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Elaidic acid leads to mitochondrial dysfunction via mitochondria-associated membranes triggers disruption of mitochondrial calcium fluxes 被引量:2
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作者 Hui Liu Xuenan Li +4 位作者 Ziyue Wang Lu Li Yucai Li Haiyang Yan Yuan Yuan 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期287-298,共12页
Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability o... Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial dysfunction.We focused on KCs to explore the damage to mitochondria by EA.After EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS release.Immunoprecipitation experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial instability.These findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial dysfunction.Meanwhile,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver mitochondria.Swelling of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets. 展开更多
关键词 elaidic acid(EA) Mitochondria-associated membranes(MAMs) Calcium Endoplasmic reticulum Mitochondria dysfunction
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Elaidic acid-induced intestinal barrier damage led to gut-liver axis derangement and triggered NLRP3 inflammasome in the liver of SD rats
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作者 Hui Liu Xuenan Li +5 位作者 Lu Li Yucai Li Haiyang Yan Yong Pang Wenliang Li Yuan Yuan 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1279-1291,共13页
Previous studies have shown that trans fatty acids(TFA) are associated with several chronic diseases,the gut microbiota is directly influenced by dietary components and linked to chronic diseases.Our research investig... Previous studies have shown that trans fatty acids(TFA) are associated with several chronic diseases,the gut microbiota is directly influenced by dietary components and linked to chronic diseases.Our research investigated the effects of elaidic acid(EA),a typical TFA,on the gut microbiota to understand the underlying mechanisms of TFA-related chronic diseases.16S rDNA gene sequencing on faecal samples from Sprague-Dawley rats were performed to explore the composition change of the gut microbiota by EA gavage for 4 weeks.The results showed that the intake of EA increased the abundance of well-documented harmful bacteria,such as Proteobacteria,Anaerotruncus,Oscillibacter and Desulfovibrionaceae.Plus,EA induced translocation of lipopolysaccharides(LPS) and the above pathogenic bacteria,disrupted the intestinal barrier,led to gut-liver axis derangement and TLR4 pathway activation in the liver.Overall,EA induced intestinal barrier damage and regulated TLR4-MyD88-NF-κB/MAPK pathways in the liver of SD rats,leading to the activation of NLRP3 inflammasome and inflammatory liver damage. 展开更多
关键词 elaidic acid(EA) Gut microbiota Intestinal barrier Gut-liver axis TLR4-MyD88-NF-κB/MAPK pathways NLRP3 inflammasome
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Effects of Various Foods Intakes on Plasma Levels of Trans Fatty Acids in Japanese Old Men
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作者 F. Shimizu Y. Ishii +3 位作者 M. Ogawa T. Takao S. Koba A. Takada 《Food and Nutrition Sciences》 2018年第7期797-805,共9页
Background: Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. In Japan, use of tr... Background: Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. In Japan, use of trans fatty acids in the foods is prohibited, thus trans fatty acids must come from foods or microbes in the digestive organs. Methods: Plasma levels of fatty acids including trans forms of healthy old men are measured by gas chromatography and correlations between various foods intakes and plasma levels of trans fatty acids such as palmitoelaidic, elaidic and linoelaidic acids are examined. Results: No correlations between various foods intakes and trans fatty acids were found except between intake of preference drinks such as tea or coffee and plasma levels of palmitoelaidic and linoelaidic acids. Conclusion: Since palmitoelaidic acid is cardioprotective, increase in plasma levels of palmitoelaidic acid may indicate that intakes of tea and coffee may be beneficial for heath by increasing palmitoelaidic acids. 展开更多
关键词 FATTY ACID Trans FATTY ACID Palmitoelaidic ACID elaidic ACID Linoelaidic ACID Saturated FATTY ACID UNSATURATED FATTY ACID ω FATTY ACID DHA (Docosahexanoic Acid) EPA (Eicosapentanoic Acid) AA (Arachidonic Acid)
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Correlation of Various Foods Intakes and Plasma Levels of Omega Fatty Acids in Healthy Japanese Old Men
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作者 Akikazu Takada Fumiko Shimizu Shinji Koba 《Food and Nutrition Sciences》 2019年第6期578-587,共10页
Background: Trans fatty acids are considered to impair health and some ω fatty acids are protective against atherosclerosis and diabetes mellitus. Trans fatty acids are said to be formed by the partial hydrogenation ... Background: Trans fatty acids are considered to impair health and some ω fatty acids are protective against atherosclerosis and diabetes mellitus. Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. It is important how much these intaken fatty acids influence their plasma levels. Methods: Plasma levels of fatty acids including transforms of healthy old men are measured by gas chromatography and correlations between various foods intakes and plasma levels of trans fatty acids, and ω fatty acids are examined. Results: Intake of fish resulted in increase in plasma levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) but intake of meat such as beef, cow and chicken meat did not increase plasma levels of arachidonic acid (AA). Intakes of oils increased plasma levels of dihomo-g-linolenic acid significantly and AA to some extent. Conclusion: Plasma levels of EPA and DHA increased upon intakes of fish in Japanese old men. Oil intake but not meat intake increased DGLA significantly. These results may explain low incidence of cardiovascular diseases in Japanese people compared with American people whose plasma levels of DHA and EPA are lower. 展开更多
关键词 FATTY ACID Trans FATTY ACID Palmitoelaidic ACID elaidic ACID Linoelaidic ACID Saturated FATTY ACID UNSATURATED FATTY ACID Ω FATTY ACID DGLA (Dihomo-G-Linolenic Acid) DHA (Docosahexanoic Acid) EPA (Eicosapentaenoic Acid) AA (Arachidonic Acid)
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反式脂肪酸分类、来源与功能研究进展 被引量:23
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作者 陈银基 周光宏 《中国油脂》 CAS CSCD 北大核心 2006年第5期7-10,共4页
反式单烯脂肪酸主要包括E laid ic Acid和Vaccenic Acid,E laid ic Acid在氢化的植物油中大量存在,大量食用含E laid ic Acid的食物导致心血管疾病发病率的上升;Vaccenic Acid主要来源于反刍动物瘤胃微生物对多聚不饱和脂肪酸的氢化作用... 反式单烯脂肪酸主要包括E laid ic Acid和Vaccenic Acid,E laid ic Acid在氢化的植物油中大量存在,大量食用含E laid ic Acid的食物导致心血管疾病发病率的上升;Vaccenic Acid主要来源于反刍动物瘤胃微生物对多聚不饱和脂肪酸的氢化作用,Vaccenic Acid及其体内代谢产物共轭亚油酸对肿瘤和心血管疾病有潜在的抑制作用。进一步对反式脂肪酸加以区分,并对反式脂肪酸各异构体功能与作用机理进行深入研究,是目前反式脂肪酸领域研究的重要方向。 展开更多
关键词 反式脂肪酸 心血管疾病 冠心病 elaidic ACID Vaccenic ACID
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