Active schedule is one of the most basic and popular concepts in production scheduling research. For identical parallel machine scheduling with jobs' dynamic arrivals, the tight performance bounds of active schedules...Active schedule is one of the most basic and popular concepts in production scheduling research. For identical parallel machine scheduling with jobs' dynamic arrivals, the tight performance bounds of active schedules under the measurement of four popular objectives are respectively given in this paper. Similar analysis method and conclusions can be generalized to static identical parallel machine and single machine scheduling problem.展开更多
We investigate the synchronization and anti-synchronization of the new 4D chaotic system and propose a same adaptive controller in the form which not only synchronizes,but also anti-synchronizes two identical new 4D c...We investigate the synchronization and anti-synchronization of the new 4D chaotic system and propose a same adaptive controller in the form which not only synchronizes,but also anti-synchronizes two identical new 4D chaotic systems.Numerical simulations verify the correctness and the effectiveness of the proposed theoretical results.展开更多
A hybrid two-stage flowshop scheduling problem was considered which involves m identical parallel machines at Stage 1 and a burn-in processor M at Stage 2, and the makespan was taken as the minimization objective. Thi...A hybrid two-stage flowshop scheduling problem was considered which involves m identical parallel machines at Stage 1 and a burn-in processor M at Stage 2, and the makespan was taken as the minimization objective. This scheduling problem is NP-hard in general. We divide it into eight subcases. Except for the following two subcases: (1) b≥ an, max{m, B} 〈 n; (2) a1 ≤ b ≤ an, m ≤ B 〈 n, for all other subcases, their NP-hardness was proved or pointed out, corresponding approximation algorithms were conducted and their worst-case performances were estimated. In all these approximation algorithms, the Multifit and PTAS algorithms were respectively used, as the jobs were scheduled in m identical parallel machines.展开更多
The formation of the identical slope surface and the method of construction are discussed. On the basement of building the parameter equation of variable-radius circle family envelope, the frequently used parameter eq...The formation of the identical slope surface and the method of construction are discussed. On the basement of building the parameter equation of variable-radius circle family envelope, the frequently used parameter equation of the identical slope surface of the top of taper moving along column helix, horizental arc and line is built. The equation can be used to construct the identical slope surface’s contours, gradient lines and three dimensional figures correctly.展开更多
An adaptive learning rule of synapses is proposed for a general asymmetric non-identical neural network.Its feasibility is proved by the Lasalle principle.Numerical simulation results show that synaptic connection wei...An adaptive learning rule of synapses is proposed for a general asymmetric non-identical neural network.Its feasibility is proved by the Lasalle principle.Numerical simulation results show that synaptic connection weight can converge to an appropriate strength and the identical network comes to synchronization.Furthermore,by this approach of learning,a non-identical neural population can still reach synchronization.This means that the learning rule has robustness on mismatch parameters.The firing rhythm of the neural population is totally dependent on topological properties,which promotes our understanding of neuron population activities.展开更多
With a comprehensive consideration of multiple product types, past-sequence-dependent ( p-s-d ) setup times, and deterioration effects constraints in processes of wafer fabrication systems, a novel scheduling model ...With a comprehensive consideration of multiple product types, past-sequence-dependent ( p-s-d ) setup times, and deterioration effects constraints in processes of wafer fabrication systems, a novel scheduling model of multiple orders per job(MOJ) on identical parallel machines was developed and an immune genetic algorithm(IGA) was applied to solving the scheduling problem. A scheduling problem domain was described. A non-linear mathematical programming model was also set up with an objective function of minimizing total weighted earliness-tardlness penalties of the system. On the basis of the mathematical model, IGA was put forward. Based on the genetic algorithm (GA), the proposed algorithm (IGA) can generate feasible solutions and ensure the diversity of antibodies. In the process of immunization programming, to guarantee the algorithm's convergence performance, the modified rule of apparent tardiness cost with setups (ATCS) was presented. Finally, simulation experiments were designed, and the results indicated that the algorithm had good adaptability when the values of the constraints' characteristic parameters were changed and it verified the validity of the algorithm.展开更多
We present a scheme to implement a one-qubit phase gate with a two-level atom crossing an optical cavity in which some identical atoms are trapped. One can conveniently acquire an arbitrary phase shift of the gate by ...We present a scheme to implement a one-qubit phase gate with a two-level atom crossing an optical cavity in which some identical atoms are trapped. One can conveniently acquire an arbitrary phase shift of the gate by properly choosing the number of atoms trapped in the cavity and the velocity of the atom crossing the cavity. The present scheme provides a very simple and efficient way for implementing one-qubit phase gate.展开更多
We investigate the collective dynamics of network-organized identical excitable nodes. We theoretically analyze the stability of the rest state and propose that there are two different transition paths: the stationar...We investigate the collective dynamics of network-organized identical excitable nodes. We theoretically analyze the stability of the rest state and propose that there are two different transition paths: the stationary path and the oscillatory path. We find that, although the onset of collective dynamics strongly depend on the network topology, the local dynamics and how local nodes interact with each other decide the transition path and the involved bifurcation.展开更多
A great number of low-spin identical bands in pairs of odd-A and their non-adjacent even-even nuclei in a region of A=150-190 are found,this fact seems to support the idea that the occurrence of identical bands in nei...A great number of low-spin identical bands in pairs of odd-A and their non-adjacent even-even nuclei in a region of A=150-190 are found,this fact seems to support the idea that the occurrence of identical bands in neighboring odd-A and even-even nuclei is caused by the cancellation of various factors which influence the moments of inertia of nuclei.展开更多
This paper first investigates the projective synchronisation problem with non-delayed and delayed coupling between drive-response dynamical networks consisting of identical nodes and different nodes. Based on Lyapunov...This paper first investigates the projective synchronisation problem with non-delayed and delayed coupling between drive-response dynamical networks consisting of identical nodes and different nodes. Based on Lyapunov stability theory, several nonlinear controllers are applied to achieve the projective synchronisation between the drive-response dynamical networks; simultaneously the topological structure of the drive dynamical complex networks can be exactly identified. Moreover, numerical examples are presented to verify the feasibility and effectiveness of the theorems.展开更多
Objective:To investigate the timing and effect of surgical ligation in the treatment of patent ductus arteriosus(PDA)in preterm identical twins.Methods:Retrospective analysis was made on the treatment of 2 cases of pr...Objective:To investigate the timing and effect of surgical ligation in the treatment of patent ductus arteriosus(PDA)in preterm identical twins.Methods:Retrospective analysis was made on the treatment of 2 cases of preterm twins with hemodynamic significant PDA(hsPDA)with corresponding clinical manifestation in our neonatology department,and literatures of PDA ligation for preterm twins were retrieved.Results:These 2 cases were naturally conceived monochorionic diamniotic twins,with gestational age 30+2 weeks,birth weight was 1510g and 780g for larger twin and smaller twin,with birth weight discordance 48.3%.They both developed hsPDA with corresponding clinical manifestation,series Echocardiography showed evidence of left to right shunting and cardiac insufficiency which were left atrial and ventricular enlargement,large PDA(2.8~3.5mm),failed two courses of ibuprofen,N-terminal pro-brain natriuretic peptide level increased significantly,finally received surgical ligation with significant clinical improvement and no related complications.12 cases were found from literature search,including our 2 cases,of these,2 died,9 were cured and 1 improved significantly.Among 6 cases whose detailed information were available,4 infants were identical twins,2 unknown.Conclusions:Preterm identical twins have the same genetic basis,the possibility of PDA ligation for both the larger twin and smaller twin should be alerted if the gestaional age is small and birth weight discordance is above 30%.If preterm twins have hsPDA who may fail ibuprofen treatment,surgical ligation should be considered early,and it is safe and effective.展开更多
Detection of the signal’s breakdown points is important for many science and engineering applications. Numerous signal processing methods have been used for this purpose. Of these, the adaptive prediction is simple a...Detection of the signal’s breakdown points is important for many science and engineering applications. Numerous signal processing methods have been used for this purpose. Of these, the adaptive prediction is simple and easy to implement, however;its simplicity and robustness are hindered by the required delay in the input signal. This paper introduces an efficient alternative to the adaptive prediction in the application of breakdown and inflection points’ detection. Unlike the adaptive predictor, the proposed filter doesn’t require a delay in the primary input to produce the filter’s reference input, which significantly improves the computation speed and overcome the problem of performance sensitivity to the delay value. The Normalized Least-Mean Squares algorithm was used to realize both the adaptive predictor and the proposed filter. The filters were implemented in LabVIEW system design software. The performances of the filters were studied using simulated signals and the simulation results were verified using an experimental signal. The simulation and experimental results showed that the proposed filter efficiently detects the signal breakdowns. Furthermore, the simplicity of the filter offered a significant improvement in the computation speed.展开更多
Soon after a woman gave birth to identical twins (双胞胎), sb.gave them up for adoption (收养). One was adopted (收养) by acouple from Spain and named Juan. The other went to a family fromEgypt. They called him Amal. ...Soon after a woman gave birth to identical twins (双胞胎), sb.gave them up for adoption (收养). One was adopted (收养) by acouple from Spain and named Juan. The other went to a family fromEgypt. They called him Amal. Years passed, and the boy from Spain discovered his mother andsent her a picture of himself. The woman said to her husband展开更多
Identical superdeformed bands in <sup>191</sup>Au and <sup>191</sup>Hg have been investigated byusing particle-rotor model within the framework of the BCS (Bardeen-Cooper-Schrieffer) pairing ...Identical superdeformed bands in <sup>191</sup>Au and <sup>191</sup>Hg have been investigated byusing particle-rotor model within the framework of the BCS (Bardeen-Cooper-Schrieffer) pairing correlation.The identity in the γ-transition energies in these bandsshows that the properties of specific individual orbitals may be important to understandidentical bands.展开更多
Focusing on the theme of“galvanizing multilateral efforts for poverty eradication,quality education,climate action and inclusion,”the general debate of the 74th Session of the United Nations General Assembly(UNGA)wa...Focusing on the theme of“galvanizing multilateral efforts for poverty eradication,quality education,climate action and inclusion,”the general debate of the 74th Session of the United Nations General Assembly(UNGA)was held at UN headquarters in New York City from September 24 to 30,2019.Representatives from 192 of the 193 member states shared opinions on a wide array of global issues during the meeting.展开更多
This work aims to give a systematic construction of the two families of mixed-integer-linear-programming (MILP) formulations, which are graph-<span style="font-family:;" "=""> </span&...This work aims to give a systematic construction of the two families of mixed-integer-linear-programming (MILP) formulations, which are graph-<span style="font-family:;" "=""> </span><span style="font-family:Verdana;">based and sequence-based, of the well-known scheduling problem<img src="Edit_41010f25-7ca5-482c-89be-790fad4616e1.png" alt="" /></span><span style="font-family:Verdana;text-align:justify;">. Two upper bounds of job completion times are introduced. A numerical test result analysis is conducted with a two-fold objective 1) testing the performance of each solving methods, and 2) identifying and analyzing the tractability of an instance according to the instance structure in terms of the number of machines, of the jobs setup time lengths and of the jobs release date distribution over the scheduling horizon.</span> <div> <span style="font-family:Verdana;text-align:justify;"><br /> </span> </div>展开更多
in the design of civil and water conservancy projects, the identical slope suffice isfrequently used. Its mathematical model may be formulated as an envelope of a cone when itS vertexmoves along the cylindrical helix....in the design of civil and water conservancy projects, the identical slope suffice isfrequently used. Its mathematical model may be formulated as an envelope of a cone when itS vertexmoves along the cylindrical helix. According to the principle of conStrUcting the envelope curves of afamily of circles, the parametric equstion for the identical slope surface is established. The parametricform makes it most convenient to draw the contour lines and grade lines, and is well suited toproduce indexed projection of identical slope surface in civil and water conservancy projects.展开更多
Background:Human leukocyte antigen-identical sibling donor(ISD)-hematopoietic stem cell transplantation(SCT)is a potentially curative treatment for high-risk pediatric acute myeloid leukemia(AML).A haploidentical dono...Background:Human leukocyte antigen-identical sibling donor(ISD)-hematopoietic stem cell transplantation(SCT)is a potentially curative treatment for high-risk pediatric acute myeloid leukemia(AML).A haploidentical donor(HID)is readily available to almost all children.Previous studies have demonstrated that patients with HID-SCT had similar outcomes compared to ISD-SCT for pediatric and adult AML.However,the role of HID-SCT in high-risk pediatric AML is unclear.Methods:To compare the overall survival of high-risk AML children who underwent either HID-SCT or ISD-SCT,we analyzed 179 cases of high-risk AML patients under 18 years of age treated with either ISD-SCT(n=23)or HID-SCT(n=156).Granulocyte colony-stimulating factor plus anti-thymocyte globulin-based regimens were used for HID-SCT.We also analyzed the subgroup data of AML patients at first complete remission(CR1)before SCT with known cytogenetic risk.Results:The numbers of adverse cytogenetic risk recipients were 8(34.8%)and 13(18.8%)in the ISD-SCT group and the HID-SCT group,and the number of patients with disease status beyond CR1 were 6(26.1%)and 14(20.3%)in the two groups.The cumulative rates of grades II-IV acute graft-versus-host disease(GVHD)were 13.0%in the ISD-SCT group and 34.8%in the HID-SCT group(P=0.062),with a three-year cumulative rates of chronic GVHD at 14.1%and 34.9%,respectively(P=0.091).The relapse rate in the ISD-SCT group was significantly higher than that in the HID-SCT group(39.1%vs.16.4%,P=0.027);with non-relapse mortality at 0.0%and 10.6%(P=0.113),respectively.The three-year overall survival rates were 73.0%for the ISD-SCT group and 74.6%for the HID-SCT group(P=0.689).In subgroup analysis,the three-year relapse rate in the ISD-SCT group was higher than that in the HID-SCT group(50.0%vs.9.2%,P=0.001)and the three-year DFS in the ISD-SCT group(50.0%)was lower than that in the HID-SCT group(81.2%)(P=0.021).Conclusions:Unmanipulated HID-SCT achieved DFS and OS outcomes comparable to those of ISD-SCT for high-risk pediatric AML patients with potentially higher rate but manageable GVHD.展开更多
基金This work was supported by the National Natural Science Foundation of China (No. 60474002, 60504026)Shanghai Development Foundation forScience and Technology (No. 04DZ11008)
文摘Active schedule is one of the most basic and popular concepts in production scheduling research. For identical parallel machine scheduling with jobs' dynamic arrivals, the tight performance bounds of active schedules under the measurement of four popular objectives are respectively given in this paper. Similar analysis method and conclusions can be generalized to static identical parallel machine and single machine scheduling problem.
基金Supported by the Natural Science Foundation of Shandong Province under Grant No ZR2010GL013.
文摘We investigate the synchronization and anti-synchronization of the new 4D chaotic system and propose a same adaptive controller in the form which not only synchronizes,but also anti-synchronizes two identical new 4D chaotic systems.Numerical simulations verify the correctness and the effectiveness of the proposed theoretical results.
基金Project supported by the Science and Technology Development Fund of Shanghai University(Grant No.A.10-0101-06-0017)
文摘A hybrid two-stage flowshop scheduling problem was considered which involves m identical parallel machines at Stage 1 and a burn-in processor M at Stage 2, and the makespan was taken as the minimization objective. This scheduling problem is NP-hard in general. We divide it into eight subcases. Except for the following two subcases: (1) b≥ an, max{m, B} 〈 n; (2) a1 ≤ b ≤ an, m ≤ B 〈 n, for all other subcases, their NP-hardness was proved or pointed out, corresponding approximation algorithms were conducted and their worst-case performances were estimated. In all these approximation algorithms, the Multifit and PTAS algorithms were respectively used, as the jobs were scheduled in m identical parallel machines.
文摘The formation of the identical slope surface and the method of construction are discussed. On the basement of building the parameter equation of variable-radius circle family envelope, the frequently used parameter equation of the identical slope surface of the top of taper moving along column helix, horizental arc and line is built. The equation can be used to construct the identical slope surface’s contours, gradient lines and three dimensional figures correctly.
基金Supported by the National Natural Science Foundation of China under Grant No 10872068the Fundamental Research Funds for the Central Universities,Youth Cultivating Foundation of Hangzhou Normal University under Grant No 2010QN02the Key Program of National Natural Science Foundation of China under Grant No 11232005(on neurodynamics research and experimental analysis of perceptual cognition and decision making)。
文摘An adaptive learning rule of synapses is proposed for a general asymmetric non-identical neural network.Its feasibility is proved by the Lasalle principle.Numerical simulation results show that synaptic connection weight can converge to an appropriate strength and the identical network comes to synchronization.Furthermore,by this approach of learning,a non-identical neural population can still reach synchronization.This means that the learning rule has robustness on mismatch parameters.The firing rhythm of the neural population is totally dependent on topological properties,which promotes our understanding of neuron population activities.
基金National Natural Science Foundations of China(No.61273035,No.71071115)
文摘With a comprehensive consideration of multiple product types, past-sequence-dependent ( p-s-d ) setup times, and deterioration effects constraints in processes of wafer fabrication systems, a novel scheduling model of multiple orders per job(MOJ) on identical parallel machines was developed and an immune genetic algorithm(IGA) was applied to solving the scheduling problem. A scheduling problem domain was described. A non-linear mathematical programming model was also set up with an objective function of minimizing total weighted earliness-tardlness penalties of the system. On the basis of the mathematical model, IGA was put forward. Based on the genetic algorithm (GA), the proposed algorithm (IGA) can generate feasible solutions and ensure the diversity of antibodies. In the process of immunization programming, to guarantee the algorithm's convergence performance, the modified rule of apparent tardiness cost with setups (ATCS) was presented. Finally, simulation experiments were designed, and the results indicated that the algorithm had good adaptability when the values of the constraints' characteristic parameters were changed and it verified the validity of the algorithm.
文摘We present a scheme to implement a one-qubit phase gate with a two-level atom crossing an optical cavity in which some identical atoms are trapped. One can conveniently acquire an arbitrary phase shift of the gate by properly choosing the number of atoms trapped in the cavity and the velocity of the atom crossing the cavity. The present scheme provides a very simple and efficient way for implementing one-qubit phase gate.
基金Supported by the National Natural Science Foundation of China under Grant No 71301012
文摘We investigate the collective dynamics of network-organized identical excitable nodes. We theoretically analyze the stability of the rest state and propose that there are two different transition paths: the stationary path and the oscillatory path. We find that, although the onset of collective dynamics strongly depend on the network topology, the local dynamics and how local nodes interact with each other decide the transition path and the involved bifurcation.
基金Supported by the National Natural Science Foundation of China under Grant No.19575023.
文摘A great number of low-spin identical bands in pairs of odd-A and their non-adjacent even-even nuclei in a region of A=150-190 are found,this fact seems to support the idea that the occurrence of identical bands in neighboring odd-A and even-even nuclei is caused by the cancellation of various factors which influence the moments of inertia of nuclei.
基金supported by the National Natural Science Foundation of China (Grant No. 10771088)Natural Science Foundation of Jiangsu Province,China (Grant No. 2007098)+3 种基金Outstanding Personnel Program in Six Fields of Jiangsu Province,China (Grant No. 6-A-029)National Natural Science (Youth) Foundation of China (Grant No. 10801140)Youth Foundation of Chongqing Normal University,China (Grant No. 08XLQ04)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grant No. CX09B 202Z)
文摘This paper first investigates the projective synchronisation problem with non-delayed and delayed coupling between drive-response dynamical networks consisting of identical nodes and different nodes. Based on Lyapunov stability theory, several nonlinear controllers are applied to achieve the projective synchronisation between the drive-response dynamical networks; simultaneously the topological structure of the drive dynamical complex networks can be exactly identified. Moreover, numerical examples are presented to verify the feasibility and effectiveness of the theorems.
基金Hainan Major Science and Technology Fund(NO.ZDKJ2019010)
文摘Objective:To investigate the timing and effect of surgical ligation in the treatment of patent ductus arteriosus(PDA)in preterm identical twins.Methods:Retrospective analysis was made on the treatment of 2 cases of preterm twins with hemodynamic significant PDA(hsPDA)with corresponding clinical manifestation in our neonatology department,and literatures of PDA ligation for preterm twins were retrieved.Results:These 2 cases were naturally conceived monochorionic diamniotic twins,with gestational age 30+2 weeks,birth weight was 1510g and 780g for larger twin and smaller twin,with birth weight discordance 48.3%.They both developed hsPDA with corresponding clinical manifestation,series Echocardiography showed evidence of left to right shunting and cardiac insufficiency which were left atrial and ventricular enlargement,large PDA(2.8~3.5mm),failed two courses of ibuprofen,N-terminal pro-brain natriuretic peptide level increased significantly,finally received surgical ligation with significant clinical improvement and no related complications.12 cases were found from literature search,including our 2 cases,of these,2 died,9 were cured and 1 improved significantly.Among 6 cases whose detailed information were available,4 infants were identical twins,2 unknown.Conclusions:Preterm identical twins have the same genetic basis,the possibility of PDA ligation for both the larger twin and smaller twin should be alerted if the gestaional age is small and birth weight discordance is above 30%.If preterm twins have hsPDA who may fail ibuprofen treatment,surgical ligation should be considered early,and it is safe and effective.
文摘Detection of the signal’s breakdown points is important for many science and engineering applications. Numerous signal processing methods have been used for this purpose. Of these, the adaptive prediction is simple and easy to implement, however;its simplicity and robustness are hindered by the required delay in the input signal. This paper introduces an efficient alternative to the adaptive prediction in the application of breakdown and inflection points’ detection. Unlike the adaptive predictor, the proposed filter doesn’t require a delay in the primary input to produce the filter’s reference input, which significantly improves the computation speed and overcome the problem of performance sensitivity to the delay value. The Normalized Least-Mean Squares algorithm was used to realize both the adaptive predictor and the proposed filter. The filters were implemented in LabVIEW system design software. The performances of the filters were studied using simulated signals and the simulation results were verified using an experimental signal. The simulation and experimental results showed that the proposed filter efficiently detects the signal breakdowns. Furthermore, the simplicity of the filter offered a significant improvement in the computation speed.
文摘Soon after a woman gave birth to identical twins (双胞胎), sb.gave them up for adoption (收养). One was adopted (收养) by acouple from Spain and named Juan. The other went to a family fromEgypt. They called him Amal. Years passed, and the boy from Spain discovered his mother andsent her a picture of himself. The woman said to her husband
基金The project supported by the National Natural Science Foundation of China.
文摘Identical superdeformed bands in <sup>191</sup>Au and <sup>191</sup>Hg have been investigated byusing particle-rotor model within the framework of the BCS (Bardeen-Cooper-Schrieffer) pairing correlation.The identity in the γ-transition energies in these bandsshows that the properties of specific individual orbitals may be important to understandidentical bands.
文摘Focusing on the theme of“galvanizing multilateral efforts for poverty eradication,quality education,climate action and inclusion,”the general debate of the 74th Session of the United Nations General Assembly(UNGA)was held at UN headquarters in New York City from September 24 to 30,2019.Representatives from 192 of the 193 member states shared opinions on a wide array of global issues during the meeting.
文摘This work aims to give a systematic construction of the two families of mixed-integer-linear-programming (MILP) formulations, which are graph-<span style="font-family:;" "=""> </span><span style="font-family:Verdana;">based and sequence-based, of the well-known scheduling problem<img src="Edit_41010f25-7ca5-482c-89be-790fad4616e1.png" alt="" /></span><span style="font-family:Verdana;text-align:justify;">. Two upper bounds of job completion times are introduced. A numerical test result analysis is conducted with a two-fold objective 1) testing the performance of each solving methods, and 2) identifying and analyzing the tractability of an instance according to the instance structure in terms of the number of machines, of the jobs setup time lengths and of the jobs release date distribution over the scheduling horizon.</span> <div> <span style="font-family:Verdana;text-align:justify;"><br /> </span> </div>
文摘in the design of civil and water conservancy projects, the identical slope suffice isfrequently used. Its mathematical model may be formulated as an envelope of a cone when itS vertexmoves along the cylindrical helix. According to the principle of conStrUcting the envelope curves of afamily of circles, the parametric equstion for the identical slope surface is established. The parametricform makes it most convenient to draw the contour lines and grade lines, and is well suited toproduce indexed projection of identical slope surface in civil and water conservancy projects.
基金This work was partly supported by grants from the National Key Research and Development Program of China(Grant No.:2017YFA0104500)from the Ministry of Science and TechnologyNational Natural Science Foundation of China(Grant No.:81770189,81621001,and 81530046)+3 种基金the Science and Technology Project of Guangdong Province of China(Grant No.:2016B030230003)Peking University Clinical Scientist Program(Grant No.:BMU2019LCKXJ003)the Fundamental Research Funds for the Central Universitiesthe project of health collaborative innovation of Guangzhou city(Grant No.:201704020214).
文摘Background:Human leukocyte antigen-identical sibling donor(ISD)-hematopoietic stem cell transplantation(SCT)is a potentially curative treatment for high-risk pediatric acute myeloid leukemia(AML).A haploidentical donor(HID)is readily available to almost all children.Previous studies have demonstrated that patients with HID-SCT had similar outcomes compared to ISD-SCT for pediatric and adult AML.However,the role of HID-SCT in high-risk pediatric AML is unclear.Methods:To compare the overall survival of high-risk AML children who underwent either HID-SCT or ISD-SCT,we analyzed 179 cases of high-risk AML patients under 18 years of age treated with either ISD-SCT(n=23)or HID-SCT(n=156).Granulocyte colony-stimulating factor plus anti-thymocyte globulin-based regimens were used for HID-SCT.We also analyzed the subgroup data of AML patients at first complete remission(CR1)before SCT with known cytogenetic risk.Results:The numbers of adverse cytogenetic risk recipients were 8(34.8%)and 13(18.8%)in the ISD-SCT group and the HID-SCT group,and the number of patients with disease status beyond CR1 were 6(26.1%)and 14(20.3%)in the two groups.The cumulative rates of grades II-IV acute graft-versus-host disease(GVHD)were 13.0%in the ISD-SCT group and 34.8%in the HID-SCT group(P=0.062),with a three-year cumulative rates of chronic GVHD at 14.1%and 34.9%,respectively(P=0.091).The relapse rate in the ISD-SCT group was significantly higher than that in the HID-SCT group(39.1%vs.16.4%,P=0.027);with non-relapse mortality at 0.0%and 10.6%(P=0.113),respectively.The three-year overall survival rates were 73.0%for the ISD-SCT group and 74.6%for the HID-SCT group(P=0.689).In subgroup analysis,the three-year relapse rate in the ISD-SCT group was higher than that in the HID-SCT group(50.0%vs.9.2%,P=0.001)and the three-year DFS in the ISD-SCT group(50.0%)was lower than that in the HID-SCT group(81.2%)(P=0.021).Conclusions:Unmanipulated HID-SCT achieved DFS and OS outcomes comparable to those of ISD-SCT for high-risk pediatric AML patients with potentially higher rate but manageable GVHD.