BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experien...BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.展开更多
Marketing channels are an important part of the circulation of agricultural products.With the development of China s agricultural industry,the marketing channels of agricultural products are continuously innovated and...Marketing channels are an important part of the circulation of agricultural products.With the development of China s agricultural industry,the marketing channels of agricultural products are continuously innovated and optimized.Taking Liujun Lotus Root as an example,on the basis of studying the existing model of marketing channels of agricultural products,this paper analyzes the problems in the existing marketing channels of Liujun Lotus Root,and puts forward relevant strategies.展开更多
OBJECTIVE:To evaluate the effectiveness and safety of Xiangsha Liujun pills(香砂六君丸) on the decreased digestive function in patients in the recovery phase of the Coronavirus disease 2019(COVID-19).METHODS:A randomi...OBJECTIVE:To evaluate the effectiveness and safety of Xiangsha Liujun pills(香砂六君丸) on the decreased digestive function in patients in the recovery phase of the Coronavirus disease 2019(COVID-19).METHODS:A randomized,double blind,placebo controlled clinical trial was conducted.A total of 200 COVID-19 patients in the recovery phase were included in our study in Ezhou Hospital of Traditional Chinese Medicine.Totally 200 subjects were randomly divided into a treatment group(Xiangsha Liujun pills) and a control group(placebo),with 100 in each group.Subjects took Xiangsha Liujun pills or placebo orally three times a day for two weeks.Three visits were scheduled at week 0(baseline),week 1(the middle of the intervention) and week 2(the end of the intervention) for each eligible patient.The total efficacy rates for improving the Traditional Chinese Medicine(TCM) symptoms(fatigue,poor appetite,abdominal distension and loose stools) and the disappearance rates of symptoms were observed and compared in the treatment and control groups.Adverse events were recorded during the study period.SAS 9.4 was used to analyze the data.RESULTS:A total of 200 patients were included in this study,among which 4 participants withdrew because the drugs did not work.Three patients were excluded for age.Before the treatment,there was no significant difference between the TCM symptoms scores of subjects.After 1 week of treatment,the full analysis set(FAS) showed that the efficacy rates for abdominal distension and loose stools in the treatment group were significantly higher than the control group(P < 0.05).There were no significant differences in the efficacy rates for fatigue and poor appetite between the two groups(P > 0.05).In addition,the disappearance rate of fatigue in the treatment group was significantly higher than the control group(P < 0.05);there were no significant differences between the two groups after treatment in the rates of poor appetite,abdominal distension,and loose stools(P > 0.05).After 2 weeks of treatment,the efficacy rates for fatigue,poor appetite,abdominal distension,and loose stools in the treatment group were significantly higher than the control group(P < 0.05).The disappearance rate of loose stools in the treatment group was significantly higher than the control group(P < 0.05).However,there were no significant differences in the disappearance rates of fatigue,poor appetite,and abdominal distension between the two groups(P > 0.05).No severe adverse events were reported by subjects during the study.CONCLUSIONS:This clinical study confirmed that Xiangsha Liujun pills can effectively improve the symptoms related to the decreased digestive function in COVID-19 convalescent patients.展开更多
目的探讨协日嘎四味汤散联合加味柴芍六君汤对原发性肝癌微创消融术后患者的疗效及安全性。方法本研究纳入原发性肝癌患者共70例,按相同男女比例随机分为对照组和观察组,每组各35例。微创消融术后1周,对照组给予常规治疗,观察组给予协...目的探讨协日嘎四味汤散联合加味柴芍六君汤对原发性肝癌微创消融术后患者的疗效及安全性。方法本研究纳入原发性肝癌患者共70例,按相同男女比例随机分为对照组和观察组,每组各35例。微创消融术后1周,对照组给予常规治疗,观察组给予协日嘎四味汤散联合加味柴芍六君汤进行治疗,疗程为一个月。通过检测谷丙转氨酶(Alanine transaminase,ALT)、谷草转氨酶(Aspartate Transaminase,AST)、碱性磷酸酶(Alkaline phosphatase,ALP)、直接胆红素(Direct Bilirubin,DBIL)和血清甲胎蛋白(Alpha-fetoprotein,AFP)等分子对肝功能以及肝癌发展进行评估;采用肝癌生命质量测定量表(Quality of Life in Liver Cancer Measurement Scale,QOL-LC)评估患者生存质量;采用中医症状积分量表评估症状严重程度。结果治疗后,观察组在血清功能相关指标方面表现出显著改善,具体表现为ALT、AST、ALP、DBIL和AFP含量显著低于对照组(P<0.05)。在生命质量评分方面,观察组在躯体功能、症状/副作用和社会功能评分上均显著优于对照组(P<0.05)。在中医症状分级方面,观察组中医症状分级为轻度和中度的患者占比明显多于对照组(P<0.05)。在安全性评估中,观察组出现不良反应的患者数亦显著少于对照组(P<0.05)。结论本研究表明了协日嘎四味汤散联合加味柴芍六君汤在原发性肝癌微创消融术后的治疗中具有一定疗效。展开更多
基金Supported by Zhangjiakou Science and Technology Plan Project,No.2021127HScientific Research Program Project of Hebei Provincial Administration of Traditional Chinese Medicine,No.2022146.
文摘BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.
文摘Marketing channels are an important part of the circulation of agricultural products.With the development of China s agricultural industry,the marketing channels of agricultural products are continuously innovated and optimized.Taking Liujun Lotus Root as an example,on the basis of studying the existing model of marketing channels of agricultural products,this paper analyzes the problems in the existing marketing channels of Liujun Lotus Root,and puts forward relevant strategies.
基金Supported by Special Fund of the Technology Division of State Administration of Traditional Chinese Medicine:a Randomized,Double Blinded,Controlled Clinical Trial to Improve the Symptoms of Decreased Digestive Function During the Convalescence of COVID-19(No.2020ZYLCYJ08-5)。
文摘OBJECTIVE:To evaluate the effectiveness and safety of Xiangsha Liujun pills(香砂六君丸) on the decreased digestive function in patients in the recovery phase of the Coronavirus disease 2019(COVID-19).METHODS:A randomized,double blind,placebo controlled clinical trial was conducted.A total of 200 COVID-19 patients in the recovery phase were included in our study in Ezhou Hospital of Traditional Chinese Medicine.Totally 200 subjects were randomly divided into a treatment group(Xiangsha Liujun pills) and a control group(placebo),with 100 in each group.Subjects took Xiangsha Liujun pills or placebo orally three times a day for two weeks.Three visits were scheduled at week 0(baseline),week 1(the middle of the intervention) and week 2(the end of the intervention) for each eligible patient.The total efficacy rates for improving the Traditional Chinese Medicine(TCM) symptoms(fatigue,poor appetite,abdominal distension and loose stools) and the disappearance rates of symptoms were observed and compared in the treatment and control groups.Adverse events were recorded during the study period.SAS 9.4 was used to analyze the data.RESULTS:A total of 200 patients were included in this study,among which 4 participants withdrew because the drugs did not work.Three patients were excluded for age.Before the treatment,there was no significant difference between the TCM symptoms scores of subjects.After 1 week of treatment,the full analysis set(FAS) showed that the efficacy rates for abdominal distension and loose stools in the treatment group were significantly higher than the control group(P < 0.05).There were no significant differences in the efficacy rates for fatigue and poor appetite between the two groups(P > 0.05).In addition,the disappearance rate of fatigue in the treatment group was significantly higher than the control group(P < 0.05);there were no significant differences between the two groups after treatment in the rates of poor appetite,abdominal distension,and loose stools(P > 0.05).After 2 weeks of treatment,the efficacy rates for fatigue,poor appetite,abdominal distension,and loose stools in the treatment group were significantly higher than the control group(P < 0.05).The disappearance rate of loose stools in the treatment group was significantly higher than the control group(P < 0.05).However,there were no significant differences in the disappearance rates of fatigue,poor appetite,and abdominal distension between the two groups(P > 0.05).No severe adverse events were reported by subjects during the study.CONCLUSIONS:This clinical study confirmed that Xiangsha Liujun pills can effectively improve the symptoms related to the decreased digestive function in COVID-19 convalescent patients.
文摘目的探讨协日嘎四味汤散联合加味柴芍六君汤对原发性肝癌微创消融术后患者的疗效及安全性。方法本研究纳入原发性肝癌患者共70例,按相同男女比例随机分为对照组和观察组,每组各35例。微创消融术后1周,对照组给予常规治疗,观察组给予协日嘎四味汤散联合加味柴芍六君汤进行治疗,疗程为一个月。通过检测谷丙转氨酶(Alanine transaminase,ALT)、谷草转氨酶(Aspartate Transaminase,AST)、碱性磷酸酶(Alkaline phosphatase,ALP)、直接胆红素(Direct Bilirubin,DBIL)和血清甲胎蛋白(Alpha-fetoprotein,AFP)等分子对肝功能以及肝癌发展进行评估;采用肝癌生命质量测定量表(Quality of Life in Liver Cancer Measurement Scale,QOL-LC)评估患者生存质量;采用中医症状积分量表评估症状严重程度。结果治疗后,观察组在血清功能相关指标方面表现出显著改善,具体表现为ALT、AST、ALP、DBIL和AFP含量显著低于对照组(P<0.05)。在生命质量评分方面,观察组在躯体功能、症状/副作用和社会功能评分上均显著优于对照组(P<0.05)。在中医症状分级方面,观察组中医症状分级为轻度和中度的患者占比明显多于对照组(P<0.05)。在安全性评估中,观察组出现不良反应的患者数亦显著少于对照组(P<0.05)。结论本研究表明了协日嘎四味汤散联合加味柴芍六君汤在原发性肝癌微创消融术后的治疗中具有一定疗效。
