A new phenolic constituent along with five known compounds were isolated from Fagopyrum dibotrys (D.Don) Hara. The new compound was characterized as 1,3-dimethoxy-2-O-β-xylo-pyranosyl-5-O-β-glucopyranosyl-benzene, b...A new phenolic constituent along with five known compounds were isolated from Fagopyrum dibotrys (D.Don) Hara. The new compound was characterized as 1,3-dimethoxy-2-O-β-xylo-pyranosyl-5-O-β-glucopyranosyl-benzene, by spectroscopic analysis and enzymatic hydrolysis.展开更多
This paper focuses on an optimal reinsurance and investment problem for an insurance corporation which holds the shares of an insurer and a reinsurer.Assume that the insurer can purchase reinsurance from the reinsurer...This paper focuses on an optimal reinsurance and investment problem for an insurance corporation which holds the shares of an insurer and a reinsurer.Assume that the insurer can purchase reinsurance from the reinsurer,and that both the insurer and the reinsurer are allowed to invest in a risk-free asset and a risky asset which are governed by the Heston model and are distinct from one another.We aim to find the optimal reinsuranceinvestment strategy by maximizing the expected Hyperbolic Absolute Risk Aversion(HARA)utility of the insurance corporation’s terminal wealth,which is the weighted sum of the insurer’s and the reinsurer’s terminal wealth.The Hamilton-Jacobi-Bellman(HJB)equation is first established.However,this equation is non-linear and is difficult to solve directly by any ordinary method found in the existing literature,because the structure of this HJB equation is more complex under HARA utility.In the present paper,the Legendre transform is applied to change this HJB equation into a linear dual one such that the explicit expressions of optimal investment-reinsurance strategies for-1≤ρi≤1 are obtained.We also discuss some special cases in a little bit more detail.Finally,numerical analyses are provided.展开更多
This paper analyzes an open pit gold mine project based on the O'Hara cost model. Hypothetical data is proposed based on different authors that have studied open pit gold projects, and variations are proposed acco...This paper analyzes an open pit gold mine project based on the O'Hara cost model. Hypothetical data is proposed based on different authors that have studied open pit gold projects, and variations are proposed according to the probability distributions associated to key variables affecting the NPV, like production level, ore grade, price of ore, and others, so as to see what if, in a gold open pit mine project of 3000 metric tons per day of ore. Two case scenarios were analyzed to simulate the NPV, one where there is low certainty data available, and the other where the information available is of high certainty. Results based on genetic algorithm metaheuristic simulations, which combine basically Montecarlo simulations provided by the Palisade Risk software, the O'Hara cost model, net smelter return and financial analysis tools offered by Excel are reported, in order to determine to which variables of the project is more sensitive the NPV.展开更多
Cerospora sojina Hara. toxin produced by mycelia of the pathogen can harm soybean plants. In this paper, 50 varieties and one resistant-susceptible combination were used to study the toxin resistance and it's inhe...Cerospora sojina Hara. toxin produced by mycelia of the pathogen can harm soybean plants. In this paper, 50 varieties and one resistant-susceptible combination were used to study the toxin resistance and it's inheritance. Comparing the results from the field under different inoculation conditions, the average coincidence rate of the toxin test is 62.37%. The inheritance of resistance to the toxin of Race 7 of Cerospora sojina Hara was proved to be controlled by a pair of single dominant genes. The toxin appraisal method can be used for many purposes owing to it's convenience.展开更多
[ Objective] This study aimed to conduct the karyotype analysis of Rabdosia lophanthoides var. gerardians and R. lophanthoides Hara var. gracilifloruschromosomes. [ Method] Vigorously growing shoot tips of R. lophanth...[ Objective] This study aimed to conduct the karyotype analysis of Rabdosia lophanthoides var. gerardians and R. lophanthoides Hara var. gracilifloruschromosomes. [ Method] Vigorously growing shoot tips of R. lophanthoides var. gerardianus and R. lophanthoides Hara var. graciliflorus were stained for section preparation to observe and analyze the chromosomes. [ Result] Karyotype formula of R. lophanthoides var. gerardianus is K （2n） =2x =24 = 18m ＋4Sm, sugges- ting that this species belongs to category 2A of Stebbins; karyotype formula of R. lophanthoides Hara var. graciliflorus is K （2n） =2x =24 = 16m ＋8Sm, sugges- ting that this species belongs to category 1B of Stebbins. [Conclusion] R. lophanthoides var. gerardianus is more primitive compared with R. lophanthoides Hara var. graciliflorus.展开更多
Two fragments SCS362o and SCS3580 of the co-dominant marker OPS0362o&580 that were linked to the resistance gene of soybean frog-eye leaf spot have been completely sequenced. A significant insertion of 30 bp is th...Two fragments SCS362o and SCS3580 of the co-dominant marker OPS0362o&580 that were linked to the resistance gene of soybean frog-eye leaf spot have been completely sequenced. A significant insertion of 30 bp is the main reason of the polymorphism between the two fragments. The results of Southern hybridization indicate that SCS362o derives from a single- or low-copy sequence and can be used as an RFLP probe. A co-dominant SCAR marker SCSSeao&sao has been developed based on the sequences. The segregation of SCS362o&58o is similar to that of RAPD marker OPS03620&580. Significant polymorphism has been shown between resistant and susceptible genotypes when 62 soybean genotypes were surveyed for the SCAR marker. Therefore, the marker can be used in the resistance breeding of soybean frog-eye leaf spot by marker-assisted selection.展开更多
为研究饲粮添加氧化油脂和金荞麦对肉鸡肉品质和空肠黏膜miRNA表达谱的影响,试验选用1日龄健康、体重相近的882肉仔鸡公鸡240只,随机分为3组,每组8个重复,每个重复10只鸡。Ctr、Ox、Fag组分别在基础日粮中添加新鲜油脂、氧化油脂、新鲜...为研究饲粮添加氧化油脂和金荞麦对肉鸡肉品质和空肠黏膜miRNA表达谱的影响,试验选用1日龄健康、体重相近的882肉仔鸡公鸡240只,随机分为3组,每组8个重复,每个重复10只鸡。Ctr、Ox、Fag组分别在基础日粮中添加新鲜油脂、氧化油脂、新鲜油脂+2%金荞麦。试验期为42 d。结果显示:氧化油脂可显著增加胸肌24 h pH和腿肌滴水损失(P<0.01),显著降低胸肌肉色a^(*)值(P<0.05);金荞麦可显著增加腿肌肉色L^(*)和a^(*)值(P<0.05);Ctr vs Ox,Ctr vs Fag,Ox vs Fag三个比较组的差异表达miRNAs分别为25、27、24个;这些差异表达miRNAs的靶基因显著富集在肌动蛋白细胞骨架、紧密链接、mTOR和TGF-β等信号通路;根据表达丰度和表达差异分析,共筛选了17个差异表达miRNAs,它们可作为氧化油脂和金荞麦调控肠道屏障功能的候选基因,进一步研究氧化油脂和金荞麦通过表观遗传学对肠道屏障功能的影响。综上所述,饲粮添加氧化油脂和2%金荞麦均可改变肉鸡肉品质,影响空肠黏膜miRNAs的表达谱。展开更多
Widely distributed in plants,ent-kaurane diterpenoids could reduce the incidence of inflammatory.The most important active ingredient of Isodon serra(Maxim.)Hara is ent-kaurane diterpenoids,which contribute to the ant...Widely distributed in plants,ent-kaurane diterpenoids could reduce the incidence of inflammatory.The most important active ingredient of Isodon serra(Maxim.)Hara is ent-kaurane diterpenoids,which contribute to the anti-inflammatory pharmacological effects of Isodon serra.However,the ingredients,the active compounds,drug targets,inflammatory targets and exact molecular mechanism of Isodon serra in treating inflammatory are still unclear.The purpose of this study was to use the method of network pharmacological analysis to find the active compounds in Isodon serra.These active compounds match the library of ent-kaurane diterpenoids compounds we established,and we find all the eligible ent-kaurane diterpenoids compounds.Isodon serra related and anti-inflammatory targets were found and then combined to get intersection,which represented potential anti-inflammatory targets of active compounds in Isodon serra.Moreover,anti-inflammatory targets and active compounds targets protein-protein interaction network were merged to get the protein-protein interaction network intersection and core genes in anti-inflammatory target protein-protein interaction network.For the anti-inflammatory targets of Isodon serra,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were executed to confirm gene functions of Isodon serra in antagonizing inflammation.Finally,TCMSP analysis identified 10 active compounds out of 48 ent-kaurane.The pathway analysis showed enrichment for different pathways like AGE-RAGE signaling pathway in diabetic complications,small cell lung cancer and human cytomegalovirus infection,which were all connected to inflammatory.On the whole,the proposed method clearly identified the ent-kaurane diterpenoids of Isodon serra and the results gave the active compounds of Isodon serra for the first time.The combining use of the qualitative analysis of traditional Chinese medicine(TCM)and network pharmacological methods could discover potential drug targets and reveal the biological process of TCM,which would open up a new approach in the study of TCM in future.展开更多
文摘A new phenolic constituent along with five known compounds were isolated from Fagopyrum dibotrys (D.Don) Hara. The new compound was characterized as 1,3-dimethoxy-2-O-β-xylo-pyranosyl-5-O-β-glucopyranosyl-benzene, by spectroscopic analysis and enzymatic hydrolysis.
基金supported by Natural Science Foundation of China(1187127511371194)。
文摘This paper focuses on an optimal reinsurance and investment problem for an insurance corporation which holds the shares of an insurer and a reinsurer.Assume that the insurer can purchase reinsurance from the reinsurer,and that both the insurer and the reinsurer are allowed to invest in a risk-free asset and a risky asset which are governed by the Heston model and are distinct from one another.We aim to find the optimal reinsuranceinvestment strategy by maximizing the expected Hyperbolic Absolute Risk Aversion(HARA)utility of the insurance corporation’s terminal wealth,which is the weighted sum of the insurer’s and the reinsurer’s terminal wealth.The Hamilton-Jacobi-Bellman(HJB)equation is first established.However,this equation is non-linear and is difficult to solve directly by any ordinary method found in the existing literature,because the structure of this HJB equation is more complex under HARA utility.In the present paper,the Legendre transform is applied to change this HJB equation into a linear dual one such that the explicit expressions of optimal investment-reinsurance strategies for-1≤ρi≤1 are obtained.We also discuss some special cases in a little bit more detail.Finally,numerical analyses are provided.
基金the Mine Planning Research Group–GIPLAMIN-of the Mines Faculty,National University of Colombia
文摘This paper analyzes an open pit gold mine project based on the O'Hara cost model. Hypothetical data is proposed based on different authors that have studied open pit gold projects, and variations are proposed according to the probability distributions associated to key variables affecting the NPV, like production level, ore grade, price of ore, and others, so as to see what if, in a gold open pit mine project of 3000 metric tons per day of ore. Two case scenarios were analyzed to simulate the NPV, one where there is low certainty data available, and the other where the information available is of high certainty. Results based on genetic algorithm metaheuristic simulations, which combine basically Montecarlo simulations provided by the Palisade Risk software, the O'Hara cost model, net smelter return and financial analysis tools offered by Excel are reported, in order to determine to which variables of the project is more sensitive the NPV.
文摘Cerospora sojina Hara. toxin produced by mycelia of the pathogen can harm soybean plants. In this paper, 50 varieties and one resistant-susceptible combination were used to study the toxin resistance and it's inheritance. Comparing the results from the field under different inoculation conditions, the average coincidence rate of the toxin test is 62.37%. The inheritance of resistance to the toxin of Race 7 of Cerospora sojina Hara was proved to be controlled by a pair of single dominant genes. The toxin appraisal method can be used for many purposes owing to it's convenience.
文摘[ Objective] This study aimed to conduct the karyotype analysis of Rabdosia lophanthoides var. gerardians and R. lophanthoides Hara var. gracilifloruschromosomes. [ Method] Vigorously growing shoot tips of R. lophanthoides var. gerardianus and R. lophanthoides Hara var. graciliflorus were stained for section preparation to observe and analyze the chromosomes. [ Result] Karyotype formula of R. lophanthoides var. gerardianus is K （2n） =2x =24 = 18m ＋4Sm, sugges- ting that this species belongs to category 2A of Stebbins; karyotype formula of R. lophanthoides Hara var. graciliflorus is K （2n） =2x =24 = 16m ＋8Sm, sugges- ting that this species belongs to category 1B of Stebbins. [Conclusion] R. lophanthoides var. gerardianus is more primitive compared with R. lophanthoides Hara var. graciliflorus.
文摘Two fragments SCS362o and SCS3580 of the co-dominant marker OPS0362o&580 that were linked to the resistance gene of soybean frog-eye leaf spot have been completely sequenced. A significant insertion of 30 bp is the main reason of the polymorphism between the two fragments. The results of Southern hybridization indicate that SCS362o derives from a single- or low-copy sequence and can be used as an RFLP probe. A co-dominant SCAR marker SCSSeao&sao has been developed based on the sequences. The segregation of SCS362o&58o is similar to that of RAPD marker OPS03620&580. Significant polymorphism has been shown between resistant and susceptible genotypes when 62 soybean genotypes were surveyed for the SCAR marker. Therefore, the marker can be used in the resistance breeding of soybean frog-eye leaf spot by marker-assisted selection.
文摘为研究饲粮添加氧化油脂和金荞麦对肉鸡肉品质和空肠黏膜miRNA表达谱的影响,试验选用1日龄健康、体重相近的882肉仔鸡公鸡240只,随机分为3组,每组8个重复,每个重复10只鸡。Ctr、Ox、Fag组分别在基础日粮中添加新鲜油脂、氧化油脂、新鲜油脂+2%金荞麦。试验期为42 d。结果显示:氧化油脂可显著增加胸肌24 h pH和腿肌滴水损失(P<0.01),显著降低胸肌肉色a^(*)值(P<0.05);金荞麦可显著增加腿肌肉色L^(*)和a^(*)值(P<0.05);Ctr vs Ox,Ctr vs Fag,Ox vs Fag三个比较组的差异表达miRNAs分别为25、27、24个;这些差异表达miRNAs的靶基因显著富集在肌动蛋白细胞骨架、紧密链接、mTOR和TGF-β等信号通路;根据表达丰度和表达差异分析,共筛选了17个差异表达miRNAs,它们可作为氧化油脂和金荞麦调控肠道屏障功能的候选基因,进一步研究氧化油脂和金荞麦通过表观遗传学对肠道屏障功能的影响。综上所述,饲粮添加氧化油脂和2%金荞麦均可改变肉鸡肉品质,影响空肠黏膜miRNAs的表达谱。
基金Hebei Administration of Traditional Chinese Medicine(Grant No.2021133)the Natural Science Foundation of Hebei Province of China(Grant No.H2019206562)the Key Projects of Hebei Education Department(Grant No.ZD2017244)。
文摘Widely distributed in plants,ent-kaurane diterpenoids could reduce the incidence of inflammatory.The most important active ingredient of Isodon serra(Maxim.)Hara is ent-kaurane diterpenoids,which contribute to the anti-inflammatory pharmacological effects of Isodon serra.However,the ingredients,the active compounds,drug targets,inflammatory targets and exact molecular mechanism of Isodon serra in treating inflammatory are still unclear.The purpose of this study was to use the method of network pharmacological analysis to find the active compounds in Isodon serra.These active compounds match the library of ent-kaurane diterpenoids compounds we established,and we find all the eligible ent-kaurane diterpenoids compounds.Isodon serra related and anti-inflammatory targets were found and then combined to get intersection,which represented potential anti-inflammatory targets of active compounds in Isodon serra.Moreover,anti-inflammatory targets and active compounds targets protein-protein interaction network were merged to get the protein-protein interaction network intersection and core genes in anti-inflammatory target protein-protein interaction network.For the anti-inflammatory targets of Isodon serra,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis were executed to confirm gene functions of Isodon serra in antagonizing inflammation.Finally,TCMSP analysis identified 10 active compounds out of 48 ent-kaurane.The pathway analysis showed enrichment for different pathways like AGE-RAGE signaling pathway in diabetic complications,small cell lung cancer and human cytomegalovirus infection,which were all connected to inflammatory.On the whole,the proposed method clearly identified the ent-kaurane diterpenoids of Isodon serra and the results gave the active compounds of Isodon serra for the first time.The combining use of the qualitative analysis of traditional Chinese medicine(TCM)and network pharmacological methods could discover potential drug targets and reveal the biological process of TCM,which would open up a new approach in the study of TCM in future.
