Cancer cells with immunogenic properties having altered protein glycosylation, modified blood group substances have been widely studied. Due to the genetic instability occurring during carcinogenesis the glycosyltrans...Cancer cells with immunogenic properties having altered protein glycosylation, modified blood group substances have been widely studied. Due to the genetic instability occurring during carcinogenesis the glycosyltransferases may suffer from posttranslation sequence modification. The author describes 2 autopsy cases, where in the background of the unusual metastatic tumor presentation, incompatible blood group antigenic determinants have been demonstrated using blood group specific lectins and monoclonal antibodies (mAb). In the first case, reported here, a 10-year-old girl developed an acute myeloid leukemia and died in a septic endotoxin shock after successful cytostatic treatment of a juvenile signet ring cell cancer of her colon. At autopsy there were no signs of tumor except bilateral apple-sized mucinous ovarian (Krukenberg) metastases. While she had erythrocyte phenotype of blood group A, the signet ring adenocarcinoma cells expressed blood group B incompatible antigenic determinants with lectin/mAb. In the second case, the autopsy of a 78-year-old female resulted in no macroscopic tumor sign except a moderately enlarged, ham hard spleen. Light microscopy revealed adenocarcinomatous infiltration in the splenic sinusoids. The patient had blood group O, while the metastatic cells in the spleen reacted with Breast Carcinoma Antigen (BioGenex) and incompatible anti-B Banderiaeasimplicifolia agglutinin I and anti-B mAb. It proved to be a case of an occult, completely regressed breast cancer. Based on these observations the expression of tumor specific incompatible blood group antigens might occur from time to time, mostly in adenocarcinomas. Accordingly, blood group-based specific immuno-oncotherapy could be considered in some cancer cases.展开更多
To describe the spatial relationship among the earth objects compactly, in this paper, we raised the concept of histo-variogram based on the analysis of the characteristics of other spatial analyzing methods such as v...To describe the spatial relationship among the earth objects compactly, in this paper, we raised the concept of histo-variogram based on the analysis of the characteristics of other spatial analyzing methods such as variogram, information entropy. And we also raised a new spatial analysis method of histogram decomposition based on the definition of standing pixel and contour pixel. At the end of this paper, we demonstrated the characteristics of histo-variogram by two experiments, one for spatial analysis, the other for image fusion.展开更多
In remote sensing applications,accurate extraction of land type area after classification is very impor-tant.But for images of land use/cover change(LUCC) obtained from the special spatial resolution re-mote sensing d...In remote sensing applications,accurate extraction of land type area after classification is very impor-tant.But for images of land use/cover change(LUCC) obtained from the special spatial resolution re-mote sensing data,it will be of great significance to obtain the land type area information with higher resolution by making use of spatial distribution characteristcs information of the land type itself first and further scaling-down in a given scale threshold on the basis of the existing spatial resolution data.An explicit expression of the relationship between the measurement scale,global fractal dimension and the land type area corresponding to different measurement scales is obtained on the research basis of the authors' histo-variogram using the standardized area index(SAI).A good attempt has been made to obtain the land type area information with higher resolution by merely using the spatial distribution characteristcs information of the land type in the image itself and further scaling-down in a given scale threshold on the basis of the existing spatial resolution data.展开更多
Laser speckle contrast imaging （LSCI） is a powerful tool for blood flow mapping. In this paper, we described a simple algorithm based on histogram analysis of laser speckle contrast image to provide rapid differenti...Laser speckle contrast imaging （LSCI） is a powerful tool for blood flow mapping. In this paper, we described a simple algorithm based on histogram analysis of laser speckle contrast image to provide rapid differentiation between macro- and microcirculations. The algorithm was successfully verified by the study of blood flow in rat cortex under functional activation.展开更多
文摘Cancer cells with immunogenic properties having altered protein glycosylation, modified blood group substances have been widely studied. Due to the genetic instability occurring during carcinogenesis the glycosyltransferases may suffer from posttranslation sequence modification. The author describes 2 autopsy cases, where in the background of the unusual metastatic tumor presentation, incompatible blood group antigenic determinants have been demonstrated using blood group specific lectins and monoclonal antibodies (mAb). In the first case, reported here, a 10-year-old girl developed an acute myeloid leukemia and died in a septic endotoxin shock after successful cytostatic treatment of a juvenile signet ring cell cancer of her colon. At autopsy there were no signs of tumor except bilateral apple-sized mucinous ovarian (Krukenberg) metastases. While she had erythrocyte phenotype of blood group A, the signet ring adenocarcinoma cells expressed blood group B incompatible antigenic determinants with lectin/mAb. In the second case, the autopsy of a 78-year-old female resulted in no macroscopic tumor sign except a moderately enlarged, ham hard spleen. Light microscopy revealed adenocarcinomatous infiltration in the splenic sinusoids. The patient had blood group O, while the metastatic cells in the spleen reacted with Breast Carcinoma Antigen (BioGenex) and incompatible anti-B Banderiaeasimplicifolia agglutinin I and anti-B mAb. It proved to be a case of an occult, completely regressed breast cancer. Based on these observations the expression of tumor specific incompatible blood group antigens might occur from time to time, mostly in adenocarcinomas. Accordingly, blood group-based specific immuno-oncotherapy could be considered in some cancer cases.
文摘To describe the spatial relationship among the earth objects compactly, in this paper, we raised the concept of histo-variogram based on the analysis of the characteristics of other spatial analyzing methods such as variogram, information entropy. And we also raised a new spatial analysis method of histogram decomposition based on the definition of standing pixel and contour pixel. At the end of this paper, we demonstrated the characteristics of histo-variogram by two experiments, one for spatial analysis, the other for image fusion.
基金Supported by the National Natural Science Foundation of China (Grant No. 40601068)the National Basic Research Program of China ("973" Project) (Grant No. 2007CB714402)the Key Science and Technology R&D Program of Qinghai Province (Grant No. 2006-6-160-01)
文摘In remote sensing applications,accurate extraction of land type area after classification is very impor-tant.But for images of land use/cover change(LUCC) obtained from the special spatial resolution re-mote sensing data,it will be of great significance to obtain the land type area information with higher resolution by making use of spatial distribution characteristcs information of the land type itself first and further scaling-down in a given scale threshold on the basis of the existing spatial resolution data.An explicit expression of the relationship between the measurement scale,global fractal dimension and the land type area corresponding to different measurement scales is obtained on the research basis of the authors' histo-variogram using the standardized area index(SAI).A good attempt has been made to obtain the land type area information with higher resolution by merely using the spatial distribution characteristcs information of the land type in the image itself and further scaling-down in a given scale threshold on the basis of the existing spatial resolution data.
文摘Laser speckle contrast imaging （LSCI） is a powerful tool for blood flow mapping. In this paper, we described a simple algorithm based on histogram analysis of laser speckle contrast image to provide rapid differentiation between macro- and microcirculations. The algorithm was successfully verified by the study of blood flow in rat cortex under functional activation.
