一种基于Mediator模式的角色实现方法

介绍一种基于Mediator模式的角色实现方法及其原型实现(Rava)。讨论了角色和面向方面程序设计(Aspect-Oriented Programming,AOP)中Aspect的异同点以及使用Rava实现动态AOP的方法,从而在实现层统一了角色和Aspect两个概念。

基于Mediator模式的参数控制法

人机交互语言工具是电信网管的重要组成部分,是网管系统中使用频率最高的模块之一,命令参数的显示控制是它的实现难点.基于Mediator模式的参数控制法分离了参数表示和逻辑控制,它让每个参数专心处理自身表示,由中介者控制显示逻辑,解除了参数间的耦合关系.这种实现方法,集中了对参数的控制,减少了耦合,有利于各参数的复用,易于逻辑关系扩展,提高了命令解析效率.实际测试表明,在PIII 1.0 G CPU环境下,解析一条命令的平均时间只需0.14 s.该方法为开发网管人机交互语言工具或处理对象强耦合问题提供了一种有参考价值的实现方法.

Mediator模式在登录界面中的应用

设计模式是人们总结出来的经验,它描述了对象之间如何通信,提高了代码复用率。以Mediator模式为例,具体介绍了Mediator模式在GUI登录界面设计中的应用。

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

低空经济的内涵、特征和运行模式

低空经济作为低空飞行活动与产业融合的新型综合性经济形态,具有空间立体性、区域依赖性、数字生态性、产业融合性以及辐射带动性等特征。党和政府高度重视发展低空经济,将其确定为国家战略性新兴产业,各地加紧布局,发展势头良好。但具体实践中仍存在发展低空经济的体制机制不畅、技术创新支持不足、新型基础设施不全、产业领域需不断拓展等问题。针对上述问题,文本依据螺旋理论,提出“政产学研金服用”的低空经济开放式创新生态模式。

基于一观两性三模式的中医药英语线上教学模式实践

疫情常态化背景下,为培养高等院校中医药复合型外向人才,此研究主要采用“一观两性三模式”的线上教学模式对中医药英语教学内容和教学方式进行改革。文章从完善线上教学资源、调整在线教学模式、教学改革拟解决重点问题、课程特色与亮点及教学反思5个方面进行论述,以期改进此课程的在线教学模式,进而提高教学效果。“一观两性三模式”教学模式有助于提升学生中医药英语能力,帮助其树立民族文化自信,培养国际化中医药人才,从而助力中医药文化的对外传播。

乡村康养旅游的发展模式及现实路径——以盐城为例

乡村旅游和康养产业融合而生的乡村康养旅游是我国贯彻乡村振兴和健康中国两大战略的绝佳选择。乡村康养旅游发展的主要模式有优势资源依托型、特色文化驱动型、康疗服务植入型以及乡村康养综合型四类。文章认为,盐城具备乡村康养旅游发展的良好条件和一定基础,优势资源依托型和特色文化驱动型应是实现康养旅游全域发展的主要模式;盐城乡村康养旅游发展应坚持“点线面”相结合的现实路径,以“点”发力做到“点上出彩”,以“线”延伸坚持“线上联动”,以“面”覆盖实现“面上开花”。

Heterostructured nickel-cobalt metal alloy and metal oxide nanoparticles as a polysulfide mediator for stable lithium-sulfur full batteries with lean electrolyte

Batteries that utilize low-cost elemental sulfur and light metallic lithium as electrodes have great potential in achieving high energy density.However,building a lithium-sulfur(Li-S)full battery by controlling the electrolyte volume generally produces low practical energy because of the limited electrochemical Li-S redox.Herein,the high energy/high performance of a Li-S full battery with practical sulfur loading and minimum electrolyte volume is reported.A unique hybrid architecture configured with Ni-Co metal alloy(NiCo)and metal oxide(NiCoO_(2))nanoparticles heterogeneously anchored in carbon nanotube-embedded selfstanding carbon matrix is fabricated as a host for sulfur.This work demonstrates the considerable improvement that the hybrid structure's high conductivity and satisfactory porosity promote the transport of electrons and lithium ions in Li-S batteries.Through experimental and theoretical validations,the function of NiCo and NiCoO_(2) nanoparticles as an efficient polysulfide mediator is established.These particles afford polysulfide anchoring and catalytic sites for Li-S redox reaction,thus improving the redox conversion reversibility.Even at high sulfur loading,the nanostructured Ni-Co metal alloy and metal oxide enable to have stable cycling performance under lean electrolyte conditions both in half-cell and full-cell batteries using a graphite anode.

Strong Interaction Between Redox Mediators and Defect-Rich Carbons Enabling Simultaneously Boosted Voltage Windows and Capacitance for Aqueous Supercapacitors

Energy density,the Achilles’heel of aqueous supercapacitors,is simultaneously determined by the voltage window and specific capacitance of the carbon materials,but the strategy of synchronously boosting them has rarely been reported.Herein,we demonstrate that the rational utilization of the interaction between redox mediators(RMs)and carbon electrode materials,especially those with rich intrinsic defects,contributes to extended potential windows and more stored charges concurrently.Using 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxyl(4OH-TEMPO)and intrinsic defect-rich carbons as the RMs and electrode materials,respectively,the potential window and capacitance are increased by 67%and sixfold in a neutral electrolyte.Moreover,this strategy could also be applied to alkaline and acid electrolytes.The first-principle calculation and experimental results demonstrate that the strong interaction between 4OH-TEMPO and defectrich carbons plays a key role as preferential adsorbed RMs may largely prohibit the contact of free water molecules with the electrode materials to terminate the water splitting at elevated potentials.For the RMs offering weaker interaction with the electrode materials,the water splitting still proceeds with a thus sole increase of the stored charges.The results discovered in this work could provide an alternative solution to address the low energy density of aqueous supercapacitors.

Mediator设计模式的研究与改进

设计模式是和编程语言相关的。一般情况下的设计模式可以适用于大部分的编程语言,特定的编程语言可以改进设计模式的效果。对C#的语言特色和中介者设计模式进行了研究,并且根据各同事类间作用的不同,提出了将中介者类分割为两个互不影响的类的改进方法,以期尽量减轻中介者作为"万能类"的负担。最后用C#实现了一个用代理改进的中介者设计模式的简单例子。

职业教育产学研协同创新模式的构建与应用研究

随着科技的飞速发展和产业结构的不断调整,各行各业对人才的需求发生了深刻变化。传统的教育模式已难以满足当前企业对高素质、高技能人才的需求,产学研协同创新模式的提出,为职业教育与产业界的深度融合提供了新思路,有助于打破教育与产业之间的壁垒,促进人才培养与产业发展的有效对接。基于此,文章旨在深入探讨职业教育产学研协同创新模式,分析现有机制的优势与不足,并提出构建更为高效、灵活的协同创新模式的策略,以期为职业教育改革和产业升级提供理论支撑和实践指导。

Scarcity and Mental Health—Multiple Mediators of Sleep Quality and Life Satisfaction

Background:In the current social environment,scarcity,as a universally present objective state,profoundly impacts individuals’decision-making and health through the subjective feeling it induces,known as a“scarcity mindset.”Particularly,the feeling of scarcity related to money and sleep time is not only widespread but also directly linked to an individual’s mental health.Purpose:This study aims to delve into the relationship between the feeling of scarcity and mental health,with a specific focus on the relationship between the feeling of money scarcity or sleep time scarcity and mental health,as well as the role of sleep quality or life satisfaction in this relationship.Procedure:We determined the sampling quotas based on the population and economic development levels of each province in the“China Statistical Yearbook(2021)”(National Bureau of Statistics,2021).Participants were selected using the Probability Proportional to Size(PPS)sampling method.Data was collected by distributing online questionnaires to participants,and the relationships between the main variables were explored using structural equation modeling.Results:1.In China,the feeling of sleep time scarcity is stronger than the feeling of money scarcity among the public.2.The feeling of money scarcity is positively correlated with depression and anxiety,whereas the feeling of sleep time scarcity is only positively correlated with depression.3.The feeling of scarcity mainly leads to depression and self-denial through reducing life satisfaction,and it leads to anxiety through reducing sleep quality.Conclusion:The feeling of scarcity in money and sleep time is related to different dimensions of mental health.Therefore,reasonably planning financial allocation and ensuring an adequate amount of sleep can reduce the sense of scarcity,thereby improving mental health.Additionally,improving sleep quality and increasing life satisfaction can alleviate the adverse effects of scarcity on mental health.

基于师徒带训制的花艺课程教学模式探讨——以安徽城市管理职业学院为例

师徒带训制是针对现代学徒制的探讨,通过学校与企业合作育人,实现深度产教融合的创新型技术人才培养模式,适用于技能实践性和传承性较强的专业。而园林相关专业的花艺课程正是实践性、操作性比较强的课程,花艺课程主要包括东方插花、西方插花、现代花艺三大模块。通过师徒带训的方式,不仅有利于花艺课程技能的学习,还有助于传承和弘扬中国传统文化。基于师徒带训制,通过修订园林相关专业的人才培养方案,调整花艺课程体系、引入企业师傅、专业教师到企业挂职锻炼、与技能大赛和创业大赛结合、建立老带新团队等措施,对安徽城市管理职业学院花艺课程开展相关人才培养和教学模式的探索和实践。

Observation on Therapeutic Effect of Lotus Needle Cupping Therapy for Removing Blood Stasis in Zhuang Medicine on PHN and Its Influ-ence on Inflammatory Mediators

[Objectives]To observe the clinical effect of the lotus needle cupping therapy for removing blood stasis in Zhuang medicine in treating PHNand its influence on inflammatory factors.[Methods]96 patients with PHN were randomly divided into three groups:lotus nee-dle cupping therapy group,TCM surrounding acupuncture group and gabapentin group.Venous blood and acupoint blood were collected at 0,21 and 42 d of treatment,and the expression levels of 5-HT,SP and CGRPinflammatory mediators were detected before and after treatment.The changes of VAS scores before,during and after treatment and the clinical efficacy were observed.[Results]The total effective rate of the lotus needle cupping group was 87.50%,which was better than that of the TCM acupuncture group(81.25%)and the gabapentin group(62.50%);after treatment,the VAS scores and the expression of inflammatory mediators in the three groups of patients were lower than those before treatment,and the decrease was more significant in the treatment group(P<0.05).[Conclusions]The lotus needle cupping therapy for removing blood stasis in Zhuang medicine is effective in treating PHN,and its mechanism is to reduce the release of inflammatory media-tors,reduce hyperalgesia,relieve pain and improve the quality of life of patients.

新业态从业者职业伤害保险运作模式研究

数字经济的主要贡献在于催生一大波新就业形态,吸纳大量就业,以平台化、灵活性为特征的新就业形态已成为“稳就业”目标实现的重要载体。在这种新业态下,从业人员普遍缺乏工伤保险,从而在遭受职业风险伤害时无法获得合理有效的保障。为了维护该群体的社会保障权益,本文借鉴相关文献,参考江苏、浙江、山东等地区灵活就业人员职业伤害保险试点相关政策文件,分析当前试点地区新业态从业者职业伤害保险的运作模式,为建立政府承办、商业保险公司参与的具有社会保险属性的职业伤害保险模式提供经验证据。

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

甘蓝型油菜漆酶基因家族成员表达模式及与茎秆抗折力的关联分析

漆酶是一种含铜的多酚氧化酶家族,在植物中主要参与木质素合成以及抵御各种逆境胁迫。本研究对甘蓝型油菜漆酶基因(BnaLACs)家族成员进行鉴定,通过氨基酸数量、分子量、等电点、不稳定系数以及脂溶性系数等指标衡量其理化性质。后对其染色体位置、进化关系、基因结构、组织部位表达模式等进行预测和分析。结果表明,甘蓝型油菜基因组共有53个BnaLACs家族成员,基本为碱性、稳定蛋白,大多数BnaLACs定位在液泡膜和细胞外。基因结构分析发现, BnaLACs结构较为保守。组织部位表达模式分析表明,除花药外, BnaLACs在各组织部位均有表达,其中在根、种子、角果皮和茎秆中表达量较高。分析茎秆中BnaLAC4s表达模式发现,BnaA05G0074200ZS与甘蓝型油菜抗倒性显著相关;单倍型分析表明,包含BnaA05G0074200ZS两种单倍型的品系间抗倒性、木质素含量均存在显著差异。研究结果将为进一步解析甘蓝型油菜漆酶基因家族功能及茎秆抗倒伏机制奠定基础。

乡村旅游驱动乡村振兴的典型模式与经验启示

乡村旅游是全面推进乡村振兴的重要动力和有效抓手。通过文献分析,结合乡村旅游开发的主要驱动要素,总结提炼了我国乡村旅游驱动乡村振兴的三种典型模式,即资源带动型、政府推动型和集体策动型模式。选取湖南省双源村、罗潭村、青苗村三个乡村为典型案例,就不同驱动模式下的做法与成效进行比较,得出了乡村旅游驱动乡村振兴的三点启示:一是坚持村民主体地位,促进集体经济发展;二是坚持市场导向原则,推动乡村品牌塑造;三是坚持产业融合理念,实现乡村经济转型。

以培养临床操作能力为核心的教学模式在中医骨伤科学的应用

目的评价以培养临床操作能力为核心的教学模式在中医骨伤科学课堂的效果。方法将辽宁中医药大学2017级中医专业的两个班级分为实验组和对照组。实验组(30例)采用以培养临床操作能力为核心的教学模式,对于查体、正骨手法、夹板固定等操作类知识点,教师予以示范操作,学生进行角色扮演,分组进行操作演示,由学生评委评分、教师点评;而对照组(31例)则采用传统教学法。观察比较两组中医骨伤科学期末考试成绩的分段与平均分数情况,并对实验组进行问卷调查。结果实验组期末成绩的分段和平均分数情况均显著优于对照组(P<0.05)。对实验组的问卷调查结果表明以培养临床操作能力为核心的教学模式有助于提高学生的临床操作能力,具有一定的创新性。结论以培养临床操作能力为核心的教学模式优于传统教学,值得在中医骨伤科学教学中推广应用。

临床医学专业硕士教学模式探讨——基于SEMINAR上BOPPPS联合PAL教学模式

目的临床医学专业学位硕士研究生参与住院医师规范化培训,在此“双轨合一”模式下,探讨基于SEMINAR上BOPPPS联合PAL教学模式的作用和意义。方法入组我院2022年8月—2023年2月至科室规培轮转时长大于2月的50名研究生,1∶1随机分为2组,对照组进行传统培养,试验组采取新型教学模式。轮转结束后学员进行专题讲座或文献PPT汇报,MINI-CEX考试,填写满意度问卷调查表。结果试验组和对照组使用PPT汇报后评分,差异具有统计学意义(P<0.05);MINI-CEX考试成绩;对自己学习情况和带教老师的满意度评分,差异没有统计学意义(P>0.05)。结论住院医师规范化培训与临床医学专业学位硕士研究生教育“双轨合一”模式下,基于SEMINAR上BOPPPS+PAL教学模式更有利于培养学生主动学习、表达、使用工具等能力。