Marginal zone lymphoma with severe rashes: A case report

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.

Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain lateral comparison profile and seismic reflection structures in the 2D seismic section, which can provide references for future worldwide exploration. Microbial mounds with larger buildups and thicker vertical reservoirs are typically targeted on the windward margin, while small-sized microbial mounds and flats with better lateral connections are typically focused on the leeward margin.

The largest CPIES array in the marginal sea:abundant dynamics in the northeast South China Sea

The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,tropical cyclones,the Kuroshio intrusion,and water exchange through the Luzon Strait(LS).

Bendamustine and rituximab as frontline therapy in extranodal marginal zone lymphoma:a single-institution experience

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one trial has evaluated frontline BR prospectively in EMZL.This retrospective study reports outcomes among EMZL patients receiving frontline BR.Twenty-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ disease.The median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)individuals.Overall response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not reached.The estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to BR.BR is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report

BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.

Marginal donor liver versus standard donor liver: A single-center observational study

Background:The effectiveness and safety of marginal donor livers remain controversial.This study aimed to investigate the clinical efficacy of marginal donor livers in patients with liver transplantation(LT).Methods:This study included 199 liver donors(including 16 split donors)and 206 liver recipients from January 1,2018 to January 27,2020,with case follow-up until July 31,2021.Clinical data of donors and recipients were retrospectively analyzed and were divided into the marginal donor and standard donor groups according to the criteria of marginal donor livers.Indices of liver and kidney functions,complications,and survival curves of the two groups were compared.Results:Compared with the standard donor group,the blood creatinine levels were significantly higher in the marginal donor group in the first week after operation(P<0.05);there were no significant differences in alanine aminotransferase,aspartate aminotransferase,and total bilirubin levels after LT(all P>0.05);there was no significant difference in the incidence of complications after LT(P>0.05);there was also no significant difference in the survival curve(P=0.335).Conclusions:There were no significant differences in liver and kidney function and survival curve between the standard donor and marginal donor groups.The marginal donor liver appears safe and reliable for LT and may be an important strategy to expand the donor pool and solve the shortage of organs.

Marginal weakening promoted rift propagation of the Petermann Ice Shelf in northwestern Greenland from 2016 to 2022

Ice-shelf rifts are precursors of glacier calving, and thus they serve as indicators of ice shelf instability, especially under oceanic and atmospheric warming conditions. Therefore, understanding the dynamic processes underlying rift propagation and the associated damage mechanisms is essential to evaluate ice-shelf instability and to predict glacier calving. In this study, we investigated the effect of marginal weakening on rift propagation on the ice shelf of the Petermann Glacier, among the largest in Greenland, during 2016-2022. First, we analyzed satellite optical images to monitor rift growth(length and width) by tracking the tip trajectory of three large rifts identified on the Petermann Ice Shelf. Then, we estimated rift depth using ArcticDEM and ICESat-2 data. Our results indicated consistent increases of the rift widths and depths over the study period, with mean values of 133 m·a^(-1) and 0.3 m·a^(-1), respectively. We also combined remote-sensing observations with an ice-sheet numerical model to calculate the stress and damage fields on the Petermann Ice Shelf and to assess the ice shelf margin stability and strength. We determined that damage and lateral shear in the fracture zone degraded ice shelf integrity by decreasing the contact length with the fjord wall. In conclusion, marginal weakening effectively promoted rift propagation on the Petermann Ice Shelf, increasing the risk of future glacier calving.

Sclerotic marginal zone lymphoma:A case report

BACKGROUND Marginal zone lymphoma(MZL)is an indolent non-Hodgkin B cell lymphoma with various architectural pattern including perifollicular,follicular colonization,nodular,micronodular,and diffuse patterns.A sclerotic variant has not been previously reported and represents a diagnostic pitfall.CASE SUMMARY A 66-year-old male developed left upper extremity swelling.Chest computed tomography(CT)in September 2020 showed 14 cm mass in left axilla.Needle core biopsy of axillary lymph node showed sclerotic tissue with atypical B lymphoid infiltrate but was non-diagnostic.Excisional biopsy was performed for diagnosis and showed extensive fibrosis and minor component of infiltrating B cells.Flow cytometry showed a small population of CD5-,CD10-,kappa restricted B cells.Monoclonal immunoglobulin heavy chain and light chain gene rearrangement were identified.Upon being diagnosed with MZL,patient was treated with rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone and achieved complete remission by positron emission tomography/CT.CONCLUSION This is an important case report because by morphology this case could have easily been overlooked as non-specific fibrosis with chronic inflammation representing a significant diagnostic pitfall.Moreover,this constitutes a new architectural pattern.While sclerotic lymphomas have rarely been described(often misdiagnosed as retroperitoneal fibrosis),we do not know of any cases describing this architectural presentation of MZL.

Marginal Conceptual Predictive Statistic for Mixed Model Selection

We focus on the development of model selection criteria in linear mixed models. In particular, we propose the model selection criteria following the Mallows’ Conceptual Predictive Statistic (Cp) [1] [2] in linear mixed models. When correlation exists between the observations in data, the normal Gauss discrepancy in univariate case is not appropriate to measure the distance between the true model and a candidate model. Instead, we define a marginal Gauss discrepancy which takes the correlation into account in the mixed models. The model selection criterion, marginal Cp, called MCp, serves as an asymptotically unbiased estimator of the expected marginal Gauss discrepancy. An improvement of MCp, called IMCp, is then derived and proved to be a more accurate estimator of the expected marginal Gauss discrepancy than MCp. The performance of the proposed criteria is investigated in a simulation study. The simulation results show that in small samples, the proposed criteria outperform the Akaike Information Criteria (AIC) [3] [4] and Bayesian Information Criterion (BIC) [5] in selecting the correct model;in large samples, their performance is competitive. Further, the proposed criteria perform significantly better for highly correlated response data than for weakly correlated data.

Temporal-Spatial Variances of Holocene Precipitation at the Marginal Area of the East Asian Monsoon Influences from Pollen Evidence

The woodland-steppe ecotone in the. southern Nei Mongol Plateau is located at the northern edge of the east Asian monsoon influences. A marked southeastern - northwestern (SE - NW) precipitation gradient exists in this region. Quantitative reconstruction of palaeo-precipitation of this region is helpful to reveal the development of monsoon climate and to predict die future desertification. Based on modern vegetation and surface pollen studies, a pollen-precipitation transfer function in the study region was established. Pollen data from three sediment sequences within the ecotone were used to reconstruct palaeo-precipitation during the Holocene. The processes of precipitation changes in the three sequences were quite different. There was a tendency of precipitation declined from the onset of the Holocene to 1 100 a BP in Haoluku. But, in Liuzhouwan and Xiaoniuchang, both located south of Haoluku, the annual precipitation reached highest values during 7 800 - 6 200 a BP and 7 200 - 5 000 a BP, respectively. The influences of southwestern (SW) monsoon and the variances of topographical conditions have possibly caused these temporal-spatial variances.

基于权重一致性优化的实时Marginalized粒子滤波算法

针对Marginalized粒子滤波中随机量测噪声对于非线性状态估计精度的不利影响以及线性状态估计中计算量较大问题,提出了一种基于权重一致性优化的实时Marginalized粒子滤波算法.首先,结合量测系统建模中先验信息的提取和利用,通过粒子权重间一致性距离和一致性矩阵的构建,提出了量测提升策略下权重的一致性优化方法,以改善粒子滤波在非线性状态估计中的滤波精度.其次,通过对Marginalized粒子滤波实现中时间更新和量测更新环节的结构优化,给出了实时Marginalized粒子滤波,以降低蒙特卡罗仿真实现下卡尔曼滤波在状态线性估计中的计算复杂度.最后,在两者的动态结合基础上给出了新算法具体实现步骤.利用基于单站雷达目标跟踪仿真场景,分析了算法性能.理论分析和仿真实验结果验证了算法的可行性和有效性.

The Margin Is not Marginal An Interpretation of Adventures of Huckleberry Finn

Adventures of Huckleberry Finn is one of the most greatest works of Mark Twain, an American literary giant in the 19th century, telling the story of fleeing and seeking for freedom along the Mississippi river. This paper will use the theory of core-periphery to analyze the encounter and mutual-helping of Huck and Jim.Their adventures reflect the fate of marginal characters, disclose some problems covered in the marginal spaces and make some marginal voices heard. What reflected behind is that the true,the good, and the beautiful of human nature and the righteousness of society are never absent.

快速Marginalized粒子滤波器在纯方位跟踪中的应用

为提高纯方位跟踪性能,降低粒子滤波方法的运算量,在原有Marginalized粒子滤波器(MPF)的基础上,对线性部分处理方法进行简化,提出了快速Marginalized粒子滤波器(FMPF),并结合纯方位跟踪模型,推导了FMPF应用的具体算法步骤,使用机动目标纯方位跟踪仿真实例,与其他滤波器进行了仿真对比,分析了跟踪性能和计算量。仿真结果表明,与标准粒子滤波器相比,FMPF可以提高线性部分的计算精度,同时减少MPF所需的计算量。

Effects of Sowing Rate on Marginal Superiority and Yield of Wheat in Wheat-cotton Intercropping System

In the wheat-cotton intercropping system, total 6 sowing rates （187.5, 225.0, 262.5, 300.0, 337.5 and 375.0 kg/hm2） were arranged, and the effects of sowing rate on marginal superiority and yield of wheat were investigated. The re- sults showed that the effect of sowing rate on inner-line wheat was greater than that on side-line wheat; with the increased sowing rate, the marginal superiority of panicle number was reduced in overall, and the difference in panicle number be- tween inner and side lines was decreased from 9.0×10^5/hm2 （sowing rate of 187.5 kg/hm2） to 7.8×10^5/hm2 （sowing rate of 375.0 kg/hm2）; the marginal superiority of grains per spike was increased first and then reduced, and the largest difference in grains per spike between the inner and side lines reached 4.6 under the sowing rate of 300.0 kg/hm2; the marginal superiority of 1 000-grain weight and yield was gradually increased, and the largest difference in 1 000-grain weight between the inner and side lines reached 3.9 g under the sowing rate of 337.5 kg/hm2, and in yield reached 3 136.5 kg/hm2under the sowing rate of 375.0 kg/hm2. The effects of sowing rate on the three yield factors of intercropped wheat ranked as panicle number 〉 grains per spike 〉 1 000-grain weight. The appropriate sowing rate of wheat was 225.0-262.0 kg/hm2 in the wheat-cotton intercropping system.

Analysis on Marginal Superiority and Yield of Different Wheat Varieties in Wheat-cotton Intercropping System

In wheat-cotton intercropping system,the spike number per unit area,grains per spike,thousand-grain weight and yield of side line and inner line were investigated in six wheat varieties to study the marginal superiority and select suitable wheat varieties intercropped with cotton.The results showed that Xingmai No.4had obvious marginal superiority with the yield of 6 919.0 kg/hm2,so it was the suitable variety for wheat-cotton intercropping system.

Analyzing our educational resource deployment of compulsory education by marginal utility

In the base of utility and marginal utility,the article put forwardthe concept of utility and marginal utilityof educational outlay and the theory of them,and analyzed the actuality of educational resource deployment in ourcountry,gave some advice about howtoi mprove our educational resource deployment of compulsory education.

The Rise of Aesthetic Anthropology in the Marginal Culture

At the turn of the century, the development of aesthetics encounters severe challenges and is trapped in a crisis. To get out of it, it is necessary to dig deeper in the study of aesthetics. The fact that the marginal areas＇ cultural heritage, agricultural culture, industrial culture and post-industrial culture often coexist in a harmonious way in a nation or the same area attracts the attention of aesthetic anthropologists. The paper mainly analyzes the constructive relationship between the culture of marginal areas and aesthetic anthropology, and discusses how to establish a relationship between them with the help of the development model of Yunnan＇s marginal culture.

The Marginal Rao-Blackwellized Particle Filter for Mixed Linear/Nonlinear State Space Models

In this paper, the marginal Rao-Blackwellized particle filter （MRBPF）, which fuses the Rao-Blackwellized particle filter （RBPF） algorithm and the marginal particle filter （MPF） algorithm, is presented. The state space is divided into linear and non-linear parts, which can be estimated separately by the MPF and the optional Kalman filter. Through simulation in the terrain aided navigation （TAN） domain, it is demonstrated that, compared with the RBPF, the root mean square errors （RMSE） and the error variance of the nonlinear state estimations by the proposed MRBPF are respectively reduced by 29% and 96%, while the unique particle count is increased by 80%. It is also found that the MRBPF has better convergence properties, and analysis has shown that the existing RBPF is nothing more than a special case of the MRBPF.

Black carbon and polycyclic aromatic hydrocarbons (PAHs) in surface sediments of China’s marginal seas

This study investigates the distribution of black carbon （BC） and its correlation with total polycyclic aromatic hydrocarbons （EPAH） in the surface sediments of China＇s marginal seas. BC content ranges from 〈0.10 to 2.45 mg/g dw （grams dry weight） in the sediments studied, and varied among the different coastal regions. The Bohai Bay sediments had the highest BC contents （average 2.18 mg/g dw）, which comprises a significant fraction （27%-41%） of the total organic carbon （TOC） preserved in the sediments. In comparison, BC in the surface sediments of the North Yellow Sea, Jiaozhou Bay, East China Sea and the South China Sea is less abundant and accounted for an average of 6%, 8%, 14% and 5%, respectively, of the sedimentary organic carbon pool. The concentration of EPAH in the surface sediments ranges from 41 to 3 667 ng/g dw and showed large spatial variations among the sampling sites of different costal regions. The Bohai Bay has the highest ZPAH values, ranging from 79 to 3 667 ng/g dw. This reflects the high anthropogenically contaminated nature of the sediments in the bay. BC is positively correlated to TOC but a strong correlation is not found between BC and ZPAH in the surface sediments studied, suggesting that BC and PAHs preserved in the sediments are derived from different sources and controlled by different biogeochemical processes. Our study suggests that the abundance of BC preserved in the sediments could represent a significant sink pool of carbon cycling in China＇s marginal seas.

Soil Properties and Characteristics of Soil Aggregate in Marginal Farmlands of Oasis in the Middle of Hexi Corridor Region, Northwest China

The composition and stability of soil aggregate are closely related to soil quality, soil erosion, and agricultural sustainability. In this study, 49 soil samples at the 0-10 cm surface layer were collected from four soil types （i.e., Ari-Sandic Primosols, Calci-Orthic Aridosols, Siltigi-Otrthic Anthrosols, and Ustic Cambosols） in the marginal farmland in the oasis of the middle Hexi Corridor region and was used to determine the characteristics of soil aggregates. The composition of dry- and wet- sieved aggregates and the physical and chemical properties （including soil particle distribution, soil organic carbon （SOC）, calcium carbonate （CaCO3）, and oxides of Fe^3＋ and Al^3＋） of the selected soils were analyzed. The results show that soil particle size distribution is dominated by fine sand fraction in most of soils except Ustic Cambosols. Soil organic carbon concentration is 5.88 ± 2.52 g kg^-1 on average, ranging from 4.75 g kg^-1 in Ari-Sandic Primosols to 10.51 g kg^-1 in Ustic Cambosols. The soils have high calcium carbonate （CaCO3） concentration, ranging from 84.7 to 164.8 g kg^-1, which is increased with soil fine particle and organic carbon content. The percentage of 〉0.25 mm dry aggregates ranges from 65.2% in Ari-Sandic Primosols to 94.6% in Ustic Cambosols, and large dry blocky aggregates （〉5 mm） is dominant in all soils. The mean weight diameter of dry aggregates （DMWD） ranges from 3.2 mm to 5.5 mm. The percentage of 〉0.25 mm water-stable aggregate is from 23.8% to 45.4%. The percentage of aggregate destruction （PAD） is from 52.4% to 66.8%, which shows a weak aggregate stability. Ari-Sandic Primosols has the highest PAD. The distribution and characteristics of soil aggregates are in favor of controlling soil wind erosion. However, the stability of aggregate of all soils is weak and soils are prone to disperse and harden after irrigation. The mass of macro-aggregates and DMWD are positively significantly correlated with the contents of soil clay and silt, soil organic carbon （SOC）, CaCO3, and oxides of Fe^3＋ and Al^3＋. Soil fine silt and clay, SOC and CaCO3 are important agents of aggregation in this region, and the effect of SOC and CaCO3 on aggregate stability is more significant than that of soil silt and clay. Converting cropland to alfalfa forage land can increase SOC concentration, and in turn, enhance the formation of aggregates and stability. For the marginal farmlands in this fragile ecological area, converting cropland to alfalfa grassland or performing crop-grass rotation is an effective and basic strategy to improve soil structure and quality, to mitigate soil wind erosion, and to enhance oasis agricultural sustainability.