This study was done to quality assure the Hawkeye SPECT/CT at the St. Olav’s hospital and create a clinical method for doing individual dosimetry with <sup>177</sup>Lu-octreotate in targeted radionuclide ...This study was done to quality assure the Hawkeye SPECT/CT at the St. Olav’s hospital and create a clinical method for doing individual dosimetry with <sup>177</sup>Lu-octreotate in targeted radionuclide therapy for neuroendocrine tumors. Various quality control parameters were performed on Infinia Hawkeye SPECT/CT. A calibration dose of 160% ± 2% MBq was ordered and first calibrated for all the dose calibrators. The uniformity test was obtained using a 40 MBq Tc-99m point source positioned 2.5 m away from the two detectors. A 200 MBq Tc-99m was diluted in 70 ml of water, dispersed in six syringes for the registration test. A Lu-177 point source was placed in front of the detectors, one at a time, to check the energy peaks. The Jaczczak phantom with a hollow sphere set (volumes: 0.5, 1, 2, 4, 8, and 16) ml with an additional 60 ml sphere was used for the 3D sensitivity and recovery with Lu-177. Total activity of 945.3 MBq was added to 160 ml of water yielding an activity concentration of 5.908 MBq/ml in the spheres. The phantom was then scanned at various time intervals. A cylindrical phantom with a volume of 6283 ml was also used to obtain the cross-calibration measurement (cps/MBq). Total activity of 995.6 MBq was added and the phantom was scanned at days 0, 6, 13 and 23. The dose calibration factor was changed from 762 to 760 to achieve correct doses. The 2D mean sensitivity factor was 5.56 cps/MBq. Uniformities for both detectors were approved after iteration calibration of the PM tubes. The X-ray to SPECT registration was found to be accurate and within specifications. The energy peak test revealed off-centered 208 keV energy peaks for the two detectors. Quality assurance of imaging devices using radiation is essential for radiation protection and ensures a high-quality image.展开更多
^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-...^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-PSMA放射性配体疗法在前列腺癌临床应用中的专家共识。展开更多
This article presents a case of a patient with relapsed esthesioneuroblastoma (ENB), an aggressive rare tumor that arises from the specialized sensory epithelial olfactory cells in the skull base area, which was initi...This article presents a case of a patient with relapsed esthesioneuroblastoma (ENB), an aggressive rare tumor that arises from the specialized sensory epithelial olfactory cells in the skull base area, which was initially treated with endoscopic surgery, followed by adjuvant radiotherapy. After local relapse, new surgical approaches and subsequent lines of platin-based chemotherapy were performed. A PET-CT with <sup>68</sup>GALIUM DOTATATOC (PET-DOTATOC) showed intense uptake of disease, compatible with the presence of somatostatin receptors, in the face, nodes, liver, bones, and meningeal area. Treatment with 4 cycles of <sup>177</sup>Lutetium-Dotatate was performed, followed by maintenance octreotide, with a major radiological and clinical response that is lasting more than 1 year after treatment. This article describes a rare case of a skull-base tumor, with multiple recurrences, in which disease control was achieved with a targeted Peptide Receptor Radionuclide Therapy (PRRT) with <sup>177</sup>Lutetium-Dotatate, and discusses factors that could influence the incorporation of this form of therapy. Previous case reports proved the potential efficacy of this therapy usually given for low-grade neuroendocrine tumors and will be carefully reviewed.展开更多
用离子液体([BSMIm]HSO4、[BSMIm]OTF)代替硫酸进行4,4'-二氨基-1,1'-二蒽醌-3,3'-二磺酸钠(简称DAS)脱磺酸基反应制备颜料红177,考察了离子液体的酸度、离子液体的加入量、反应时间、反应温度及离子液体的循环套用对颜料红...用离子液体([BSMIm]HSO4、[BSMIm]OTF)代替硫酸进行4,4'-二氨基-1,1'-二蒽醌-3,3'-二磺酸钠(简称DAS)脱磺酸基反应制备颜料红177,考察了离子液体的酸度、离子液体的加入量、反应时间、反应温度及离子液体的循环套用对颜料红177收率的影响。离子液体的酸度可以满足DAS脱磺酸基的酸度要求,且离子液体循环套用方便,并且减少工业废水的排放,是一种环境友好的合成工艺。较适宜的工艺条件为:2.0 g DAS,10 g[BSMIm]OTF,反应温度150℃,反应时间5 h,[BSMIm]OTF经二氯甲烷萃取提纯后可至少循环利用6次,颜料红177平均收率为92.3%。展开更多
文摘This study was done to quality assure the Hawkeye SPECT/CT at the St. Olav’s hospital and create a clinical method for doing individual dosimetry with <sup>177</sup>Lu-octreotate in targeted radionuclide therapy for neuroendocrine tumors. Various quality control parameters were performed on Infinia Hawkeye SPECT/CT. A calibration dose of 160% ± 2% MBq was ordered and first calibrated for all the dose calibrators. The uniformity test was obtained using a 40 MBq Tc-99m point source positioned 2.5 m away from the two detectors. A 200 MBq Tc-99m was diluted in 70 ml of water, dispersed in six syringes for the registration test. A Lu-177 point source was placed in front of the detectors, one at a time, to check the energy peaks. The Jaczczak phantom with a hollow sphere set (volumes: 0.5, 1, 2, 4, 8, and 16) ml with an additional 60 ml sphere was used for the 3D sensitivity and recovery with Lu-177. Total activity of 945.3 MBq was added to 160 ml of water yielding an activity concentration of 5.908 MBq/ml in the spheres. The phantom was then scanned at various time intervals. A cylindrical phantom with a volume of 6283 ml was also used to obtain the cross-calibration measurement (cps/MBq). Total activity of 995.6 MBq was added and the phantom was scanned at days 0, 6, 13 and 23. The dose calibration factor was changed from 762 to 760 to achieve correct doses. The 2D mean sensitivity factor was 5.56 cps/MBq. Uniformities for both detectors were approved after iteration calibration of the PM tubes. The X-ray to SPECT registration was found to be accurate and within specifications. The energy peak test revealed off-centered 208 keV energy peaks for the two detectors. Quality assurance of imaging devices using radiation is essential for radiation protection and ensures a high-quality image.
文摘^(177)Lu标记的前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)放射性配体疗法已在国外获批应用于晚期前列腺癌治疗,且正在国内开展多项临床试验。专家组参考国外经验和观点,并结合国内临床实践和实测数据,形成^(177)Lu-PSMA放射性配体疗法在前列腺癌临床应用中的专家共识。
文摘This article presents a case of a patient with relapsed esthesioneuroblastoma (ENB), an aggressive rare tumor that arises from the specialized sensory epithelial olfactory cells in the skull base area, which was initially treated with endoscopic surgery, followed by adjuvant radiotherapy. After local relapse, new surgical approaches and subsequent lines of platin-based chemotherapy were performed. A PET-CT with <sup>68</sup>GALIUM DOTATATOC (PET-DOTATOC) showed intense uptake of disease, compatible with the presence of somatostatin receptors, in the face, nodes, liver, bones, and meningeal area. Treatment with 4 cycles of <sup>177</sup>Lutetium-Dotatate was performed, followed by maintenance octreotide, with a major radiological and clinical response that is lasting more than 1 year after treatment. This article describes a rare case of a skull-base tumor, with multiple recurrences, in which disease control was achieved with a targeted Peptide Receptor Radionuclide Therapy (PRRT) with <sup>177</sup>Lutetium-Dotatate, and discusses factors that could influence the incorporation of this form of therapy. Previous case reports proved the potential efficacy of this therapy usually given for low-grade neuroendocrine tumors and will be carefully reviewed.
文摘用离子液体([BSMIm]HSO4、[BSMIm]OTF)代替硫酸进行4,4'-二氨基-1,1'-二蒽醌-3,3'-二磺酸钠(简称DAS)脱磺酸基反应制备颜料红177,考察了离子液体的酸度、离子液体的加入量、反应时间、反应温度及离子液体的循环套用对颜料红177收率的影响。离子液体的酸度可以满足DAS脱磺酸基的酸度要求,且离子液体循环套用方便,并且减少工业废水的排放,是一种环境友好的合成工艺。较适宜的工艺条件为:2.0 g DAS,10 g[BSMIm]OTF,反应温度150℃,反应时间5 h,[BSMIm]OTF经二氯甲烷萃取提纯后可至少循环利用6次,颜料红177平均收率为92.3%。
