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早期肺康复联合ESCAPE集束化护理对ICU有创机械通气患者呼吸机相关膈肌功能障碍的影响
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作者 刘红伟 倪平娟 +3 位作者 李丽 黄来刚 王建扬 王玉辉 《齐鲁护理杂志》 2024年第10期20-23,共4页
目的:探讨早期肺康复联合ESCAPE集束化护理对ICU有创机械通气患者呼吸机相关膈肌功能障碍(VIDD)的影响。方法:将2023年2月1日~12月31日综合ICU收治的41例成人有创机械通气患者随机分为实验组20例和对照组21例,其中实验组3例、对照组4例... 目的:探讨早期肺康复联合ESCAPE集束化护理对ICU有创机械通气患者呼吸机相关膈肌功能障碍(VIDD)的影响。方法:将2023年2月1日~12月31日综合ICU收治的41例成人有创机械通气患者随机分为实验组20例和对照组21例,其中实验组3例、对照组4例因转出ICU而脱落,最终纳入实验组和对照组各17例。实验组给予早期肺康复训练联合ESCAPE集束化护理,对照组给予ESCAPE集束化护理。比较两组膈肌移动度及增厚率、临床肺部感染评分(CPIS)、急性生理学与慢性健康状况评分(APACHEⅡ)。结果:实验组治疗后膈肌移动度高于治疗前(P<0.05),膈肌增厚率比较差异无统计学意义(P>0.05);实验组治疗后CPIS、APACHEⅡ评分均低于治疗前(P<0.05)。结论:早期肺康复联合ESCAPE集束化护理可改善ICU有创机械通气患者的膈肌移动度,降低肺部感染发生风险、改善健康状况,减轻膈肌萎缩,控制ICU呼吸机相关性肺炎。 展开更多
关键词 有创机械通气 早期肺康复 escape集束化护理管理 呼吸机相关膈肌功能障碍 呼吸训练
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Escape room游戏宣教对阴道分娩初产妇分娩恐惧及产程进展的影响
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作者 陈丽云 尹婷 李春华 《当代护士(上旬刊)》 2024年第1期39-42,共4页
目的探究Escape room游戏宣教对阴道分娩初产妇分娩恐惧及产程进展的影响。方法采用便利抽样法,选取本院2021年1月—2022年6月收治的140例阴道分娩初产妇为研究对象,按随机数字表法将其分为对照组和观察组,每组各70例。对照组采取常规... 目的探究Escape room游戏宣教对阴道分娩初产妇分娩恐惧及产程进展的影响。方法采用便利抽样法,选取本院2021年1月—2022年6月收治的140例阴道分娩初产妇为研究对象,按随机数字表法将其分为对照组和观察组,每组各70例。对照组采取常规教育模式,观察组在常规护理基础上应用Escape room游戏宣教,比较两组初产妇分娩恐惧水平、产程进展。结果观察组分娩恐惧中高水平初产妇占比为57.14%小于对照组的80.00%,差异有统计学意义(P<0.05);观察组初产妇第一产程时间、第二产程时间均短于对照组,差异有统计学意义(P<0.05),两组第三产程时间比较差异无统计学意义(P>0.05)。结论Escape room游戏宣教在阴道分娩初产妇中的应用,能缓解产妇分娩恐惧情绪,可一定程度上加快产程进展。 展开更多
关键词 阴道分娩 初产妇 分娩恐惧 产程进展 escape room游戏宣教
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优化ESCAPE集束化策略对ICU亚临床谵妄患者的效果评价
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作者 倪海莲 袁薇 《云南医药》 CAS 2024年第3期98-100,共3页
目的 分析优化ESCAPE集束化策略对ICU亚临床谵妄患者的效果。方法 选取本院入住ICU超过24h的亚临床谵妄患者,对照组予常规护理,观察组在常规护理上给优化ESCAPE集束化策略。比较2组睡眠质量、认知水平、谵妄发生率及48h内亚临床谵妄持... 目的 分析优化ESCAPE集束化策略对ICU亚临床谵妄患者的效果。方法 选取本院入住ICU超过24h的亚临床谵妄患者,对照组予常规护理,观察组在常规护理上给优化ESCAPE集束化策略。比较2组睡眠质量、认知水平、谵妄发生率及48h内亚临床谵妄持续时间。结果 观察组睡眠质量、认知水平、谵妄发生率、亚临床谵妄持续时间低于对照组,差异有统计学意义(P<0.05)。结论 优化ESCAPE集束化策略可提高患者睡眠质量,改善亚临床谵妄患者认知水平,缩短亚临床谵妄持续时间,降低谵妄发生率。 展开更多
关键词 优化escape集束化策略 重症监护室 亚临床谵妄
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When Fleeing Matters:Differences in Escape Behaviours of Three Northeast Asian Anurans
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作者 Yoonjung YI Zoljargal PUREVDORJ +2 位作者 Irina MASLOVA Yikweon JANG Amaël BORZÉE 《Asian Herpetological Research》 SCIE CSCD 2024年第1期41-48,共8页
Prey species may have their own optimal escape strategy to balance predation risks and the energetic cost of fleeing.Some species have an advantage when maintaining a short fleeing distance,while others may favour an ... Prey species may have their own optimal escape strategy to balance predation risks and the energetic cost of fleeing.Some species have an advantage when maintaining a short fleeing distance,while others may favour an earlier escape based on microhabitat,size,or body condition.Here,we examined the escape behaviour of the three syntopic Northeast Asian anuran species:Mongolian toads(Strauchbufo raddei),Amur brown frogs(Rana amurensis),and Japanese treefrogs(Dryophytes japonicus)in Mongolia,Russia,China and DPR Korea.We examined flight initiation distance(FID;the distance from a potential predator to the point when the individual starts to flee)and distance fled(DF;distance between flight initiation and flight termination points)of each species and the effects of microhabitat,sex,and body size.Strauchbufo raddei and R.amurensis had a longer FID than D.japonicus,and S.raddei also had a longer DF than D.japonicus.These trends remained similar when dividing FID and DF by a size proxy(snout-vent length)for all individuals.This suggests that the treefrog D.japonicus used a strategy to stay immobile even when they were detected,and the toad S.raddei reacted quicker and more sensitively to predators despite the presence of toxin.Female S.raddei had a significantly longer FID than males suggesting that females are more sensitive to predation risk in this species,but body size was not significant for any of the three species.Our results indicate that the three sympatric species have different escaping strategies,likely related to differences in physiology and crypticity. 展开更多
关键词 AMPHIBIAN distance fled escape behaviour flight initiation distance PREDATION
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Correction:The escape mechanisms of the proto-atmosphere on terrestrial planets:“boil-off”escape,hydrodynamic escape and impact erosion
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作者 Ziqi Wang You Zhou Yun Liu 《Acta Geochimica》 EI CAS CSCD 2024年第3期623-623,共1页
In the original publication of the article,the affiliation“College of Earth and Planetary Sciences,University of Chinese Academy of Sciences,Beijing,People’s Republic of China”for author Ziqi Wang was missing and i... In the original publication of the article,the affiliation“College of Earth and Planetary Sciences,University of Chinese Academy of Sciences,Beijing,People’s Republic of China”for author Ziqi Wang was missing and included in this correction article. 展开更多
关键词 escape PLANET COLLEGE
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ESCAPE策略在机械通气患者谵妄管理的应用 被引量:17
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作者 骆艳妮 王秀莹 +3 位作者 王小闯 吴媛 苏丹 刘佳 《护理学杂志》 CSCD 北大核心 2019年第19期37-40,共4页
目的评价ESCAPE策略用于机械通气患者谵妄管理的效果。方法将165例机械通气患者采用随机数字软件分为干预组(n=86)、对照组(n=79)。对照组采用ICU常规护理,包括观察患者生命体征、呼吸机及循环监测、常规镇痛镇静护理、药物不良反应及... 目的评价ESCAPE策略用于机械通气患者谵妄管理的效果。方法将165例机械通气患者采用随机数字软件分为干预组(n=86)、对照组(n=79)。对照组采用ICU常规护理,包括观察患者生命体征、呼吸机及循环监测、常规镇痛镇静护理、药物不良反应及脏器功能监测。干预组采用ICU常规护理的同时应用ESCAPE策略,包括早期活动、睡眠管理、每日唤醒及自主呼吸试验、精神状态评估、情感支持、镇痛镇静管理。比较两组患者谵妄发生率、谵妄持续时间、镇痛镇静药物使用量、机械通气时间、ICU住院时间。结果干预组患者谵妄发生率、谵妄持续时间、镇痛镇静药物使用量、机械通气时间、ICU住院时间显著低于/短于对照组(P<0.05,P<0.01)。结论实施ESCAPE策略可有效降低ICU机械通气患者谵妄发生率,缩短谵妄持续时间,提高临床护理质量。 展开更多
关键词 机械通气 谵妄 escape策略 ICU住院时间 镇痛 镇静
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Initial Study on Immune Escape Mechanism of Mouse Acute Myelomonocytic Leukemic Cell Line WEHI-3
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作者 黎纬明 刘凌波 +1 位作者 何伟 邹萍 《The Chinese-German Journal of Clinical Oncology》 CAS 2006年第4期291-293,共3页
Objective: To investigate the expression of Fas, Fas ligand (FasL) and CD80 on the cell surface of mouse acute myelomonocytic leukemia cell line WEHI-3 and the function of FasL. Methods: The expression of Fas, Fas... Objective: To investigate the expression of Fas, Fas ligand (FasL) and CD80 on the cell surface of mouse acute myelomonocytic leukemia cell line WEHI-3 and the function of FasL. Methods: The expression of Fas, FasL and CD80 was detected on WEHI-3 cell surface by flow cytometry. Simultaneously the function of FasL was determined by Thymidine (^3H-TdR) Incorporation. Results: The expression of CD80 and Fas on WEHI-3 cell surface was 5.06%±0.41% and 6.75%±2.31% (n=5) respectively, and the expression of FasL was up to 63.73%±5.23% (n=5). The apoptotic rate of YAC-1 cells was 26%±4.5%, 35%±3.2% and 43%±2.7% (n=5) respectively when WEHI-3 (effector cell, E) and Fas^+ YAC-1 cells (target cell, T) were cultured in the ratio of 3:1, 10:1 and 30:1. Conclusion: WEHI-3 cells express high FasL, low Fas and CD80, and can induce apoptosis of Fas^+ YAC-1 cells. 展开更多
关键词 acute myelomonocytic leukemia FASL FAS CD80 immune escape
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改良ESCAPE集束化策略在急性呼吸衰竭有创机械通气脱机患者中的应用价值
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作者 陈新龙 赵宏胜 +3 位作者 陆舒 许惠芬 王乃学 王林华 《交通医学》 2023年第6期582-585,共4页
目的:探讨改良ESCAPE集束化策略在急性呼吸衰竭有创机械通气脱机患者中的应用价值。方法:接受有创机械通气治疗的急性呼吸衰竭患者116例,随机分为观察组60例和对照组56例。对照组由主管医师制定整体治疗方案,采用常规治疗护理。观察组... 目的:探讨改良ESCAPE集束化策略在急性呼吸衰竭有创机械通气脱机患者中的应用价值。方法:接受有创机械通气治疗的急性呼吸衰竭患者116例,随机分为观察组60例和对照组56例。对照组由主管医师制定整体治疗方案,采用常规治疗护理。观察组在常规治疗护理基础上,实施改良ESCAPE集束化策略。结果:观察组脱机后1 h、12 h、24 h时SaO_(2)分别为(96.7±3.7)%、(97.3±3.8)%和(97.4±3.3)%,高于对照组的(92.1±4.3)%、(92.5±2.1)%和(93.3±3.9)%,观察组脱机后1 h、12 h、24 h时PaO_(2)/FiO_(2)分别为255.5±33.5 mmHg、257.5±28.7 mmHg和271.3±32.6 mmHg,高于对照组的213.4±30.7 mmHg、218.1±30.4 mmHg和225.5±30.3 mmHg,差异均有统计学意义(P<0.05);观察组患者脱机后1 h RR 20.5±3.7次/min,低于对照组的25.6±4.1次/min,差异有统计学意义(P<0.05)。观察组机械通时间5.9±2.7 d,短于对照组的8.6±3.1 d,差异有统计学意义(P<0.05);观察组48 h内再插管5例(8.3%),对照组48 h内再插管6例(10.7%),两组再插管率的差异无统计学意义(P>0.05)。观察组谵妄发生率18.3%,低于对照组的35.7%,观察组ICU-AW发生率16.7%,低于对照组的25.0%,差异均有统计学意义(P<0.05);观察组ICU住院时间8.3±3.7 d,短于对照组的11.2±4.1 d,差异有统计学意义(P<0.05)。结论:改良ESCAPE策略可改善急性呼吸衰竭患者呼吸机撤机后的氧合指标,降低谵妄及ICU获得性衰弱的发生率,缩短机械通气时间和ICU住院时间。 展开更多
关键词 改良escape集束化策略 急性呼吸衰竭 机械通气 脱机
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A new escape time algorithm of constructing Julia set
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作者 袁杰 Li Xiali +1 位作者 Hou Zhiling Cao Maosheng 《High Technology Letters》 EI CAS 2007年第2期194-197,共4页
Escape time algorithm is an effective theoretical algorithm of constructing fractal graphics. The key of this algorithm lies in the construction of escape time function. A new escape time function is presented based o... Escape time algorithm is an effective theoretical algorithm of constructing fractal graphics. The key of this algorithm lies in the construction of escape time function. A new escape time function is presented based on the research of escape time algorithm. An accelerated escape time algorithm is carried out in this paper. The experiments have demonstrated that the new algorithm is not only as precise as the old, but also faster when it is used to construct Julia set. 展开更多
关键词 FRACTAL escape time algorithm escape time function Julia set
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A Case of Hepatitis B Reactivation due to the Hepatitis B Virus Escape Mutant in a Patient undergoing Chemotherapy 被引量:7
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作者 Chunchen Wu Hui Shi +3 位作者 Yun Wang Mengji LU Yang Xu Xinwen Chen 《Virologica Sinica》 SCIE CAS CSCD 2012年第6期369-372,共4页
A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg... A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while antibody to hepatitis B surface antigen (anti-HBs) and HBV DNA were negative. Later the patient received chemotherapy for malignancy. However, this was interrupted due to elevated liver enzymes. At the same time HBV DNA became positive. Lamivudine (LMV) therapy was administered immediately. However, the levels of serum aminotransferase and total bilirubin (TB) were still rising. Finally the patient died of fulminant hepatic failure. A sequence revealed HBV genotype C (HBsAg subtype adw) with immune escape mutations, F8L, $34L, F41S, G44V, F93C, V96G, Lll0I, C149Y and F161Y. The high morbidity and mortality of this complication is one of the major obstacles to completing the standard treatment for malignancy in HBV carriers. Therefore, the relative risk of antiviral prophylactic failure should be further assessed and the optimal strategy for antiviral prophylaxis in HBsAg-positive patients with oncologic and hematologic malignancies undergoing chemotherapy should be revised. 展开更多
关键词 Hepatitis B reactivation escape mutant LAMIVUDINE MALIGNANCY
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Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma 被引量:7
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作者 Liang Wang Steven Mo +2 位作者 Xin Li Yingzhi He Jing Yang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第3期726-739,共14页
Objective:Mantle cell lymphoma(MCL)is a rare subtype of non-Hodgkin lymphoma(NHL)with high heterogeneity and a high recurrence rate.How heterogenous cell populations contribute to relapse remains to be elucidated.Meth... Objective:Mantle cell lymphoma(MCL)is a rare subtype of non-Hodgkin lymphoma(NHL)with high heterogeneity and a high recurrence rate.How heterogenous cell populations contribute to relapse remains to be elucidated.Methods:We performed single cell RNA sequencing(scRNA-seq)on approximately 4,000 bone marrow cells sampled from one patient with multidrug resistant MCL.We identified 10 subpopulations comprising 4 malignant B cell subtypes,3 T cell subtypes,2 dendritic cell subtypes and 1 natural killer(NK)cell subtype.Subsequently,we identified cell markers,including a series of genes associated with immune escape and drug resistance.In addition,we explored the roles of these genes in the mechanism of immune escape and drug resistance,and we verified the expression imbalance and clinical prognostic potential by using GEO datasets including 211 MCL samples.Results:The major immune escape mechanisms of MCL included anti-perforin activity,decreased immunogenicity and direct inhibition of apoptosis and cell killing,as mediated by type I and II B cells.The drug resistance mechanisms of different cell clusters included drug metabolism,DNA damage repair,apoptosis and survival promotion.Type III B cells closely communicate with other cells.The key genes involved in the resistance mechanisms showed dysregulated expression and may have significant clinical prognostic value.Conclusion:This study investigated potential immune escape and drug resistance mechanisms in MCL.The results may guide individualized treatment and promote the development of therapeutic drugs. 展开更多
关键词 Cell heterogeneity immune escape mantle cell lymphoma multidrug resistance scRNA-seq
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Escape from the Besieged Fortress——An Analysis of Alice Munro's "Runaway" 被引量:1
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作者 王琴 徐晓娜 《海外英语》 2011年第12X期252-253,共2页
Alice Munro is one of the famous Canadian writers and is renowned above all for the astonishing subtlety of her short stories.Her theme has often been the dilemmas of the female coming to terms with family, friends in... Alice Munro is one of the famous Canadian writers and is renowned above all for the astonishing subtlety of her short stories.Her theme has often been the dilemmas of the female coming to terms with family, friends in a small town. This paper attempts to make a brief introduction about the stories of Alice Munro's Runaway and explores the protagonist's choices in the dilemma situation, and then exposes the cruelty of reality is that they cannot get rid of the ineluctable reality of life. Escape is only a temporary action which cannot save them from endless triviality of life. What they should do is not to escape from life, but to adapt to the reality of life. 展开更多
关键词 ALICE Munro RUNAWAY escape REALITY
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Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma 被引量:6
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作者 Li-NingXu Sheng-QuanZou Jian-MingWang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第24期3719-3723,共5页
AIM: To study the role of Fas and Fas ligand (FasL) in biological behaviors of gallbladder carcinoma, and their correlated action and mechanism in tumor escape.METHODS: Streptavidin-biotin-peroxidase immunohistochemis... AIM: To study the role of Fas and Fas ligand (FasL) in biological behaviors of gallbladder carcinoma, and their correlated action and mechanism in tumor escape.METHODS: Streptavidin-biotin-peroxidase immunohistochemistry technique was used to study the expression of Fas and FasL protein in 26 gallbladder carcinoma tissues,18 gallbladder adenoma tissues, 3 gallbladder dysplasia tissues and 20 chronic cholecystitis tissues. Apoptosis of the infiltrating lymphocytes in these tissues was studied by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) method. Expression of both proteins and apoptosis of the tumor infiltrating lymphocytes in cancer tissues of primary foci was compared with clinicopathological features of gallbladder carcinoma.RESULTS: The positive rates of Fas were not significantly different among carcinoma, adenoma, dysplasia and chronic cholecystitis. The positive rate of FasL in carcinoma was significantly higher than that in chronic cholecystitis (x2 = 4.89, P<0.05). The apoptotic index (AI) in carcinoma was significantly higher than that in adenoma (t'= 4.19, P<0.01) and chronic cholecystitis (t'= 8.06, P<0.01). The AI was significantly lower in well-differentiated carcinoma and Nevin Ⅰ-Ⅲ carcinoma than that in poorly-differentiated carcinoma (t'= 2.63, P<0.05) and Nevin Ⅳ-Ⅴ carcinoma(t'= 3.33, P<0.01). The confidence interval (CI) ofinfiltrating lymphocytes in adenoma, chronic cholecystitis, well-differentiated carcinoma and Nevin Ⅰ-Ⅲ carcinoma wasvery significantly lower than that in carcinoma (t' = 6.99,P<0.01), adenoma (t' = 3.66, P<0.01), poorly-differentiated carcinoma (t' = 5.31, P<0.01) and Nevin Ⅳ-Ⅴ carcinoma(t' = 3.76, P<0.01), respectively. The CI of apoptosis of infiltrating lymphocytes in well-differentiated carcinoma was significantly lower than that in poorly-differentiated carcinoma (t = 2.52, P<0.05), and was not significantly lower in Nevin Ⅰ-Ⅲ carcinoma than in Nevin Ⅳ-Ⅴ carcinoma (t = 1.42, P>0.05). Apoptosis of infiltrating lymphocytes was not discovered in adenoma and chronic cholecystitis. CONCLUSION: FasL expressed in gallbladder carcinoma cells permits tumor cells to escape from immune surveillance of organism by inducing apoptosis in infiltrating lymphocytes of carcinoma tissues. Up-regulation of FasL expression plays an important role in invasive depth, histological classification and metastasis of gallbladder carcinoma. 展开更多
关键词 FAS Fas ligand Immune escape Gallbladder carcinoma
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Costimulatory Molecule B7-H1 on the Immune Escape of Bladder Cancer and Its Clinical Significance 被引量:7
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作者 王永华 庄乾元 +2 位作者 周四维 胡志全 兰儒竹 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2009年第1期77-79,共3页
B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in tumor immune escape by inducing T-cell apoptosis. In order to investigate the relationship between B7-H1 and... B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in tumor immune escape by inducing T-cell apoptosis. In order to investigate the relationship between B7-H1 and immune escape of bladder cancer, B7-H1 expression in 50 cases of bladder cancer was detected by using immunohistochemical method. Survival curves were con- structed using the Kaplan-Meier method and independent prognostic factors were evaluated using the Cox regression model. Our results showed that the positive rate of B7-H1 immunostaining in normal bladder tissue and bladder cancer was 0 and 72% respectively. The expression of B7-H1 was strongly associated with the pathological grade, clinical stage and recurrence (P〈0.05). The survival rate was significantly lower in patients with B7-H1 positive group than in those with B7-H1 negative group and multi-variable analysis revealed that B7-H1 could be regarded as an independent factor in evaluating the prognosis of bladder cancer. It is concluded that the expression of B7-H1 is strongly associated with neoplastic progression and prognosis of bladder cancer. The manipulation of B7-H1 may become a beneficial target for immunotherapy in human bladder cancer. 展开更多
关键词 bladder neoplasm costimulatory molecule B7-H1 immune escape
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Overwhelming low ammonia escape and low temperature denitration efficiency via MnOx-decorated two-dimensional MgAl layered double oxides 被引量:5
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作者 Junqi Tian Yanqin Li +6 位作者 Xia Zhou Yongbin Yao DenghaoWang Jianming Dan Bin Dai Qiang Wang Feng Yu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2020年第7期1925-1934,共10页
Low temperature catalysts are attracting increasing attention in the selective catalytic reduction(SCR)of NO with NH3.Mn Ox-decorated Mg Al layered double oxide(Mn/Mg Al-LDO)was synthesized via a facile fast pour assi... Low temperature catalysts are attracting increasing attention in the selective catalytic reduction(SCR)of NO with NH3.Mn Ox-decorated Mg Al layered double oxide(Mn/Mg Al-LDO)was synthesized via a facile fast pour assisted co-precipitation(FP-CP)process.Compared to the Mn/Mg Al-LDO obtained via slow drop assisted coprecipitation(SD-CP)method,the Mn/Mg Al-LDO(FP-CP)has excellent activity.The Mn/Mg Al-LDO(FP-CP)catalyst was shown to possess a high NO conversion rate of 76%-100%from 25 to 150℃,which is much better than the control Mn/Mg Al-LDO(SD-CP)(29.4%-75.8%).In addition,the Mn/Mg Al-LDO(FP-CP)offered an enhanced NO conversion rate of 97%and a N2selectivity of 97.3%at 100℃;the NO conversion rate was 100%and the N2selectivity was 90%at 150℃with a GHSV of 60,000 h^-1.The Mn/Mg Al-LDO(FP-CP)catalyst exhibited a smaller fragment nano-sheet structure(sheet thickness of 7.23 nm).An apparent lattice disorder was observed in the HRTEM image confirming the presence of many defects.The H2-TPR curves show that the Mn/Mg Al-LDO(FP-CP)catalyst has abundant reducing substances.Furthermore,the enhanced surface acidity makes the NH3concentration of the Mn/Mg Al-LDO(FP-CP)catalyst lower than 100 ml·m^-3after the reaction from 25 to 400℃.This can effectively reduce the ammonia escape rate in the SCR reaction.Thus,the Mn/Mg Al-LDO(FP-CP)catalyst has potential applications in stationary industrial installations for environmentally friendly ultra-low temperature SCR. 展开更多
关键词 Layered double oxide Fast pour assisted co-precipitation Selective catalytic reduction Low temperature catalytic Ammonia escape
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Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma 被引量:6
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作者 Zhe Deng Yong-Jie Teng +10 位作者 Qing Zhou Zhao-Guang Ouyang Yu-Xing Hu Hong-Ping Long Mei-Jie Hu Si Mei Feng-Xia Lin Xin-Jun Dai Bo-Yu Zhang Ting Feng Xue-Fei Tian 《World Journal of Gastrointestinal Oncology》 SCIE 2021年第11期1725-1740,共16页
BACKGROUND Hepatocellular carcinoma(HCC)is characterized by dysregulation of the immune microenvironment and the development of chemoresistance.Specifically,expression of the programmed cell death protein 1(PD-1)/prog... BACKGROUND Hepatocellular carcinoma(HCC)is characterized by dysregulation of the immune microenvironment and the development of chemoresistance.Specifically,expression of the programmed cell death protein 1(PD-1)/programmed cell death 1 ligand 1(PD-L1)axis,an immune checkpoint,may lead to tumour immune escape,resulting in disease progression.The latest research shows that tumour immune escape may be caused by the upregulation of PD-L1 mediated by hypoxia-inducible factor-1 alpha(HIF-1α),and simultaneous inhibition of HIF-1αand PD-L1 has the potential to enhance the host’s antitumour immunity.Moreover,inhibition of the PD-1/PD-L1 axis may mitigate tumour chemoresistance.Shuyu pills(SYPs)contain immunity-enhancing and antitumour components,making them a potential HCC treatment.AIM To investigate the efficacy of SYPs for HCC treatment via simultaneous HIF-1α and PD-L1 inhibition and the mechanism involved.METHODS A subcutaneous xenograft tumour model was first established in BALB/c nude mice by the subcutaneous injection of 1×107 SMMC-7721 cells.Male mice(male,5 weeks old;n=24)were then randomly divided into the following four groups(n=6):Control(0.9%normal saline),SYP(200 mg/kg),SYP+cisplatin(DDP)(200 mg/kg+5 mg/kg DDP weekly via intraperitoneal injection),and DDP(5 mg/kg cisplatin weekly via intraperitoneal injection).The dose of saline or SYPs for the indicated mouse groups was 0.2 mL/d via intragastric administration.The tumour volumes and body weights of the mice were measured every 2 d.The mice were euthanized by cervical dislocation after 14 d of continuous treatment,and the xenograft tissues were excised and weighed.Western blot assays were used to measure the protein expression of HIF-1α,PD1,PD-L1,CD4+T cells,and CD8+T cells in HCC tumours from mice.Quantitative reverse transcription polymerase chain reaction was used for real-time quantitative detection of PD-1,PD-L1,and HIF-1α mRNA expression.An immunofluorescence assay was conducted to examine the expression of CD4+T cells and CD8+T cells.RESULTS Compared to mice in the control group,those in the SYP and SYP+DDP groups exhibited reduced tumour volumes and tumour weights.Moreover,the protein and mRNA expression levels of the oncogene HIF1α and that of the negative immunomodulatory factors PD-1 and PD-L1 were decreased in both the SYP and SYP+DDP groups,with the decrease effects being more prominent in the SYP+DDP group than in the SYP group(HIF-1α protein:Control vs SYP,P=0.0129;control vs SYP+DDP,P=0.0004;control vs DDP,P=0.0152,SYP+DDP vs DDP,P=0.0448;HIF-1αmRNA:control vs SYP,P=0.0009;control vs SYP+DDP,P<0.0001;control vs DDP,P=0.0003,SYP vs SYP+DDP,P=0.0192.PD-1 protein:Control vs SYP,P=0.0099;control vs SYP+DDP,P<0.0001,SPY vs SYP+DDP,P=0.0009;SYP+DDP vs DDP,P<0.0001;PD-1 mRNA:control vs SYP,P=0.0002;control vs SYP+DDP,P<0.0001;control vs DDP,P=0.0003,SPY vs SYP+DDP,P=0.0003;SYP+DDP vs DDP,P=0.0002.PD-L1 protein:control vs SYP,P<0.0001;control vs SYP+DDP,P<0.0001;control vs DDP,P<0.0001,SPY vs SYP+DDP,P=0.0040;SYP+DDP vs DDP,P=0.0010;PD-L1 mRNA:Control vs SYP,P<0.0001;control vs SYP+DDP,P<0.0001;control vs DDP,P<0.0001,SPY vs SYP+DDP,P<0.0001;SYP+DDP vs DDP,P=0.0014).Additionally,the quantitative and protein expression levels of CD4+T cells and CD8+T cells were simultaneously upregulated in the SYP+DDP group,whereas only the expression of CD4+T cells was upregulated in the SYP group.(CD4+T cell quantitative:Control vs SYP+DDP,P<0.0001,SYP vs SYP+DDP,P=0.0005;SYP+DDP vs DDP,P=0.0002.CD4+T cell protein:Control vs SYP,P=0.0033;Control vs SYP+DDP,P<0.0001;Control vs DDP,P=0.0021,SYP vs SYP+DDP,P=0.0004;SYP+DDP vs DDP,P=0.0006.Quantitative CD8+T cells:Control vs SYP+DDP,P=0.0013;SYP vs SYP+DDP,P=0.0347;SYP+DDP vs DDP,P=0.0043.CD8+T cell protein:Control vs SYP+DDP,P<0.0001;SYP vs SYP+DDP,P<0.0001;SYP+DDP vs DDP,P<0.0001).Finally,expression of HIF-1αwas positively correlated with that of PD-1/PD-L1 and negatively correlated with the expression of CD4+T cells and CD8+T cells.CONCLUSION SYPs inhibit immune escape and enhance chemosensitization in HCC via simultaneous inhibition of HIF-1α and PD-L1,thus inhibiting the growth of subcutaneous xenograft HCC tumours. 展开更多
关键词 Shuyu pills Hepatocellular carcinoma Tumour microenvironment Immune escape CHEMORESISTANCE
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Selectivity of escape-hole size in tube traps for white-spotted conger Conger myriaster 被引量:2
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作者 杨炳忠 唐衍力 梁振林 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2011年第5期1041-1047,共7页
Comparative fishing experiments were carried out in 2010 using tube traps with five hole diameters (8, 15, 18, 20 and 22 mm) to establish the size selectivity of escape holes for white-spotted conger. Selectivity and ... Comparative fishing experiments were carried out in 2010 using tube traps with five hole diameters (8, 15, 18, 20 and 22 mm) to establish the size selectivity of escape holes for white-spotted conger. Selectivity and split parameters of the SELECT model were calculated using the estimated-split and equal-spilt model. From likelihood ratio tests and AIC (Akaike's Information Criterion) values, the estimated-split model was selected as the best-fit model. Size selectivity of escape holes in the tube traps was expressed as a logistic curve, similar to mesh selectivity. The 50% selection length of white-spotted conger in the estimated-split model was 28.26, 33.35, 39.31 and 47.30 cm for escape-hole diameters of 15, 18, 20 and 22 mm, respectively. The optimum escape-hole size is discussed with respect to management of the white-spotted conger fishery. The results indicate that tube traps with escape holes of 18 mm in diameter would benefit this fishery. 展开更多
关键词 Conger myriaster escape hole size selectivity SELECT model
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Asymmetric Effects on Escape Rates of Bistable System 被引量:2
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作者 王参军 戴祖诚 梅冬成 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第12期1041-1044,共4页
The asymmetric effects on the escape rates from the stable states x±in the bistable system are analyzed. The results indicate that the multiplicative noise and the additive noise always enhance the particle escap... The asymmetric effects on the escape rates from the stable states x±in the bistable system are analyzed. The results indicate that the multiplicative noise and the additive noise always enhance the particle escape from stable states x±of bistable.However,the asymmetric parameter r enhances the particle escape from stable state x_+,and holds back the particle escape from stable state x_-. 展开更多
关键词 bistable system escape rate asymmetric effects noise
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New high-resolution 2D seismic imaging of fluid escape structures in the Makran subduction zone,Arabian Sea 被引量:4
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作者 Bin Liu Jiang-xin Chen +3 位作者 Syed Waseem Haider Xi-guang Deng Li Yang Min-liang Duan 《China Geology》 2020年第2期269-282,共14页
Seabed fluid escape is active in the Makran subduction zone,Arabian Sea.Based on the new highresolution 2D seismic data,acoustic blanking zones and seafloor mounds are identified.Acoustic blanking zones include three ... Seabed fluid escape is active in the Makran subduction zone,Arabian Sea.Based on the new highresolution 2D seismic data,acoustic blanking zones and seafloor mounds are identified.Acoustic blanking zones include three kinds of geometries:Bell-shaped,vertically columnar and tilted zones.The bellshaped blanking zone is characterized by weak and discontinuous reflections in the interior and upbending reflections on the top,interpreted as gas chimneys.Vertically columnar blanking zone is interpreted as side-imaged gas chimneys associated with focused fluid flow and topped by a seafloor anomaly expressed as a localized reflection discontinuity,which may together serve as a vent structure.Tilted acoustic blanking zone could be induced by accretionary thrust activity and rapid sedimentation surrounding slope.Seafloor mounds occur at the sites of bell-shaped acoustic blanking zone and may be associated with the material intrusion.Bottom simulating refectors(BSRs)are widely distributed and exhibit a series of characteristics including diminished amplitude,low continuity as well as local shoaling overlapping with these acoustic blanking zones.The large amount of gases dissociated from the gas hydrates migrated upwards and then arrived at the near-seafloor sediments,followed by the formation of the gas hydrates and hence the seafloor mound. 展开更多
关键词 MAKRAN Fluid escape structure Gas hydrate Gas chimney Seafloor mound Marine geological survey engineering Pakistan Arabian Sea
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Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer 被引量:2
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作者 Kaiyuan Wang Jian Wang +7 位作者 Ting Liu Wenwen Yu Nan Dong Chen Zhang Wenbin Xia Feng Wei Lili Yang Xiubao Ren 《Cancer Biology & Medicine》 SCIE CAS CSCD 2021年第1期155-171,共17页
Objective:Patients with cancer pain are highly dependent on morphine analgesia,but studies have shown a negative correlation between morphine demand and patient outcomes.The long-term use of morphine may result in abn... Objective:Patients with cancer pain are highly dependent on morphine analgesia,but studies have shown a negative correlation between morphine demand and patient outcomes.The long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide(M3G)levels.Hence,the effects of M3G on tumor progression are worth studying.Methods:The effects of M3G on PD-L1 expressions in human non-small cell lung cancer(NSCLC)cell lines were first evaluated.Activation of TLR4 downstream pathways after M3G treatment was then determined by Western blot.The effects of M3G on human cytotoxic T lymphocytes(CTL)cytotoxicity and INF-γrelease was also detected.Finally,the LLC murine lung adenocarcinoma cell line were used to establish a murine lung cancer model,and the effects of M3G on tumor growth and metastasis were determined.Results:M3G promoted the expressions of PD-L1 in the A549 and H1299 cell lines in a TLR4-dependent manner(P<0.05).M3G activated the PI3 K and the NFκB signaling pathways,and this effect was antagonized by a TLR4 pathway inhibitor.A PI3 K pathway inhibitor reversed the M3G-mediated PD-L1 upregulation.M3G inhibited the cytotoxicity of CTL on A549 cells and decreased the level of INF-γ.Repeated M3G intraperitoneal injections promoted LLC tumor growth and lung metastasis through the upregulation of tumor expressed PD-L1 and the reduction of CTL in the tumor microenvironment.Conclusions:M3G specifically activated TLR4 in NSCLC cells and upregulated PD-L1 expression through the PI3 K signaling pathway,thereby inhibiting CTL cytotoxicity and finally promoting tumor immune escape. 展开更多
关键词 Non-small cell lung cancer TLR4 PD-L1 morphine-3-glucuronide immune escape
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