Aim： To examine whether a relationship exists between glutathione S-transferase Mu-1 （GSTM1） gene polymorphism and the susceptibility of sperm and seminal plasma from patients with idiopathic infertility to oxidati...Aim： To examine whether a relationship exists between glutathione S-transferase Mu-1 （GSTM1） gene polymorphism and the susceptibility of sperm and seminal plasma from patients with idiopathic infertility to oxidative stress. Methods： Fifty-two men with idiopathic infertility and 60 healthy fertile men were recruited to this study. GSTM1 gene polymorphism was determined by polymerase chain reaction （PCR） and both the infertile and control individuals were divided into GSTM1 null and GSTM1 positive groups according to their GSTM1 gene structure. We compared reactive oxygen species （ROS） generation, malondialdehyde （MDA）, protein carbonyls and glutathione （GSH） concentrations, and glutathione S-transferase （GST） activity in seminal plasma and spermatozoa from infertile patients and controls with respect to GSTM1 genotype. Results： Significantly higher levels of oxidative stress and damage markers were found in idiopathic infertile men with the GSTM1 null genotype compared with those with the GSTM1 positive genotype. There was no significant difference in genotype distribution for theGSTM1 variant between the idiopathic infertile subjects and fertile subjects. Patients with the GSTM1 null genotype also had lower sperm concentrations than those with GSTM1 positive genotype. Conclusion： Our results suggest that the susceptibility of sperm and seminal plasma to oxidative stress is significantly greater in idiopathic infertile men with the GSTM1 null genotype compared with those possessing the gene. Therefore, in patients with idiopathic infertility, GSTM1 polymorphism might be an important source of variation in susceptibility of spermatozoa to oxidative damage.展开更多
This paper investigates the device-to-device(D2 D) communication underlaying multi-user multi-input multi-output(MU-MIMO) cellular networks. It is assumed that D2 D users reuse the downlink time-frequency resources of...This paper investigates the device-to-device(D2 D) communication underlaying multi-user multi-input multi-output(MU-MIMO) cellular networks. It is assumed that D2 D users reuse the downlink time-frequency resources of cellular links, and the base station(BS) is assumed to be equipped with multiple antennas. We investigate the ergodic achievable sum rate of the system when the interference cancellation(IC) precoding strategy is employed at the BS. The distributions of the received signal-to-interference-plus-noise ratio(SINR) for each link are firstly analyzed, and an exact ergodic achievable sum rate of the whole system with closedform expressions is then derived. Furthermore, we present novel upper and lower bounds with simpler expressions, which are later verified to be fairly close to the Monte-Carlo simulations. All the expressions we presented are suitable for arbitrary network topology and arbitrary number of antennas at BS. Based on the derived bounds, the influence of the antennas at BS on system performance is then analyzed. We reveal that the system performance increases along with the number of antennas at BS in a logarithmic way. The accuracy of our analytical results is validated via comparisons with Monte-Carlo simulations.展开更多
针对多用户多输入多输出(Multi-User Multiple Input Multiple Output,MU-MIMO)系统中用户调度和预编码传统算法性能不佳和分层设计导致系统复杂度高的问题,利用最大信漏噪比(Signal to Leakage plus Noise Ratio,SLNR)算法的优越性,提...针对多用户多输入多输出(Multi-User Multiple Input Multiple Output,MU-MIMO)系统中用户调度和预编码传统算法性能不佳和分层设计导致系统复杂度高的问题,利用最大信漏噪比(Signal to Leakage plus Noise Ratio,SLNR)算法的优越性,提出一种基于SLNR算法的用户调度和预编码的跨层联合优化策略,利用迭代搜索最优用户组,并在预编码中加入功率分配。仿真结果表明,新策略比传统算法能够提升系统吞吐量,并改善误码率性能,同时使系统具有较低的复杂度。展开更多
文摘Aim： To examine whether a relationship exists between glutathione S-transferase Mu-1 （GSTM1） gene polymorphism and the susceptibility of sperm and seminal plasma from patients with idiopathic infertility to oxidative stress. Methods： Fifty-two men with idiopathic infertility and 60 healthy fertile men were recruited to this study. GSTM1 gene polymorphism was determined by polymerase chain reaction （PCR） and both the infertile and control individuals were divided into GSTM1 null and GSTM1 positive groups according to their GSTM1 gene structure. We compared reactive oxygen species （ROS） generation, malondialdehyde （MDA）, protein carbonyls and glutathione （GSH） concentrations, and glutathione S-transferase （GST） activity in seminal plasma and spermatozoa from infertile patients and controls with respect to GSTM1 genotype. Results： Significantly higher levels of oxidative stress and damage markers were found in idiopathic infertile men with the GSTM1 null genotype compared with those with the GSTM1 positive genotype. There was no significant difference in genotype distribution for theGSTM1 variant between the idiopathic infertile subjects and fertile subjects. Patients with the GSTM1 null genotype also had lower sperm concentrations than those with GSTM1 positive genotype. Conclusion： Our results suggest that the susceptibility of sperm and seminal plasma to oxidative stress is significantly greater in idiopathic infertile men with the GSTM1 null genotype compared with those possessing the gene. Therefore, in patients with idiopathic infertility, GSTM1 polymorphism might be an important source of variation in susceptibility of spermatozoa to oxidative damage.
基金supported by the Natural Science Foundation of Jiangsu Province (No. BK20170758)the National Natural Science Foundation for Young Scholars of China (No. 61701201)+1 种基金the Natural Science Foundation for colleges and universities of Jiangsu Province (No. 17KJB510011)Project of Key Laboratory of Wireless Communications of Jiangsu Province
文摘This paper investigates the device-to-device(D2 D) communication underlaying multi-user multi-input multi-output(MU-MIMO) cellular networks. It is assumed that D2 D users reuse the downlink time-frequency resources of cellular links, and the base station(BS) is assumed to be equipped with multiple antennas. We investigate the ergodic achievable sum rate of the system when the interference cancellation(IC) precoding strategy is employed at the BS. The distributions of the received signal-to-interference-plus-noise ratio(SINR) for each link are firstly analyzed, and an exact ergodic achievable sum rate of the whole system with closedform expressions is then derived. Furthermore, we present novel upper and lower bounds with simpler expressions, which are later verified to be fairly close to the Monte-Carlo simulations. All the expressions we presented are suitable for arbitrary network topology and arbitrary number of antennas at BS. Based on the derived bounds, the influence of the antennas at BS on system performance is then analyzed. We reveal that the system performance increases along with the number of antennas at BS in a logarithmic way. The accuracy of our analytical results is validated via comparisons with Monte-Carlo simulations.
文摘针对多用户多输入多输出(Multi-User Multiple Input Multiple Output,MU-MIMO)系统中用户调度和预编码传统算法性能不佳和分层设计导致系统复杂度高的问题,利用最大信漏噪比(Signal to Leakage plus Noise Ratio,SLNR)算法的优越性,提出一种基于SLNR算法的用户调度和预编码的跨层联合优化策略,利用迭代搜索最优用户组,并在预编码中加入功率分配。仿真结果表明,新策略比传统算法能够提升系统吞吐量,并改善误码率性能,同时使系统具有较低的复杂度。
