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Controlled Drying Effect on the Quality of Sorghum Malts Used for the Chakpalo Production in Benin
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作者 Vénérande Y. Ballogou Joseph Dossou Comlan A. de Souza 《Food and Nutrition Sciences》 2011年第2期156-161,共6页
Traditionally, sorghum malts used for the chakpalo production are dried under the sun in not controlled conditions in Benin. In order to improve drying operation in a rural approach, a shell drier was tested and the q... Traditionally, sorghum malts used for the chakpalo production are dried under the sun in not controlled conditions in Benin. In order to improve drying operation in a rural approach, a shell drier was tested and the quality of the dried malts was evaluated. The germinated capacity, thousand kernel weight, moisture, protein and fat contents of the red sorghum used for malting were respectively 94 %, 27.81 %, 11.65 %, 11.4 % and 3.57 %. The quality of the dried malt in the shell drier and those of the dried malt directly under the sun was compared. The results showed that the speed of malt drying was higher in the shell drier than under the sun. Indeed, the moisture contents of the dried malts directly under the sun and in the shell drier after 12 hours were respectively 12.56 % and 7.66 %. The microbiological quality of the dried malts in the shell drier was better. There were free of faecal coliforms.The results of this study indicate that the controlled drying of sorghum malts by using a shell drier improved the drying speed and the microbiological characteristics of the dried malts. Shell drier would be easy to use in the rural areas to dry sorghum malt. 展开更多
关键词 SORGHUM malts SHELL DRIER QUALITY
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Effects of Cereal Malts Used as Improver on Physico-Chemical, Nutritional and Sensory Characteristics of Wheat and Millet Composites Breads
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作者 Fidèle Wend-Bénédo Tapsoba Diarra Compaore-Sereme +4 位作者 Clarisse Sidbéwendé Compaore Thomas Jean Ndig-Yenouba Wendkuni Anne Christelle Yaogho Ndegwa Henri Maina Hagrétou Sawadogo-Lingani 《Food and Nutrition Sciences》 CAS 2022年第7期669-689,共21页
The aim of this study was to optimize composite breads of wheat and whole millet flour by the use of natural improvers. Three types of local malted cereals were used as natural improvers. The millet flour was fermente... The aim of this study was to optimize composite breads of wheat and whole millet flour by the use of natural improvers. Three types of local malted cereals were used as natural improvers. The millet flour was fermented with EPSs producing LAB strain prior to use. The technological characteristics of the composite flours were determined using an alveograph. The physico-chemical and nutritional characteristics of the composite breads were determined using standard methods and their sensory profiles were evaluated by a panel of 35 consumers. The alveograph results showed an increase in dough resistance, deformation and a decrease in extensibility and elasticity with the level of incorporation of millet flour. From the results of physico-chemical analyses of composite breads, no significant difference (p > 0.05) was observed in the use of the three types of local cereal malts except for the incorporation of 50% of the millet flour. The control sample presented the lowest acidity and dry matter value, the highest water content and pH value. No significant difference (p > 0.05) was observed in the use of the three types of cereal malts for the macronutrient contents of the composite bread samples. However, differences were observed according to the levels of incorporation. Macronutrients results showed an increase in protein content (11.17% ± 0.28% - 14.01% ± 0.10%/DM);crude fat content (1.86% ± 0.05% - 2.48% ± 0.20%/DM) and a decrease in carbohydrates content (85.36% ± 0.54% - 81.06% ± 0.36%/ DM). Regarding the content of mineral elements, significant differences (p < 0.05) were observed in the use of the three types of cereal malts for the incorporation of 15% (Mg and Fe content), 30% (Fe, Zn and K) and 50% (content of Zn, K, Na and Mg) of millet flour. The free amino acid profile revealed three essential amino acids such as valine, isoleucine and lysine. Breads incorporated with 30% of whole millet flour were the most appreciated by consumers. 展开更多
关键词 Composite Bread Cereal malts IMPROVER MILLET Sensorial Characteristics
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Assessment of Some Heavy Metals Concentration and Antioxidant Activity in Barley Grain Cultivars and Their Malts from Iran
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作者 Naficeh Sadeghi Mohammad Reza Oveisi +3 位作者 Behrooz Jannat Manan Hjimahmoodi Neda Malayeri Masoomeh Behzad 《Journal of Agricultural Chemistry and Environment》 2016年第3期121-131,共11页
Global industrialization could be considered as a major cause of environmental contamination with heavy metals. Barley and malt, vastly used in the food industries, are of no exception. Therefore, we aimed to measure ... Global industrialization could be considered as a major cause of environmental contamination with heavy metals. Barley and malt, vastly used in the food industries, are of no exception. Therefore, we aimed to measure the levels of trace elements Zinc, Copper and heavy metals Lead and Cadmium by Differential Pulse Anodic Stripping Voltammetry in 19 barley grain cultivars and their malts in Iran. Ferric reducing antioxidant power (FRAP) assay was also used for determination of antioxidant activity of the samples. The mean levels of Zn, Cd, Pb and Cu were measured to be 18.813 ± 8.575, 0.212 ± 0.116, 0.278 ± 0.163, 3.746 ± 1.118 mg/100g in the barley samples and 14.364 ± 6.391, 0.153 ± 0.098, 0.179 ± 0.082 and 3.033 ± 1.392 mg/100g in the malt samples, respectively. The highest concentration of Zn was measured in the Bahman cultivar of barley and Mb-82-4 sample of malt while the Sahra cultivar of barley and Valfajr sample of malt had the lowest concentration of Pb and the Nimrooz cultivar of barley and Rihane-03 sample of malt had the lowest concentration Cu. The mean levels of zinc and lead in the evaluated samples of barley and the mean levels of zinc, lead and cadmium in the samples of malt were significantly lower than standard limits. Although not significant, the mean levels of cadmium in barley samples and copper in malt samples were higher than the standard limits, but the mean level of copper was found to be significantly higher than the standard limits in the samples of barley (p = 0.008). Antioxidant acitivity was found to be highest in the Mb-82-12 sample of malt and Nik cultivar of barley. The average antioxidant activity was found to be significantly higher in the malt compared to barley grain;1.584 ± 0.596 mg/kg vs. 0.633 ± 0.221 mg/kg (p < 0.001). The mean level of copper in barley samples was significantly higher than the standard limit that needs further investigations to be controlled. 展开更多
关键词 BARLEY CADMIUM Copper Lead MALT VOLTAMMETRY Zinc
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SUPPLIER PERSPECTIVE Kilned Versus Roasted: A Differentiation of Caramelized Specialty Malts
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作者 Cassandra Liscomb Robert Hansen 《中外酒业》 2019年第13期63-68,共6页
"The term ucaramel malt” is used worldwide to describe a specialty malt that exhibits at least some degree of caramelization. The exact methods of caramel malt production are proprietary to the maltsters that ma... "The term ucaramel malt” is used worldwide to describe a specialty malt that exhibits at least some degree of caramelization. The exact methods of caramel malt production are proprietary to the maltsters that make them, but these specialty malts are generally produced by means of drying green malt on a kiln or in a roaster. This article will provide readers with a clear understanding of the physical, sensorial, and fimctional differences that distinguish kilned and roasted caramel malts from one another. 展开更多
关键词 Caramelized SPECIALTY malts DIFFERENTIATION TERM ucaramel MALT
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泪腺黏膜相关淋巴组织淋巴瘤的病理特征及BCL10和MALT1的表达和意义
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作者 姜帅 董志军 +4 位作者 董微莉 刘俊茹 张子平 黑砚 杨新吉 《中国医科大学学报》 CAS 北大核心 2024年第9期804-808,共5页
目的探讨泪腺黏膜相关淋巴组织(MALT)淋巴瘤的病理形态特征及肿瘤组织中BCL10和MALT1的表达和意义。方法选取19例泪腺MALT淋巴瘤患者(19眼,其中右眼9例,左眼10例)的病变泪腺组织标本为实验组,8例行眶内容物摘除患者(8眼,其中右眼3例,左... 目的探讨泪腺黏膜相关淋巴组织(MALT)淋巴瘤的病理形态特征及肿瘤组织中BCL10和MALT1的表达和意义。方法选取19例泪腺MALT淋巴瘤患者(19眼,其中右眼9例,左眼10例)的病变泪腺组织标本为实验组,8例行眶内容物摘除患者(8眼,其中右眼3例,左眼5例)的正常泪腺组织标本为对照组。采用HE染色观察泪腺组织形态特征,采用免疫组织化学染色观察泪腺中BCL10和MALT1的表达情况。结果实验组出现边缘区B细胞以及单核细胞样、小淋巴细胞样和浆细胞样肿瘤细胞浸润,偶见大细胞分布其中,可见肿瘤细胞侵入淋巴滤泡和上皮内,破坏正常结构,形成滤泡定植和淋巴上皮病变。实验组BCL10和MALT1的阳性表达面积明显高于对照组,差异均有统计学意义(Z=-2.177,P=0.029;t=3.237,P=0.003)。结论泪腺MALT淋巴瘤出现了弥漫分布的边缘区B细胞和形态多样的肿瘤细胞、获得性淋巴滤泡及大细胞散在分布的病理改变,这可能与BCL10和MALT1表达上调导致的细胞凋亡阻断有关。 展开更多
关键词 泪腺黏膜相关淋巴组织淋巴瘤 病理形态学 HE染色 免疫组织化学染色 BCL10 MALT1
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原发性气管粘膜相关淋巴组织淋巴瘤1例
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作者 王传海 吴宗青 徐桂香 《临床肺科杂志》 2024年第6期968-970,共3页
原发于气管的恶性肿瘤较为少见,病理类型多为鳞癌、腺样囊性癌,淋巴瘤相对少见。粘膜相关淋巴组织淋巴瘤(mucosa associated lymphoid tissue, MALT)淋巴瘤多发生于胃肠道、眼眶、甲状腺、唾液腺、肺等部位,原发于气管的MALT淋巴瘤十分... 原发于气管的恶性肿瘤较为少见,病理类型多为鳞癌、腺样囊性癌,淋巴瘤相对少见。粘膜相关淋巴组织淋巴瘤(mucosa associated lymphoid tissue, MALT)淋巴瘤多发生于胃肠道、眼眶、甲状腺、唾液腺、肺等部位,原发于气管的MALT淋巴瘤十分罕见,相关文献多为个案报道。其临床表现不典型,影像学多表现为孤立或多发的结节状突起,治疗方式各异,大多预后良好。 展开更多
关键词 个案报道 MALT淋巴瘤 粘膜相关淋巴组织淋巴瘤 预后良好 鳞癌 腺样囊性癌 恶性肿瘤 唾液腺
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Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report
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作者 Makoto Saito Zen-Ichi Tanei +7 位作者 Masumi Tsuda Toma Suzuki Emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第10期4281-4288,共8页
BACKGROUND Helicobacter pylori(H.pylori)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been established.However,t(11;18)(q21;q21)/API2-MALT1 translocation-positive... BACKGROUND Helicobacter pylori(H.pylori)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been established.However,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to achieve.In addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT lymphoma.CASE SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and biopsy.Two years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for H.pylori,and eradication treatment was administered.Two years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the fundus.One year later(4 years and 3 months after H.pylori eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of DLBCL.Both MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also detected.After 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 years.In addition,both the colonic and gastric lesions were proven to have the same clonality.CONCLUSION Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of H.pylori infection and progressed. 展开更多
关键词 Gastric mucosa-associated lymphoid tissue lymphoma TRANSFORM Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report
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Massive bleeding in small intestinal mucosa-associated lymphoid tissue lymphoma associated with COVID-19 infection:a case report
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作者 Meiling Huang Xiaowei Wu Ji Wang 《Oncology and Translational Medicine》 CAS 2024年第2期93-98,共6页
The increased risk of mucosa-associated lymphoid tissue(MALT)lymphoma is closely associated with chronic antigenic stimulation,with infection being the most common cause of recurrence.Lesions are usually associated wi... The increased risk of mucosa-associated lymphoid tissue(MALT)lymphoma is closely associated with chronic antigenic stimulation,with infection being the most common cause of recurrence.Lesions are usually associated with the gastrointestinal tract,and the involvement of small intestinal is rare.Recent studies have established a close relationship between novel coronavirus 2019(COVID-19)and the occurrence and progression of various diseases.This article presents a rare case of a small intestinal MALT lymphoma.The patient was initially admitted with COVID-19 pneumonia and subsequently developed gastrointestinal bleeding during hospitalization.Medical and endoscopic treatments were ineffective,and an emergency exploratory laparotomy was performed.The affected segment of the small intestine was excised,and a pathological biopsy confirmed the diagnosis of MALT lymphoma.This case underscores the significance of raising clinical awareness of this condition among health care professionals. 展开更多
关键词 COVID-19 Non-Hodgkin lymphoma Small intestine MALT lymphoma Gastrointestinal hemorrhage Severe pneumonia
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异时性腮腺和肺黏膜相关淋巴组织淋巴瘤1例并文献复习
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作者 刘峥璐 暴欣然 徐晓艳 《诊断病理学杂志》 2024年第2期155-157,共3页
黏膜相关淋巴组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤是一种结外低级别B细胞淋巴瘤,常原发于胃、肺、甲状腺、腮腺、乳腺、眼附件等,通常被认为是一种生物学行为相对惰性的肿瘤,偶见复发与转移[1-5]。现已有原发于胃[6]、... 黏膜相关淋巴组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤是一种结外低级别B细胞淋巴瘤,常原发于胃、肺、甲状腺、腮腺、乳腺、眼附件等,通常被认为是一种生物学行为相对惰性的肿瘤,偶见复发与转移[1-5]。现已有原发于胃[6]、肝脏[7]和甲状腺[8]的MALT淋巴瘤在经过最初的诊断和治疗后发生肺转移的报道。 展开更多
关键词 腮腺肿瘤 肺肿瘤 MALT淋巴瘤 基因重排
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C反应蛋白/白蛋白比值在胃黏膜相关淋巴组织淋巴瘤中的预后预测价值
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作者 施淼颉 魏征 刘澎 《中国临床医学》 2024年第1期78-84,共7页
目的 探讨C反应蛋白与白蛋白比值(C-creative protein/albumin ratio, CAR)预测胃黏膜相关淋巴组织(MALT)淋巴瘤患者预后的价值。方法 纳入2004年1月至2020年6月在复旦大学附属中山医院初诊的胃MALT淋巴瘤患者,计算其CAR。通过X-tile软... 目的 探讨C反应蛋白与白蛋白比值(C-creative protein/albumin ratio, CAR)预测胃黏膜相关淋巴组织(MALT)淋巴瘤患者预后的价值。方法 纳入2004年1月至2020年6月在复旦大学附属中山医院初诊的胃MALT淋巴瘤患者,计算其CAR。通过X-tile软件获取最佳CAR临界值,将患者分为低CAR组和高CAR组。收集两组患者的基线数据及生存资料。应用Cox分析和Kaplan-Meier法分析CAR在胃MALT淋巴瘤的预后预测意义。结果 CAR的最佳临界值为0.05。与低CAR组(CAR<0.05,n=66)相比,高CAR组(CAR≥0.05,n=27)中高龄(70岁以上)、贫血患者更多,C反应蛋白水平、β2-微球蛋白水平更高,白蛋白水平更低(P<0.05)。Cox多因素分析示IgG为患者预后的独立预测因素(HR=0.528,95%CI 0.304~0.915, P=0.023)。低CAR组中位总生存期(overall survival,OS)长于高CAR组(172.8个月vs 112.7个月,P=0.020)。不同MALT-IPI评分组患者OS差异无统计学意义;CAR联合MALT-IPI评分2分患者OS明显短于0分和1分患者(P<0.05)。结论 高CAR组患者预后更差,CAR可用于评估胃MALT淋巴瘤患者预后。 展开更多
关键词 胃黏膜相关淋巴组织淋巴瘤 C反应蛋白/白蛋白比值 生存 MALT淋巴瘤国际预后指数
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肺原发性黏膜相关淋巴组织淋巴瘤23例临床病理分析 被引量:7
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作者 岳冰 谢建兰 +5 位作者 滕孝静 刘伟 郑媛媛 张晓敬 许传杰 周小鸽 《诊断病理学杂志》 CSCD 2015年第5期264-268,共5页
研究肺原发性黏膜相关淋巴组织(MALT)淋巴瘤的临床表现、病理学形态特征、免疫表型、分子生物学特点及预后情况,总结肺原发性MALT淋巴瘤的临床及病理学特点.方法 通过临床资料总结、病理学形态观察、免疫表型分析,对23例肺原发性MALT... 研究肺原发性黏膜相关淋巴组织(MALT)淋巴瘤的临床表现、病理学形态特征、免疫表型、分子生物学特点及预后情况,总结肺原发性MALT淋巴瘤的临床及病理学特点.方法 通过临床资料总结、病理学形态观察、免疫表型分析,对23例肺原发性MALT淋巴瘤病例进行研究,并且对其中5例行IgH基因克隆性重排检测,4例行荧光原位杂交(FISH) MALT1基因检测.结果 23例肺原发性MALT淋巴瘤中12例无症状,于体检时发现肺部病变,其余表现为咳嗽、胸痛等.影像学均表现为肺部肿块影或实变影,19例病变位于右肺.病理学形态特点,5例肿瘤呈结节状,18例弥漫性生长,肿瘤与肺组织交界处均可见孤岛样或串珠样结构.肿瘤由3种形态细胞构成:中心细胞样细胞、单核样B细胞、小淋巴细胞样细胞,其中13例伴浆细胞分化,均可见到淋巴上皮病变及滤泡殖入现象.免疫组化染色,肿瘤细胞CD20(+),Ki-67指数5% ~20%,8例IgK、Igλ显示肿瘤细胞为单克隆性B细胞.分子生物学方面,IgH克隆性重排检测均检测到单克隆条带,4例中2例FISH检测出MALT1基因断裂.本组4例失访,其余19例随访3个月~6年5个月,全部存活,其中5例可疑肿瘤局部复发.8例仅行肿瘤局部切除,11例行手术切除并于术后行化疗.结论 肺原发性MALT淋巴瘤无症状或仅有轻微症状,影像学显示肺部肿块或阴影,组织形态表现为结节状或弥漫性单核样小淋巴细胞浸润,周边伴特征性孤岛样或串珠样结构,呈B细胞免疫表型并无其他小B细胞性淋巴瘤的表型特征,IgH克隆性检测呈单克隆,FISH检测可见MALT1基因断裂.本病预后较好,可局部复发. 展开更多
关键词 MALT淋巴瘤 基因重排 MALT1
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胃肠道粘膜相关淋巴组织原发淋巴瘤病理学研究 被引量:7
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作者 张雅洁 李玉林 +1 位作者 朱桂彬 张丽红 《临床与实验病理学杂志》 CAS CSCD 北大核心 1994年第2期119-122,T002,共5页
为明确胃肠道原发NHL特别是MALT淋巴瘤的发病特征及组织学起源,本研究使用LN_(1~3)系列抗体对34例胃肠道原发NHL进行免疫组化检测。结果显示:34例中MALT淋巴瘤5例(14.7%),其中3例由滤泡中心细胞样细胞构成,另2例由中心母细胞样细胞构... 为明确胃肠道原发NHL特别是MALT淋巴瘤的发病特征及组织学起源,本研究使用LN_(1~3)系列抗体对34例胃肠道原发NHL进行免疫组化检测。结果显示:34例中MALT淋巴瘤5例(14.7%),其中3例由滤泡中心细胞样细胞构成,另2例由中心母细胞样细胞构成。肿瘤细胞在LN_1显示核周边点状阳性,LN_2显示核膜线状阳性,与正常肠道Peyet板僧帽带处的Marginal zone cell具有相似的形态及染色特性,提示MALT淋巴瘤可能来源于Marginal zone cells。 展开更多
关键词 胃肠道 MALT 淋巴瘤 免疫组织化学
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胃B细胞淋巴瘤API2-MALT1融合基因表达与幽门螺杆菌感染的相关性 被引量:7
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作者 杨文秀 李甘地 +2 位作者 周桥 刘卫平 李俸媛 《临床与实验病理学杂志》 CAS CSCD 北大核心 2005年第1期35-38,共4页
目的 探讨胃MALT淋巴瘤和弥漫性大B细胞淋巴瘤演进中t(11;18)(q21;q21)与幽门螺杆菌(HP)感染的关系, 以及检测API2-MALT1融合基因的意义。方法 47例胃淋巴瘤病例(MALT淋巴瘤31例,弥漫性大B细胞淋巴瘤16例),经 复查诊断后,用RT PCR和巢... 目的 探讨胃MALT淋巴瘤和弥漫性大B细胞淋巴瘤演进中t(11;18)(q21;q21)与幽门螺杆菌(HP)感染的关系, 以及检测API2-MALT1融合基因的意义。方法 47例胃淋巴瘤病例(MALT淋巴瘤31例,弥漫性大B细胞淋巴瘤16例),经 复查诊断后,用RT PCR和巢式PCR,检测肿瘤组织中API2-MALT1融合基因的表达,用半巢式PCR和特殊染色检查HP感染 情况。根据淋巴瘤类型及融合基因检测结果将病例分组,观察各组病例HP感染的差异。结果 47例胃淋巴瘤中20例API2 - MALT1融合基因mRNA检测阳性,包括16例MALT淋巴瘤和4例弥漫大B细胞淋巴瘤。HP感染检出率:API2- MALT1阳性 组为25%(5/20),API2- MALT1阴性组25.92%(7/27)。统计学分析表明两组间差异无显著性。2例API2 MALT1融合基因 检测阴性的胃MALT淋巴瘤病例经抗HP治疗后病情稳定。结论 胃MALT淋巴瘤和DLBCL中API2- MALT1mRNA表达与 胃淋巴瘤HP感染无明显相关,API2- MALT1融合基因可能成为胃MALT淋巴瘤抗HP治疗效果不良的预测因子。 展开更多
关键词 胃MALT淋巴瘤 融合基因 AP HP感染 胃淋巴瘤 表达 弥漫性大B细胞淋巴瘤 结论 差异 显著性
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粘膜相关淋巴组织(MALT)型淋巴瘤的临床特点和处理 被引量:11
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作者 王佳蕾 许立功 施达仁 《中国癌症杂志》 CAS CSCD 2003年第6期591-594,596,共5页
粘膜相关淋巴组织 (MALT)型淋巴瘤是非霍奇金恶性淋巴瘤中一个独立的亚型 ,有其独特的临床病理特点。它是结外低度恶性B细胞淋巴瘤中最常见的一型。此型淋巴瘤病人常有慢性感染病史或自身免疫性疾病。MALT淋巴瘤是一种惰性病变 ,可较长... 粘膜相关淋巴组织 (MALT)型淋巴瘤是非霍奇金恶性淋巴瘤中一个独立的亚型 ,有其独特的临床病理特点。它是结外低度恶性B细胞淋巴瘤中最常见的一型。此型淋巴瘤病人常有慢性感染病史或自身免疫性疾病。MALT淋巴瘤是一种惰性病变 ,可较长时间局限于局部。局部治疗有效。胃MALT淋巴瘤最常见。本文以胃MALT淋巴瘤为重点 ,对MALT淋巴瘤的临床特点和处理作一个综述。 展开更多
关键词 淋巴瘤 MALT型 病理 治疗 胃淋巴瘤
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原发性胃肠非MALT型淋巴瘤的临床与病理分析 被引量:7
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作者 范钦和 徐天蓉 +1 位作者 周青 郑肇巽 《临床与实验病理学杂志》 CAS CSCD 1999年第2期135-137,I023,共4页
目的:研究胃肠原发性非MALT型淋巴瘤形态特征、诊断要点和鉴别诊断,为临床治疗和预后提供依据。方法:胃肠淋巴瘤标本常规制片,免疫组化ABC法标记,光镜观察。结果:31例非MALT型淋巴瘤中:(1)肠病相关/不相关T细... 目的:研究胃肠原发性非MALT型淋巴瘤形态特征、诊断要点和鉴别诊断,为临床治疗和预后提供依据。方法:胃肠淋巴瘤标本常规制片,免疫组化ABC法标记,光镜观察。结果:31例非MALT型淋巴瘤中:(1)肠病相关/不相关T细胞淋巴瘤21例,其中肠病相关16例;(2)MMCL3例在肠道呈息肉样,套细胞增生或浸润反应性滤泡内。(3)MFL2例亦呈息肉样或形成肿块,由中心细胞和中心母细胞组成;(4)大多叶核淋巴瘤2例;(5)组织细胞性3例。结论:MALT型、MMCL和MFLB细胞性淋巴瘤为3种不同细胞起源,形态相似、免疫表型相同和不相同之处,有助于诊断和鉴别诊断。肠病相关T细胞淋巴瘤有独特临床病理特征,易误诊为肠道炎性病变而延误诊断和治疗。 展开更多
关键词 胃肠肿瘤 非MALT型 淋巴瘤 病理学
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一线化疗治疗眼附属器MALT淋巴瘤临床疗效 被引量:5
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作者 宁丰 叶进 +2 位作者 魏立强 李鑫 王景文 《中国实验血液学杂志》 CAS CSCD 北大核心 2012年第4期912-916,共5页
本研究分析一线化疗治疗眼附属器黏膜相关淋巴组织结外边缘区B细胞淋巴瘤(MALT)的临床疗效。回顾性分析8例眼附属器MALT淋巴瘤患者的临床资料。给予3例ⅠE期患者COP/CHOP方案治疗。给予5例Ⅳ期患者COP/CHOP联合利妥昔单克隆抗体。结果表... 本研究分析一线化疗治疗眼附属器黏膜相关淋巴组织结外边缘区B细胞淋巴瘤(MALT)的临床疗效。回顾性分析8例眼附属器MALT淋巴瘤患者的临床资料。给予3例ⅠE期患者COP/CHOP方案治疗。给予5例Ⅳ期患者COP/CHOP联合利妥昔单克隆抗体。结果表明:完全缓解(CR)加部分缓解(PR)的有效率100%,3例ⅠE期患者获得PR,5例Ⅳ期患者获CR,中位随访时间21个月,患者疾病无进展,3例ⅠE期患者仍持续PR,5例Ⅳ期患者持续CR。结论:眼附属器MALT淋巴瘤呈惰性临床过程,化疗安全有效,联合利妥昔单克隆抗体方案能明显提高缓解率,可以作为一线治疗方案。 展开更多
关键词 MALT淋巴瘤 眼附属器淋巴瘤 化疗
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附睾MALT型淋巴瘤的临床病理学研究 被引量:8
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作者 徐天蓉 张智弘 郑肇巽 《临床与实验病理学杂志》 CAS CSCD 1998年第3期241-243,I033,共4页
目的:探讨附睾粘膜相关淋巴组织(MALT)型淋巴瘤与附睾肉芽肿性炎的诊断、鉴别诊断及其发病机制。方法:手术切除标本常规石蜡切片和免疫组化ABC法标记。结果:4例附睾MALT型淋巴瘤均为CCL细胞型,并有淋巴上皮病变。... 目的:探讨附睾粘膜相关淋巴组织(MALT)型淋巴瘤与附睾肉芽肿性炎的诊断、鉴别诊断及其发病机制。方法:手术切除标本常规石蜡切片和免疫组化ABC法标记。结果:4例附睾MALT型淋巴瘤均为CCL细胞型,并有淋巴上皮病变。免疫表型4例LCA、L26均呈阳性,IgM·κ2例,IgG·κ1例及IgA·λ1例呈阳性。结论:附睾MALT型淋巴瘤大多为低度恶性,以手术治疗为主,应对附睾慢性炎进行病因治疗,以免附睾形成获得性MALT。 展开更多
关键词 病理学 附睾肿瘤 淋巴病 MALT型
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MALT淋巴瘤57例临床病理及克隆性分析 被引量:8
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作者 孙志刚 李春梅 +1 位作者 李静 关宏伟 《诊断病理学杂志》 CSCD 2015年第7期394-398,共5页
目的通过观察57例MALT淋巴瘤的组织形态学特点,结合免疫组化和分子病理学诊断方法,完善对MALT淋巴瘤的诊断与鉴别诊断。方法根据HE染色和免疫组化(CD20、bcl-2、CD3、CD5、CD10、CD23和cyclin D1)检测,对所有标本进行组织学评价,并应用D... 目的通过观察57例MALT淋巴瘤的组织形态学特点,结合免疫组化和分子病理学诊断方法,完善对MALT淋巴瘤的诊断与鉴别诊断。方法根据HE染色和免疫组化(CD20、bcl-2、CD3、CD5、CD10、CD23和cyclin D1)检测,对所有标本进行组织学评价,并应用DNA-PCR和免疫组化(kappa/lambda)检测免疫球蛋白基因重排和轻链的限制性表达。结果 157例MALT淋巴瘤,镜下常呈弥漫性生长,少数表现为结节样。MALT淋巴瘤细胞类型多样,在具有腺上皮的组织,如胃、肠、唾液腺等处常出现淋巴上皮病变(LEL)。LEL的形成是其诊断的重要依据。2肿瘤细胞的克隆性检测:57例MALT淋巴瘤中有35例出现Ig H基因单克隆性重排,占61.4%(35/57)。免疫组化:15例kappa或lambda的表达具有优势,敏感性为26.3%(15/57);其中4例Ig H基因单克隆性重排(-),而kappa或lambda(+)。两者联合应用的阳性率为68.4%。结论尽管MALT淋巴瘤缺乏特异性诊断性抗体,但是通过组织形态学特征以及免疫组化的检测,可以将MALT淋巴瘤与其他B细胞性淋巴瘤鉴别。将检测免疫球蛋白重链基因重排及轻链限制性表达,作为MALT淋巴瘤诊断的辅助检查方法具有明显的应用价值。 展开更多
关键词 MALT淋巴瘤 免疫组化 IGH基因重排 PCR
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甲状腺淋巴瘤患者的临床病理特征研究 被引量:6
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作者 朱向兰 赵莎 +3 位作者 刘卫平 王健超 张文燕 李甘地 《西部医学》 2016年第7期1003-1008,共6页
目的甲状腺淋巴瘤(TL)较少见,目前国内缺少大样本综合报道。本研究旨在探讨TL的临床病理特征。方法对95例TL的临床病理特征进行回顾性研究。收集95例患者临床资料、观察组织形态学、免疫组化及基因重排检测结果,对该类肿瘤的临床表现、... 目的甲状腺淋巴瘤(TL)较少见,目前国内缺少大样本综合报道。本研究旨在探讨TL的临床病理特征。方法对95例TL的临床病理特征进行回顾性研究。收集95例患者临床资料、观察组织形态学、免疫组化及基因重排检测结果,对该类肿瘤的临床表现、组织形态学病理类型、免疫表型、治疗以及预后生存情况进行总结及统计学分析。结果 95例TL患者中,男性23例,女性72例;根据组织学及免疫组化等检测,结果可分为8类淋巴瘤:分别为弥漫大B细胞淋巴瘤(DLBCL)53例、粘膜相关淋巴组织结外边缘区B细胞淋巴瘤(MALT lymphoma)28例、结外边缘区淋巴瘤伴大B细胞淋巴瘤转化(Mixed DLBCL and MZBL)7例、滤泡淋巴瘤(FL)2例、伯基特淋巴瘤(BL)2例、套细胞淋巴瘤(MCL)1例、T淋巴母细胞淋巴瘤(T-LBL)1例、间变大细胞淋巴瘤(ALCL)1例;其中根据Hans分型将DLBCL分为生发中心型(GCB)32例,非生发中心型(Non-GCB)21例。手术标本中55/69例存在淋巴细胞性甲状腺炎背景。单纯手术治疗24例;手术+放/化疗40例;单纯放/化疗20例。TL中位随访时间36个月。总体生存时间为(38.801±1.974)。DLBCL 1、3、5年生存率为92%、85%、83%。DLBCL病人单因素预后分析示:年龄(P=0.012)、分期(P=0.014)、治疗方式(P=0.025)对患者的生存时间有统计学意义,而GCB和Non-GCB分类预后无统计学差异(P>0.05)。结论尽管甲状腺淋巴瘤发病率低,但其病理组织类型多样,大多数为原发性淋巴瘤,总体生存时间及预后相对较好。以B细胞来源多见,主要为DLBCL、MALT。大部分淋巴瘤伴慢性淋巴细胞甲状腺炎背景,相关机制有待进一步研究。 展开更多
关键词 甲状腺淋巴瘤 DLBCL MALT 临床病理 预后
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结外B细胞性非霍奇金淋巴瘤中MALT1基因表达的检测及意义 被引量:3
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作者 郭宏伟 杨文秀 +4 位作者 钟愉 陈玉梅 王松 刘启兰 刘辉 《中国肿瘤临床》 CAS CSCD 北大核心 2010年第6期320-322,326,共4页
目的:探讨结外B细胞淋巴瘤中MALT1基因(mRNA)的表达与MALT和弥漫大B细胞淋巴瘤发生发展的关系,及其对淋巴瘤临床病理特征和预后的影响。方法:用HE和免疫组化染色筛选出本院确诊的MALT和结外弥漫大B细胞淋巴瘤106例,检查肿瘤组织Bcl-2和K... 目的:探讨结外B细胞淋巴瘤中MALT1基因(mRNA)的表达与MALT和弥漫大B细胞淋巴瘤发生发展的关系,及其对淋巴瘤临床病理特征和预后的影响。方法:用HE和免疫组化染色筛选出本院确诊的MALT和结外弥漫大B细胞淋巴瘤106例,检查肿瘤组织Bcl-2和Ki-67的表达,用RT-PCR检测肿瘤中的MALT1基因mRNA水平,收集临床病理资料并随访。结果:MALT1 mRNA的表达:在DLBCL与MALT淋巴瘤组、淋巴结累及组和无累及组、临床分期Ⅲ~Ⅳ组和Ⅰ~Ⅱ组间均有统计学差异(P<0.05),在Ki-67≥30%与<30%组间未见统计学差异(P>0.05),而Bcl-2阳性组却高于阴性组(P<0.05);MALT1mRNA表达与不表达病例之间患者生存状况有明显差异(P<0.05),表达组生存状况较差。结论:MALT1基因在MALT淋巴瘤与DLBCL中有不同程度的表达,MALT1基因活化NF-κB后可能通过调控Bcl-2使细胞凋亡抑制而导致淋巴瘤发生,MALT1mRNA表达与B细胞淋巴瘤的类型、淋巴结累及、临床分期有关,与患者的生存状况有关,MALT1可能是一个MALT和弥漫大B细胞淋巴瘤预后不良的相关因子。 展开更多
关键词 MALT1基因 淋巴瘤 RT-PCR 预后
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