Drug-induced liver injury(DILI)is a term used to describe an unexpected liver reaction to drugs,but also to herbal products and dietary supplements(HDS).In the current therapeutic armamentarium,only a small number of ...Drug-induced liver injury(DILI)is a term used to describe an unexpected liver reaction to drugs,but also to herbal products and dietary supplements(HDS).In the current therapeutic armamentarium,only a small number of available drugs are still capable of causing liver damage in overdose.These include,in addition to paracetamol-the prototypical example of this group-niacin(now rarely used to treat hypercholesterolaemia),intravenous methotrexate and probably ketamine(an intravenous hypnotic used in critically ill patients for rapid sequence induction)(1).展开更多
As the Electrical and Electronic Equipment （EEE） are upgraded more frequently in China, a large quantity of Waste Electrical and Electronic Equipment （WEEE） was and will be generated. It becomes an urgent issue to...As the Electrical and Electronic Equipment （EEE） are upgraded more frequently in China, a large quantity of Waste Electrical and Electronic Equipment （WEEE） was and will be generated. It becomes an urgent issue to develop and adopt an effective End-of-Life （EoL） strategy for EEE in order to balance the resource recovery and environmental impacts. In an EoL strategy hierarchy for EEE, reuse strategy is usually deemed to be prior to materials recovery and other strategies. But in practice, the advantages and disadvantages of different strategies are always context-dependent. Therefore, main EoL strategies for EEE in China need to be evaluated in environment and resources aspects from the life cycle perspective. In this study, the obsolete refrigerator and Power Supply Unit （PSU） ofdesktop PC are both taken as the target products. Life Cycle Assessment （LCA） is applied to assess the environmental impacts of different EoL scenarios in China： Unit Reuse Scenario （URS）, Component Reuse Scenario （CRS） and Materials Recovery Scenario （MRS）. The LCA results show that the EoL strategies hierarchy is reasonable for the part＇of computer, bui not necessarily suitable for obsolete refrigerators. When the policy makers promote or demote one EoL strategy especially reuse, it is necessary to take subsequent impacts into consideration.展开更多
基金supported by grants from Instituto de Salud Carlos III cofounded by Fondo Europeo de Desarrollo Regional-FEDER[contract numbers:FIS 21_01248PI18/00901,UMA18-FEDERJA-193].CIBERehd is funded by Instituto de Salud Carlos III(ISCIII).All authors are members of the COST ACTION“CA-17112”-Prospective European Drug-Induced Liver Injury Network,supported by COST(European Cooperation in Science and Technology).www.cost.eu.JMPB holds a Rio Hortega contract from ISCIII.
文摘Drug-induced liver injury(DILI)is a term used to describe an unexpected liver reaction to drugs,but also to herbal products and dietary supplements(HDS).In the current therapeutic armamentarium,only a small number of available drugs are still capable of causing liver damage in overdose.These include,in addition to paracetamol-the prototypical example of this group-niacin(now rarely used to treat hypercholesterolaemia),intravenous methotrexate and probably ketamine(an intravenous hypnotic used in critically ill patients for rapid sequence induction)(1).
基金This study was supported by National Natural Science Foundation of China Key Program （No. 71533005） and Open Program of State Key Laboratory of Urban and Regional Ecology （SKLURE2017-2-1）.
文摘As the Electrical and Electronic Equipment （EEE） are upgraded more frequently in China, a large quantity of Waste Electrical and Electronic Equipment （WEEE） was and will be generated. It becomes an urgent issue to develop and adopt an effective End-of-Life （EoL） strategy for EEE in order to balance the resource recovery and environmental impacts. In an EoL strategy hierarchy for EEE, reuse strategy is usually deemed to be prior to materials recovery and other strategies. But in practice, the advantages and disadvantages of different strategies are always context-dependent. Therefore, main EoL strategies for EEE in China need to be evaluated in environment and resources aspects from the life cycle perspective. In this study, the obsolete refrigerator and Power Supply Unit （PSU） ofdesktop PC are both taken as the target products. Life Cycle Assessment （LCA） is applied to assess the environmental impacts of different EoL scenarios in China： Unit Reuse Scenario （URS）, Component Reuse Scenario （CRS） and Materials Recovery Scenario （MRS）. The LCA results show that the EoL strategies hierarchy is reasonable for the part＇of computer, bui not necessarily suitable for obsolete refrigerators. When the policy makers promote or demote one EoL strategy especially reuse, it is necessary to take subsequent impacts into consideration.
