Myeloid sarcomas （MS） preceding acute myeloid leukemia （AML） are rare, which presenting as acute spinal cord compression is even rare. Here we report two new cases of myeloid sarcoma patients, whose outcomes were ...Myeloid sarcomas （MS） preceding acute myeloid leukemia （AML） are rare, which presenting as acute spinal cord compression is even rare. Here we report two new cases of myeloid sarcoma patients, whose outcomes were different. Twenty-seven patients with spinal MS preceding AML have been reported to date, including the two cases presented in this article. Surgical decompression was performed in 25 of the 27 patients, and 23 of these received additional anti-AML therapy. Considering our patients and the published cases in the literature we suggest that immunohistochemical study plays an essential role in arriving at a correct diagnosis of MS, and that emergency surgery to resect spinal MS is an available treatment to make neural function recovery, and that the disease must be treated with intensive chemotherapy similar to that used to treat AML as soon as possible after resection or irradiation of the tumor.展开更多
The expression of PCNA and EGFr in chemically induced hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats were immunohistochemically observed. The results showed that the carcinoma cells o...The expression of PCNA and EGFr in chemically induced hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats were immunohistochemically observed. The results showed that the carcinoma cells of both tumors revealed a positive immunreaction to PCNA and EGFr. The histochemical observation of mast cell (MC) in both tumor tissues showed that the amount of MC in the surroundings of tumor cell nests was markedly different. According to the amount of the surrounding MCs the tumor cell nests could be divided into two groups : Gourp A with abundant MC infiltration and Group B with only scarce or without MC infiltration. The PCNA-positive cells in the tumor cell nests of both groups were calculated respectively. The results revealed that the amount of PCNA-positive cells in the group B was markedly more than that in the group A. The numerical ratio between two groups was 3 : 1 in the liver carcinoma and 2 : 1 in the stomach carcinoma approximately. An overexpression of EGFr was observed in tumor tissues of both groups , but there was also a marked difference in the amount of positively expressed cells and in the intensity of their staining reaction between both groups. The positively expressed cells in group B were much more and their staining intensity was much stronger than those in group A. According to the above mentioned results of observation, the expression state ofboth factors (PCNA and EGFr) was basically identical, suggesting that the MC may possess some inhibitory effect upon the growth rate of tumor cells of the experimental hepatocellular carcinoma of liver and the squamous cell carcinoma f stomach in rats.展开更多
Introduction In this paper we present a case of monocytic sarcoma of the vertebral canal with a review of relevant literature references. According to the extensive morphological and immunohistochemical analyses, mono...Introduction In this paper we present a case of monocytic sarcoma of the vertebral canal with a review of relevant literature references. According to the extensive morphological and immunohistochemical analyses, monocytic sarcoma is one type of myeloid sarcoma, and can be diagnosed from extensive morphological and immunohistochemical analysis. Most cases of myeloid sarcomas are associated with acute, or chronic leukemia, or myelo-proliferative disorders, as well as monocytic sarcoma. Rarely, the tumors may be identified before the diagnosis of any hematological malignancy and most of them predict portend existing, or pending acute myeloid leukemia （AML）. Myeloid sarcomas may occur in almost every part of the bodyt, but spinal monocytic sarcomas are relatively uncommon.展开更多
文摘Myeloid sarcomas （MS） preceding acute myeloid leukemia （AML） are rare, which presenting as acute spinal cord compression is even rare. Here we report two new cases of myeloid sarcoma patients, whose outcomes were different. Twenty-seven patients with spinal MS preceding AML have been reported to date, including the two cases presented in this article. Surgical decompression was performed in 25 of the 27 patients, and 23 of these received additional anti-AML therapy. Considering our patients and the published cases in the literature we suggest that immunohistochemical study plays an essential role in arriving at a correct diagnosis of MS, and that emergency surgery to resect spinal MS is an available treatment to make neural function recovery, and that the disease must be treated with intensive chemotherapy similar to that used to treat AML as soon as possible after resection or irradiation of the tumor.
文摘The expression of PCNA and EGFr in chemically induced hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats were immunohistochemically observed. The results showed that the carcinoma cells of both tumors revealed a positive immunreaction to PCNA and EGFr. The histochemical observation of mast cell (MC) in both tumor tissues showed that the amount of MC in the surroundings of tumor cell nests was markedly different. According to the amount of the surrounding MCs the tumor cell nests could be divided into two groups : Gourp A with abundant MC infiltration and Group B with only scarce or without MC infiltration. The PCNA-positive cells in the tumor cell nests of both groups were calculated respectively. The results revealed that the amount of PCNA-positive cells in the group B was markedly more than that in the group A. The numerical ratio between two groups was 3 : 1 in the liver carcinoma and 2 : 1 in the stomach carcinoma approximately. An overexpression of EGFr was observed in tumor tissues of both groups , but there was also a marked difference in the amount of positively expressed cells and in the intensity of their staining reaction between both groups. The positively expressed cells in group B were much more and their staining intensity was much stronger than those in group A. According to the above mentioned results of observation, the expression state ofboth factors (PCNA and EGFr) was basically identical, suggesting that the MC may possess some inhibitory effect upon the growth rate of tumor cells of the experimental hepatocellular carcinoma of liver and the squamous cell carcinoma f stomach in rats.
文摘Introduction In this paper we present a case of monocytic sarcoma of the vertebral canal with a review of relevant literature references. According to the extensive morphological and immunohistochemical analyses, monocytic sarcoma is one type of myeloid sarcoma, and can be diagnosed from extensive morphological and immunohistochemical analysis. Most cases of myeloid sarcomas are associated with acute, or chronic leukemia, or myelo-proliferative disorders, as well as monocytic sarcoma. Rarely, the tumors may be identified before the diagnosis of any hematological malignancy and most of them predict portend existing, or pending acute myeloid leukemia （AML）. Myeloid sarcomas may occur in almost every part of the bodyt, but spinal monocytic sarcomas are relatively uncommon.
