The publisher would like to draw the reader's attention to the following errors.Informed consents were not included in the published version of the following articles that appeared in previous issues of Grain&...The publisher would like to draw the reader's attention to the following errors.Informed consents were not included in the published version of the following articles that appeared in previous issues of Grain&Oil Science and Technology.The authors were contacted after publication to request informed consents for the following articles.The appropriate informed consents,provided by the authors,are included below.展开更多
Recent advancements in next generation sequencing have allowed for genetic information become more readily available in the clinical setting for those affected by cancer and by treating clinicians.Given the lack of ac...Recent advancements in next generation sequencing have allowed for genetic information become more readily available in the clinical setting for those affected by cancer and by treating clinicians.Given the lack of access to geneticists,medical oncologists and other treating physicians have begun ordering and interpreting genetic tests for individuals with cancer through the process of"mainstreaming".While this process has allowed for quicker access to genetic tests,the process of"mainstreaming"has also brought several challenges including the dissemination of variants of unknown significance results,ordering of appropriate tests,and accurate interpretation of genetic results with appropriate followup testing and interventions.In this editorial,we seek to explore the process of informed consent of individuals before obtaining genetic testing and offer potential solutions to optimize the informed consent process including categorization of results as well as a layered consent model.展开更多
Informed consent is necessary in good clinical practice.It is based on the patient’s ability to understand the information about the proposed procedure,the potential consequences and complications,and alternative opt...Informed consent is necessary in good clinical practice.It is based on the patient’s ability to understand the information about the proposed procedure,the potential consequences and complications,and alternative options.The information is written in understandable language and is fortified by verbal discussion between physician and patient.The aim is to explain the problem,answer all questions and to ensure that the patient understands the problems and is able to make a decision.The theory is clear but what happens in daily practice?展开更多
Since the first publication describing the identification of prostate-specific antigen （PSA） in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used ...Since the first publication describing the identification of prostate-specific antigen （PSA） in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used as a diagnostic tool. Over time, the test has been heavily debated due to its lack of sensitivity and specificity. However, up to now the PSA test is still the only biomarker for the detection and monitoring of prostate cancer. PSA-based screening for prostate cancer is associated with a high proportion of unnecessary testing and overdiagnosis with subsequent overtreatment. In the early years of screening for prostate cancer, high rates of uptake were very important. However, over time the opinion on PSA-based screening has shifted towards the notion of informed choice. Nowadays, it is thought to be unethical to screen men without them being aware of the pros and cons of PSA testing, as well as the fact that an informed choice is related to better patient outcomes. Now, as the results of three major screening studies have been presented and the downsides of screening are becoming better understood, informed choice is becoming more relevant.展开更多
Similar to many fields of sciences,recent deep learning advances have been applied extensively in geosciences for both small-and large-scale problems.However,the necessity of using large training data and the’black ...Similar to many fields of sciences,recent deep learning advances have been applied extensively in geosciences for both small-and large-scale problems.However,the necessity of using large training data and the’black box’nature of learning have limited them in practice and difficult to interpret.Furthermore,including the governing equations and physical facts in such methods is also another challenge,which entails either ignoring the physics or simplifying them using unrealistic data.To address such issues,physics informed machine learning methods have been developed which can integrate the governing physics law into the learning process.In this work,a 1-dimensional(1 D)time-dependent seismic wave equation is considered and solved using two methods,namely Gaussian process(GP)and physics informed neural networks.We show that these meshless methods are trained by smaller amount of data and can predict the solution of the equation with even high accuracy.They are also capable of inverting any parameter involved in the governing equation such as wave velocity in our case.Results show that the GP can predict the solution of the seismic wave equation with a lower level of error,while our developed neural network is more accurate for velocity(P-and S-wave)and density inversion.展开更多
In this paper, we propose a novel approach to automatically building Informed Virtual Geographic Environments (IVGE) using data provided by Geographic Information Systems (GIS). The obtained IVGE provides 2D and 3D ge...In this paper, we propose a novel approach to automatically building Informed Virtual Geographic Environments (IVGE) using data provided by Geographic Information Systems (GIS). The obtained IVGE provides 2D and 3D geographic information for visualization and simulation purposes. Conventional VGE approaches are generally built upon a grid-based representation, raising the well-known problems of the lack of accuracy of the localized data and the difficulty to merge data with multiple semantics. On the contrary, our approach uses a topological model and provides an exact representation of GIS data, allowing an accurate geometrical exploitation. Moreover, our model can merge semantic information, even if spatially overlapping. In addition, the proposed IVGE contains spatial information which can be enhanced thanks to a geometric abstraction method. We illustrate this model with an application which automatically extracts the required data from standard GIS files and allows a user to navigate and retrieve information from the computed IVGE.展开更多
This study explores how doctors and patients in Papua New Guinea(PNG)perceive informed consent in medical settings.Doctors and patients from National Capital District and Central Province who responded to the survey w...This study explores how doctors and patients in Papua New Guinea(PNG)perceive informed consent in medical settings.Doctors and patients from National Capital District and Central Province who responded to the survey were the participants of the study.Researchers asked the participants to fill out questionnaires regarding their knowledge about informed consent for each group,namely,the doctors and participants.From those who responded,six randomly selected participants were chosen to join the focus group discussion which aimed to get experiences from the doctors and patients regarding medical procedures.Results show that both doctors and patients lack knowledge of the legalities of informed consent.Based on the experiences of doctors,they do not use consent forms when seeking permission from patients.Patients,on the other hand,do not see consent forms as important and only served as a formality.Customs,culture surrounding PNG were found to have an impact on how patients perceived informed consent.展开更多
Neural network methods have been widely used in many fields of scientific research with the rapid increase of computing power.The physics-informed neural networks(PINNs)have received much attention as a major breakthr...Neural network methods have been widely used in many fields of scientific research with the rapid increase of computing power.The physics-informed neural networks(PINNs)have received much attention as a major breakthrough in solving partial differential equations using neural networks.In this paper,a resampling technique based on the expansion-shrinkage point(ESP)selection strategy is developed to dynamically modify the distribution of training points in accordance with the performance of the neural networks.In this new approach both training sites with slight changes in residual values and training points with large residuals are taken into account.In order to make the distribution of training points more uniform,the concept of continuity is further introduced and incorporated.This method successfully addresses the issue that the neural network becomes ill or even crashes due to the extensive alteration of training point distribution.The effectiveness of the improved physics-informed neural networks with expansion-shrinkage resampling is demonstrated through a series of numerical experiments.展开更多
BACKGROUND Hip fractures are the most common reason for inpatient orthopaedic trauma admission.Urgent surgical intervention for hip fractures has remained a clinical priority throughout the coronavirus disease 2019(CO...BACKGROUND Hip fractures are the most common reason for inpatient orthopaedic trauma admission.Urgent surgical intervention for hip fractures has remained a clinical priority throughout the coronavirus disease 2019(COVID-19)pandemic.Despite this,there is a paucity of clinical guidance addressing the informed consent process for hip fracture surgery in COVID-19 positive patients.This is of paramount medicolegal importance in a high-risk patient population.AIM To quantify the additional perioperative risks for COVID-19 positive patients undergoing hip fracture surgery and provide clinicians with an evidence-based framework to establish an informed consent process.METHODS Two hundred and fifty nine consecutive patients undergoing surgical intervention for hip fractures in four hospitals in the United Kingdom were recruited.51 patients were confirmed positive for COVID-19.Predefined outcomes were analyzed over a 30-d postoperative period.COVID-19 positive and COVID-19 negative patients were compared after adjustment for confounding factors.RESULTS COVID-19 positive patients had more intensive care admissions(27%vs 5%,P<0.001),longer inpatient stays(median 23 d vs 9 d,P<0.001)and a higher 30-d mortality(29%vs 10%,P=0.001)than COVID-19 negative patients.Postoperative complications were evident in 74.5%of COVID-19 positive patients.35.3%of COVID-19 positive patients suffered postoperative lower respiratory tract infections with 13.7%developing acute respiratory distress syndrome(ARDS)and 9.8%experiencing symptomatic thromboembolic events.CONCLUSION The COVID-19 pandemic has created uncertainty in the medical community worldwide and poses unique challenges in providing informed consent for surgery.COVID-19 positive patients undergoing hip fracture surgery should be consented for the additional risk of postoperative complications(including lower respiratory tract infection,ARDS,deep vein thrombosis and pulmonary embolism),increased requirement for intensive care admission,longer inpatient stay and higher risk of mortality.Further,clinicians must be transparent about the potential for unknown risks as research into the long-term surgical outcomes of COVID-19 positive patients continues to evolve.展开更多
During the last four decades the doctrine of in- formed consent (IC) has become a legal stan- dard and an essential component of ethical guidelines in medicine, due to its relevance for basic human rights such as auto...During the last four decades the doctrine of in- formed consent (IC) has become a legal stan- dard and an essential component of ethical guidelines in medicine, due to its relevance for basic human rights such as autonomy and re- spect of dignity. Over the last few years, this legal formula has gained importance in veteri- nary medicine, thereby influencing the everyday activities of the veterinary practitioners. This paper briefly describes the ethical and legal background of IC in Italy and examines how it relates to the practice of veterinary medicine, considering the change in social sensibility to- wards animals. It also outlines the discussion that should take place between Veterinarian and client before a planned procedure.展开更多
Model-informed drug develop⁃ment(MIDD)is the application of a various math⁃ematical,statistical,and biological models to facilitate drug development,decision making and regulatory review.As a quantitative tool,MIDD ap...Model-informed drug develop⁃ment(MIDD)is the application of a various math⁃ematical,statistical,and biological models to facilitate drug development,decision making and regulatory review.As a quantitative tool,MIDD approaches allow an integration of information obtained from non-clinical studies and clinical trials in a drug development program.General understandings of the underlying biology,patho⁃physiology,and pharmacology can also be incor⁃porated into the model.MIDD is centered on knowledge and inferences generated from inte⁃grated models of the physicochemical character⁃istics of a molecule,its disposition in the body,and its mechanism of action,and how the drug might affect a disease from both an efficacy and a safety perspective.MIDD approaches have the potential to significantly streamline drug develop⁃ment,by improving clinical trial efficiency,opti⁃mizing dose and regimen and waive unneces⁃sary clinical studies.This presentation will use cases studies to demonstrate how to apply MIDD in early phase of clinical trials.展开更多
In this paper, we present a comparative study between informed and predictive prefetching mechanisms that were presented to leverage the performance gap between I/O storage systems and CPU. In particular, we will focu...In this paper, we present a comparative study between informed and predictive prefetching mechanisms that were presented to leverage the performance gap between I/O storage systems and CPU. In particular, we will focus on transparent informed prefetching (TIP) and predictive prefetching using probability graph approach (PG). Our main objective is to show the main features, motivations, and implementation overview of each mechanism. We also conducted a performance evaluation discussion that shows a comparison between both mechanisms performance when using different cache size values.展开更多
In this paper,we introduce a new deep learning framework for discovering the phase-field models from existing image data.The new framework embraces the approximation power of physics informed neural networks(PINNs)and...In this paper,we introduce a new deep learning framework for discovering the phase-field models from existing image data.The new framework embraces the approximation power of physics informed neural networks(PINNs)and the computational efficiency of the pseudo-spectral methods,which we named pseudo-spectral PINN or SPINN.Unlike the baseline PINN,the pseudo-spectral PINN has several advantages.First of all,it requires less training data.A minimum of two temporal snapshots with uniform spatial resolution would be adequate.Secondly,it is computationally efficient,as the pseudo-spectral method is used for spatial discretization.Thirdly,it requires less trainable parameters compared with the baseline PINN,which significantly simplifies the training process and potentially assures fewer local minima or saddle points.We illustrate the effectiveness of pseudo-spectral PINN through several numerical examples.The newly proposed pseudo-spectral PINN is rather general,and it can be readily applied to discover other FDE-based models from image data.展开更多
Background: Every human being of adult years and sound mind has a right to determine what shall be done with his/her own body. Patient autonomy and the practice of informed patient consent are now pivotal in medical p...Background: Every human being of adult years and sound mind has a right to determine what shall be done with his/her own body. Patient autonomy and the practice of informed patient consent are now pivotal in medical practice. Aim: To assess patient’s knowledge of Patients’ Rights Charter and whether patients receive adequate information to enable them make an informed consent to a particular treatment. Methodology: Patients who were undergoing elective surgery from selected surgical departments of Komfo Anokye teaching hospital in Kumasi were randomly selected and assisted to answer structured questionnaire without the knowledge of their doctors. The study period was in June to December (2014). Descriptive analysis was done using SPSS (II) of the results. Results: 84.7% (144) had no idea about the Patients’ Rights Charter of the Ghana Health Service. 75% (128) did not know or had not heard of informed patient consent. Of those who knew of the charter, 85% (37) had ever stayed in a developed country. 60% (102) did not know of their diagnosis. 79% (134) said the doctor only asked them to either sign or thumb print the consent document without giving them treatment options or possible complications. Conclusion: Most of respondents undergoing various surgical procedures at the Komfo Anokye Teaching Hospital were not aware of the existence of the Patients’ Rights Charter of the Ghana Health Service. Again, practitioners did not provide sufficient information to patients for them to make an informed decision about their health.展开更多
Objective To evaluate the impacts of clinic-based informed choice program on quality of individualized service in family planning clinics in ChinaMethods During the program, family planning service staff in interventi...Objective To evaluate the impacts of clinic-based informed choice program on quality of individualized service in family planning clinics in ChinaMethods During the program, family planning service staff in intervention clinics , were trained on counseling skills and key points of individualized counseling service. Questionnaire surveys were conducted pre- and post-informed choice program to evaluate the 'impacts of the program.Results Informed choice program had significantly improved the quality of individualized counseling service. The multivariate regression analysis showed that clients of the clinic were more likely to give the better evaluation of the service, the OR of evaluation score of individualized service is 1/712 (95% CI is 1. 146 to 2. 564) in Experiment Group of post-program in contrast with pre-program. The program also could satisfy individual needs of clients and increase the satisfaction degree of the service. Conclusions Informed choice program is helpful for the improvement of the quality of individualized counseling service. It is necessary and imperative to improve the skills of counseling service provided in family planning clinics.展开更多
Biological residual materials can be obtained from surgical activities or from pathological waste material collected for analysis and stored in formalin. This material can be stored in biobanks with the purpose of fut...Biological residual materials can be obtained from surgical activities or from pathological waste material collected for analysis and stored in formalin. This material can be stored in biobanks with the purpose of future research. Formalin-fixed tissue and also formalin-fixed paraffin embedded tissues are not suitable for all kinds of genetic studies on DNA or RNA, as formalin solution is well known for damaging nucleic acids. Therefore, for the purpose of conducting genetic studies, samples should be frozen in order to maintain a good quality of DNA/RNA over time Biobanks, in which waste samples are frozen, are undoubtedly expensive to maintain; however, it could be useful and important to consider their possible implication in particular research, regarding for example the tumor cells growth process, or when the procurement of samples is difficult. Regarding the relationship between informed consent and tissue collection, storage and research, two choices are possible： irreversible or reversible sample anonymization. These procedures involve different approaches and possible solutions that we will seek to define. Also, an important ethical aspect in regard to the role of biobanks is encouraging sample donation. For donors, seeing human sample being kept rather than discarded and seeing them become useful for research highlight the importance of the human body and improve the attitude towards donation. This process might also facilitate the giving of informed consent more trustfully and willingly.展开更多
文摘The publisher would like to draw the reader's attention to the following errors.Informed consents were not included in the published version of the following articles that appeared in previous issues of Grain&Oil Science and Technology.The authors were contacted after publication to request informed consents for the following articles.The appropriate informed consents,provided by the authors,are included below.
文摘Recent advancements in next generation sequencing have allowed for genetic information become more readily available in the clinical setting for those affected by cancer and by treating clinicians.Given the lack of access to geneticists,medical oncologists and other treating physicians have begun ordering and interpreting genetic tests for individuals with cancer through the process of"mainstreaming".While this process has allowed for quicker access to genetic tests,the process of"mainstreaming"has also brought several challenges including the dissemination of variants of unknown significance results,ordering of appropriate tests,and accurate interpretation of genetic results with appropriate followup testing and interventions.In this editorial,we seek to explore the process of informed consent of individuals before obtaining genetic testing and offer potential solutions to optimize the informed consent process including categorization of results as well as a layered consent model.
基金Supported by The research project,No.MZO 00179906 from the Ministry of Health,Czech Republic
文摘Informed consent is necessary in good clinical practice.It is based on the patient’s ability to understand the information about the proposed procedure,the potential consequences and complications,and alternative options.The information is written in understandable language and is fortified by verbal discussion between physician and patient.The aim is to explain the problem,answer all questions and to ensure that the patient understands the problems and is able to make a decision.The theory is clear but what happens in daily practice?
文摘Since the first publication describing the identification of prostate-specific antigen （PSA） in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used as a diagnostic tool. Over time, the test has been heavily debated due to its lack of sensitivity and specificity. However, up to now the PSA test is still the only biomarker for the detection and monitoring of prostate cancer. PSA-based screening for prostate cancer is associated with a high proportion of unnecessary testing and overdiagnosis with subsequent overtreatment. In the early years of screening for prostate cancer, high rates of uptake were very important. However, over time the opinion on PSA-based screening has shifted towards the notion of informed choice. Nowadays, it is thought to be unethical to screen men without them being aware of the pros and cons of PSA testing, as well as the fact that an informed choice is related to better patient outcomes. Now, as the results of three major screening studies have been presented and the downsides of screening are becoming better understood, informed choice is becoming more relevant.
文摘Similar to many fields of sciences,recent deep learning advances have been applied extensively in geosciences for both small-and large-scale problems.However,the necessity of using large training data and the’black box’nature of learning have limited them in practice and difficult to interpret.Furthermore,including the governing equations and physical facts in such methods is also another challenge,which entails either ignoring the physics or simplifying them using unrealistic data.To address such issues,physics informed machine learning methods have been developed which can integrate the governing physics law into the learning process.In this work,a 1-dimensional(1 D)time-dependent seismic wave equation is considered and solved using two methods,namely Gaussian process(GP)and physics informed neural networks.We show that these meshless methods are trained by smaller amount of data and can predict the solution of the equation with even high accuracy.They are also capable of inverting any parameter involved in the governing equation such as wave velocity in our case.Results show that the GP can predict the solution of the seismic wave equation with a lower level of error,while our developed neural network is more accurate for velocity(P-and S-wave)and density inversion.
文摘In this paper, we propose a novel approach to automatically building Informed Virtual Geographic Environments (IVGE) using data provided by Geographic Information Systems (GIS). The obtained IVGE provides 2D and 3D geographic information for visualization and simulation purposes. Conventional VGE approaches are generally built upon a grid-based representation, raising the well-known problems of the lack of accuracy of the localized data and the difficulty to merge data with multiple semantics. On the contrary, our approach uses a topological model and provides an exact representation of GIS data, allowing an accurate geometrical exploitation. Moreover, our model can merge semantic information, even if spatially overlapping. In addition, the proposed IVGE contains spatial information which can be enhanced thanks to a geometric abstraction method. We illustrate this model with an application which automatically extracts the required data from standard GIS files and allows a user to navigate and retrieve information from the computed IVGE.
文摘This study explores how doctors and patients in Papua New Guinea(PNG)perceive informed consent in medical settings.Doctors and patients from National Capital District and Central Province who responded to the survey were the participants of the study.Researchers asked the participants to fill out questionnaires regarding their knowledge about informed consent for each group,namely,the doctors and participants.From those who responded,six randomly selected participants were chosen to join the focus group discussion which aimed to get experiences from the doctors and patients regarding medical procedures.Results show that both doctors and patients lack knowledge of the legalities of informed consent.Based on the experiences of doctors,they do not use consent forms when seeking permission from patients.Patients,on the other hand,do not see consent forms as important and only served as a formality.Customs,culture surrounding PNG were found to have an impact on how patients perceived informed consent.
基金Project supported by the National Key Research and Development Program of China(Grant No.2020YFC1807905)the National Natural Science Foundation of China(Grant Nos.52079090 and U20A20316)the Basic Research Program of Qinghai Province(Grant No.2022-ZJ-704).
文摘Neural network methods have been widely used in many fields of scientific research with the rapid increase of computing power.The physics-informed neural networks(PINNs)have received much attention as a major breakthrough in solving partial differential equations using neural networks.In this paper,a resampling technique based on the expansion-shrinkage point(ESP)selection strategy is developed to dynamically modify the distribution of training points in accordance with the performance of the neural networks.In this new approach both training sites with slight changes in residual values and training points with large residuals are taken into account.In order to make the distribution of training points more uniform,the concept of continuity is further introduced and incorporated.This method successfully addresses the issue that the neural network becomes ill or even crashes due to the extensive alteration of training point distribution.The effectiveness of the improved physics-informed neural networks with expansion-shrinkage resampling is demonstrated through a series of numerical experiments.
文摘BACKGROUND Hip fractures are the most common reason for inpatient orthopaedic trauma admission.Urgent surgical intervention for hip fractures has remained a clinical priority throughout the coronavirus disease 2019(COVID-19)pandemic.Despite this,there is a paucity of clinical guidance addressing the informed consent process for hip fracture surgery in COVID-19 positive patients.This is of paramount medicolegal importance in a high-risk patient population.AIM To quantify the additional perioperative risks for COVID-19 positive patients undergoing hip fracture surgery and provide clinicians with an evidence-based framework to establish an informed consent process.METHODS Two hundred and fifty nine consecutive patients undergoing surgical intervention for hip fractures in four hospitals in the United Kingdom were recruited.51 patients were confirmed positive for COVID-19.Predefined outcomes were analyzed over a 30-d postoperative period.COVID-19 positive and COVID-19 negative patients were compared after adjustment for confounding factors.RESULTS COVID-19 positive patients had more intensive care admissions(27%vs 5%,P<0.001),longer inpatient stays(median 23 d vs 9 d,P<0.001)and a higher 30-d mortality(29%vs 10%,P=0.001)than COVID-19 negative patients.Postoperative complications were evident in 74.5%of COVID-19 positive patients.35.3%of COVID-19 positive patients suffered postoperative lower respiratory tract infections with 13.7%developing acute respiratory distress syndrome(ARDS)and 9.8%experiencing symptomatic thromboembolic events.CONCLUSION The COVID-19 pandemic has created uncertainty in the medical community worldwide and poses unique challenges in providing informed consent for surgery.COVID-19 positive patients undergoing hip fracture surgery should be consented for the additional risk of postoperative complications(including lower respiratory tract infection,ARDS,deep vein thrombosis and pulmonary embolism),increased requirement for intensive care admission,longer inpatient stay and higher risk of mortality.Further,clinicians must be transparent about the potential for unknown risks as research into the long-term surgical outcomes of COVID-19 positive patients continues to evolve.
文摘During the last four decades the doctrine of in- formed consent (IC) has become a legal stan- dard and an essential component of ethical guidelines in medicine, due to its relevance for basic human rights such as autonomy and re- spect of dignity. Over the last few years, this legal formula has gained importance in veteri- nary medicine, thereby influencing the everyday activities of the veterinary practitioners. This paper briefly describes the ethical and legal background of IC in Italy and examines how it relates to the practice of veterinary medicine, considering the change in social sensibility to- wards animals. It also outlines the discussion that should take place between Veterinarian and client before a planned procedure.
文摘Model-informed drug develop⁃ment(MIDD)is the application of a various math⁃ematical,statistical,and biological models to facilitate drug development,decision making and regulatory review.As a quantitative tool,MIDD approaches allow an integration of information obtained from non-clinical studies and clinical trials in a drug development program.General understandings of the underlying biology,patho⁃physiology,and pharmacology can also be incor⁃porated into the model.MIDD is centered on knowledge and inferences generated from inte⁃grated models of the physicochemical character⁃istics of a molecule,its disposition in the body,and its mechanism of action,and how the drug might affect a disease from both an efficacy and a safety perspective.MIDD approaches have the potential to significantly streamline drug develop⁃ment,by improving clinical trial efficiency,opti⁃mizing dose and regimen and waive unneces⁃sary clinical studies.This presentation will use cases studies to demonstrate how to apply MIDD in early phase of clinical trials.
文摘In this paper, we present a comparative study between informed and predictive prefetching mechanisms that were presented to leverage the performance gap between I/O storage systems and CPU. In particular, we will focus on transparent informed prefetching (TIP) and predictive prefetching using probability graph approach (PG). Our main objective is to show the main features, motivations, and implementation overview of each mechanism. We also conducted a performance evaluation discussion that shows a comparison between both mechanisms performance when using different cache size values.
基金the support from NSF DMS-1816783NVIDIA Corporation for their donation of a Quadro P6000 GPU for conducting some of the numerical simulations in this paper.
文摘In this paper,we introduce a new deep learning framework for discovering the phase-field models from existing image data.The new framework embraces the approximation power of physics informed neural networks(PINNs)and the computational efficiency of the pseudo-spectral methods,which we named pseudo-spectral PINN or SPINN.Unlike the baseline PINN,the pseudo-spectral PINN has several advantages.First of all,it requires less training data.A minimum of two temporal snapshots with uniform spatial resolution would be adequate.Secondly,it is computationally efficient,as the pseudo-spectral method is used for spatial discretization.Thirdly,it requires less trainable parameters compared with the baseline PINN,which significantly simplifies the training process and potentially assures fewer local minima or saddle points.We illustrate the effectiveness of pseudo-spectral PINN through several numerical examples.The newly proposed pseudo-spectral PINN is rather general,and it can be readily applied to discover other FDE-based models from image data.
文摘Background: Every human being of adult years and sound mind has a right to determine what shall be done with his/her own body. Patient autonomy and the practice of informed patient consent are now pivotal in medical practice. Aim: To assess patient’s knowledge of Patients’ Rights Charter and whether patients receive adequate information to enable them make an informed consent to a particular treatment. Methodology: Patients who were undergoing elective surgery from selected surgical departments of Komfo Anokye teaching hospital in Kumasi were randomly selected and assisted to answer structured questionnaire without the knowledge of their doctors. The study period was in June to December (2014). Descriptive analysis was done using SPSS (II) of the results. Results: 84.7% (144) had no idea about the Patients’ Rights Charter of the Ghana Health Service. 75% (128) did not know or had not heard of informed patient consent. Of those who knew of the charter, 85% (37) had ever stayed in a developed country. 60% (102) did not know of their diagnosis. 79% (134) said the doctor only asked them to either sign or thumb print the consent document without giving them treatment options or possible complications. Conclusion: Most of respondents undergoing various surgical procedures at the Komfo Anokye Teaching Hospital were not aware of the existence of the Patients’ Rights Charter of the Ghana Health Service. Again, practitioners did not provide sufficient information to patients for them to make an informed decision about their health.
基金This study was supported by the United Nations Population Funds(UNFPA)
文摘Objective To evaluate the impacts of clinic-based informed choice program on quality of individualized service in family planning clinics in ChinaMethods During the program, family planning service staff in intervention clinics , were trained on counseling skills and key points of individualized counseling service. Questionnaire surveys were conducted pre- and post-informed choice program to evaluate the 'impacts of the program.Results Informed choice program had significantly improved the quality of individualized counseling service. The multivariate regression analysis showed that clients of the clinic were more likely to give the better evaluation of the service, the OR of evaluation score of individualized service is 1/712 (95% CI is 1. 146 to 2. 564) in Experiment Group of post-program in contrast with pre-program. The program also could satisfy individual needs of clients and increase the satisfaction degree of the service. Conclusions Informed choice program is helpful for the improvement of the quality of individualized counseling service. It is necessary and imperative to improve the skills of counseling service provided in family planning clinics.
文摘Biological residual materials can be obtained from surgical activities or from pathological waste material collected for analysis and stored in formalin. This material can be stored in biobanks with the purpose of future research. Formalin-fixed tissue and also formalin-fixed paraffin embedded tissues are not suitable for all kinds of genetic studies on DNA or RNA, as formalin solution is well known for damaging nucleic acids. Therefore, for the purpose of conducting genetic studies, samples should be frozen in order to maintain a good quality of DNA/RNA over time Biobanks, in which waste samples are frozen, are undoubtedly expensive to maintain; however, it could be useful and important to consider their possible implication in particular research, regarding for example the tumor cells growth process, or when the procurement of samples is difficult. Regarding the relationship between informed consent and tissue collection, storage and research, two choices are possible： irreversible or reversible sample anonymization. These procedures involve different approaches and possible solutions that we will seek to define. Also, an important ethical aspect in regard to the role of biobanks is encouraging sample donation. For donors, seeing human sample being kept rather than discarded and seeing them become useful for research highlight the importance of the human body and improve the attitude towards donation. This process might also facilitate the giving of informed consent more trustfully and willingly.
