目的:分析血清IL-33及IL-37对不同水平血嗜酸性粒细胞的慢性阻塞性肺疾病患者肺功能的预测价值及相关性。方法:采用ELISA法检测IL-33、IL-37、CRP及PCT在30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮...目的:分析血清IL-33及IL-37对不同水平血嗜酸性粒细胞的慢性阻塞性肺疾病患者肺功能的预测价值及相关性。方法:采用ELISA法检测IL-33、IL-37、CRP及PCT在30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者血清中的表达情况,采用肺功能仪检测30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者的FEV1%pred及FEV1/FVC。结果:COPD组患者血清IL-33、IL-37、CRP及PCT表达水平较健康对照组显著升高,肺功能指标FEV1%pred及FEV1/FVC较对照组显著降低(P 1%pred及FEV1/FVC进一步降低(P 1%pred、FEV1/FVC呈负相关(P Objective: To analyze the predictive value and correlation of serum IL-33 and IL-37 in patients with chronic obstructive pulmonary disease (COPD) with different levels of blood eosinophils in predicting lung function. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression of IL-33, IL-37, C-reactive protein (CRP), and procalcitonin (PCT) in the serum of 30 patients with high eosinophil counts, 30 patients with moderate eosinophil counts, 34 patients with low eosinophil counts, and 30 healthy individuals. Lung function was assessed by measuring forced expiratory volume in one second as a percentage of predicted (FEV1%pred) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) using a spirometer in the same groups. Results: The expression levels of serum IL-33, IL-37, CRP, and PCT in the COPD group were significantly higher than those in the healthy control group (P 1%pred and FEV1/FVC were significantly lower than those in the control group (P 1%pred and FEV1/FVC further decreased (P 1%pred and FEV1/FVC (P < 0.05). Conclusion: IL-33 and IL-37 may be closely related to the progression of COPD and may become new indicators for clinical diagnosis and assessment of disease severity in COPD, as well as providing new targets for clinical intervention.展开更多
文摘目的:分析血清IL-33及IL-37对不同水平血嗜酸性粒细胞的慢性阻塞性肺疾病患者肺功能的预测价值及相关性。方法:采用ELISA法检测IL-33、IL-37、CRP及PCT在30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者血清中的表达情况,采用肺功能仪检测30例嗜酸性粒细胞丰富组患者、30例嗜酸性粒细胞中间组患者、34例嗜酸性粒细胞匮乏组患者及30例健康体检者的FEV1%pred及FEV1/FVC。结果:COPD组患者血清IL-33、IL-37、CRP及PCT表达水平较健康对照组显著升高,肺功能指标FEV1%pred及FEV1/FVC较对照组显著降低(P 1%pred及FEV1/FVC进一步降低(P 1%pred、FEV1/FVC呈负相关(P Objective: To analyze the predictive value and correlation of serum IL-33 and IL-37 in patients with chronic obstructive pulmonary disease (COPD) with different levels of blood eosinophils in predicting lung function. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression of IL-33, IL-37, C-reactive protein (CRP), and procalcitonin (PCT) in the serum of 30 patients with high eosinophil counts, 30 patients with moderate eosinophil counts, 34 patients with low eosinophil counts, and 30 healthy individuals. Lung function was assessed by measuring forced expiratory volume in one second as a percentage of predicted (FEV1%pred) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) using a spirometer in the same groups. Results: The expression levels of serum IL-33, IL-37, CRP, and PCT in the COPD group were significantly higher than those in the healthy control group (P 1%pred and FEV1/FVC were significantly lower than those in the control group (P 1%pred and FEV1/FVC further decreased (P 1%pred and FEV1/FVC (P < 0.05). Conclusion: IL-33 and IL-37 may be closely related to the progression of COPD and may become new indicators for clinical diagnosis and assessment of disease severity in COPD, as well as providing new targets for clinical intervention.
