In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily ...In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018.展开更多
On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings...On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings are obtained. The results gained by caleulation in the paper are consistent with that measured in the field. And this provides a basis for the roadway sidepacking support design.展开更多
Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the q...Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the quality and efficiency have improved,and momentum of steady growth has been further consolidated.展开更多
In 2007, the national economy kept steady and fast growth with the features of rapid economic growth, optimized structure, increased efficiency and improved livelihood of the people.
Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at t...Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at the University of Science and Technology of China(USTC)and Yale University School of Medicine reveals an unexpected role of a protein called gasdermin D(GSDMD)in inducing immune tolerance to food in the small intestine.展开更多
With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chines...With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chinese Academy of Sciences,reported comparative analysis of bacterial communities in soils that have been subjected to 30years of chemical fertilization(NPK)with the addition of either cow manure,pig manure or wheat straw residues,which was published in Soil Biology&Biochemistry(2015,88:9—18).展开更多
Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade ...Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade depends on optimal recognition of tumor cells through the activation of receptors on antitumor effector immune cells,such as CD8^(+)T cells and NK cells.Therefore,sufficient and maintained expression levels of activating receptors on these effector immune cells are essential for antitumor immunity and checkpoint blockade immunotherapy.展开更多
When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene express...When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).展开更多
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental...Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.展开更多
Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE pr...Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.展开更多
Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formu...Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formula φ_N(x) in the展开更多
Homeostasis in internal environment and cellular metabolism ensures cells’ functions to be stable in living organisms. Neuronal spike encoding in the brain needs to be precise
In the year 2010,the exports and imports of Chinese textile machinery maintained rapid growth,owing to the industrial upgrading and a strong recovery in demand.
In 2007,the national economy kept steady and fast growth with the features of rapid economic growth,optimized structure,increased efficiency and improved livelihood of the people. According to preliminary estimation,t...In 2007,the national economy kept steady and fast growth with the features of rapid economic growth,optimized structure,increased efficiency and improved livelihood of the people. According to preliminary estimation,the gross domestic product (GDP)for the year was 24,661.9 billion yuan,up by 11.4 percent,or 0.3 percentage point higher than that in the previous year,represent-展开更多
HUNAN Province at one time was known as Chudi, which means the land of Chu. Every year, when the floods would come to Chudi, the local people would carry their stores out of the high mountains using a technique they c...HUNAN Province at one time was known as Chudi, which means the land of Chu. Every year, when the floods would come to Chudi, the local people would carry their stores out of the high mountains using a technique they called "fang pai," or rafting. It took about six months to carry a raftload of goods down the mountain,展开更多
Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst s...Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst stimulation(iTBS)is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD.However,the long-term effects of iTBS on cognitive decline and brain structure in patients with AD areunknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised,assessor-blinded,controlled trial,iTBS was administered to the left dorsolateral prefrontal cortex(DLPFC)of 42 patients with AD for 14days every 13weeks.Measurements included the Montreal Cognitive Assessment(MoCA),a comprehensive neuropsychological battery,and the grey matter volume(GMV)of the hippocampus.Patients were evaluated at baseline and after follow-up.The longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over time.Results The iTBS group maintained MoCA scores relative to the control group(t=3.26,p=0.013)and reduced hippocampal atrophy,which was significantly correlated with global degeneration scale changes.The baseline Mini-Mental State Examination(MMSE)score,apolipoprotein E genotype and Clinical Dementia Rating were indicative of MoCA scores at follow-up.Moreover,the GMV of the left(t=0.08,p=0.996)and right(t=0.19,p=0.977)hippocampus were maintained in the active group but significantly declined in the control group(left:t=4.13,p<0.001;right:t=5.31,p<0.001).GMV change in the left(r=0.35,p=0.023)and right(r=0.36,p=0.021)hippocampus across the intervention positively correlated with MoCA changes;left hippocampal GMV change was negatively correlated with global degeneration scale(r=-0.32,p=0.041)changes.Conclusions DLPFC-iTBS maybe a feasible and easy-to-implement non-pharmacological intervention to slow down the progressive decline of overall cognition and quality of life in patients with AD,providing a new AD treatment option.Trial registration number NCT04754152.展开更多
AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodie...AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.展开更多
AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FA0.It embodie...AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FA0.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.展开更多
AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodie...AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.展开更多
It has been 24 years since the first Ministerial Conference of the Forum on China-Africa Cooperation(FOCAC)was held.At that time,China’s economy was the sixth largest in the world,while South Africa,the most moderniz...It has been 24 years since the first Ministerial Conference of the Forum on China-Africa Cooperation(FOCAC)was held.At that time,China’s economy was the sixth largest in the world,while South Africa,the most modernized African economy,ranked only 30th.Following its accession to the WTO in 2001,China entered a period of rapid economic development.In 2009,one year before surpassing Japan to become the world’s second-largest economy,China became Africa’s la rgest trading partner-a position it has maintained ever since.Commodities,raw materials,and agricultural products are the primary exports from Africa to China,while China predominantly exports mechanical and electrical goods to Africa.展开更多
文摘In the first two months of 2019,the economy performed within the reasonable range and maintained a generally stable and growing momentum;a positive trend has gradually been unveiled.The service industry grew steadily and the modern service industry developed fast In the first two months, the Index of Services Production increased by 7.3%year on year, maintaining the same speed as in December 2018.
文摘On the basis of practice this paper studies the effect mechanism of roadway sidepackings of sing-cement material with high water content, the mechanical model and formula for caleulating the parameters of sidepackings are obtained. The results gained by caleulation in the paper are consistent with that measured in the field. And this provides a basis for the roadway sidepacking support design.
文摘Imports and exports In the period of January-October,Chinese imports and exports have maintained rapid growth,the structure has continued to be optimized,the transformation of growth drivers has been accelerated,the quality and efficiency have improved,and momentum of steady growth has been further consolidated.
文摘In 2007, the national economy kept steady and fast growth with the features of rapid economic growth, optimized structure, increased efficiency and improved livelihood of the people.
文摘Eating a meal normally doesn’t trigger an inflammatory immune reaction,but how the body maintains tolerance to food has been unclear.Now,a new study published in Cell(doi:10.1016/j.cell.2023.05.027)by scientists at the University of Science and Technology of China(USTC)and Yale University School of Medicine reveals an unexpected role of a protein called gasdermin D(GSDMD)in inducing immune tolerance to food in the small intestine.
文摘With the support by the National Natural Science Foundation of China and the Strategic Priority Research Program of the Chinese Academy of Sciences,Prof.Chu Haiyan’s laboratory at the Institute of Soil Science,Chinese Academy of Sciences,reported comparative analysis of bacterial communities in soils that have been subjected to 30years of chemical fertilization(NPK)with the addition of either cow manure,pig manure or wheat straw residues,which was published in Soil Biology&Biochemistry(2015,88:9—18).
基金This work was supported by the National Key R&D Program of China(2020YFA0710802)the Natural Science Foundation of China(reference number 82071768).
文摘Inhibitory receptors expressed on the immune cell surface have emerged as checkpoint molecules that could be therapeutically targeted for tumor immunotherapy.However,antitumor immunity mediated by checkpoint blockade depends on optimal recognition of tumor cells through the activation of receptors on antitumor effector immune cells,such as CD8^(+)T cells and NK cells.Therefore,sufficient and maintained expression levels of activating receptors on these effector immune cells are essential for antitumor immunity and checkpoint blockade immunotherapy.
基金supported by the National Key R&D Program of China(2019YFA0802501)the National Natural Science Foundation of China(31770843,31971231)。
文摘When certain genes are exposed to repeated stimuli, they can be rapidly reactivated after prior expression and show enhanced expression signals, known as transcriptional memory. Such reinduction memory of gene expression is an essential adaptation to the recurring environmental changes, which facilitates divergent organisms evolve the capacity to reduce the need for genetic fitness(New et al., 2014).
基金supported by funds from the Italian Ministry of Health,Ricerca Finalizzata,(Grant N.GR-2013-02355882 and GR-2021-12373946 to AL)5x1000 Project of the Istituto Superiore di Sanità(Project code:ISS5x1000_21-949432e8c9be to AL)the European Union–NextGeneration EU through the Italian Ministry of University and Research under PNRR-M4C2-I1.3 Project PE_00000019“HEAL ITALIA”to EA(CUP I83C22001830006)。
文摘Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.
基金supported by core funding provided by Temasek Life Sciences Laboratory(to CTO)。
文摘Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.
文摘Based on the birth and death process, Gu Xun et al., (1987) inferred a frequency distribution density function φ(x) of the neutral genes maintained in a nonsynchronized population, and obtained a corresponding formula φ_N(x) in the
基金granted by National Award for Outstanding Young Scientist (30325021)National Basic Research Program (2006CB500804)+1 种基金NSFC (30870517 and 30621130077)CAS Program for Knowledge Innovation (KSCX2-YWR-39)
文摘Homeostasis in internal environment and cellular metabolism ensures cells’ functions to be stable in living organisms. Neuronal spike encoding in the brain needs to be precise
文摘In the year 2010,the exports and imports of Chinese textile machinery maintained rapid growth,owing to the industrial upgrading and a strong recovery in demand.
文摘In 2007,the national economy kept steady and fast growth with the features of rapid economic growth,optimized structure,increased efficiency and improved livelihood of the people. According to preliminary estimation,the gross domestic product (GDP)for the year was 24,661.9 billion yuan,up by 11.4 percent,or 0.3 percentage point higher than that in the previous year,represent-
文摘HUNAN Province at one time was known as Chudi, which means the land of Chu. Every year, when the floods would come to Chudi, the local people would carry their stores out of the high mountains using a technique they called "fang pai," or rafting. It took about six months to carry a raftload of goods down the mountain,
基金the National Natural Science Foundation of China(No.82101498 to XW)STI2030-Major Prjects of China(No.20212D0201801 to PH)+1 种基金National Natural Science Foundation of China(No.82171917 to PH,No.82090034 and 31970979 to KW and 32071054 to YT)the 2021 Youth Foundation Training Program of the First Affiliated Hospital of Anhui Medical University(No.2021kj19 to XW).
文摘Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst stimulation(iTBS)is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD.However,the long-term effects of iTBS on cognitive decline and brain structure in patients with AD areunknown.Aims We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.Methods In this randomised,assessor-blinded,controlled trial,iTBS was administered to the left dorsolateral prefrontal cortex(DLPFC)of 42 patients with AD for 14days every 13weeks.Measurements included the Montreal Cognitive Assessment(MoCA),a comprehensive neuropsychological battery,and the grey matter volume(GMV)of the hippocampus.Patients were evaluated at baseline and after follow-up.The longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over time.Results The iTBS group maintained MoCA scores relative to the control group(t=3.26,p=0.013)and reduced hippocampal atrophy,which was significantly correlated with global degeneration scale changes.The baseline Mini-Mental State Examination(MMSE)score,apolipoprotein E genotype and Clinical Dementia Rating were indicative of MoCA scores at follow-up.Moreover,the GMV of the left(t=0.08,p=0.996)and right(t=0.19,p=0.977)hippocampus were maintained in the active group but significantly declined in the control group(left:t=4.13,p<0.001;right:t=5.31,p<0.001).GMV change in the left(r=0.35,p=0.023)and right(r=0.36,p=0.021)hippocampus across the intervention positively correlated with MoCA changes;left hippocampal GMV change was negatively correlated with global degeneration scale(r=-0.32,p=0.041)changes.Conclusions DLPFC-iTBS maybe a feasible and easy-to-implement non-pharmacological intervention to slow down the progressive decline of overall cognition and quality of life in patients with AD,providing a new AD treatment option.Trial registration number NCT04754152.
文摘AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.
文摘AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FA0.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.
文摘AGRIS(The Agricultural Sciences and Technology)is a booklist-style international agricultural database which is established by the international agricultural technology information system subordinate to FAO.It embodies continued publications,documents,corpuses,books,technology reports,patents,maps,meeting papers,and other literatures,which are collected by 135 countries and regions,146 branches of AGRIS,and 22 international organizations.Its content comprises all the agricultural fields in the world,as well as forestry,economy,aquatic sciences,fishery,human dietetics,and so on.This database is an international intelligence communication system maintained by FAO,which updates quarterly and increases by 0.13 million records annually,with large data amount.
文摘It has been 24 years since the first Ministerial Conference of the Forum on China-Africa Cooperation(FOCAC)was held.At that time,China’s economy was the sixth largest in the world,while South Africa,the most modernized African economy,ranked only 30th.Following its accession to the WTO in 2001,China entered a period of rapid economic development.In 2009,one year before surpassing Japan to become the world’s second-largest economy,China became Africa’s la rgest trading partner-a position it has maintained ever since.Commodities,raw materials,and agricultural products are the primary exports from Africa to China,while China predominantly exports mechanical and electrical goods to Africa.