Objective:To systematically study the key active ingredients of Jiuwei Huaban pill in the treatment of psoriasis and explore its mechanism of action.Methods:The chemical components of Jiuwei Huaban pill were systemati...Objective:To systematically study the key active ingredients of Jiuwei Huaban pill in the treatment of psoriasis and explore its mechanism of action.Methods:The chemical components of Jiuwei Huaban pill were systematically identified by UPLC-QTOF/MSE,and network pharmacology method was used to study the main pharmacodynamic substances of Jiuwei Huaban pill and discuss the mechanism of action.Molecular docking technology was used to verify the binding activity of key components and target proteins.Results:A total of 75 components of Jiuwei Huaban pill were identified,35 of which were key components for psoriasis treatment,including luteolin,baicalin,baicalin,paeoniflorin and geniposide.Enrichment analysis of 30 core target pathways showed that Jiuwei Huaban pill played its role in the treatment of psoriasis from the IL-17 signaling pathway,TNF signaling pathway,PI3K-Akt signaling pathway,Th17 signaling pathway,and MAPK signaling pathway.The key active components in Jiuwei Huaban pill and targets with the highest DGREE value in the"component target disease"network have strong binding activity.Conclusion:The active ingredients and mechanism of action of Jiuwei Huaban pill in the treatment of psoriasis were preliminarily clarified,which provids reference for quality control.展开更多
It has been applied for many diseases such as plague fever, cold cough, sore throat and so on. In order to better study Huhegaridi-9, this paper started from the production process of Mongolian Patent Medicine Huhegar...It has been applied for many diseases such as plague fever, cold cough, sore throat and so on. In order to better study Huhegaridi-9, this paper started from the production process of Mongolian Patent Medicine Huhegaridi-9. It analyzed and discussed the clinical application, chemical components and pharmacological research of Huhegaridi-9. It is expected to provide a reference for relevant researchers and workers.展开更多
Objective:To assess the effectiveness of Jiuwei Zhuhuang Powder(JWZH),a Tibetan patent medicine in treating upper respiratory tract infection(URTI)associated cough in children.Methods:The study was a multicenter,rando...Objective:To assess the effectiveness of Jiuwei Zhuhuang Powder(JWZH),a Tibetan patent medicine in treating upper respiratory tract infection(URTI)associated cough in children.Methods:The study was a multicenter,randomized,open-label,controlled trial.A total of 142 children aged 2 to 14 years old,with URTIassociated cough within 48 h of onset,were randomly assigned to two groups at a 1:1 ratio by computer-generated randomization sequence.Children were treated with JWZH(1 to 1.5 g,twice to thrice daily)in the treatment group or conventional treatment(Pediatric Paracetamol,Artificial Cow-bezoar and Chlorphenamine Maleate Granules,0.25 to 1 g,thrice daily)in the control group for 5 days.The primary endpoints were the time to cough resolution and 4-day cough resolution rate.The secondary endpoints were the daily improvement in symptom scores and cough resolution rate during the study period.Results:A total of 138 children were included in the intention-to-treat analysis,with 71 cases in the treatment group and 67 cases in the control group.Compared with the conventional treatment,the children receiving JWZH had a shorter time to cough resolution[hazard ratio,2.10;95%confidence interval(CI),1.29-3.40;P=0.003].The median time to cough resolution for children receiving JWZH was shorter than that of the conventional treatment(2 days vs.3 days;P<0.001).The 4-day cough resolution rate in the JWZH group was higher than that of the control group(94.4%vs.74.6%;risk difference:19.8%,95%CI:8.1%-31.5%;relative risk:1.265,95%CI:1.088-1.470;P=0.001).There were no statistically significant differences in the improvement of other symptoms caused by URTI(P>0.05).Adverse events was reported in 5.6%(4/71)and 4.5%(3/67)in participants of JWZH and PPACCM groups(P>0.05),respectively,which were all mild and resolved without treatment.Conclusion:JWZH seemed to be a safe and effective therapy for URTI-associated cough in children.(Trial registration No.Chi CTR2000039421)展开更多
目的:研究龙蛇九味汤联合坎地沙坦酯片治疗高血压的疗效及其对患者肾素(Renin)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)及醛固酮(aldosterone,ALD)水平的影响。方法:将高血压患者99例按照随机数字表法分为观察组(50例,予龙蛇九味汤联合坎...目的:研究龙蛇九味汤联合坎地沙坦酯片治疗高血压的疗效及其对患者肾素(Renin)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)及醛固酮(aldosterone,ALD)水平的影响。方法:将高血压患者99例按照随机数字表法分为观察组(50例,予龙蛇九味汤联合坎地沙坦酯片治疗)和对照组(49例,予坎地沙坦酯片治疗)。比较两组治疗效果,观察两组患者治疗前后甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)及低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平。检测两组患者治疗前后血浆Renin、AngⅡ及ALD水平。结果:观察组疗效优于对照组(P<0.05);治疗后观察组TG、TC、LDL-C及血压晨峰值、收缩压、舒张压以及血浆Renin、AngⅡ、ALD均低于对照组(P<0.05),HDL-C高于对照组(P<0.05)。结论:龙蛇九味汤联合坎地沙坦酯有助于纠正高血压患者血脂紊乱情况,提高治疗效果,可能与其降低Renin、AngⅡ及ALD水平,调节肾素-血管紧张素-醛固酮系统有关。展开更多
基金National Major Science and Technology Project for"Major New Drug Development"(No.2017ZX09301005)。
文摘Objective:To systematically study the key active ingredients of Jiuwei Huaban pill in the treatment of psoriasis and explore its mechanism of action.Methods:The chemical components of Jiuwei Huaban pill were systematically identified by UPLC-QTOF/MSE,and network pharmacology method was used to study the main pharmacodynamic substances of Jiuwei Huaban pill and discuss the mechanism of action.Molecular docking technology was used to verify the binding activity of key components and target proteins.Results:A total of 75 components of Jiuwei Huaban pill were identified,35 of which were key components for psoriasis treatment,including luteolin,baicalin,baicalin,paeoniflorin and geniposide.Enrichment analysis of 30 core target pathways showed that Jiuwei Huaban pill played its role in the treatment of psoriasis from the IL-17 signaling pathway,TNF signaling pathway,PI3K-Akt signaling pathway,Th17 signaling pathway,and MAPK signaling pathway.The key active components in Jiuwei Huaban pill and targets with the highest DGREE value in the"component target disease"network have strong binding activity.Conclusion:The active ingredients and mechanism of action of Jiuwei Huaban pill in the treatment of psoriasis were preliminarily clarified,which provids reference for quality control.
文摘It has been applied for many diseases such as plague fever, cold cough, sore throat and so on. In order to better study Huhegaridi-9, this paper started from the production process of Mongolian Patent Medicine Huhegaridi-9. It analyzed and discussed the clinical application, chemical components and pharmacological research of Huhegaridi-9. It is expected to provide a reference for relevant researchers and workers.
基金Supported by the National Natural Science Foundation of China(No.81704197)。
文摘Objective:To assess the effectiveness of Jiuwei Zhuhuang Powder(JWZH),a Tibetan patent medicine in treating upper respiratory tract infection(URTI)associated cough in children.Methods:The study was a multicenter,randomized,open-label,controlled trial.A total of 142 children aged 2 to 14 years old,with URTIassociated cough within 48 h of onset,were randomly assigned to two groups at a 1:1 ratio by computer-generated randomization sequence.Children were treated with JWZH(1 to 1.5 g,twice to thrice daily)in the treatment group or conventional treatment(Pediatric Paracetamol,Artificial Cow-bezoar and Chlorphenamine Maleate Granules,0.25 to 1 g,thrice daily)in the control group for 5 days.The primary endpoints were the time to cough resolution and 4-day cough resolution rate.The secondary endpoints were the daily improvement in symptom scores and cough resolution rate during the study period.Results:A total of 138 children were included in the intention-to-treat analysis,with 71 cases in the treatment group and 67 cases in the control group.Compared with the conventional treatment,the children receiving JWZH had a shorter time to cough resolution[hazard ratio,2.10;95%confidence interval(CI),1.29-3.40;P=0.003].The median time to cough resolution for children receiving JWZH was shorter than that of the conventional treatment(2 days vs.3 days;P<0.001).The 4-day cough resolution rate in the JWZH group was higher than that of the control group(94.4%vs.74.6%;risk difference:19.8%,95%CI:8.1%-31.5%;relative risk:1.265,95%CI:1.088-1.470;P=0.001).There were no statistically significant differences in the improvement of other symptoms caused by URTI(P>0.05).Adverse events was reported in 5.6%(4/71)and 4.5%(3/67)in participants of JWZH and PPACCM groups(P>0.05),respectively,which were all mild and resolved without treatment.Conclusion:JWZH seemed to be a safe and effective therapy for URTI-associated cough in children.(Trial registration No.Chi CTR2000039421)
文摘目的:研究龙蛇九味汤联合坎地沙坦酯片治疗高血压的疗效及其对患者肾素(Renin)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)及醛固酮(aldosterone,ALD)水平的影响。方法:将高血压患者99例按照随机数字表法分为观察组(50例,予龙蛇九味汤联合坎地沙坦酯片治疗)和对照组(49例,予坎地沙坦酯片治疗)。比较两组治疗效果,观察两组患者治疗前后甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)及低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平。检测两组患者治疗前后血浆Renin、AngⅡ及ALD水平。结果:观察组疗效优于对照组(P<0.05);治疗后观察组TG、TC、LDL-C及血压晨峰值、收缩压、舒张压以及血浆Renin、AngⅡ、ALD均低于对照组(P<0.05),HDL-C高于对照组(P<0.05)。结论:龙蛇九味汤联合坎地沙坦酯有助于纠正高血压患者血脂紊乱情况,提高治疗效果,可能与其降低Renin、AngⅡ及ALD水平,调节肾素-血管紧张素-醛固酮系统有关。
