The writer O.Henry was famous for surprising endings,which is a common feature of his short stories.They have original plots and usually end in a way that you can never imagine.Because of his humorous language,his uni...The writer O.Henry was famous for surprising endings,which is a common feature of his short stories.They have original plots and usually end in a way that you can never imagine.Because of his humorous language,his unique narrative skills,and his unexpected and reasonable ending,O.Henry got a high reputation.His execllent technique of writng is more obvious for the irony of reality and the return of human nature.The O.Henry-style ending opened up the pluralistic development of later realistic literature.The highly critical ending of its turning point also promotes the practical significance of the reaction of world literature to society.展开更多
A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners spac...A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners space for further thinking.展开更多
A case of ideal fluid flow in a moving ending rigid constant diameter circular pipeline is investigated. A model of the pipeline was established based on distributed-parameter theory. The comparisons on a quotient mod...A case of ideal fluid flow in a moving ending rigid constant diameter circular pipeline is investigated. A model of the pipeline was established based on distributed-parameter theory. The comparisons on a quotient module of output and input pressure of the moving ending model and neglected ending moving model are made on the frequency response. It is revealed that the moving ending of pipeline influences largely the quotient amplitude of output and input pressure, and the peak value of frequency resonance increases with the increase of pipeline’s length.展开更多
The mechanisms for the regulation of synaptic dopamine (DA) include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transport...The mechanisms for the regulation of synaptic dopamine (DA) include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transporter (DAT), the diffusion of DA and its metabolism by mono-amine oxidase (MAO) and cate- chol-O-methyl transferase (COMT). DA controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesis (Popolo et al., 2004; Reimer et al., 2013) and neuroregeneration (Hoglinger et al., 2004; Yang et al., 2008). These functions are varied and of high fidelity. Movement, as an example, requires regulatory mechanisms for initiating, stopping, slowing-down speed- ing-up, changing directions, for governing the relentless urges to move in the young and sedentariness in the old as well as in motor-freezing, catalepsy, tremor and stereotypy.展开更多
Background: In this experimental study, we aimed to determine the possible changes in fracture healing due to denervation and/or nerve ending interpositioning. Methods: 50 Wistar Albino type male rats were divided int...Background: In this experimental study, we aimed to determine the possible changes in fracture healing due to denervation and/or nerve ending interpositioning. Methods: 50 Wistar Albino type male rats were divided into three study groups. A standard transverse diaphysial fracture in the femurs of the same side of all subjects under anesthesia was created and the fracture were fixed intramedullarily. While preserving the structural integrity of the sciatic nerve in the first group, neurectomy to the nerve in the second group was performed. In the third group, following the sciatic nerve cut, the proximal end of the nerve were interposed the fracture line. After a 28-day observational period, the callus formation in the subjects was examined radiologically, biomechanically and histopathologically. Results: Among all groups, the third group subjects showed significant increase in radiological area measurements when they are compared to the second group rats. There was no significant difference in biomechanical measurements of fractured femurs of the three groups. In histopathological evaluations, it was observed that denervation had increased the thickness of the cartilage and the number of the chondrocytes and osteoclasts significantly but decreased the number of fibroblasts compared to the control group. In addition to the denervation nerve ending interpositioning increased the bone thickness and the number of the osteoblasts but decreased the number of the osteoclasts significantly. Conclusions: While radiological observations exhibit that nerve ending interpositioning has resulted more hypertrophic callus formation, histopathological evaluations led us to that denervation created partial (immature) callus formation and nerve ending interpositioning demonstrated larger but immature callus formation.展开更多
As one of the first and most original creations of literary postmodernism, published in the year 1961, Catch-22's (1961) position in American literature remains secure. Yet its ending has been held as unconvincing ...As one of the first and most original creations of literary postmodernism, published in the year 1961, Catch-22's (1961) position in American literature remains secure. Yet its ending has been held as unconvincing ever since its publication. Taking the overall structure, tone, and the theme of the novel into consideration, this paper aims to prove the credibility of this controversial part. It consists of five sections apart from an introduction and a conclusion. Section One provides general information on the life and works of Joseph Heller. Section Two traces the impact of existentialism and the generation of black humor to clarify the literary position of Catch-22. Section Three brings out the disputative opinions on the ending part. Sections Four and Five, try to prove Yossarian's final desertion a natural and convincing ending from different perspectives: Section Four analyses how Yossarian gains an entropic vision of the cosmos; section Five studies his existential vision of physical life and searches for the immediate factors that propel Yossarian's desertion. Section five also explains the ending's change in tone and structure. The conclusion summarizes the paper and points out the social significance of the novel.展开更多
A roll-bending process that minimizes the flat areas on the leading and trailing ends of formed plates will produce more accurate and easier assemble final shapes. There are several methods of minimizing flat areas, b...A roll-bending process that minimizes the flat areas on the leading and trailing ends of formed plates will produce more accurate and easier assemble final shapes. There are several methods of minimizing flat areas, but they are costly or difficult to apply for thick plates. This study proposes a new, simple approach that reduces these flat areas. This approach includes moving the bottom roll slightly along the feeding direction and adjusting the bottom roll location. Sensitivity analyses were performed using a developed 3D dynamic FE (finite element) model of an asymmetrical roll-bending process in the Ansys/LS-Dyna software package. Simulations were validated by experiments run on an instrumented roll-bending machine. The FE results indicate that this new approach not only minimizes the flat areas but also reduces the forming forces.展开更多
The French Lieutenant's Woman is the best-known novel written by John Fowles and is also called the post-modern metafiction.In the novel the mysterious woman Sarah is introduced,who rebels against Victorian conven...The French Lieutenant's Woman is the best-known novel written by John Fowles and is also called the post-modern metafiction.In the novel the mysterious woman Sarah is introduced,who rebels against Victorian conventions to pursue independence and freedom.Undoubtedly,Sarah is an independent woman ahead of her times.This paper is attempted to interpret the last ending of The French Lieutenant's woman written by John Fowles,thus finding relevant evidence to support this interpretation that Sarah has finally got her freedom which is not allowed against the Victorian background.展开更多
at 11:26 on December 22,a LM-4B launch vehicle lifted the ZY-1 02C satellite into space from the Taiyuan Satellite Launch Center,marking the complete success of the final launch mission of this year.13 minutes later,t...at 11:26 on December 22,a LM-4B launch vehicle lifted the ZY-1 02C satellite into space from the Taiyuan Satellite Launch Center,marking the complete success of the final launch mission of this year.13 minutes later,the satellite entered into sun-synchronous circular orbit after separating with the rocket.展开更多
Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in...Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in many of which beams are often subjected to axial loads and static end moments. In the present study, an analytical solution is developed to study the coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments. Euler-Bernoulli beam theory and the "free mode" assumption in delamination vibration are adopted. This is the first study of the influences of static end moments upon the effects of delaminations on natural frequencies, critical buckling loads and critical moments for lateral instability. The results show that the effects of delamination on reducing natural frequencies, critical buckling load and critical moment for lateral instability are aggravated by the presence of static end moment. In turn, the effects of static end moments on vibration and instability characteristics are affected by the presence of delamination. The analytical results of this study can serve as a benchmark for finite element method and other numerical solutions.展开更多
Background Prior research about N400 has been mainly based on English stimuli,while the cognitive.processing of Chinese characters is still unclear.The aim of the present study was to further investigate the semantic ...Background Prior research about N400 has been mainly based on English stimuli,while the cognitive.processing of Chinese characters is still unclear.The aim of the present study was to further investigate the semantic processing of Chinese idioms.Methods Event related potentials (ERP) component N400 was elicited by 38 pairs of matching (congruent) and mismatching (incongruent) ended Chinese idioms:ending words with same phoneme but different shape and meaning (sPdSdM),with similar shape but different phoneme and meaning(sSdPdM),with same meaning but different phoneme and shape(sMdPdS),and words with different phoneme,shape and meaning(dPdSdM)and recorded by Guangzhou Runjie WJ-1 ERP instruments.In 62 right-handed healthy adults(age 19-50 years),N400 amplitudes and latencies were compared between matching and mismatching conditions at Fz,Cz and Pz.Results N400 showed a midline distribution and could be elicited in electrodes Fz, Cz and Pz.The mean values of N400 latencies and amplitudes were obtained for matching and mismatching ending werds in healthy adults.Significant differences were found in N400 latencies and amplitudes in matching and mismatching ending-werds idioms in healthy adults(P〈0.05).Compared with matching ending-werds jdioms, N400 latencies were prolonged and the amplitudes were increased in mismatching ones.N400s elicited by different types of stimuli showed different latencies and amplitudes.and longest N400 latency and largest N400 amplitude were elicited by ending-werds with dPdSdM.No gender difference was found of N400 latency and amplitude in this study (P〉0.05).Conclusions Compared with English stimuli.Chinese ideographic words could provide more flexible stimuli for N400 research in that the werds have 3-dimension changes-phoneme.shape and meaning.Features of N400 elicited by matching and mismatching ending words in Chinese idioms are mainly determined by the meaning of the werd.Some issues of N400 elicited by Chinese characters deserve further research.展开更多
Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangle...Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the brain.The NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and aggregation.Because NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory cytokines.Here,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau phosphorylation.Using biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in neurons.In primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis present.In the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical neurons.Transcriptome analysis suggested that FUBP3 plays a role in neuron-mediated immune responses.We also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced responses.These findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in neurons.Given that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.展开更多
The 2010 Nuclear Non-proliferation Treaty Review Conference is a milestone for international arms control efforts The 2010 Nuclear Non-proliferation Treaty (NPT) Review Conference (RevCon) at the UN
Chinese composer writes a new score for the last 18 minutes of Puccini’s Turandot It has long been the wishes of many clas- sical opera fans and sopranos alike that the heroine of Italian composer Giacomo Puccini’s ...Chinese composer writes a new score for the last 18 minutes of Puccini’s Turandot It has long been the wishes of many clas- sical opera fans and sopranos alike that the heroine of Italian composer Giacomo Puccini’s classic Turandot,Princess Turandot,had her own aria.And now that wish has just come true.In the new edi- tion of the opera presented by the National Center for the Performing Arts (NCPA) of China in March,the princess sang a beauti- ful and moving aria,named The First Tears, transforming herself in the process from a cold-hearted woman with infinite power into an ordinary girl falling in love with Prince Calaf,the hero of the opera.展开更多
协会简介"Ending轮滑社"成立于2009年,Ending寓意为even ending are together.即使结束了我们还是在一起,凝结了我们对轮滑社一份深切的感情。"Ending轮滑社"是集健身、竞技、娱乐、趣味、技巧、艺术、休闲于一体...协会简介"Ending轮滑社"成立于2009年,Ending寓意为even ending are together.即使结束了我们还是在一起,凝结了我们对轮滑社一份深切的感情。"Ending轮滑社"是集健身、竞技、娱乐、趣味、技巧、艺术、休闲于一体的学生社团,现已发展会员200余人。社团成员在训练之余还积极参加南京市的各种比赛和校内外的各种表演,社团元老钱家元在苏州"米高杯"中获得第四名,在上海"展开更多
On March,16,2014,27-year-old Renjianyu and his girlfriend got married in Chongqing.It was not just any wedding—in some ways,it celebrated the end of an era.Their officiator,49-year-old lawyer Pu Zhiqiang,announced in...On March,16,2014,27-year-old Renjianyu and his girlfriend got married in Chongqing.It was not just any wedding—in some ways,it celebrated the end of an era.Their officiator,49-year-old lawyer Pu Zhiqiang,announced in the speech he gave at their wedding,hopefully and enthusiastically:'We are overjoyed to see the changes taking place in this country,and we remain optimistic about them.'The changes to which Pu展开更多
With plenty of popular and effective ternary organic solar cells(OSCs)construction strategies proposed and applied,its power conversion efficiencies(PCEs)have come to a new level of over 19%in single-junction devices....With plenty of popular and effective ternary organic solar cells(OSCs)construction strategies proposed and applied,its power conversion efficiencies(PCEs)have come to a new level of over 19%in single-junction devices.However,previous studies are heavily based in chloroform(CF)leaving behind substantial knowledge deficiencies in understanding the influence of solvent choice when introducing a third component.Herein,we present a case where a newly designed asymmetric small molecular acceptor using fluoro-methoxylated end-group modification strategy,named BTP-BO-3FO with enlarged bandgap,brings different morphological evolution and performance improvement effect on host system PM6:BTP-eC9,processed by CF and ortho-xylene(o-XY).With detailed analyses supported by a series of experiments,the best PCE of 19.24%for green solvent-processed OSCs is found to be a fruit of finely tuned crystalline ordering and general aggregation motif,which furthermore nourishes a favorable charge generation and recombination behavior.Likewise,over 19%PCE can be achieved by replacing spin-coating with blade coating for active layer deposition.This work focuses on understanding the commonly met yet frequently ignored issues when building ternary blends to demonstrate cutting-edge device performance,hence,will be instructive to other ternary OSC works in the future.展开更多
文摘The writer O.Henry was famous for surprising endings,which is a common feature of his short stories.They have original plots and usually end in a way that you can never imagine.Because of his humorous language,his unique narrative skills,and his unexpected and reasonable ending,O.Henry got a high reputation.His execllent technique of writng is more obvious for the irony of reality and the return of human nature.The O.Henry-style ending opened up the pluralistic development of later realistic literature.The highly critical ending of its turning point also promotes the practical significance of the reaction of world literature to society.
文摘A good beginning grasps the audience's attention,arouses their interest,and presents the gist of your speech,while a good ending reinforces your stance,creates a sense of completeness and leaves the listeners space for further thinking.
文摘A case of ideal fluid flow in a moving ending rigid constant diameter circular pipeline is investigated. A model of the pipeline was established based on distributed-parameter theory. The comparisons on a quotient module of output and input pressure of the moving ending model and neglected ending moving model are made on the frequency response. It is revealed that the moving ending of pipeline influences largely the quotient amplitude of output and input pressure, and the peak value of frequency resonance increases with the increase of pipeline’s length.
文摘The mechanisms for the regulation of synaptic dopamine (DA) include its release from presynaptic vesicles, its interaction with post-synaptic and pre-synaptic DA receptors, the reuptake of DA, via dopamine transporter (DAT), the diffusion of DA and its metabolism by mono-amine oxidase (MAO) and cate- chol-O-methyl transferase (COMT). DA controls complex and specialized functions including, movements, behavior, mood, perception, reward, and more recently, neurogenesis (Popolo et al., 2004; Reimer et al., 2013) and neuroregeneration (Hoglinger et al., 2004; Yang et al., 2008). These functions are varied and of high fidelity. Movement, as an example, requires regulatory mechanisms for initiating, stopping, slowing-down speed- ing-up, changing directions, for governing the relentless urges to move in the young and sedentariness in the old as well as in motor-freezing, catalepsy, tremor and stereotypy.
文摘Background: In this experimental study, we aimed to determine the possible changes in fracture healing due to denervation and/or nerve ending interpositioning. Methods: 50 Wistar Albino type male rats were divided into three study groups. A standard transverse diaphysial fracture in the femurs of the same side of all subjects under anesthesia was created and the fracture were fixed intramedullarily. While preserving the structural integrity of the sciatic nerve in the first group, neurectomy to the nerve in the second group was performed. In the third group, following the sciatic nerve cut, the proximal end of the nerve were interposed the fracture line. After a 28-day observational period, the callus formation in the subjects was examined radiologically, biomechanically and histopathologically. Results: Among all groups, the third group subjects showed significant increase in radiological area measurements when they are compared to the second group rats. There was no significant difference in biomechanical measurements of fractured femurs of the three groups. In histopathological evaluations, it was observed that denervation had increased the thickness of the cartilage and the number of the chondrocytes and osteoclasts significantly but decreased the number of fibroblasts compared to the control group. In addition to the denervation nerve ending interpositioning increased the bone thickness and the number of the osteoblasts but decreased the number of the osteoclasts significantly. Conclusions: While radiological observations exhibit that nerve ending interpositioning has resulted more hypertrophic callus formation, histopathological evaluations led us to that denervation created partial (immature) callus formation and nerve ending interpositioning demonstrated larger but immature callus formation.
文摘As one of the first and most original creations of literary postmodernism, published in the year 1961, Catch-22's (1961) position in American literature remains secure. Yet its ending has been held as unconvincing ever since its publication. Taking the overall structure, tone, and the theme of the novel into consideration, this paper aims to prove the credibility of this controversial part. It consists of five sections apart from an introduction and a conclusion. Section One provides general information on the life and works of Joseph Heller. Section Two traces the impact of existentialism and the generation of black humor to clarify the literary position of Catch-22. Section Three brings out the disputative opinions on the ending part. Sections Four and Five, try to prove Yossarian's final desertion a natural and convincing ending from different perspectives: Section Four analyses how Yossarian gains an entropic vision of the cosmos; section Five studies his existential vision of physical life and searches for the immediate factors that propel Yossarian's desertion. Section five also explains the ending's change in tone and structure. The conclusion summarizes the paper and points out the social significance of the novel.
文摘A roll-bending process that minimizes the flat areas on the leading and trailing ends of formed plates will produce more accurate and easier assemble final shapes. There are several methods of minimizing flat areas, but they are costly or difficult to apply for thick plates. This study proposes a new, simple approach that reduces these flat areas. This approach includes moving the bottom roll slightly along the feeding direction and adjusting the bottom roll location. Sensitivity analyses were performed using a developed 3D dynamic FE (finite element) model of an asymmetrical roll-bending process in the Ansys/LS-Dyna software package. Simulations were validated by experiments run on an instrumented roll-bending machine. The FE results indicate that this new approach not only minimizes the flat areas but also reduces the forming forces.
文摘The French Lieutenant's Woman is the best-known novel written by John Fowles and is also called the post-modern metafiction.In the novel the mysterious woman Sarah is introduced,who rebels against Victorian conventions to pursue independence and freedom.Undoubtedly,Sarah is an independent woman ahead of her times.This paper is attempted to interpret the last ending of The French Lieutenant's woman written by John Fowles,thus finding relevant evidence to support this interpretation that Sarah has finally got her freedom which is not allowed against the Victorian background.
文摘at 11:26 on December 22,a LM-4B launch vehicle lifted the ZY-1 02C satellite into space from the Taiyuan Satellite Launch Center,marking the complete success of the final launch mission of this year.13 minutes later,the satellite entered into sun-synchronous circular orbit after separating with the rocket.
文摘Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in many of which beams are often subjected to axial loads and static end moments. In the present study, an analytical solution is developed to study the coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments. Euler-Bernoulli beam theory and the "free mode" assumption in delamination vibration are adopted. This is the first study of the influences of static end moments upon the effects of delaminations on natural frequencies, critical buckling loads and critical moments for lateral instability. The results show that the effects of delamination on reducing natural frequencies, critical buckling load and critical moment for lateral instability are aggravated by the presence of static end moment. In turn, the effects of static end moments on vibration and instability characteristics are affected by the presence of delamination. The analytical results of this study can serve as a benchmark for finite element method and other numerical solutions.
基金This study was supported by the grants from the National Natural Science Foundation of China (No. 30770772 and No. 30971046), the Fund of the Municipal Committee of Shanghai Science and Technology (No. 09411968200), the Joint Key Project of New Frontier Technology in Shanghai Municipal Hospitals (No. SHDC12006105) and the National High Technology Research and Development Program of China (No. 2008AA02Z412 and No. 2007AA02Z420).
文摘Background Prior research about N400 has been mainly based on English stimuli,while the cognitive.processing of Chinese characters is still unclear.The aim of the present study was to further investigate the semantic processing of Chinese idioms.Methods Event related potentials (ERP) component N400 was elicited by 38 pairs of matching (congruent) and mismatching (incongruent) ended Chinese idioms:ending words with same phoneme but different shape and meaning (sPdSdM),with similar shape but different phoneme and meaning(sSdPdM),with same meaning but different phoneme and shape(sMdPdS),and words with different phoneme,shape and meaning(dPdSdM)and recorded by Guangzhou Runjie WJ-1 ERP instruments.In 62 right-handed healthy adults(age 19-50 years),N400 amplitudes and latencies were compared between matching and mismatching conditions at Fz,Cz and Pz.Results N400 showed a midline distribution and could be elicited in electrodes Fz, Cz and Pz.The mean values of N400 latencies and amplitudes were obtained for matching and mismatching ending werds in healthy adults.Significant differences were found in N400 latencies and amplitudes in matching and mismatching ending-werds idioms in healthy adults(P〈0.05).Compared with matching ending-werds jdioms, N400 latencies were prolonged and the amplitudes were increased in mismatching ones.N400s elicited by different types of stimuli showed different latencies and amplitudes.and longest N400 latency and largest N400 amplitude were elicited by ending-werds with dPdSdM.No gender difference was found of N400 latency and amplitude in this study (P〉0.05).Conclusions Compared with English stimuli.Chinese ideographic words could provide more flexible stimuli for N400 research in that the werds have 3-dimension changes-phoneme.shape and meaning.Features of N400 elicited by matching and mismatching ending words in Chinese idioms are mainly determined by the meaning of the werd.Some issues of N400 elicited by Chinese characters deserve further research.
基金supported by a grant from Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,No.ZJAD-2021002(to ZW)。
文摘Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the brain.The NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and aggregation.Because NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory cytokines.Here,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau phosphorylation.Using biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in neurons.In primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis present.In the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical neurons.Transcriptome analysis suggested that FUBP3 plays a role in neuron-mediated immune responses.We also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced responses.These findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in neurons.Given that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.
文摘The 2010 Nuclear Non-proliferation Treaty Review Conference is a milestone for international arms control efforts The 2010 Nuclear Non-proliferation Treaty (NPT) Review Conference (RevCon) at the UN
文摘Chinese composer writes a new score for the last 18 minutes of Puccini’s Turandot It has long been the wishes of many clas- sical opera fans and sopranos alike that the heroine of Italian composer Giacomo Puccini’s classic Turandot,Princess Turandot,had her own aria.And now that wish has just come true.In the new edi- tion of the opera presented by the National Center for the Performing Arts (NCPA) of China in March,the princess sang a beauti- ful and moving aria,named The First Tears, transforming herself in the process from a cold-hearted woman with infinite power into an ordinary girl falling in love with Prince Calaf,the hero of the opera.
文摘协会简介"Ending轮滑社"成立于2009年,Ending寓意为even ending are together.即使结束了我们还是在一起,凝结了我们对轮滑社一份深切的感情。"Ending轮滑社"是集健身、竞技、娱乐、趣味、技巧、艺术、休闲于一体的学生社团,现已发展会员200余人。社团成员在训练之余还积极参加南京市的各种比赛和校内外的各种表演,社团元老钱家元在苏州"米高杯"中获得第四名,在上海"
文摘On March,16,2014,27-year-old Renjianyu and his girlfriend got married in Chongqing.It was not just any wedding—in some ways,it celebrated the end of an era.Their officiator,49-year-old lawyer Pu Zhiqiang,announced in the speech he gave at their wedding,hopefully and enthusiastically:'We are overjoyed to see the changes taking place in this country,and we remain optimistic about them.'The changes to which Pu
基金R.Ma thanks the support from PolyU Distinguished Postdoc Fellowship(1-YW4C)Z.Luo thanks the National Natural Science Foundation of China(NSFC,No.22309119)+7 种基金J.Wu thanks the Guangdong government and the Guangzhou government for funding(2021QN02C110)the Guangzhou Municipal Science and Technology Project(No.2023A03J0097 and 2023A03J0003)H.Yan appreciates the support from the National Key Research and Development Program of China(No.2019YFA0705900)funded by MOST,the Basic and Applied Research Major Program of Guangdong Province(No.2019B030302007)the Shen Zhen Technology and Innovation Commission through(Shenzhen Fundamental Research Program,JCYJ20200109140801751)the Hong Kong Research Grants Council(research fellow scheme RFS2021-6S05,RIF project R6021-18,CRF project C6023‐19G,GRF project 16310019,16310020,16309221,and 16309822)Hong Kong Innovation and Technology Commission(ITC‐CNERC14SC01)Foshan‐HKUST(Project NO.FSUST19‐CAT0202)Zhongshan Municipal Bureau of Science and Technology(NO.ZSST20SC02)and Tencent Xplorer Prize。
文摘With plenty of popular and effective ternary organic solar cells(OSCs)construction strategies proposed and applied,its power conversion efficiencies(PCEs)have come to a new level of over 19%in single-junction devices.However,previous studies are heavily based in chloroform(CF)leaving behind substantial knowledge deficiencies in understanding the influence of solvent choice when introducing a third component.Herein,we present a case where a newly designed asymmetric small molecular acceptor using fluoro-methoxylated end-group modification strategy,named BTP-BO-3FO with enlarged bandgap,brings different morphological evolution and performance improvement effect on host system PM6:BTP-eC9,processed by CF and ortho-xylene(o-XY).With detailed analyses supported by a series of experiments,the best PCE of 19.24%for green solvent-processed OSCs is found to be a fruit of finely tuned crystalline ordering and general aggregation motif,which furthermore nourishes a favorable charge generation and recombination behavior.Likewise,over 19%PCE can be achieved by replacing spin-coating with blade coating for active layer deposition.This work focuses on understanding the commonly met yet frequently ignored issues when building ternary blends to demonstrate cutting-edge device performance,hence,will be instructive to other ternary OSC works in the future.