[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0....[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/（kg d）, a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase （SOD）, Glutathione peroxidase （GSH-Px） and Malondialdehyde （MDA） content in plasma, brain and liver tissue were determined. [ Result.] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [ Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.展开更多
A practical chemical synthesis of L-camitine （1） has been accomplished from （R）-3-chloro-1,2-propanediol （（R）-4）, which is a main by-product originated from （R,R）-Salen Co（III） catalyzed hydrolytic kinetic...A practical chemical synthesis of L-camitine （1） has been accomplished from （R）-3-chloro-1,2-propanediol （（R）-4）, which is a main by-product originated from （R,R）-Salen Co（III） catalyzed hydrolytic kinetic resolution （HKR） of （±）-epichlorohydrin. （R）-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite （（R）-S）. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.展开更多
基金Yantai Science and Technology Development Plan (2011074)
文摘[Objective] To study the antioxidant effects of LC on D-galactose induced aging mice. [Method] 50 mice were randomly divided into blank control group, D-galactose model group, LC treatment groups at three levels of 0.25, 0.5 and 1.0 g/（kg d）, a total of 5 groups. Using the subacute D-galactose induced aging models, the mice were killed after 6 weeks of experiment and the activity of Superoxide dismutase （SOD）, Glutathione peroxidase （GSH-Px） and Malondialdehyde （MDA） content in plasma, brain and liver tissue were determined. [ Result.] The activity of SOD and GSH-Px in plasma, brain and liver tissue were significantly increased after treated with LC, while the content of MDA were decreased with a dose-dependent manner. [ Conclusion] LC had anti-aging effects in mice, and the mechanism may be correlated with the antioxidation.
基金Sponsored by the National Natural Science Foundation of China(No.20972015)the Natural Science Foundation of Beijing(No.2082016)the Science and Technology Innovation Foundation for the College Students of Beijing(No.B091000814)
文摘A practical chemical synthesis of L-camitine （1） has been accomplished from （R）-3-chloro-1,2-propanediol （（R）-4）, which is a main by-product originated from （R,R）-Salen Co（III） catalyzed hydrolytic kinetic resolution （HKR） of （±）-epichlorohydrin. （R）-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite （（R）-S）. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.
