The Role of Music Therapy in Supporting Intellectually Disabled Youth in Senegal

Introduction: Music therapy is a practice for helping and supporting people with intellectual and relational difficulties. This study illustrated the benefits of music therapy for young people living with intellectual disabilities (YLID) in an African context. Methodology: This study investigated six young individuals with intellectual disabilities who had undergone three years of music therapy. They were participants in the inclusive non-academic training program at the National School of Arts in Dakar from 2017 to 2019. Data collection utilized individual interviews with the youths, evaluation grids from teachers and psychiatrists. Guardians provided informed consent along with the assent of the young participants. Results: The six young were aged between 18 and 30 years old, with an average age of 24.6 years. Four of the YLID were male. Three young people with intellectual disabilities had delayed psychomotor development. Observations revealed the beneficial influence of music therapy on the health and well-being of young individuals. Music played a role in alleviating stress and anxiety among youth with intellectual disabilities (YLID), enhancing their mood and mental health. It assisted in navigating challenging situations and heightened alertness among YLID. Additionally, music therapy contributed to improvements in dyslexia, fine and gross motor skills, and memory development among intellectually disabled youth, ultimately facilitating their integration into society. Conclusion: In light of our results, music therapy makes a major contribution to the empowerment of YLID. Engaging in musical activities helps young people connect with others through instrumental expression and a sense of accomplishment. By facilitating music therapy, it becomes possible to combat discrimination and stigmatization, thus promoting the social inclusion of intellectually disabled youth. Therefore, it is important to promote music therapy in Senegal to meet the needs of YLID.

The Application and Development of Music Therapy in Rehabilitation Medicine

Music therapy,as an ancient and continually evolving therapeutic approach,has demonstrated unique effects and extensive potential applications in the field of rehabilitation medicine.This paper first explores the physiological and psychological impacts of music and theoretical models of its therapeutic mechanisms.It further details the specific applications of music therapy in neurological rehabilitation,motor function recovery,psychological and emotional adjustment,and chronic disease and pain management.The article also investigates the prospects of integrating music therapy with modern technologies such as virtual reality and artificial intelligence and emphasizes the importance of interdisciplinary collaboration and policy support in advancing this field.Through comprehensive analysis,the paper identifies future development directions and research needs for music therapy in rehabilitation medicine.

Effect of music therapy on chemotherapy-induced nausea and vomiting in gastrointestinal cancer:A systematic review and metaanalysis

BACKGROUND Chemotherapy is the primary treatment for patients with advanced gastrointestinal cancer,but it has many adverse reactions,particularly nausea and vomiting.Music therapy can reduce anxiety symptoms,avoid the response to the human body under various stress conditions through psychological adjustment,and improve the adverse reactions of chemotherapy.AIM To investigate the impact of music therapy on relieving gastrointestinal adverse reactions in chemotherapy for patients with digestive tract cancer by metaanalysis.METHODS EMBASE,PubMed,OVID,WoS,CNKI,CBM,and VIP database were all used for searching relevant literature,and the efficacy after treatment was combined for analysis and evaluation.RESULTS This study included seven articles.The results of meta-analysis indicated that music therapy could reduce the nausea symptom score of patients after chemotherapy[mean difference(MD)=-3.15,95%confidence interval(CI):-4.62 to-1.68,Z=-4.20,P<0.0001].Music therapy could reduce the vomiting symptom score of patients after chemotherapy(MD=-2.28,95%CI:-2.46 to-2.11,Z=-25.15,P<0.0001).Furthermore,music therapy could minimize the incidence of grade I and above nausea or vomiting in patients after chemotherapy(odds ratio=0.38,95%CI:0.26-0.56,Z=-4.88,P<0.0001).Meta-regression analysis found that publication year was not a specific factor affecting the combined results.There was no significant publication bias(P>0.05).CONCLUSION Music therapy can significantly improve the scores of nausea and vomiting symptoms in patients with digestive system cancer during chemotherapy and reduce the incidence of grade I and above nausea and vomiting after chemotherapy,making it an effective psychological intervention method worthy of clinical promotion.

Significance of music therapy in treating depression and anxiety disorders among people with cancer

Globally,cancer cases and mortality have recently escalated and have attracted global concern.The clinical diagnosis and manifestation of cancer can result in significant mental health issues like depression and anxiety disorders.The tendency of people with cancer to suffer from psychological disorders such as anxiety and depression is usually high.A significant number of deaths related to cancer may likely not be from the killer disease but from psychological disorders associated with the illness.The utilization of music as a remedial approach to healing mental disorders cannot be overstated.Thus,identifying the impacts of music therapy in dealing with depression and anxiety disorders among people with cancer is relevant,as the majority of methods used in treating cancer have some side effects which may trigger psychological disorders in cancer patients.Ultimately,this study explored the significance of music therapy in treating depression and anxiety disorders among people with cancer.To achieve the aim of this study,the authors employed a narrative literature review to investigate the significance of music therapy in addressing depression and anxiety disorders among people with cancer.The type of literature review employed in this study is to provide an understanding of the selected research papers.The review found that music therapy significantly reduces depression and anxiety disorders among breast cancer,lung cancer,prostate cancer,and colorectal cancer patients.It is needful for healthcare providers to incorporate music therapy interventions while treating people with cancer.This will help reduce cancer deaths resulting from psychological disorders rather than the killer disease,cancer.However,the standardized procedures and evaluation criteria for applying music-based intervention strategies in oncology medicine still need to be further established and improved.

Enhancing the awakening to family engagement bundle with music therapy

Survivors of prolonged intensive care unit(ICU)admissions may present undesirable long-term outcomes.In particular,physical impairment and cognitive dysfunction have both been described in patients surviving episodes requiring mechanical ventilation and sedation.One of the strategies to prevent the aforementioned outcomes involves the implementation of a bundle composed by:(1)Spontaneous awakening trial;(2)Spontaneous breathing trial;(3)Choosing proper sedation strategies;(4)Delirium detection and management;(5)Early ICU mobility;and(6)Family engagement(ABCDEF bundle).The components of this bundle contribute in shortening length of stay on mechanical ventilation and reducing incidence of delirium.Since the first description of the ABCDEF bundle,other relevant therapeutic factors have been proposed,such as introducing music therapy.This mini-review describes the current evidence supporting the use of the ABCDEF bundle,as well as current knowledge on the implementation of music therapy.

Application Research of Music Therapy in Mental Health of Special Children

A healthy psychological state is the premise for children to carry out various activities.Previous surveys have shown that children with special needs are affected by their own obstacles and are more prone to psychological problems such as sensitivity,low self-esteem,and impulsiveness.Therefore,it is necessary to provide more sys-tematic mental health education support for special children.Mental health education programs are an efficient form of maintaining children’s mental health.However,in thefield of special education,the number of mental health education courses developed according to the physical and mental characteristics and developmental needs of special children is relatively small,and there are many difficulties in the implementation process.Autism dis-order(ASD)is a kind of pervasive developmental dysfunction that is relatively common and representative in clinical practice.In recent years,the number of autistic children has continued to surge,and has gradually expanded from a family problem to a serious social problem.At present,the evaluation of the effect of autism intervention mainly relies on various behavioral scales,which are subjective to a certain extent.At the same time,due to the unclear pathogenesis of autism,the treatment of autism cannot be predicated on the right medicine,and can only be intervened in various ways.The purpose of this paper is to explore the difference between the EEG signals of autistic children and typically developing control(TD)children through the analysis method of EEG signals,and based on the analysis of EEG signals from an objective point of view,to study whether the music therapy method of Chinese Zither playing training can effectively Improving the brain functional status of chil-dren with autism yields positive therapeutic outcomes.The experimental results show that the complexity of brain electrical signals of ASD children is much lower than that of TD children,and there is a significant difference in the brain functional state between the two.The music therapy method based on Chinese zither playing training can improve the brain function of autistic patients,and there is a positive therapeutic effect.And with the exten-sion of the training period,the effect may be more significant.Chinese zither playing training can provide a new direction for the intervention of autism.

Effects of Physical Exercise and Music Therapy on Cognitive Aspects in Tunisian Patients with Mild Alzheimer’s Type Dementia

Aim: The objective of this research is to highlight the effectiveness of physical exercise and music therapy in older patients with Alzheimer’s disease (AD). Methods: Patients with a mild level of AD were included in this study, divided into the therapy group (TG;N = 30, aged 68 ± 3.2 years) and the control group (CG;N=30, aged 65 ± 2.6 years). The therapy group was enrolled in an exercise-training program (walking, resistance and balance exercises) combined with musical therapy for 10 weeks (three sessions of 60 minutes per week). The Control group was instructed to follow their daily rhythm of life (e.g., rest, reading) under the same conditions. The intervention program was enrolled under the supervision of;one psychologist;a neurologist;two music therapists, and two physiotherapists, all belonging to the same hospital unit. After 10 weeks of participation in the combined program, cognitive parameters were improved in the therapy group measured with the Behavior Pathology in Alzheimer Disease (BEHAVE-AD), (p < 0.05) for activity disturbance, diurnal rhythm disturbances, anxieties and phobias, affective disturbance. The percentage range of improvements is 1.07% to 2.96%. Results: Our results demonstrate that physical exercise combined with music therapy improves cognitive function in patients with Alzheimer’s disease. Conclusions: Physical exercise and music therapy are beneficial combined treatments for improving life quality in older patients. This approach may be useful to help patients with a mild level of Alzheimer’s disease improve their behavioral and psychological parameters.

Effect of moxibustion combined with five‑element music therapy on postoperative pain relief after mixed hemorrhoid operation

Objective:To investigate the effect of moxibustion combined with five‑element music therapy on the postoperative pain relief of patients undergoing surgical operation for mixed hemorrhoid with damp‑heat syndrome.Methods:Totally,159 patients meeting the inclusion criteria were assigned to the control group,study group 1,and study group 2,with 53 cases in each group.All patients received routine care after surgical treatment,including acupoint application and Chinese herbal fumigation.In addition,patients in the study group 1 received moxibustion,and those in the study group 2 were given moxibustion combined with five‑element music therapy.The degree of postoperative pain was evaluated using visual analog scale(VAS).Results:There was no significant difference in VAS score on pain during dressing changes among three groups(P>0.05).After 3,5,and 7 days of intervention,there was a significant difference in VAS score on pain at rest among three groups(P<0.001),and VAS score in the study group 2 was lower than that in the study group 1 and the control group after 3 and 5 days of intervention,respectively(P<0.05).Conclusion:Moxibustion combined with five‑element music therapy is effective to relieve the postoperative pain of patients undergoing a surgical operation for mixed hemorrhoids with damp‑heat syndrome.

Combined treatment using acupuncture and music therapy on children with cerebral palsy Gross motor function measure comparison in 60 cases

BACKGROUND： The use of acupuncture has received recognition to effectively treat cerebral palsy. Moreover, music therapy can be used to modify treatment of cerebral palsy. OBJECTIVE： To study the effects of combined treatment using acupuncture and music therapy on gross motor function measure （GMFM） of children with cerebral palsy, compared with acupuncture treatment alone. DESIGN, TIME AND SETTING： Randomized, controlled, clinical study. The experiment was conducted in Shenzhen Hospital of Traditional Chinese Medicine between January 2007 and September 2007. PARTICIPANTS： All children with cerebral palsy in the trial were from the outpatient department of Shenzhen Hospital of Traditional Chinese Medicine. The children were randomly divided into two groups： 30 children in Group B received acupuncture and music therapy, while 30 children in Group A received only acupuncture therapy. METHODS： Subjects in Groups A and B received acupuncture based on syndrome differentiation. The main acupoints were necessary for all participants. At first, flash needling was applied to the acupoints. For the remaining acupoints, the technique of transverse needling was applied to the head acupoints, and perpendicular needling was used for the other points. The inserted needles were twirled and then maintained for 30 minutes. The needle was twirled for one second every other 10 minutes, without reinforcing-reducing techniques. The therapy was performed every other day. The trial consisted of three periods each, and lasted for 84 days. Subjects in Group B received music therapy. They listened to music that they preferred while acupuncture was being performed. Following acupuncture, they were allowed to perform musical activities, such as percussion, singing, and dancing. The music therapy was scheduled for one hour, including listening to music for 30 minutes and music activities for 30 minutes. MAIN OUTCOME MEASURES： The comprehensive functional evaluation scale of cerebral palsy and the GMFM were applied to test symptoms before and after respective treatment. RESULTS： All 60 children were included in final analysis. The general function of all children with cerebral palsy improved, but the general efficiency in Group B was obviously higher than in Group A （93% and 73%, Х^2 = 4.32, P 〈 0.05）. GMFM evaluation showed that the function of crawling and kneeling, standing, and walking improved more significantly in Group B than in Group A （P 〈 0.05）, while the function of lying down, rolling, and sitting remained similar between the two groups （P 〉 0.05）. CONCLUSION： The combination of acupuncture and music therapy on the treatment of cerebral palsy is more effective than acupuncture alone. The various activities in music therapy may affect treatment of cerebral palsy.

Application of five-element music therapy in pain coping skills training in patients with knee osteoarthritis

Objective:The objective of this study is to assess the application effect of five elements music therapy introduced in the pain coping skills training of knee osteoarthritis(KOA).Materials and Methods:Totally,80 patients with KOA were selected and randomly divided into the experimental group(39 cases)and the control group(41 cases).The control group was only given routine nursing measures,and the experimental group was additionally treated with five-element music therapy on the basis of the control group,twice a day,28 days in total.The Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)was used to evaluate the functional status of the knee joint of the two groups.The clinical efficacy of the two groups was evaluated by Guiding Principles for Clinical Research of New Chinese Medicine in the Treatment of Osteoarthritis.Results:WOMAC score statistically significantly decreased in the experimental group(35.92±9.48 vs.16.17±5.43,P<0.01)and the control group(36.73±6.42 vs.22.53±7.51,P<0.01)after 28 days of intervention when compared with that before intervention;WOMAC score in the experimental group was lower than that of the control group after 28 days of intervention(16.17±5.43 vs.22.53±7.51,P<0.01).The total effective rate of the experimental group was statistically higher than that of the control group(82.0%vs.51.2%,χ2=11.97,P=0.003).Conclusion:The combination of five-element music therapy and routine nursing measures has better effect in relieving pain and bad emotions of patients with KOA when compared with routine nursing measures alone.

EEG Analysis of the Contribution of Music Therapy and Virtual Reality to the Improvement of Cognition in Alzheimer’s Disease

Alzheimer’s disease is the most common form of dementia, affecting nearly 9.9 million new people every year. The disease provokes important memory and cognitive impairment, eventually causing individuals to forget their loved ones and rendering them completely dependent on their caretakers. Alzheimer’s patients typically experience more negative emotions, such as frustration and apathy, than healthy older adults. There is currently no cure for the disease. Our research group explores how the integration of virtual reality (VR) and an EEG-based intelligent agent in music therapy can alleviate psychological and cognitive symptoms of the disease. We propose a theory explaining how, through activation of the brain reward system, music can reduce negative emotions, increase positive emotions and as a result increase performance on cognitive tasks. The results of our experimental study concord with our theory: emotional states of participants are improved, as per recorded through EEG, and performances on memory tasks show improvement following the intervention. We believe that the combination of EEG brain assessment, VR and music therapy is a promising method for emotional states and cognitive symptoms of Alzheimer’s disease.

Music Therapy and Music Selection--a Case Study of Music Intervention during Pregnancy

“Music Therapy”is an emerging interdisciplinary subject based on social development,which has merged together with psychology,medicine,neuroscience and musicology.Music therapy abandons the traditional diagnostic model,which only focuses on patients’pathological changes.It simultaneously heals patients’body and mind,hence to achieve a better therapeutic effect.Music therapy has analgesic effect,which has been clinically applied to puerperia and used to divert puerperia’s attention from pain during labor.Applying music therapy during pregnancy to relieve tension and prevent negative emotions that may cause harmful effect to pregnant woman and the fetus.

Effects of music therapy on mood,language,behavior,and social skills in children with autism：A meta-analysis

Objective：To investigate the effects of music therapy on mood,language,behavior,and social skills in children with autism.Methods：A literature search was conducted using the following Chinese databases：the China National Knowledge Infrastructure（CNKI）,Wanfang Data,the Chinese Biomedical Literature（CBM） Database,and the VIP Chinese Science and Technology Periodicals Database.The search terms were ＂autistic children＂ or ＂children with autism＂ and ＂music therapy＂ or ＂music treatment.＂ Studies of randomized controlled trials（RCTs） were included,and each publication included was assessed for quality.A meta-analysis was conducted using RevMan 5.1.Results：Publications were selected based on the inclusion and exclusion criteria.Six research articles describing RCTs were included;the total sample size was 300 patients.The results of meta-analysis showed that music therapy improved mood[Risk ratio（RR） = 3.02,95%confidence interval（CI）=1.93-4.11,Z=5.45,P〈 0.000 01]and behavior（RR=7.36,95%CI=4.28-10.44,Z=4.69,P=0.00001） in children with autism.Additionally,music therapy improved language（RR=4.05,95%CI=3.38-4.73,Z=11.71,P=0.000 01）,sensory perception（RR=4.62,95%CI=1.55-7.69,Z=2.95,P=0.003）,and social skills（RR=4.66,95%CI=1.90-7.42,Z=3.31,P=0.000 9） in children with autism.Conclusions：Music therapy can improve mood,language,sensory perception,behavior,and social skills in children with autism.

A review of the research on music therapy in hospice care

Objective:To summarize the research progress of music therapy in hospice care and to provide reference for further research.Methods:A wide range of literatures on music therapy and hospice care at home and abroad were searched and read,and the literature was integrated,judged,analyzed,and summarized.Results:The related research on music therapy in hospice care mainly focused on western developed countries such as Europe and the United States.China is still in the stage of theoretical exploration,lacking qualitative research based on case investigation and empirical research based on data statistics.Conclusions:Music therapy supports the management of symptoms in hospice care,which can meet the diverse needs of patients and their family members including physical,psychological,social,and spiritual.

Neural correlates of the Heidelberg Music Therapy: indicators for the regeneration of auditory cortex in tinnitus patients?

Tinnitus, the phenomenon of ringing or buzzing in the ears without an external sound source is one of the most commonly reported symptoms in otorhinolaryngology and affects 10 - 15% of the general population. Models have been developed to account for neural basis of tinnitus, its pathogenesis and its consequences on mental health （deRidder et al., 2013）. In most cases tinnitus onset follows a partial hearing impairment. Peripheral sensory deprivation due to cochlear damages may prompt increased neuronal activity in the central auditory system in order to adapt the neural sensitivity to the reduced sensory inputs. This central gain could over amplify the ＂neural noise＂ and thus trigger a homeostatic down-regulation of inhib- itory synapses in the auditory cortical map leading to specific reorganization of the cortical representation of the tinnitus percept. Dysfunctional feedback connections from limbic regions to auditory brain areas, interacting at the thalamic level, may account for the psychological impairment.

The Effect of Music Therapy for Patients With Huntington＇s Disease： A Systematic Literature Review

Huntington＇s disease is a progressive, neurodegenerative, and autosomal dominant disease characterized by motor- and psychiatric disturbances, and cognitive decline. Since there is no cure, all treatment is aimed at improving quality of life. One form of non-drug therapy which is barely recognized, is music therapy. The literature on its use and effect in patients with Huntington＇s disease is limited. We therefore performed a detailed literature survey in order to delineate the different types of music therapy interventions and their aims. Music therapy studies were included when targeting： （1） motor disturbances; （2） cognitive disturbances; （3） psychiatric disturbances; and （4） emotional/social disturbances. A total of eight studies that met these criteria were analyzed. We found that music therapy interventions vary throughout the different stages of the disease and are not yet applied optimally. Not the stage of the disease but the individual treatment goals seem to be more determinative for the music therapy indications. In conclusion, precise aims and methods in relation to the stage of the disease are not well determined. There is a need for systematic study of this treatment option.

Methodological quality evaluation of systematic reviews of music therapy for Alzheimer’s disease in the recent five years

Aims:This study aims to investigate the methodological quality of the systematic reviews of music therapy for Alzheimer’s Disease in the past five years,and to explore their compliance with each AMSTAR(A Measure Tool to Assess Systematic Reviews)item.Based on the above,this study is intended to facilitate the evidence transformation of music therapy in Alzheimer's Disease.Method:Cochrane Library,Web of Science,Embase and PubMed were searched from 2017-2021,to obtain the systematic reviews of music therapy among Alzheimer’s Disease.We used the AMSTAR,to evaluate their methodological quality.Additionally,their compliance with 16 AMSTAR items was investigated.Results:12 systematic reviews were included in this study.The methodological quality of 10 articles was“very low”,1 article was“low”,and 1 article was“high”.The 12 systematic reviews had 25%to 100%compliance with 16 AMSTAR items.Conclusion:The methodological quality of systematic reviews of music therapy among Alzheimer’s Disease in the recent five years is not high,and needs to be further improved.Future research should continue to explore the factors that affect their methodological quality,to promote the transformation of evidence-based evidence.

The effect of music therapy on the level of anxiety in the patients undergoing coronary angiography

The sedative effects of music on healthy and sick individuals are known for centuries. Nowadays, nursing has used the efficacy of music therapy in interventions. The aim of the study was to determine the effect of music, which the patients undergoing a coronary angiography for the first time listened to during the intraoperative period, on the level of anxiety in the patients. The study was conducted experimentally as a pretest/posttest control group design. Data collection form;state-trait anxiety inventory, CDs and CD player were used. Inventories were applied to the patients before the process. The study group (100 patients) listened to music throughout the intervention, whilst the control group (100 patients) listened to no music. At the end of the process, all patients were given the same state anxiety inventory once more. The data was assessed by number, percentage, mean distribution with The paired t-test and t test. It was found that the difference between the mean state anxiety scores obtained before and during the coronary angiography were significantly higher in the study group (4.04 ± 1.15) than the control group (2.01 ± 0.10) (p = 0.000). It was concluded that the music listened to during the coronary angiography process had an impact on the intraoperative anxiety levels of the patients.

Effects of music therapy on the anxiety level and physiological responses of patients undergoing ophthalmic surgery:A systematic review and meta-analysis

Objective:To evaluate the effectiveness of music therapy on the anxiety level and physiological response of patients undergoing ophthalmic surgery.Methods:Relevant randomized controlled trials that compared the combined effect of music therapy for patients undergoing ophthalmic surgery were included.Four English databases and three Chinese databases were searched from inception to Jan.2022.Two reviewers independently performed data extraction and risk of bias assessments.The Cochrane Collaboration tool was used to assess the risk of bias.Meta-analysis was performed using Review Manager 5.3.The outcomes were overall anxiety,blood pressure,heart rate and pain.Results:A total of 11 trials with 1,469 participants were included in the meta-analysis.Compared to standard care,music therapy had a good effect on reducing the anxiety levels of patients undergoing ophthalmic surgery(P<0.05).The results also suggested that music therapy produced a significant improvement in blood pressure(P<0.05)and heart rate(P<0.05).The visual analogue scale(VAS)showed that music therapy significantly reduced pain compared to standard care(P<0.05).Conclusions:This meta-analysis provided evidence that music therapy has an obvious effect on relieving anxiety levels,while it is also more effective in alleviating pain and improving physiological responses than standard care alone.Our findings may provide accurate evidence-based guidance for the clinical implementation of music therapy.In the future,more high-quality studies are required for verifying these results.

Effect of music therapy on short-term psychological and physiological outcomes in mechanically ventilated patients:A randomized clinical pilot study

Background:Elevated anxiety levels are common in patients on mechanical ventilation(MV)and may challenge recovery.Research suggests music-based interventions may reduce anxiety during MV.However,studies inves-tigating specific music therapy techniques,addressing psychological and physiological well-being in patients on MV,are scarce.Methods:This three-arm randomized clinical pilot study was conducted with MV patients admitted to the intensive care unit(ICU)of Hospital San Joséin Bogotá,Colombia between March 7,2022,and July 11,2022.Patients were divided into three groups:intervention group 1(IG1),music-assisted relaxation;intervention group 2(IG2),patient-preferred therapeutic music listening;and control group(CG),standard care.The main outcome measure was the 6-item State-Anxiety Inventory.Secondary outcomes were:pain(measured with a visual analog scale),resilience(measured with the Brief Resilience Scale),agitation/sedation(measured with the Richmond Agitation-Sedation Scale),vital signs(including heart rate,blood pressure,oxygen saturation,and respiratory rate),days of MV,extubation success,and days in the ICU.Additionally,three patients underwent electroencephalography during the interventions.Results:Data from 23 patients were analyzed in this study.The age range of the patients was 24.0-84.0 years,with a median age of 66.0 years(interquartile range:57.0-74.0).Of the 23 patients,19 were female(82.6%).No statistically significant differences between the groups were observed for anxiety(P=0.330),pain(P=0.624),resilience(P=0.916),agitation/sedation(P=0.273),length of ICU stay(P=0.785),or vital signs.A statistically significant difference between the groups was found for days of MV(P=0.019).Electroencephalography mea-surements showed a trend toward delta and theta band power decrease for two patients and a power increase on both beta frequencies(slow and fast)in the frontal areas of the brain for one patient.Conclusions:In this pilot study,music therapy did not significantly affect the anxiety levels in patients on MV.However,the interventions were widely accepted by the staff,patients,and caregivers and were safe,considering the critical medical status of the participants.Further large-scale randomized controlled trials are needed to investigate the potential benefits of music therapeutic interventions in this population.