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CLINICAL REPORT ON MULTI-CENTER RANDOMIZED CONTROLLED TRIAL OF TREATMENT OF MIGRAINE BY ELECTRO-ACUPUNCTURE AT QI■X■(丘墟GB40) 被引量:1
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作者 贾春生 马小顺 +10 位作者 石晶 王耀民 李永方 袁军 李梅 郑利星 张祥建 王少锦 高建英 李晓峰 霍永利 《World Journal of Acupuncture-Moxibustion》 2008年第1期1-9,共9页
Objective To observe the therapeutic effect of electro acupuncture at QIǖXǖ(丘墟GB40) for treating migraine and provide clinical study for Acupoints Dictionary of People's Republic of China. Methods Multi-center ... Objective To observe the therapeutic effect of electro acupuncture at QIǖXǖ(丘墟GB40) for treating migraine and provide clinical study for Acupoints Dictionary of People's Republic of China. Methods Multi-center (3 First-Class hospitals) study was adopted, and the involved 3 hospitals did clinical observation according to the requirements of the project. The methods are as follows. All cases were randomized into treatment group and control group according to their sequence. QIǖXǖ(丘墟GB40) was selected in treatment group, while Tiānshū (天枢 ST25) was selected in control group. Both groups were performed electro acupuncture, and syndromes indexes of migraine and 5-HT were observed before and after treatment. All data were analyzed by statistic software SPSS11.5. Results There was significant difference of VAS margin between two groups in each center and the combined center (u= -3. 362, P=0. 001 ). There was significant difference of therapeutic effect of 4-week treatment between two groups in each clinical center and the combined center. The therapeutic effect of 3-month treatment between two groups in No. 1 and No. 3 hospitals, showed significant difference, the treatment group was better; while that of No. 2 hospital had no obvious difference. The therapeutic effect of 6-month treatment between two groups in each center and the combined center had significant difference, the treatment group was better. Conclusion The therapy of electro acupuncture at QIǖXǖ(丘墟GB40) is effective for migraine. 展开更多
关键词 QIǖXǖ(丘墟GB40) Electro acupuncture Migraine multi-center clinical observation
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Probing the structure of multi-center molecules with odd–even high harmonics 被引量:4
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作者 Ning Su Shujuan Yu +2 位作者 Weiyan Li Shiping Yang Yanjun Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第5期274-280,共7页
We study high-order harmonic generation(HHG)from multi-center asymmetric linear molecules numerically and analytically.Our simulations show that odd and even HHG spectra of the asymmetric multi-center system respond d... We study high-order harmonic generation(HHG)from multi-center asymmetric linear molecules numerically and analytically.Our simulations show that odd and even HHG spectra of the asymmetric multi-center system respond differently to the change of the molecular structure.Specifically,when the internuclear distances between these nuclei of the molecule have a small change,the odd spectra usually do not change basically,but the even spectra differ remarkably.Based on this phenomenon,a simple procedure is proposed to probe the positions of these nuclei with odd–even HHG.Our results shed light on attosecond probing of the structure of multi-center molecules using HHG. 展开更多
关键词 odd-even harmonics multi-center asymmetric molecules molecular structure
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Minimum MSE Weights of Adjusted Summary Estimator of Risk Difference in Multi-Center Studies 被引量:1
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作者 Chukiat Viwatwongkasem Jirawan Jitthavech +1 位作者 Dankmar Bohning Vichit Lorchirachoonkul 《Open Journal of Statistics》 2012年第1期48-59,共12页
The simple adjusted estimator of risk difference in each center is easy constructed by adding a value c on the number of successes and on the number of failures in each arm of the proportion estimator. Assessing a tre... The simple adjusted estimator of risk difference in each center is easy constructed by adding a value c on the number of successes and on the number of failures in each arm of the proportion estimator. Assessing a treatment effect in multi-center studies, we propose minimum MSE (mean square error) weights of an adjusted summary estimate of risk difference under the assumption of a constant of common risk difference over all centers. To evaluate the performance of the proposed weights, we compare not only in terms of estimation based on bias, variance, and MSE with two other conventional weights, such as the Cochran-Mantel-Haenszel weights and the inverse variance (weighted least square) weights, but also we compare the potential tests based on the type I error probability and the power of test in a variety of situations. The results illustrate that the proposed weights in terms of point estimation and hypothesis testing perform well and should be recommended to use as an alternative choice. Finally, two applications are illustrated for the practical use. 展开更多
关键词 Minimum MSE WEIGHTS Optimal WEIGHTS Cochran-Mantel-Haenszel WEIGHTS Inverse Variance WEIGHTS multi-center STUDIES Risk Difference
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Effect of a disposable endoscope precleaning kit in the cleaning procedure of gastrointestinal endoscope:A multi-center observational study 被引量:1
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作者 Yi-Fan Wang Yu Wu +10 位作者 Xiao-Wei Liu Jian-Guo Li Yan-Qiong Zhan Bin Liu Wen-Ling Fan Zi-Heng Peng Jin-Tao Xiao Bing-Bing Li Jian He Jun Yi Zhao-Xia Lu 《World Journal of Gastrointestinal Endoscopy》 2023年第12期705-714,共10页
BACKGROUND Precleaning is a key step in endoscopic reprocessing.AIM To develop an effective and economic endoscope cleaning method by using a disposable endoscope bedside precleaning kit.METHODS Altogether,228 used ga... BACKGROUND Precleaning is a key step in endoscopic reprocessing.AIM To develop an effective and economic endoscope cleaning method by using a disposable endoscope bedside precleaning kit.METHODS Altogether,228 used gastrointestinal endoscopes were selected from five high-volume endoscopy units and precleaned by a traditional precleaning bucket(group T)or a disposable endoscope bedside precleaning kit(group D).Each group was further subdivided based on the replacement frequency of the cleaning solution,which was replaced every time in subgroups T1 and D1 and every several times in subgroups Ts and Ds.The adenosine triphosphate(ATP)level and residual proteins were measured three times:Before and after precleaning and after manual cleaning.RESULTS After precleaning,the precleaning kit significantly reduced the ATP levels(P=0.034)and has a more stable ATP clearance rate than the traditional precleaning bucket.The precleaning kit also saved a quarter of the cost of enzymatic detergent used during the precleaning process.After manual cleaning,the ATP levels were also significantly lower in the precleaning kit group than in the traditional precleaning bucket group(P<0.05).Meanwhile,the number of uses of the cleaning solution(up to four times)has no significant impact on the cleaning effect(P>0.05).CONCLUSION Considering its economic cost and cleaning effect,the use of a disposable endoscope bedside precleaning kit can be an optimal option in the precleaning stage with the cleaning solution being replaced several times in the manual cleaning stage. 展开更多
关键词 Cleaning effect Economic cost ENDOSCOPE multi-center study Precleaning
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Multi-Order and Multi-Center Metallogenic Zoning of Yinshan Cu-Au Polymetallic Ore Deposit,Jiangxi Province,China
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作者 Mo Cehui Liu Danying Feng Zhiwen Xia WeflwaChina University of Geosciences , Wuhan 430074 《Journal of Earth Science》 SCIE CAS CSCD 1993年第1期70-73,共4页
Yinshan anticline is the product of tectono-dynamic deformation - metamorphism .Along the axis of the anticline exists a brittle-ductile shearing zone which obviously controls the ore-formation . Mineralization occurs... Yinshan anticline is the product of tectono-dynamic deformation - metamorphism .Along the axis of the anticline exists a brittle-ductile shearing zone which obviously controls the ore-formation . Mineralization occurs along the axis of the anticline in a width of about 1000m .In the mining area .volcano- subvolcanic rocks of Early Yanshan period are divided into three cycles :Ⅰ intermediate acidic dacite lava and dacite porphyry ;Ⅱ acidic amphibole liparite and quartz porphyry;Ⅲ intermediate andesite porphyrite . Among them activities of ⅠandⅡ cycles are more intensive and are intimately related to the mineralization . Yinshan ore deposit is the result of combinative processes of tectono -dynamic and volcano -magmatic hydrothermal fluids, so that mere are two centers of metallogenic zoning, one being the axial strain zone of Yinshan anticline which is the center of first order, and the other being porphyry stock , 2nd order. 展开更多
关键词 Yinshan polymetallic deposit multi-order and multi-center metallogenic zoning brittle-ductile shearing zone porphyry stock .
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Theoretical study of(e,2e) triple differential cross section of 1b3g orbital of ethylene by vibrational multi-center distorted-wave method
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作者 王振鹏 宫毛毛 +2 位作者 李星宇 张松斌 陈向军 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第11期306-312,共7页
The vibrational motions are usually neglected when calculating(e,2e) triple differential cross sections(TDCSs) of molecules. Here, multi-center distorted-wave method(MCDW) has been modified by including molecular vibr... The vibrational motions are usually neglected when calculating(e,2e) triple differential cross sections(TDCSs) of molecules. Here, multi-center distorted-wave method(MCDW) has been modified by including molecular vibrations. This vibrational MCDW method is employed to calculate the TDCSs of 1b3gorbital of ethylene at low(100 eV) and medium(250 eV) incident electron energies in coplanar asymmetric kinematic condition. The results show that molecular vibrations significantly influence the angular distributions of the TDCSs, especially in the binary region along momentum transfer near the Bethe ridge. 展开更多
关键词 (e 2e) multi-center distorted-wave method(MCDW) vibrational effect
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Theoretical study of (e,2e) triple differential cross sections of pyrimidine and tetrahydrofurfuryl alcohol molecules using multi-center distorted-wave method
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作者 Yiao Wang Zhenpeng Wang +2 位作者 Maomao Gong Chunkai Xu Xiangjun Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第1期118-123,共6页
We report theoretical studies of electron impact triple differential cross sections of two bio-molecules,pyrimidine and tetrahydrofurfuryl alcohol,in the coplanar asymmetric kinematic conditions with the impact energy... We report theoretical studies of electron impact triple differential cross sections of two bio-molecules,pyrimidine and tetrahydrofurfuryl alcohol,in the coplanar asymmetric kinematic conditions with the impact energy of 250 eV and ejected electron energy of 20 eV at three scattering angles of-5°,-10°,and-15°.Present multi-center distorted-wave method well describes the experimental data,which was obtained by performing(e,2e)experiment.The calculations show that the secondary electron produced by the primary impact electron is strongly influenced by the molecular ionic multi-center potential,which must be considered when the low energy electron interacts with DNA analogues. 展开更多
关键词 (E 2E) bio-molecules multi-center distorted-wave method(MCDW)
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The Volume Effect and Safety of 6% Hydroxyethyl Starch 130/0.4 in Patients Undergoing Major Elective Surgery: An Uncontrolled, Open-Labeled, Multi-Center Study
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作者 Nobutada Morioka Makoto Ozaki +6 位作者 Michiaki Yamakage Hiroshi Morimatsu Yasuyuki Suzuki Frank Bepperling Hideki Miyao Akiyoshi Namiki Kiyoshi Morita 《Open Journal of Anesthesiology》 2013年第7期326-337,共12页
Purpose: The primary aim of this study was to investigate volume effect and safety of up to 50 mL/kg BW 6% hydroxyethyl starch (HES) 130/0.4 in adult and pediatric patients undergoing major elective surgery. The need ... Purpose: The primary aim of this study was to investigate volume effect and safety of up to 50 mL/kg BW 6% hydroxyethyl starch (HES) 130/0.4 in adult and pediatric patients undergoing major elective surgery. The need to infuse human albumin may be reduced or avoided in Japan if these large doses 6% HES 130/0.4 can be infused. Methods: The study was an uncontrolled, open-labeled, multi-center trial. Fifteen adult and 5 pediatric patients undergoing major elective surgery received 6% HES 130/0.4 (Voluven&#174) with a maximum dose of 50 mL/kg from the start of surgery until 2 hours after the end of surgery according to a treatment algorithm. The primary efficacy endpoint was the volume effect of 6% HES 130/0.4 determined by the volume of saved albumin during the investigational period and the time course of hemodynamic stability in adult and pediatric patients. Safety parameters were fluid balance, hemodynamic and laboratory parameters ECG, local and systemic tolerance and adverse events. Results: Adult patients received a mean of 32.0 mL/kg of 6% HES 130/0.4. For 12 out of 15 adult patients an average amount of 1033.8 mL (18.6 mL/kg) albumin could be saved. The other 3 adult patients did not receive more than 1000 mL of HES 130/0.4. All pediatric patients received approximately 50 mL/kg of HES 130/0.4;for these patients an average amount of 39.9 mL/kg body weight albumin could be saved. The majority of adult patients, and all pediatric patients were hemodynamically stable at all 3 time points. The observed changes of the assessed laboratory parameters including hematological and coagulation parameters or in any other safety parameter determined did not reveal any safety concern related to the administration of 6% HES 130/0.4 up to doses of 50 mL/kg body weight. Conclusion: The study results indicate that 6% HES 130/0.4 has a reliable volume effect, could contribute to significant human albumin savings and was safe and well tolerated up to a maximum dose of 50 mL/kg body weight in adult and pediatric patients undergoing major elective surgery. 展开更多
关键词 High DOSE Volume Effect SAFETY 6% Hydroxyethyl STARCH 130/0.4 ELECTIVE Surgery multi-center Study
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Xi-Feng-Hua-Shi granules for diarrhea-predominant irritable bowel syndrome:protocol for a randomized,double-blind,placebo-controlled multi-center clinical trial
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作者 Hui Li Kai-Li Luo +13 位作者 Dan Wang Yun Huang Xiao-Mei Xu Xue Zou Ren-Jing Qiu Ting Chen Chuan-Wang Zhu Jie Li Yong-Shuang Wang Han-Lin Wang Zu Yang Yong-Yue Wei Yao-Zhou Tian Xu-Dong Tang 《Clinical Research Communications》 2022年第2期15-21,共7页
Background:Irritable bowel syndrome(IBS)is a common functional bowel disorder that can severely affect the quality of life of patients.Limited drugs have been reported for modern medical IBS treatment.The advantages o... Background:Irritable bowel syndrome(IBS)is a common functional bowel disorder that can severely affect the quality of life of patients.Limited drugs have been reported for modern medical IBS treatment.The advantages of traditional Chinese medicine(TCM)treatment are gradually becoming prominent.Xi-Feng-Hua-Shi granules have been clinically used for diarrhea-predominant IBS(IBS-D)treatment for many years in TCM practice.Thus,this study aimed to further verify the effectiveness and safety of Xi-Feng-Hua-Shi(XFHS)granules in IBS-D treatment through a randomized,double-blind,placebo-controlled multi-center clinical trial and provide high-quality evidence for its effectiveness and safety in treatment,as well as provide a basis for clinical rational drug use and explore new clinical IBS-D treatment plans.Methods:A randomized,double-blind,placebo-controlled multi-center clinical trial will be performed in 23 hospitals.A total of 300 participants will be randomly divided into the experimental group(prescribed with XFHS granules)and the control group(prescribed with the placebo granules),with 150 participants in each group.The appearance,shape,color,and taste of the placebo granules are the same as those of XFHS granules.All participants will receive a 4-week treatment and a 6-month follow-up.The primary outcome is the overall clinical efficacy;the secondary outcomes are the IBS-Symptom Severity Score(IBS-SSS),TCM Syndrome Evaluation,and the IBS-Quality of Life(IBS-QoL)score,mental state assessment,and recurrence rate.Outcome measures(including primary and secondary outcome measures)are collected at baseline,as well as 2,4,16,and 28 weeks post-intervention.Discussion:This randomized,placebo-controlled,multi-center trial may provide high-quality evidence for the clinical XFHS granule efficacy in IBS-D treatment.Additionally,this study will conduct safety evaluations to provide a basis for clinical rational drug use. 展开更多
关键词 Xi-Feng-Hua-Shi granules diarrhea-predominant irritable bowel syndrome Randomized double-blind placebo-controlled multi-center clinical trial protocol
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Minimally invasive perventricular VSD closure without cardiopulmonary bypass mid-term results from multi-centers
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作者 邢泉生 《外科研究与新技术》 2011年第3期170-171,共2页
Objective Transesophageal echocardiography (TEE) guided,minimally invasive perventricular device occlusion of ventricular septal defects (VSDs) without cardiopulmonary bypass (CPB) has been applied in multiple centers... Objective Transesophageal echocardiography (TEE) guided,minimally invasive perventricular device occlusion of ventricular septal defects (VSDs) without cardiopulmonary bypass (CPB) has been applied in multiple centers. We reported experiences and the mid-term results. Methods Four hundred and thirty-two cases from 4 cardiac centers were involved in the study. There were 235 maled and 197 females,aged from 3 months to 15 years,with a body weight varying from 4.0 to 26.0 kg. 展开更多
关键词 VSD Minimally invasive perventricular VSD closure without cardiopulmonary bypass mid-term results from multi-centers
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Helicobacter pylori infection is associated with the risk and phenotypes of cholelithiasis:A multi-center study and meta-analysis
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作者 Shuo-Yi Yao Xin-Meng Li +6 位作者 Ting Cai Ying Li Lun-Xi Liang Xiao-Ming Liu Yu-Feng Lei Yong Zhu Fen Wang 《World Journal of Gastroenterology》 SCIE CAS 2024年第47期4991-5006,共16页
BACKGROUND Helicobacter pylori(H.pylori)is a prevalent pathogen associated with various diseases.Cholelithiasis is also a common condition.H.pylori infection has been identified in the biliary system,suggesting its po... BACKGROUND Helicobacter pylori(H.pylori)is a prevalent pathogen associated with various diseases.Cholelithiasis is also a common condition.H.pylori infection has been identified in the biliary system,suggesting its potential involvement in biliary diseases.However,the specific role of H.pylori in the development of cholelithiasis remains inconclusive.AIM To investigate the potential association between H.pylori infection and the development of cholelithiasis.METHODS We performed a retrospective study in more than 70000 subjects in health examination center from 3 institutions in the middle,northern and eastern China,from October 2018 to December 2021,to explore the potential association between H.pylori and cholelithiasis through univariate and multivariate analysis.Meanwhile,the influence of H.pylori on biliary-related parameters was investigated.A comprehensive analysis of previous studies concerned about H.pylori and cholelithiasis was also executed.RESULTS In our multi-center study,H.pylori was positively associated with cholelithiasis[odds ratio(OR)=1.103,95%confidence interval(CI):1.001-1.216,P=0.049].Furthermore,H.pylori patients had less total and direct bilirubin than uninfected patients,while the total cholesterol and low-density lipoprotein cholesterol were more in H.pyloripositive participants(P<0.05).In the published articles,the cohort studies indicated H.pylori was a risk factor of cholelithiasis(hazard ratio=1.3280,95%CI:1.1810-1.4933,P<0.0001).The pooled results of case-control and crosssectional studies showed positive association between H.pylori and cholelithiasis in Asia(OR=1.5993,95%CI:1.0353-2.4706,P=0.034)but not in Europe(OR=1.2770,95%CI:0.8446-1.9308,P=0.246).Besides,H.pylori was related to a higher choledocholithiasis/cholecystolithiasis ratio(OR=3.3215,95%CI:1.1034-9.9986,P=0.033).CONCLUSION H.pylori is positively correlated with cholelithiasis,choledocholithiasis phenotype particularly,especially in Asia,which may be relevant to bilirubin/cholesterol metabolism.Cohort studies confirm an increased risk of cholelithiasis in H.pylori patients. 展开更多
关键词 Helicobacter pylori Cholelithiasis Bilirubin Cholesterol multi-center
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Effect of meridian sinew row needling combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis: a multi-center randomized controlled trial 被引量:3
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作者 韩淑凯 郝海燕 +3 位作者 刘风辉 李卿 李学飞 杨伟红 《World Journal of Acupuncture-Moxibustion》 CSCD 2015年第1期13-18,共6页
Objective To explore the effect of meridian sinew row needling combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis. Methods Four hundred and eighty-eight cases of post-str... Objective To explore the effect of meridian sinew row needling combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis. Methods Four hundred and eighty-eight cases of post-stroke patients with upper limb spasticity were randomly divided into two groups at the ratio of 1: 1, the group of meridian sinew row needling combined with dermal needling (group A, 244 cases) and western medication group (group B, 244 cases). Coupled with rehabilitation, the patients in the group A were given meridian sinew row needling combined with dermal needling where five shu points were specifically selected, and three yang meridians of the hand were treated with acupuncture with muscle region, and three yin meridians of the hand were treated with dermal needles; the patients in the group B was treated with conventional western medication with piracetam injection and cerebroprotein hydrolysate included. Clinical efficacy was evaluated among patients in the two groups after three weeks of continuous treatment, and upper limb spasticity and motor functions were observed through modified Asworth Scale and FugI-Meyer Assessment Scale (FMA) before and after treatment. Results For Asworth Scale, group A was significantly superior to group B (3.04 ± 1.29 vs 3.88 ± 1.54, P〈0.05); for FMA scale, group A was also significantly superior to group B (48.67± 15.64 vs 42.96±14.72, P〈0.05); mitigations of motor status of upper limb joints in group A, such as remission of shoulder adduction (90.5%), pronation of forearm (70.7%), elbow joint flexion (73.1%), wrist joint flexion (80.9%) and finger flexion (88.1%), were superior to those of group B (70.0%, 60.0%, 61.9%, 57.4%, 63.2%, all P〈0.05). Conclusion Good clinical efficacy of the treatment with combined with dermal needling on spasticity of post-stroke patients with upper limb hemiparalysis is achieved. 展开更多
关键词 meridian sinew row needling dermal needling spasticity upper limbs stroke sequelae multi-center randomized controlled trial (RCT)
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A multi-center investigation of breast-conserving surgery based on data from the Chinese Society of Breast Surgery(CSBrS-005) 被引量:17
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作者 Li-Xiang Yu Peng Shi +2 位作者 Xing-Song Tian Zhi-Gang Yu 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第22期2660-2664,共5页
Background:Although breast-conserving surgery is one of the standard treatments for breast cancer,few studies have assessed its recent implementation in China.We aimed to clarify the current real-world status of breas... Background:Although breast-conserving surgery is one of the standard treatments for breast cancer,few studies have assessed its recent implementation in China.We aimed to clarify the current real-world status of breast-conserving surgery in China.Methods:This cross-sectional survey relied on data collected by the Chinese Society of Breast Surgery(CSBrS)to examine patients who underwent this surgery between January 2018 and December 2018.The survey was conducted using a uniform electronic questionnaire to collect information,including clinical and pathological data on these patients.Results:Overall,4459 breast-conserving surgeries were performed in 34 member units of CSBrS,accounting for 14.6%of all breast cancer surgeries performed in these units during the study period.In patients who underwent breast-conserving surgery with information on tumor size available,more than half(61.2%)of the tumors were smaller than 2 cm in diameter,and only 87(3.2%)tumors were larger than 4 cm in diameter.Among patients who underwent breast-conserving surgeries,457(10.2%)patients received neoadjuvant therapy before the surgery.Among patients with a reported margin width,34(2.0%)patients had a margin of≤2 mm,and 1530(88.2%)of them had a margin of>5 mm.Conclusions:This study demonstrated the rates of breast-conserving surgery in member units of the CSBrS,and introduced the characteristics and surgical margins of patients who underwent this surgery.This information helps describe the real-world status of breast-conserving surgery in China. 展开更多
关键词 Breast cancer Breast-conserving surgery multi-center research Real-world study
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Multi-center Study Finds Therapy Boosts Kvidney Transplants in "Highly Sensitized" Patients
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作者 Sandra Van 何大咪 《当代外语研究》 2005年第3期12-14,共3页
到目前为止,对于肾脏疾病晚期患者的最好的救治方法是实施肾脏移植手术,但是手术后患者不得不做大量透析以抵抗肾脏移植引起的排异。现在,科学家们发明了一种治疗排异的药物来替代费用昂贵且痛苦的透析,那就是静脉内免疫球蛋白(IVIG)。... 到目前为止,对于肾脏疾病晚期患者的最好的救治方法是实施肾脏移植手术,但是手术后患者不得不做大量透析以抵抗肾脏移植引起的排异。现在,科学家们发明了一种治疗排异的药物来替代费用昂贵且痛苦的透析,那就是静脉内免疫球蛋白(IVIG)。与其他抗排异药物不同,它不会破坏人本身的免疫系统。 展开更多
关键词 免疫球蛋白 Highly Sensitized PATIENTS multi-center Study Finds Therapy Boosts Kvidney Transplants in 静脉内
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A multi-center clinical observation on safety and efficacy of a plasma derived coagulator factor Ⅷ for treatment of patients with hemophilia A
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作者 张建华 《China Medical Abstracts(Internal Medicine)》 2016年第3期179-180,共2页
Objective To evaluate the efficacy and safety of home-made plasma derived coagulation factorⅧin patients with hemophilia A.Methods Patients with congenital hemophilia A who met the inclusive and exclusive criteria we... Objective To evaluate the efficacy and safety of home-made plasma derived coagulation factorⅧin patients with hemophilia A.Methods Patients with congenital hemophilia A who met the inclusive and exclusive criteria were enrolled in the study after informed consent. 展开更多
关键词 for treatment of patients with hemophilia A A multi-center clinical observation on safety and efficacy of a plasma derived coagulator factor
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数据中心多能互补分布式能源系统设计与运行优化研究
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作者 任效效 李小龙 +4 位作者 薛凯 吴炫 韩小渠 王进仕 严俊杰 《西安交通大学学报》 EI CAS 北大核心 2025年第1期93-104,共12页
为实现数据中心的低碳转型和能效提升,提出了一种集成多种可再生能源和储能设备的多能互补分布式能源系统作为其供能系统。建立了包含生命周期成本、碳排放、能耗、电网购电率和热量浪费率等指标的优化目标体系。制定了两种考虑负荷特... 为实现数据中心的低碳转型和能效提升,提出了一种集成多种可再生能源和储能设备的多能互补分布式能源系统作为其供能系统。建立了包含生命周期成本、碳排放、能耗、电网购电率和热量浪费率等指标的优化目标体系。制定了两种考虑负荷特征的运行策略,采用改进的多目标蝗虫优化算法对系统容量配置进行求解。为了分析优化目标和运行策略对系统优化的影响,通过组合不同优化目标和运行策略形成了多种优化设计方案,采用层次分析法和熵权法确定评价指标的权重,并利用多准则妥协解排序法进行评价排序。针对青海省某数据中心的案例,获得其能源系统的优化设计与运行方案。研究表明:运行策略主要影响吸收式制冷机和地源热泵的容量,而优化目标主要影响储能设备的容量;在相同的运行策略下,增加优化目标可提升系统的综合性能;对于不同的方案,生命周期成本、碳排放、能耗等基础优化目标值变化较小,而电网购电率和热量浪费率变化较大;通过实施五目标优化,即在基础优化目标的基础上增加热量浪费率、电网购电率,系统的综合性能得到了显著提升,其中热量浪费率和电网购电率分别降低了62.30%和25.92%,可再生能源发电占比增加了2%。 展开更多
关键词 数据中心 多能互补分布式能源系统 优化设计 运行策略 多目标蝗虫优化算法
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基于块合并策略的三维装箱多目标优化算法
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作者 杨欣 李明 《包装工程》 北大核心 2025年第1期193-202,共10页
目的针对货车三维装箱的多目标优化问题,旨在提升货车货物的装载效率,降低装载成本,并确保货物在运输过程中的安全性。方法结合货物在运输转弯过程中的力学分析,求解货物重心的安全区域,构建货车三维装箱多目标优化模型;提出一种基于块... 目的针对货车三维装箱的多目标优化问题,旨在提升货车货物的装载效率,降低装载成本,并确保货物在运输过程中的安全性。方法结合货物在运输转弯过程中的力学分析,求解货物重心的安全区域,构建货车三维装箱多目标优化模型;提出一种基于块合并的策略,以减少决策空间;设计一种基于强化学习、Q-Learning算法的双种群约束多目标优化框架,以提高算法的收敛性和解的多样性;利用公共数据集和实例数据进行验证。结果在满足转弯重心约束及其他约束的基础上,所提算法的平均空间利用率为92.07%,显著高于其他算法。结论本文所提的多目标优化算法能有效提高三维装箱问题的空间利用率和载重利用率,为工程实践中的三维装箱问题提供了有效的解决方案和参考。此外,该算法在保障货物运输安全性的前提下,显著提升了装箱规划的效率。 展开更多
关键词 三维装箱 多目标优化 块组合 强化学习 转弯重心约束
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多中心协同治理:何以可能,何以可为?——基于江苏C县农村人居环境治理的经验诠释 被引量:7
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作者 陈利根 陶嘉诚 《西北农林科技大学学报(社会科学版)》 CSSCI 北大核心 2024年第1期10-21,共12页
从多中心协同治理的理论逻辑出发,构建“政府、企业、村民、社会组织”多中心主体下的协同治理机制,聚焦主体之间互动关系的生成机制和运行逻辑,并以江苏省C县农村人居环境的治理实践作为典型案例进行解析。研究表明,多中心协同治理是... 从多中心协同治理的理论逻辑出发,构建“政府、企业、村民、社会组织”多中心主体下的协同治理机制,聚焦主体之间互动关系的生成机制和运行逻辑,并以江苏省C县农村人居环境的治理实践作为典型案例进行解析。研究表明,多中心协同治理是一种节本增效且具备操作性的治理方案,具备中国乡村场域的现实支撑,即主要通过沟通协作、资源整合、目标耦合以及利益联结,明确治理体系中各主体的功能定位,进而对行政规制、市场经济、村民自治、社会参与等进行界定分工,由此有效调动各方的积极性和能动性,实现激励相容与优势互补,最终形成治理合力。 展开更多
关键词 多中心 协同治理 农村人居环境 治理方案
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“里和”与“外应”:气候变化下环湖地区的适应性治理 被引量:1
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作者 张倩 扎登太 《北京工业大学学报(社会科学版)》 CSSCI 北大核心 2024年第3期14-28,共15页
气候变化给青藏高原带来显著影响,更是对当地农牧民的生计造成冲击,研究当地气候变化影响及牧民应对策略,不仅是提高气候变化适应能力的起点,也是建立适应气候变化区域格局的重要支撑。基于2020和2023年对案例地Z村的两次实地调研,通过... 气候变化给青藏高原带来显著影响,更是对当地农牧民的生计造成冲击,研究当地气候变化影响及牧民应对策略,不仅是提高气候变化适应能力的起点,也是建立适应气候变化区域格局的重要支撑。基于2020和2023年对案例地Z村的两次实地调研,通过牧户问卷调查和深度访谈,按照适应性治理的三层特征,分析当地气候变化适应的成效与挑战。研究发现:面对降水和气温的变化、湖面扩大、植被变化和灾害影响,牧民积极采取多种办法来减少气候变化的影响,呈现较高的适应性与恢复力。这些适应行动的成功经验源于“里和”,包括人与人之间的合作以及人与自然间的和谐律动。但是“外应”不足仍是挑战,即案例地缺少必要的外部支持,不仅包括直接灾害救助,还包括对其适应能力可持续性的保护和应对潜在的草原生态变化。如果“外应”持续低迷,现有的适应能力终会耗尽。提出建立适应气候变化区域格局应遵循多中心治理的思路,将多个利益相关者联合起来,汇总不同地区气候变化应对的成功经验,形成多种知识的融合,才能形成对地方的有效“外应”,提高中国气候变化适应能力。 展开更多
关键词 气候变化 适应性治理 多中心治理 区域格局 雪灾
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多中心产业共治的区域现代产业集群建设策略——以广东省精密仪器设备产业集群为例
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作者 黄怡淳 孙锴 +4 位作者 万晶晶 朱妍 邱丹逸 刘少芳 文晓芸 《科技管理研究》 CSSCI 2024年第2期53-60,共8页
在国际高端技术封锁日益严峻的新形势下,从任务解构的角度将区域现代产业集群建设进行分层任务细化尤为重要,且需要从目标需求导向的角度出发,针对具体分层任务明确多元治理主体的结构关系及对应主体的治理举措。基于现代产业体系的内... 在国际高端技术封锁日益严峻的新形势下,从任务解构的角度将区域现代产业集群建设进行分层任务细化尤为重要,且需要从目标需求导向的角度出发,针对具体分层任务明确多元治理主体的结构关系及对应主体的治理举措。基于现代产业体系的内涵特征提出区域现代产业集群建设逻辑,并基于多中心治理理论构建多中心产业共治建设区域现代产业集群的理论框架。研究认为,面向区域现代产业集群建设的战略层、发展层、支撑层等五大分层建设任务,政府部门、企业、科研机构、行业协会与服务机构等多元主体通过自发互动博弈,形成分类主导的多中心产业共治模式。为进一步阐述及试验理论,以广东省精密仪器设备产业集群主导咨询机构的集群治理为实践案例,认为其存在多中心联动的积极性和共治模式均有待加强的问题,且关键核心技术短缺问题较为突出。针对此,提出健全多中心联动协调工作机制、政企双中心共治提升产业安全度、多维支撑中心有序推进关键核心技术攻关、政府牵引多中心集聚融通、数字治理创新助推区域产业集群智慧建设等共治效能提升的建议。 展开更多
关键词 现代产业 产业集群 产业共治 共治模式 多中心治理理论 精密仪器设备 广东省
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