit for 40 Gbit/s optical communications system is proposed. Compared with the traditional e...A novel 10 GHz eight-phase voltage-controlled oscillator (VCO) architecture applied in clock and data recovery (CDR) circuit for 40 Gbit/s optical communications system is proposed. Compared with the traditional eight-phase oscillator, a new ring CL ladder filter structure with four inductors is proposed. The VCO is designed and fabricated in IBM 90 nm complementary metal-oxide-semiconductor transistor (CMOS) technology. Measurement results show the tuning range is 9.2 GHz-11.0 GHz and the phase noise of - 108.85 dBc/Hz at 1 MHz offset from the carrier frequency of 10 GHz. The chip area of VCO is 500 μm × 685 μm and the power dissipation is 17.4 mW with the 1.2 V supply voltage.展开更多
Based on experimental results, we obtain five types of single-walled carbon nanotube (SWNT) clusters with different chirality indices and diameters using density functional theory (DFT). We then obtain the corresp...Based on experimental results, we obtain five types of single-walled carbon nanotube (SWNT) clusters with different chirality indices and diameters using density functional theory (DFT). We then obtain the corresponding SWNTs by using periodic boundary conditions. Studies of the stability and elec- tronic properties show that the stability of the novel SWNTs is independent of the chirality index and relates only to the tube diameter; larger diameters correspond to more stable SWNTs. The electronic properties all show metallic characteristics independent of the chirality indices and tube diameters, thereby promoting the application of metallic-type SWNTs.展开更多
文摘The cultural details and characteristics of 'Eight sights',which were existent but ignored,were found out through the introduction of the origin and the development of 'Eight sights'.The influences of the 'Eight sights' on modern landscape design were summarized,reflecting the regional and cultural characteristics.The practical significance of re-examining the 'Eight sights' for the development of our garden landscape was pointed out.
基金Supported by Hebei Provincial Social Science Foudation " Ecological Environment and Urban Development in the Upper Reaches of the Yellow River (1368 - 1928) " (HB10GJ016) ~~
文摘By studying typical "Top Eight Views" in cities like Xining,Lanzhou and Yinchuan in the upper reaches of the Yellow River,mountain and water landscapes in the study area were analyzed in terms of natural ecology;bridges,canals,ferries,pavilions,mansions,towers,temples,historical sites,production and living landscapes were analyzed in terms of humanistic ecology.On this basis,"Top Eight Views" in the upper reaches of the Yellow River were compared and the following conclusions obtained:mountain landscapes were distributed in the whole region,waterscapes unevenly valued in different cities,bridges,canals and ferries mostly located in Ningxia,temples commonly found in all cities,garden arts introduced into cities,traditional cultures carried forward by historical relics.Then the relationship between "Top Eight Views" and regional eco-cultures was analyzed,and it was proposed that humanistic and cultural connotations of these "Top Eight Views" contributed a lot to beautifying urban environment,satisfying needs of the locals' spiritual life,carrying forward local history and culture,enriching urban cultural connotations,expanding living spaces of local residents and improving integrated functions of cities."Top Eight Views" culture complied with the construction gist of urban ecological cultures,and was of great referential value for the construction of urban ecological cultures in the upper reaches of the Yellow River,and also the healthy,scientific and sustainable development of local cities.
基金supported by the National Key Research and Development Program of China (2016YFD0101804)the National Natural Science Foundation of China (31671280)HarvestPlus (part of the CGIAR Research Program on Agriculture for Nutrition and Health, http://www.harvestplus.org/)
文摘Pure lines derived from multiple parents provide abundant variation for genetic study.However,efficient genetic analysis methods and user-friendly software are still lacking.In this study, we developed linkage analysis methods and integrated analysis software for pure-line populations derived from four-way and eight-way crosses.First, polymorphic markers are classified into different categories according to the number of identifiable alleles in the inbred parents.Expected genotypic probability is then derived for each pair of complete markers, and based on them a maximum likelihood estimate(MLE) of recombination frequency is calculated.An EM algorithm is proposed for calculating recombination frequencies in scenarios that at least one marker is incomplete.A linkage map can thus be constructed using estimated recombination frequencies.We describe a software package called GAPL for recombination frequency estimation and linkage map construction in multi-parental pure-line populations.Both simulation studies and results from a reported four-way cross recombinant inbred line population demonstrate that the proposed method and software can build more accurate linkage maps in shorter times than other published software packages.The GAPL software is freely available from www.isbreeding.net and can also be used for QTL mapping in multi-parental populations.
文摘Edge detection is an important aspect to improve image edge quality in image processing. The purpose of edge detection is to identify the points in digital images with great brightness variation. However, the accuracy of traditional edge detection methods in edge extraction is low. For the actual image, the grey edge is sometimes not very clear, the image also contains noise. The detection result of </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">traditional Sobel operator is relatively accurate, but the detection result is rough and sensitive to noise. To solve the above problems, this paper proposes an improved eight-direction Sobel operator based on grey relevancy degree, which combines 5</span><span style="font-family:""> </span><span style="font-family:Verdana;">×</span><span style="font-family:""> </span><span style="font-family:Verdana;">5 Sobel operator with </span><span style="font-family:Verdana;">a </span><span style="font-family:Verdana;">grey relational degree and a new eight-direction grey relevancy method. The results show that this method can detect the useful information of edge more accurately and improve the anti-noise performance. However, the drawback is that the algorithm is not automatic.
文摘With the help of computers,we have made statistics as to the frequency of se-lecting points for the eight categories of patterns of imbalance.We suggest that for the heat syn-drome,the points in the upper part should usually be selected,for the cold syndrome,the points inthe lower part should generally be adopted;for the exterior syndrome,the points on the yang surfaceshould mostly be selected,for the interior syndrome,the points on the yin surface should generally beadopted;for the asthenic syndrome,the points in the trunk should mostly be selected,for the sthenicsyndrome,the points at the extremities generally be adopted.
基金the NNSFC (No. 20471061) the Science & Technology Innovation Foundation for the Young Scholars of Fujian Province (No. 2005J059)
文摘The title compound [Mn(O2CMe)2(phen)2] (phen = 1,10-phenanthroline) 1 has been synthesized and structurally determined by single-crystal X-ray diffraction. The crystal is of orthor- hombic, space group Pbcn, with a = 12.554(4), b = 10.168(3), c = 17.704(5)A, V= 2259.7(12)A^3 Z = 4, C28H22MnN4O4, Mr= 533.44, Dc= 1.568 g]cm^3, F(000) = 1100, Rint = 0.0242, T= 293(2) K and p = 0.631 mm^-1. The final R = 0.0687 and wR = 0.1960 for 2046 observed reflections with I 〉 20(/). The structure of the complex consists of one Mn(II) core coordinated by two bidentate-bound CH3COO^- groups and two η^2-phen groups forming an eight-coordinate geometrical configuration.
基金supported by the National Natural Science Foundation of China (No. 20701005 and 20701006)
文摘One interesting coordination polymer, [Zn2(1,2,4-BTC)(OH)(H2O)2]2·2H2O 1, has been synthesized from 1,2,4-BTC (1,2,4-BTC = 1,2,4-bentricarboxylate) under hydrothermal conditions and characterized by elemental analyses, IR, TG and single-crystal X-ray diffraction. Complex I crystallizes in triclinic, space group P^-1, with a = 6.5200(13), b = 9,0600(18), c = 10.968(2) A^°, α = 111.55(3), β = 92.07(3),γ= 95.03(3)°, C9H10O10Zn2, Mr = 408.91, V= 598.7(2) A^°^3, Dc = 2.268 g/cm^3, F(000) = 408 and Z = 2. X-ray diffraction analysis reveals that complex 1 is a three-dimensional network built from tetranuclear Zn(Ⅱ) building unit. In this complex, the Zn4 unit is an eight-connected knot, while 1,2,4-BTC a four-connected knot. This results in a CaF2 topology. To the best of our knowledge, such Zn4 unit is the first 8-connected building block built from asymmetry ligand.
基金Project supported by the National Natural Science Foundation of China Grant Nos.11075126 and 11031005)
文摘With the help of the F-basis provided by the Drinfeld twist or factorising F-matrix for the spatial optical soliton model associated with the eight-vertex model, we calculate the partition function for the eight-vertex model on an N ×N square lattice with domain wall boundary condition.
基金Project supported by the '100 Talents Program' of Chinese Academy of Sciences,China
文摘We investigate the band structure of a compressively strained In(Ga)As/In0.53Ga0.47As quantum well (QW) on an InP substrate using the eight-band k.p theory. Aiming at the emission wavelength around 2.33 μm, we discuss the influences of temperature, strain and well width on the band structure and on the emission wavelength of the QW. The wavelength increases with the increase of temperature, strain and well width. Furthermore, we design an InAs /In0.53Ga0.47As QW with a well width of 4.1 nm emitting at 2.33 μm by optimizing the strain and the well width.
文摘The main goal of this paper is to compute the Figure-eight solutions for the planar Newtonian 3-body problem with equal masses by finding the critical points of the functional associated with the motion equations of 3-body in plane R2. The algorithm adopted here is the steepest descent method, which is simple but very valid for our problem.
基金The NSFC (10071030) of ChinaThe Volkswagen Foundation of Germany The Project-sponsored by SRP for ROCS, SEM (2002).
文摘In this paper we investigate the homoclinic bifurcation properties near an eight-figure homoclinic orbit of co-dimension two of a planar dynamical system. The corresponding local bifurcation diagram is also illustrated by numerical computation.
基金Acknowledgment This work was financially supported by the National Natural Science Foundation of China (No. 60317101), Key Research and Development Plan of Shandong Province (No. 2015GSF11500), and Natural Science Foundation of Shandong Province (No. ZR2013FL029).
文摘Fiber laser hydrophones have got widespread concems due to the unique advantages and broad application prospects. In this paper, the research results of the eight-element multiplexed fiber laser acoustic pressure array and the interrogation system are introduced, containing low-noise distributed feedback fiber laser (DFB-FL) fabrication, sensitivity enhancement packaging, and interferometric signal demodulation. The frequency response range of the system is 10Hz-10kHz, the laser frequency acoustic pressure sensitivity reaches 115 dB re Hz/Pa, and the equivalent noise acoustic pressure is less than 60μa/Hz^1/2. The dynamic range of the system is greater than 120 dB.
基金The present work is being supported by the Natural Sciences and Engineering Research Council of Canada under Grant No. OGP0007929.
文摘The physical model describing the Yin-Yang balance in the tai-chi diagram via the melting and freezing processes in a rotating device presented in parts 1 and 2 is further developed for the contemporary tai-chi diagram and in the yuan-chi diagram. The contemporary tai-chi diagram shown in Fig.1 is a simplification form of the ancient tai-chi diagram presented in Reference [2]. There are two semi-circles forming the interface curve between the yin and yang in the contemporary tai-chi diagram. By knowing the location of the interface between the yin and yang in the contemporary tai-chi diagram, the requirement for the simulation model is to find the condition to match the interface location. The simplification changes not only the structure but also the physical insight of the ancient tai-chi diagram, which will be described in the present study.The yuan-chi diagram shown in Fig.2 is the combination of the Master Chen’s tai-chi diagram presented in References [1,2] and the contemporary tai-chi diagram.
基金supported by the National Natural Science Foundation of China (20772019)NSF of Shanghai (08dj1400100)the Doctoral Program of National Education Ministry of China
文摘Self-assembly of cadmium ions and the rigid bridging ligand 4,4′-methylenebis(3-hydroxy-2-naphthoic acid) (pamoic acid, H4PA) leads to a one-dimensional metal-organic framework with open cube-like M2(H2PA)2 cages within its backbone, and exhibiting interesting yellow fluorescence.
文摘Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;2 1)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML. By focusing on the anti-leukemia effects of eyes absent 4 (EYA4) gene on AML cells, we investigated the biologic and molecular mechanism associated with AML 1 -ETO expressed in t(8;21) AML. Methods: Qualitative polymerase chain reaction (PCR), quantitative reverse transcription PCR (RT-PCR), and Western blotting analysis were used to observe the mRNA and protein expression levels of EYA4 in cell lines. Different plasmids (including mutant plasmids) of dual luciferase reporter vector were built to study the binding status of AML1-ETO to the promoter region of EYA4. Chromatin immunoprecipitation assay was used to study the epigenetic silencing mechanism of EYA4. Bisulfite sequencing was applied to detect the methylation status in EYA4 promoter region. The influence ofEYA4 gene in the cell proliferation, apoptosis, and cell clone-forming ability was detected by the technique of Cell Counting Kit-8, flow cytometry, and clonogenic assay. Results: EYA4 gene was hyperrnethylated in AMLI-ETO+ patients and its expression was down-regulated by 6-fold in Kasumi-1 and SKNO-1 cells, compared to HL-60 and SKNO-1-siA/E cells, respectively. We demonstrated that AML1-ETO triggered the epigenetic silencing of EYA 4 gene by binding at AML 1-binding sites and recruiting histone deacetylase 1 and DNA methyltransferases. Enhanced EYA4 expression levels inhibited cellular proliferation and suppressed cell colony formation in AMLI-ETO cell lines. We also found EYA4 transfection increased apoptosis of Kasumi- 1 and SKNO-1 cells by 1.6-fold and 1.4-fold compared to negative control, respectively. Conclusions: Our study identified EYA4 gene as targets for AML1-ETO and indicated it as a novel tumor suppressor gene. In addition, we provided evidence that EYA4 gene might be a novel therapeutic target and a potential candidate for treating AML 1-ETO+ t (8;21 ) AML.
基金supported by the National High Technology Research and Development Program of China(2011AA010301)the National Natural Science Foundation of China(60976029)
文摘A novel 10 GHz eight-phase voltage-controlled oscillator (VCO) architecture applied in clock and data recovery (CDR) circuit for 40 Gbit/s optical communications system is proposed. Compared with the traditional eight-phase oscillator, a new ring CL ladder filter structure with four inductors is proposed. The VCO is designed and fabricated in IBM 90 nm complementary metal-oxide-semiconductor transistor (CMOS) technology. Measurement results show the tuning range is 9.2 GHz-11.0 GHz and the phase noise of - 108.85 dBc/Hz at 1 MHz offset from the carrier frequency of 10 GHz. The chip area of VCO is 500 μm × 685 μm and the power dissipation is 17.4 mW with the 1.2 V supply voltage.
基金The authors acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 11464044), the Foundation of Key Laboratory of Min- eral Luminescent Material and Microstructure of Xinjiang (Project No. KWFG1701), and the "13th Five-Year" Plan for Key Discipline Physics Bidding Project, Xinjiang Normal University.
文摘Based on experimental results, we obtain five types of single-walled carbon nanotube (SWNT) clusters with different chirality indices and diameters using density functional theory (DFT). We then obtain the corresponding SWNTs by using periodic boundary conditions. Studies of the stability and elec- tronic properties show that the stability of the novel SWNTs is independent of the chirality index and relates only to the tube diameter; larger diameters correspond to more stable SWNTs. The electronic properties all show metallic characteristics independent of the chirality indices and tube diameters, thereby promoting the application of metallic-type SWNTs.