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Morel-Lavallee Lesion of the Lower Back Mimicking an Abscess: A Case Report
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作者 Sandra de Montbrun Korosh Khalili +1 位作者 Steven MacLellan Alexandra Easson 《Surgical Science》 2012年第4期213-215,共3页
A closed degloving injury, or Morel-Lavallee lesion, is the result of a severe, traumatic, shearing injury, causing separation of the skin and subcutaneous tissue from the underlying deep fascia. Though well described... A closed degloving injury, or Morel-Lavallee lesion, is the result of a severe, traumatic, shearing injury, causing separation of the skin and subcutaneous tissue from the underlying deep fascia. Though well described in the orthopedic trauma literature, this lesion is not well recognized by the general surgeon in the poly-trauma setting. We present a case of a 41 year old man who was referred to the general surgery service for a “back abscess”. Upon patient interview, history of a recent motor vehicle collision (MVC) was obtained, including a pelvic fracture. Imaging demonstrated a large Morel-Lavellee lesion extending from the pelvis into the lower back. Knowledge of this entity is crucial to avoid unnecessary procedures in the management of these patients. 展开更多
关键词 CLOSED Degloving INJURY morel-lavallee lesion TRAUMA Case Report
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Morel-Lavallee lesion 被引量:1
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作者 Li Hui Zhang Fangjie Lei Guanghua 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第7期1351-1356,共6页
Objective To review current knowledge of the Morel-Lavallee lesion (MLL) to help clinicians become familiar with this entity.Familiarization may decrease missed diagnoses and misdiagnoses.It could also help steer th... Objective To review current knowledge of the Morel-Lavallee lesion (MLL) to help clinicians become familiar with this entity.Familiarization may decrease missed diagnoses and misdiagnoses.It could also help steer the clinician to the proper treatment choice.Data sources A search was performed via PubMed and EMBASE from 1966 to July 2013 using the following keywords:Morel-Lavallee lesion,closed degloving injury,concealed degloving injury,Morel-Lavallee effusion,Morel-Lavallee hematoma,posttraumatic pseudocyst,posttraumatic soft tissue cyst.Study selection Chinese and English language literatures relevant to the subject were collected.Their references were also reviewed.Results Morel-Lavallee lesion is a relatively rare condition involving a closed degloving injury.It is characterized by a filled cystic cavity created by separation of the subcutaneous tissue from the underlying fascia.Apart from the classic location over the region of the greater trochanter,MLLs have been described in other parts of the body.The natural history of MLL has not yet been established.The lesion may decrease in volume,remain stable,enlarge progressively or show a recurrent pattern.Diagnosis of MLL was often missed or delayed.Ultrasonography,computed tomography,and magnetic resonance imaging have great value in the diagnosis of MLL.Treatment of MLL has included compression,local aspiration,open debridement,and sclerodesis.No standard treatment has been established.Conclusions A diagnosis of MLL should be suspected when a soft,fluctuant area of skin or chronic recurrent fluid collection is found in a region exposed to a previous shear injury.Clinicians and radiologists should be aware of both the acute and chronic appearances to make the correct diagnosis.Treatment decisions should base on association with fractures,the condition of the lesion,symptom and desire of the patient. 展开更多
关键词 morel-lavallee lesion closed degloving injury posttraumatic pseudocyst pelvic trauma posttraumatic soft tissue cyst
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Morel-Lavallee lesion-radiological spectrum
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作者 Bharat Bhushan Sharma Sandeep Sharma +3 位作者 Priya Ramchandran Narendar Kumar Magu Mir Rizwan Aziz Shilpa Singh 《Plastic and Aesthetic Research》 2016年第1期335-338,共4页
Morel-Lavallee lesion(MLL)entity represents as a haemolymph mass as a result of closed degloving injury following focal trauma.The swelling can be mistaken as a tumor or simple hematoma formation,and it can be of conc... Morel-Lavallee lesion(MLL)entity represents as a haemolymph mass as a result of closed degloving injury following focal trauma.The swelling can be mistaken as a tumor or simple hematoma formation,and it can be of concern as it gradually increases in size.It is important to diagnose the entity promptly as proper management can avoid skin necrosis and further complications.We present a 20-year-old female nursing student who fell down from a scooter and developed painful massive right thigh swelling over a 3-week course following trauma.She underwent plain radiography which was unremarkable.Ultrasound and magnetic resonance imaging revealed the diagnosis of MLL and she was treated accordingly. 展开更多
关键词 morel-lavallee lesion HAEMOLYMPH ULTRASOUND magnetic resonance imaging
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A rare case of severe third degree friction burns and large Morel-Lavallee lesion of the abdominal wall 被引量:3
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作者 Darnell J.Brown Kuo Jung G.Lu +3 位作者 Kristina Chang Jennifer Levin John T.Schulz Jeremy Goverman 《Burns & Trauma》 2018年第1期63-66,共4页
Background: Morel-Lavallee lesions (MLLs) are rare internal degloving injuries typically caused by blunt traumatic injuries and most commonly occur around the hips and in association with pelvic or acetabular fracture... Background: Morel-Lavallee lesions (MLLs) are rare internal degloving injuries typically caused by blunt traumatic injuries and most commonly occur around the hips and in association with pelvic or acetabular fractures. MLL is often overlooked in the setting of poly-trauma;therefore, clinicians must maintain a high degree of suspicion and be familiar with the management of such injuries, especially in obese poly-trauma patients. Case presentation: We present a 30-year-old female pedestrian struck by a motor vehicle who sustained multiple long bone fractures, a mesenteric hematoma, and full-thickness abdominal skin friction burn which masked a significant underlying abdominal MLL. The internal degloving caused significant devascularization of the overlying soft tissue and skin which required surgical drainage of hematoma, abdominal wall reconstruction with tangential excision, allografting, negative pressure wound therapy, and ultimately autografting. Conclusion: MLL is a rare, often overlooked, internal degloving injury. Surgeons must maintain a high index of suspicion when dealing with third degree friction burns as they may mask underlying injuries such as MLL, and a delay in diagnosis can lead to increased morbidity. 展开更多
关键词 FRICTION BURNS BLUNT trauma FRICTION BURNS nternal degloving injuries morel-lavallee lesion Traumatic PSEUDOCYST
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Can Emax and platelet count truly differentiate between benign and malignant liver lesions?
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作者 Manjeet Kumar Goyal Omesh Goyal 《World Journal of Gastroenterology》 SCIE CAS 2025年第3期120-122,共3页
This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretat... This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretative limitations are identified.The study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold values.The nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with cirrhosis.Moreover,the study's limitations,such as selection bias and confounding factors,are not adequately addressed.Future research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability. 展开更多
关键词 Emax Platelet count Benign liver lesions Malignant liver lesions Hepatocellular carcinoma CIRRHOSIS Diagnostic biomarkers Shear wave elastography Methodological limitations Clinical utility
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小儿Morel-Lavallee损伤的治疗体会
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作者 曾晓辉 万玲玲 +1 位作者 熊斌 吴欣乐 《现代医院》 2018年第7期1020-1021,共2页
目的探讨小儿Morel-Lavallee损伤的诊断与治疗。方法 2010年3月-2016年3月收治小儿Morel-Lavallee损伤患儿22例,包括大转子部7例,侧腰部4例,环骨盆环5例,腰骶部2例,臀部4例。所有病例均合并骨盆骨折,并合并不同程度会阴部损伤。主要治... 目的探讨小儿Morel-Lavallee损伤的诊断与治疗。方法 2010年3月-2016年3月收治小儿Morel-Lavallee损伤患儿22例,包括大转子部7例,侧腰部4例,环骨盆环5例,腰骶部2例,臀部4例。所有病例均合并骨盆骨折,并合并不同程度会阴部损伤。主要治疗方法包括彻底清创、骨折固定、生殖器重建、肛门造瘘、负压真空封闭式引流(VSD)、功能恢复。观察患儿的手术情况、阴部创面愈合时间、住院时间及术后随访时间、预后情况、Majeed评分判定患儿的骨盆骨折愈合情况。结果 1例死亡,死因:感染中毒性休克;2例截肢。手术次数平均(3.7±0.4)次,平均住院天数(53.1±2.6)天,平均阴部创面愈合时间(9.5±0.9)月,平均术后随访时间(6.2±0.9)个月,平均Majeed评分(86.7±2.7)分。结论小儿患者因皮下脂肪丰富,症状容易忽视而使病程延长,病情加重,早期彻底清创+负压真空封闭式引流效果明显。 展开更多
关键词 morel-lavallee损伤 清创 负压封闭式引流(VSD)
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关节镜结合经皮缝合引流治疗迟发性Morel-lavallee损伤并感染的疗效分析 被引量:2
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作者 龙智生 龚飞鹏 +3 位作者 李宇旭 陈钢 廖观祥 李晨 《江西医药》 CAS 2020年第12期1801-1803,共3页
目的比较关节镜结合经皮缝合引流和传统切开VSD两种手术方式治疗迟发性Morel-lavallee损伤并感染的疗效。方法选取我院2018年1月至2020年10月收治的20例诊断为Morel-lavallee损伤合并感染的患者,根据手术方式分为关节镜组及传统治疗组... 目的比较关节镜结合经皮缝合引流和传统切开VSD两种手术方式治疗迟发性Morel-lavallee损伤并感染的疗效。方法选取我院2018年1月至2020年10月收治的20例诊断为Morel-lavallee损伤合并感染的患者,根据手术方式分为关节镜组及传统治疗组各10例。关节镜组采用镜下清创+经皮缝合引流,传统组采取开放性清创+VSD引流。对比两组间手术次数,手术时间,住院时间,住院费用,术前VAS评分及术后7dVAS评分,白细胞计数,血沉及C反应蛋白。结果术前两组间年龄,性别构成及VAS评分无显著差别(P>0.05),关节镜组手术次数,手术时间,住院费用,术中总计出血量,术后7dVAS评分,术后7d白细胞计数及血沉明显优于传统治疗组,差异具有统计学意义(P<0.05),两组术后7dC反应蛋白无显著差别(P>0.05)。结论关节镜结合经皮缝合引流治疗迟发性Morel-lavallee损伤并感染疗效显著,值得推广。 展开更多
关键词 morel-lavallee损伤 感染 关节镜 经皮缝合
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点状缝合结合持续封闭负压吸引治疗Morel-Lavallee损伤 被引量:2
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作者 师红立 马洪亮 +1 位作者 王宏林 陈金钢 《医学理论与实践》 2021年第24期4301-4303,共3页
目的:观察点状缝合结合持续封闭负压吸引在Morel-Lavallee损伤手术治疗中的应用效果。方法:收集本科室2014年10月-2020年10月收治的Morel-Lavallee损伤患者8例,采用点状缝合结合持续封闭负压吸引方法治疗,观察疗效。结果:所有患者伤口... 目的:观察点状缝合结合持续封闭负压吸引在Morel-Lavallee损伤手术治疗中的应用效果。方法:收集本科室2014年10月-2020年10月收治的Morel-Lavallee损伤患者8例,采用点状缝合结合持续封闭负压吸引方法治疗,观察疗效。结果:所有患者伤口均顺利愈合,未出现继发感染、皮肤坏死等并发症。复查彩超结果显示皮下组织及筋膜层愈合良好,皮下无残留空腔及积液。随访2~24个月,无复发,皮肤弹性良好,皮肤感觉无明显异常,患肢功能无障碍。结论:采用点状缝合结合持续封闭负压吸引治疗Morel-Lavallee损伤安全,能预防复发和感染,效果满意。 展开更多
关键词 morel-lavallee损伤 持续封闭负压吸引 点状缝合
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Molecular Mechanism of Rice Necrotic Lesion for Optimized Yield and Disease Resistance 被引量:1
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作者 HOU Xinyue WANG Yuping +1 位作者 QIAN Qian REN Deyong 《Rice science》 SCIE CSCD 2024年第3期285-299,共15页
How to balance rice resistance and yield is an important issue in rice breeding.Plants with mutated necrotic lesion genes often have persistent broad-spectrum resistance,but this broad-spectrum resistance usually come... How to balance rice resistance and yield is an important issue in rice breeding.Plants with mutated necrotic lesion genes often have persistent broad-spectrum resistance,but this broad-spectrum resistance usually comes at the expense of yield.Currently,many necrotic lesion mutants in rice have been identified,and these genes are involved in disease resistance pathways.This review provides a detailed introduction to the characteristics,classification,and molecular mechanisms of necrotic lesion formation.Additionally,we review the molecular regulatory pathways of genes involved in rice disease resistance.Concurrently,we summarize the relationship between resistance and yield in rice using newly developed gene editing methods.We discuss a rational and precise breeding strategy to better utilize molecular design technology for breeding disease-resistant and high-yield rice varieties. 展开更多
关键词 RICE necrotic lesion regulation mechanism high yield high resistance
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Scheme Based on Multi-Level Patch Attention and Lesion Localization for Diabetic Retinopathy Grading 被引量:1
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作者 Zhuoqun Xia Hangyu Hu +4 位作者 Wenjing Li Qisheng Jiang Lan Pu Yicong Shu Arun Kumar Sangaiah 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期409-430,共22页
Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional ... Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional attention schemes have not considered the impact of lesion type differences on grading,resulting in unreasonable extraction of important lesion features.Therefore,this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator(MPAG)and a lesion localization module(LLM).Firstly,MPAGis used to predict patches of different sizes and generate a weighted attention map based on the prediction score and the types of lesions contained in the patches,fully considering the impact of lesion type differences on grading,solving the problem that the attention maps of lesions cannot be further refined and then adapted to the final DR diagnosis task.Secondly,the LLM generates a global attention map based on localization.Finally,the weighted attention map and global attention map are weighted with the fundus map to fully explore effective DR lesion information and increase the attention of the classification network to lesion details.This paper demonstrates the effectiveness of the proposed method through extensive experiments on the public DDR dataset,obtaining an accuracy of 0.8064. 展开更多
关键词 DDR dataset diabetic retinopathy lesion localization multi-level patch attention mechanism
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Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients 被引量:1
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作者 Nhu Thi Hanh Vu Huy Minh Le +4 位作者 Diem Thi-Ngoc Vo Hoang Anh Vu Nhan Quang Le Dung Dang Quy Ho Duc Trong Quach 《World Journal of Clinical Oncology》 2024年第2期290-301,共12页
BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal cancer.Previous studies in Vietnam mainly investigated the adenoma path... BACKGROUND Sessile serrated lesions(SSLs)are considered precancerous colorectal lesions that should be detected and removed to prevent colorectal cancer.Previous studies in Vietnam mainly investigated the adenoma pathway,with limited data on the serrated pathway.AIM To evaluate the prevalence,risk factors,and BRAF mutations of SSLs in the Vietnamese population.METHODS This is a cross-sectional study conducted on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital in Vietnam.SSLs were diagnosed on histopathology according to the 2019 World Health Organi-zation classification.BRAF mutation analysis was performed using the Sanger DNA sequencing method.The multivariate logistic regression model was used to determine SSL-associated factors.RESULTS There were 2489 patients,with a mean age of 52.1±13.1 and a female-to-male ratio of 1:1.1.The prevalence of SSLs was 4.2%[95%confidence interval(CI):3.5-5.1].In the multivariate analysis,factors significantly associated with SSLs were age≥40[odds ratio(OR):3.303;95%CI:1.607-6.790],male sex(OR:2.032;95%CI:1.204-3.429),diabetes mellitus(OR:2.721;95%CI:1.551-4.772),and hypertension(OR:1.650,95%CI:1.045-2.605).The rate of BRAF mutations in SSLs was 35.5%.CONCLUSION The prevalence of SSLs was 4.2%.BRAF mutations were present in one-third of SSLs.Significant risk factors for SSLs included age≥40,male sex,diabetes mellitus,and hypertension. 展开更多
关键词 Colorectal cancer Sessile serrated lesion BRAF mutation Risk factors Diabetes mellitus Hypertension
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Expert consensus on the diagnosis and therapy of endo-periodontal lesions
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作者 Bin Chen Yanan Zhu +19 位作者 Minkui Lin Yangheng Zhang Yanfen Li Xiangying Ouyang Song Ge Jiang Lin Yaping Pan Yan Xu Yi Ding Shaohua Ge Faming Chen Zhongchen Song Shaoyun Jiang Jiang Sun Lijun Luo Junqi Ling Zhi Chen Lin Yue Xuedong Zhou Fuhua Yan 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第3期381-389,共9页
Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple cont... Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple contributing factors.This etiological complexity leads to difficulties in determining patient prognosis,posing great challenges in clinical practice.Furthermore,EPL-affected teeth require multidisciplinary therapy,including periodontal therapy,endodontic therapy and others,but there is still much debate about the appropriate timing of periodontal therapy and root canal therapy.By compiling the most recent findings on the etiology,pathogenesis,clinical characteristics,diagnosis,therapy,and prognosis of EPL-affected teeth,this consensus sought to support clinicians in making the best possible treatment decisions based on both biological and clinical evidence. 展开更多
关键词 DIAGNOSIS PERIODONTAL lesionS
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Hepatic cystic lesions mimicking liver abscess on imaging: A report oftwo cases
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作者 Yun-Wen Jiang Yong-Hong Yu +1 位作者 Tian-An Jiang Shu-Yuan Tian 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第1期86-89,共4页
Hepatic cystic lesions include congenital dysplasia,inflammatory cystic lesions,neoplastic cystic lesions and parasitic cystic lesions.As different treatment modalities can be chosen for these lesions,differential dia... Hepatic cystic lesions include congenital dysplasia,inflammatory cystic lesions,neoplastic cystic lesions and parasitic cystic lesions.As different treatment modalities can be chosen for these lesions,differential diagnosis is particularly important[1].Clinical features or imaging findings of cystic lesions of the liver are typical;for instance,liver abscess often shows thick-walled enhancement on contrast-enhanced CT. 展开更多
关键词 lesionS HEPATIC CYSTIC
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Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study
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作者 Yi XU Tian XU +13 位作者 Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-Na MENG Yu-He ZHOU Xiang-Qi WU Zhi-Ming WU Mei-En ZHAN Yan-Qing WANG De-Feng PAN Fei YE 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2024年第5期506-522,共17页
OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the c... OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent strategy.METHODS A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of RI.RESULTS In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P < 0.0001)was significantly higher in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR group.CONCLUSION The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up. 展开更多
关键词 lesionS REMODELING INTRAVASCULAR
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Two-Stent Strategy for Bifurcation Lesions in Percutaneous Transluminal Coronary Angioplasty: Real-World Evidence
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作者 Dilip Kumar Amit Malviya +8 位作者 Animesh Mishra Rabin Chakraborty Sanjeev S. Mukherjee Soumya Patra Arindam Pande Rana Rathor Roy Debopriyo Mondal Ashesh Halder Sumit Shanker 《World Journal of Cardiovascular Diseases》 CAS 2024年第3期140-156,共17页
Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation le... Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation lesions in India is limited. This study aimed to evaluate the clinical outcomes of various 2SSs for percutaneous transluminal coronary angioplasty for bifurcation lesions in India. Materials and Methods: This retrospective, observational, multicentric, real-world study included 64 patients over 8 years. Data on demographics, medical history, PCI procedures, and outcomes were recorded. Descriptive statistics were computed using the SPSS software. Results: Patients (n = 64) had an average age of 65.3 ± 11.1 years, with 78.1% males. Acute coronary syndrome was reported in 18.8%, chronic stable angina in 40.6%, and unstable angina in 34.4% of participants. Two-vessel disease was observed in 98.4% of patients, and 99.4% had true bifurcation lesions. The commonly involved vessels were the left anterior descending artery (50%), left circumflex coronary artery (34.4%), and first diagonal artery (43.8%). Mean percent diameter stenosis was 87.2% ± 10.1%. The mean number of stents used was 2.00 ± 0.34. The 2SS techniques included the T and small protrusion (TAP) (39.1%), double kissing (DK) crush (18.8%), and the culotte techniques (14.1%). Procedural and angiographic success rate was 92.18%. Major adverse cardiovascular events at 1-year follow-up occurred in 7.8% of cases. Conclusion: The 2SS for bifurcation lesions showed favorable in-hospital and follow-up outcomes. Findings can serve as a resource for bifurcation angioplasty in India. Larger real-world studies with robust methodology are needed to validate these results. 展开更多
关键词 Bifurcation Stenting Coronary Bifurcation lesions PERCUTANEOUS
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Evaluating the efficacy of percutaneous puncture biopsy guided by contrast-enhanced ultrasound for peripheral pulmonary lesions
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作者 Xiao Jiang Jun Chen +8 位作者 Fang-Fang Gu Zhong-Rong Li Yu-Shan Song Jing-Jing Long Shu-Zhen Zhang Ting-Ting Xu Yong-Jun Tang Ji-Ying Gu Xiang-Ming Fang 《World Journal of Clinical Cases》 SCIE 2024年第19期3791-3799,共9页
BACKGROUND The incidence and mortality of lung cancer have increased annually.Accurate diagnosis can help improve therapeutic efficacy of interventions and prognosis.Percutaneous lung biopsy is a reliable method for t... BACKGROUND The incidence and mortality of lung cancer have increased annually.Accurate diagnosis can help improve therapeutic efficacy of interventions and prognosis.Percutaneous lung biopsy is a reliable method for the clinical diagnosis of lung cancer.Ultrasound-guided percutaneous lung biopsy technology has been widely promoted and applied in recent years.AIM To investigate the diagnostic value of contrast-enhanced ultrasound(CEUS)-guided percutaneous biopsy in peripheral pulmonary lesions.METHODS We retrospectively collected data on 237 patients with peripheral thoracic focal lesions who underwent puncture biopsy at Wuxi People’s Hospital.The patients were randomly divided into two groups:The CEUS-guided before lesion puncture group(contrast group)and conventional ultrasound-guided group(control group).Analyze the diagnostic efficacy of the puncture biopsy,impact of tumor size,and number of puncture needles and complications were analyzed and compared between the two groups.RESULTS Accurate pathological results were obtained for 92.83%(220/237)of peripheral lung lesions during the first biopsy,with an accuracy rate of 95.8%(113/118)in the contrast group and 89.9%(107/119)in the control group.The difference in the area under the curve(AUC)between the contrast and the control groups was not statistically significant(0.952 vs 0.902,respectively;P>0.05).However,when the lesion diameter≥5 cm,the diagnostic AUC of the contrast group was higher than that of the control group(0.952 vs 0.902,respectively;P<0.05).In addition,the average number of puncture needles in the contrast group was lower than that in the control group(2.58±0.53 vs 2.90±0.56,respectively;P<0.05).CONCLUSION CEUS guidance can enhance the efficiency of puncture biopsy of peripheral pulmonary lesions,especially for lesions with a diameter≥5 cm.Therefore,CEUS guidance has high clinical diagnostic value in puncture biopsy of peripheral focal lung lesions. 展开更多
关键词 Contrast-enhanced ultrasound Peripheral lung lesions Ultrasound guidance BIOPSY Peripheral thoracic focal lesions
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Challenges in Diagnosing and Managing Dieulafoy’s Lesions: A Case Report Highlighting the Importance of Clinical Suspicion and Multidisciplinary Approach in Obscure Gastrointestinal Bleeding
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作者 Feruza Abraamyan Neeladri Misra +3 位作者 Kenneth Tran Khalid Mahmood Benjamin Coombs Shilpa Lingala 《Open Journal of Gastroenterology》 CAS 2024年第3期80-86,共7页
Upper gastrointestinal bleeding remains a significant cause of hospital admissions. Even though the incidence of peptic ulcer disease and gastritis is decreasing, the incidence rates in neoplasm, Dieulafoy’s lesions,... Upper gastrointestinal bleeding remains a significant cause of hospital admissions. Even though the incidence of peptic ulcer disease and gastritis is decreasing, the incidence rates in neoplasm, Dieulafoy’s lesions, angiodysplasia, and esophagitis are trending up, which necessities physicians to be aware of those pathologies and their specifics. Here, we represent a case of a 62-year-old male on dual antiplatelet therapy who was transferred to our hospital due to severe melena with suspicion of upper gastrointestinal bleeding. Due to hemodynamic instability, the patient was intubated and started on vasopressors. However, several repeated EGDs and CTs of the abdomen with GI bleeding protocol did not reveal the location of active bleeding to stop it. At the same time, clinically, the patient was hemodynamically unstable with continued melena. On the last EGD, a small area of concern resembling gastric varix was clipped for identification purposes, and the patient underwent a selective angiogram with further diagnosis of Dieulafoy’s lesion, which was successfully embolized. Our case demonstrates that Dieulafoy’s lesions can present as severe life-threatening hemorrhage, hard to diagnose with traditional methods such as EGD or CTs, in which case it is recommended to proceed with an angiogram sooner rather than later for further diagnosis and treatment if needed. 展开更多
关键词 Upper Gastrointestinal Bleeding Dieulafoy’s lesion ANGIODYSPLASIA MELENA HEMATOCHEZIA EGD ANGIOGRAM EMBOLIZATION
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Argon Laser Treatment of Retinal Lesions at the CHU-IOTA in Bamako, Mali
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作者 Awa Ibrahim Toure Kadiatou Ba +9 位作者 Brainima Coulibaly Mariam Konate Oumar Touré Mory Coulibaly Cheick Sogodogo Aissata Tall Jérémi Dembele Mohamed Kolé Sidibe Souleymane Sissoko Gounon Saye 《Open Journal of Ophthalmology》 2024年第4期412-417,共6页
Introduction: There are many types of retinal lesions: exudative, degenerative and post-traumatic. Some can lead to retinal detachment (RD). The treatment indicated for these neovascular diseases of the eye is retinal... Introduction: There are many types of retinal lesions: exudative, degenerative and post-traumatic. Some can lead to retinal detachment (RD). The treatment indicated for these neovascular diseases of the eye is retinal photocoagulation with the Argon laser. The aim of this study was to investigate retinal lesions treated with the Argon laser at IOTA University Hospital. Patients and Method: This was a prospective cross-sectional study over a 9-month period. All patients seen at CHU IOTA during our study period who presented with a retinal pathology treated with the Argon laser or a retinal detachment with a giant tear in the contralateral eye and who had given their consent were included. One session consisted of treating the maximum surface area of half a retina. Results: We collected 263 cases. The age group 40 to 60 years was the most represented with 48.7%. Diabetes was the most frequent antecedent with 47.1%. Neovessels were the most common type of lesion, accounting for 68.4% of cases. Pan-retinal photocoagulation was performed in 74.5% of patients. Conclusion: Retinal lesions represent a major risk of functional visual loss. Physical treatment with retinal photocoagulation has a curative effect on ischaemic lesions and a preventive effect on retinal detachment. 展开更多
关键词 Retinal lesions DIABETES Argon Laser DDR
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Uremic Bleeding in 2 Patients with Dieulafoy’s Lesion: Case Report and Literature Review
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作者 Gustavo Adolfo Hernández Valdez Diana Estefanía Ibarra García +7 位作者 Juan Antonio Contreras Escamilla Janette Alejandra Gamiño Gutierrez Francisco Manuel Tonatiuh Carrillo Beltran Ulises Solis Gomez Jocelyn Nataly Quintero Meléndez Ivan Alejandro Medina Jimenez Marco Antonio González Villar Jorge Rojas Morales 《Open Journal of Gastroenterology》 CAS 2024年第5期167-173,共7页
Dieulafoy’s lesions are rare vascular malformations of the gastrointestinal tract. A Dieulafoy’s lesion is an aberrant vessel that does not reduce in caliber when it extends from the submucosa to the mucosa. Damage ... Dieulafoy’s lesions are rare vascular malformations of the gastrointestinal tract. A Dieulafoy’s lesion is an aberrant vessel that does not reduce in caliber when it extends from the submucosa to the mucosa. Damage to this artery can cause severe and intermittent arterial bleeding from small vascular stumps that are difficult to visualize. Furthermore, these catastrophic bleeding episodes frequently result in hemodynamic instability and the need for transfusion of multiple blood products. Recently, uremic syndrome has been identified as a risk factor for gastric mucosal lesions. We present two clinical cases of acute digestive bleeding due to Dielafoy lesion with chronic kidney disease as the main cause, where two different therapies were performed endoscopically. We concluded with the results of our patients that the best therapy was the application of the hemostatic hemoclip on the injury vs the injection with adrenaline on the wound site. Uremia is identified as a risk factor for upper gastrointestinal bleeding in patients with pre-existing Dieulafoy’s lesion, as well as a higher incidence of new bleeding. 展开更多
关键词 Dieulafoy’s lesion Gastrointestinal Bleeding ENDOSCOPY ENDOSCOPY Hemostatic Clips Kidney Disease ADRENALINE Thermal Coagulation DIEULAFOY
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The gene encoding flavonol synthase contributes to lesion mimic in wheat
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作者 Tingting Dong Hongchun Xiong +8 位作者 Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Huiyuan Li Shirong Zhao Yuping Ding Xiyun Song Luxiang Liu 《The Crop Journal》 SCIE CSCD 2024年第3期814-825,共12页
Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection,and is characterized by a hypersensitive-response(HR)that closely linked to plant disease resistance.Despite this,only a... Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection,and is characterized by a hypersensitive-response(HR)that closely linked to plant disease resistance.Despite this,only a few lesion mimic genes have been identified in wheat.In this investigation,a lesion mimic wheat mutant named je0297 was discovered,showing no alteration in yield components when compared to the wild type(WT).Segregation ratio analysis of the F_(2)individuals resulting from the cross between the WT and the mutant revealed that the lesion mimic was governed by a single recessive gene in je0297.Using Bulked segregant analysis(BSA)and exome capture sequencing,we mapped the lesion mimic gene designated as lm6 to chromosome 6BL.Further gene fine mapping using 3315 F_(2)individuals delimited the lm6 within a 1.18 Mb region.Within this region,we identified 16 high-confidence genes,with only two displaying mutations in je0297.Notably,one of the two genes,responsible for encoding flavonol synthase,exhibited altered expression levels.Subsequent phenotype analysis of TILLING mutants confirmed that the gene encoding flavonol synthase was indeed the causal gene for lm6.Transcriptome sequencing analysis revealed that the DEGs between the WT and mutant were significantly enriched in KEGG pathways related to flavonoid biosynthesis,including flavone and flavonol biosynthesis,isoflavonoid biosynthesis,and flavonoid biosynthesis pathways.Furthermore,more than 30 pathogen infection-related(PR)genes exhibited upregulation in the mutant.Corresponding to this expression pattern,the flavonoid content in je0297 showed a significant decrease in the 4^(th)leaf,accompanied by a notable accumulation of reactive oxygen,which likely contributed to the development of lesion mimic in the mutant.This investigation enhances our comprehension of cell death signaling pathways and provides a valuable gene resource for the breeding of disease-resistant wheat. 展开更多
关键词 lesion mimic mutant WHEAT Gene mapping Flavonol synthase gene Flavonoid
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