ASYMPTOTIC PROPERTIES OF ESTIMATORS IN PARTIALLY LINEAR SINGLE-INDEX MODEL FOR LONGITUDINAL DATA

In this article, a partially linear single-index model /or longitudinal data is investigated. The generalized penalized spline least squares estimates of the unknown parameters are suggested. All parameters can be estimated simultaneously by the proposed method while the feature of longitudinal data is considered. The existence, strong consistency and asymptotic normality of the estimators are proved under suitable conditions. A simulation study is conducted to investigate the finite sample performance of the proposed method. Our approach can also be used to study the pure single-index model for longitudinal data.

Empirical Likelihood Based Longitudinal Data Analysis

In longitudinal data analysis, our primary interest is in the estimation of regression parameters for the marginal expectations of the longitudinal responses, and the longitudinal correlation parameters are of secondary interest. The joint likelihood function for longitudinal data is challenging, particularly due to correlated responses. Marginal models, such as generalized estimating equations (GEEs), have received much attention based on the assumption of the first two moments of the data and a working correlation structure. The confidence regions and hypothesis tests are constructed based on the asymptotic normality. This approach is sensitive to the misspecification of the variance function and the working correlation structure which may yield inefficient and inconsistent estimates leading to wrong conclusions. To overcome this problem, we propose an empirical likelihood (EL) procedure based on a set of estimating equations for the parameter of interest and discuss its characteristics and asymptotic properties. We also provide an algorithm based on EL principles for the estimation of the regression parameters and the construction of its confidence region. We have applied the proposed method in two case examples.

Transition Logic Regression Method to Identify Interactions in Binary Longitudinal Data

Logic regression is an adaptive regression method which searches for Boolean (logic) combinations of binary variables that best explain the variability in the outcome, and thus, it reveals interaction effects which are associated with the response. In this study, we extended logic regression to longitudinal data with binary response and proposed “Transition Logic Regression Method” to find interactions related to response. In this method, interaction effects over time were found by Annealing Algorithm with AIC (Akaike Information Criterion) as the score function of the model. Also, first and second orders Markov dependence were allowed to capture the correlation among successive observations of the same individual in longitudinal binary response. Performance of the method was evaluated with simulation study in various conditions. Proposed method was used to find interactions of SNPs and other risk factors related to low HDL over time in data of 329 participants of longitudinal TLGS study.

ROBUST ESTIMATION IN PARTIAL LINEAR MIXED MODEL FOR LONGITUDINAL DATA

In this article, robust generalized estimating equation for the analysis of partial linear mixed model for longitudinal data is used. The authors approximate the nonparametric function by a regression spline. Under some regular conditions, the asymptotic properties of the estimators are obtained. To avoid the computation of high-dimensional integral, a robust Monte Carlo Newton-Raphson algorithm is used. Some simulations are carried out to study the performance of the proposed robust estimators. In addition, the authors also study the robustness and the efficiency of the proposed estimators by simulation. Finally, two real longitudinal data sets are analyzed.

Trends and characteristics of enrolment in the National Health Insurance Scheme in Ghana:a quantitative analysis of longitudinal data

Background:In 2004,Ghana started experimenting a National Health Insurance Scheme(NHIS)to reduce out-ofpocket payment for healthcare.Like many other social health insurance schemes in Africa,the NHIS is striving for universal health coverage(UHC).This paper examines trends and characteristics of enrolment in the scheme to inform policy decisions on attainment of UHC.Methods:We conducted trend analysis of longitudinal enrolment data of the NHIS for the period,2010-2017.Descriptive statistics were used to examine trends and characteristics of enrolment by geographical region and member groups.Results:Over the 8-year period,the population enrolled in the scheme increased from 33%(8.2 million)to 41%(11.3 million)between 2010 and 2015 and dropped to 35%(10.3 million)in 2017.Members who renewed their membership increased from 44%to 75.4%between 2010 and 2013 and then dropped to 73%in 2017.On average,the urban regions had significantly higher number of new enrolments than the rural ones.Similarly,the urban and peri-urban regions recorded significantly higher number of renewals than the other regions.In addition,persons below the age of 18 years and the informal sector workers had significantly higher number of enrolment than any other member group.Conclusions:Enrolment in the NHIS is declining and there are significant differences among geographical regions and member groups.Managers of the NHIS need to enforce the mandatory enrolment provision in the Act governing the scheme,employ innovative strategies such as mobile phone application for registration and renewals and address delays in healthcare provider claims to improve enrolment.

Partial Linear Model Averaging Prediction for Longitudinal Data

Prediction plays an important role in data analysis.Model averaging method generally provides better prediction than using any of its components.Even though model averaging has been extensively investigated under independent errors,few authors have considered model averaging for semiparametric models with correlated errors.In this paper,the authors offer an optimal model averaging method to improve the prediction in partially linear model for longitudinal data.The model averaging weights are obtained by minimizing criterion,which is an unbiased estimator of the expected in-sample squared error loss plus a constant.Asymptotic properties,including asymptotic optimality and consistency of averaging weights,are established under two scenarios:(i)All candidate models are misspecified;(ii)Correct models are available in the candidate set.Simulation studies and an empirical example show that the promise of the proposed procedure over other competitive methods.

Empirical likelihood-based inference in a partially linear model for longitudinal data

A partially linear model with longitudinal data is considered, empirical likelihood to infer- ence for the regression coefficients and the baseline function is investigated, the empirical log-likelihood ratios is proven to be asymptotically chi-squared, and the corresponding confidence regions for the pa- rameters of interest are then constructed. Also by the empirical likelihood ratio functions, we can obtain the maximum empirical likelihood estimates of the regression coefficients and the baseline function, and prove the asymptotic normality. The numerical results are conducted to compare the performance of the empirical likelihood and the normal approximation-based method, and a real example is analysed.

Generalized Empirical Likelihood Inference in Semiparametric Regression Model for Longitudinal Data

In this paper, we consider the semiparametric regression model for longitudinal data. Due to the correlation within groups, a generalized empirical log-likelihood ratio statistic for the unknown parameters in the model is suggested by introducing the working covariance matrix. It is proved that the proposed statistic is asymptotically standard chi-squared under some suitable conditions, and hence it can be used to construct the confidence regions of the parameters. A simulation study is conducted to compare the proposed method with the generalized least squares method in terms of coverage accuracy and average lengths of the confidence intervals.

Average Estimation of Semiparametric Models for High-Dimensional Longitudinal Data

Model average receives much attention in recent years.This paper considers the semiparametric model averaging for high-dimensional longitudinal data.To minimize the prediction error,the authors estimate the model weights using a leave-subject-out cross-validation procedure.Asymptotic optimality of the proposed method is proved in the sense that leave-subject-out cross-validation achieves the lowest possible prediction loss asymptotically.Simulation studies show that the performance of the proposed model average method is much better than that of some commonly used model selection and averaging methods.

Reducing component estimation for varying coefficient models with longitudinal data

Varying-coefficient models with longitudinal observations are very useful in epidemiology and some other practical fields.In this paper,a reducing component procedure is proposed for es- timating the unknown functions and their derivatives in very general models,in which the unknown coefficient functions admit different or the same degrees of smoothness and the covariates can be time- dependent.The asymptotic properties of the estimators,such as consistency,rate of convergence and asymptotic distribution,are derived.The asymptotic results show that the asymptotic variance of the reducing component estimators is smaller than that of the existing estimators when the coefficient functions admit different degrees of smoothness.Finite sample properties of our procedures are studied through Monte Carlo simulations.

A moving average Cholesky factor model in joint mean-covariance modeling for longitudinal data

Modeling the mean and covariance simultaneously is a common strategy to efficiently estimate the mean parameters when applying generalized estimating equation techniques to longitudinal data. In this article, using generalized estimation equation techniques, we propose a new kind of regression models for parameterizing covariance structures. Using a novel Cholesky factor, the entries in this decomposition have moving average and log innovation interpretation and are modeled as the regression coefficients in both the mean and the linear functions of covariates. The resulting estimators for eovarianee are shown to be consistent and asymptotically normally distributed. Simulation studies and a real data analysis show that the proposed approach yields highly efficient estimators for the parameters in the mean, and provides parsimonious estimation for the covariance structure.

Local asymptotic behavior of regression splines for marginal semiparametric models with longitudinal data

In this paper, we study the local asymptotic behavior of the regression spline estimator in the framework of marginal semiparametric model. Similarly to Zhu, Fung and He (2008), we give explicit expression for the asymptotic bias of regression spline estimator for nonparametric function f. Our results also show that the asymptotic bias of the regression spline estimator does not depend on the working covariance matrix, which distinguishes the regression splines from the smoothing splines and the seemingly unrelated kernel. To understand the local bias result of the regression spline estimator, we show that the regression spline estimator can be obtained iteratively by applying the standard weighted least squares regression spline estimator to pseudo-observations. At each iteration, the bias of the estimator is unchanged and only the variance is updated.

Empirical Likelihood Analysis of Longitudinal Data Involving Within-subject Correlation

In this paper we use profile empirical likelihood to construct confidence regions for regression coefficients in partially linear model with longitudinal data. The main contribution is that the within-subject correlation is considered to improve estimation efficiency. We suppose a semi-parametric structure for the covariances of observation errors in each subject and employ both the first order and the second order moment conditions of the observation errors to construct the estimating equations. Although there are nonparametric variable in distribution after estimators, the empirical log-likelihood ratio statistic still tends to a standard Xp2 the nuisance parameters are profiled away. A data simulation is also conducted.

Model Detection and Variable Selection for Varying Coefficient Models with Longitudinal Data

In this puper, we consider the problem of variabie selection and model detection in varying coefficient models with longitudinM data. We propose a combined penalization procedure to select the significant variables, detect the true structure of the model and estimate the unknown regression coefficients simultaneously. With appropriate selection of the tuning parameters, we show that the proposed procedure is consistent in both variable selection and the separation of varying and constant coefficients, and the penalized estimators have the oracle property. Finite sample performances of the proposed method are illustrated by some simulation studies and the real data analysis.

Empirical Likelihood for Partially Linear Errors-in-variables Models with Longitudinal Data

Empirical likelihood inference for partially linear errors-in-variables models with longitudinal data is investigated.Under regularity conditions,it is shown that the empirical log-likelihood ratio at the true parameters converges to the standard Chi-squared distribution.Furthermore,we consider some estimates of the unknown parameter and the resulting estimators are shown to be asymptotically normal.Some simulations and a real data analysis are given to illustrate the performance of the proposed method.

Composite Quantile Regression Estimation for Left Censored Response Longitudinal Data

For left censored response longitudinal data, we propose a composite quantile regression estimator（CQR） of regression parameter. Statistical properties such as consistency and asymptotic normality of CQR are studied under relaxable assumptions of correlation structure of error terms. The performance of CQR is investigated via simulation studies and a real dataset analysis.

Double Penalized Variable Selection Procedure for Partially Linear Models with Longitudinal Data

Based on the double penalized estimation method,a new variable selection procedure is proposed for partially linear models with longitudinal data.The proposed procedure can avoid the effects of the nonparametric estimator on the variable selection for the parameters components.Under some regularity conditions,the rate of convergence and asymptotic normality of the resulting estimators are established.In addition,to improve efficiency for regression coefficients,the estimation of the working covariance matrix is involved in the proposed iterative algorithm.Some simulation studies are carried out to demonstrate that the proposed method performs well.

Weighted estimating equation： modified GEE in longitudinal data analysis

The method of generalized estimating equations （GEE） introduced by K. Y. Liang and S. L. Zeger has been widely used to analyze longitudinal data. Recently, this method has been criticized for a failure to protect against misspecification of working correlation models, which in some cases leads to loss of efficiency or infeasibility of solutions. In this paper, we present a new method named as ＇weighted estimating equations （WEE）＇ for estimating the correlation parameters. The new estimates of correlation parameters are obtained as the solutions of these weighted estimating equations. For some commonly assumed correlation structures, we show that there exists a unique feasible solution to these weighted estimating equations regardless the correlation structure is correctly specified or not. The new feasible estimates of correlation parameters are consistent when the working correlation structure is correctly specified. Simulation results suggest that the new method works well in finite samples.

PARAMETER ESTIMATION IN LINEAR REGRESSION MODELS FOR LONGITUDINAL CONTAMINATED DATA

The parameter estimation and the coefficient of contamination for the regression models with repeated measures are studied when its response variables are contaminated by another random variable sequence.Under the suitable conditions it is proved that the estimators which are established in the paper are strongly consistent estimators.

Sleep quality and mental health of the elderly in China: evidence from longitudinal data

Against a macro backdrop of accelerating population aging,the mental health and sleep quality of China’s elderly have become subjects of interest because these fac-tors are both closely linked to seniors’quality of life.Based on multi-period track-ing data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS),this study uses a fixed-effects model to examine the correlation between the sleep quality and mental health of China’s elderly and found that:(1)the elderly in China gener-ally had good sleep quality and mental health;(2)better sleep quality has a posi-tive effect on the mental health of the elderly,while better mental health also posi-tively boosts sleep quality of the elderly;and(3)there may be a causal relationship between the sleep quality and mental health of the elderly.