The integration of optical images and elevation data is of great importance for 3D-assisted mapping applications. Very high resolution (VHR) satellite images provide ideal geo-data for mapping building information. Si...The integration of optical images and elevation data is of great importance for 3D-assisted mapping applications. Very high resolution (VHR) satellite images provide ideal geo-data for mapping building information. Since buildings are inherently elevated objects, these images need to be co-registered with their elevation data for reliable building detection results. However, accurate co-registration is extremely difficult for off-nadir VHR images acquired over dense urban areas. Therefore, this research proposes a Disparity-Based Elevation Co-Registration (DECR) method for generating a Line-of-Sight Digital Surface Model (LoS-DSM) to efficiently achieve image-elevation data co-registration with pixel-level accuracy. Relative to the traditional photogrammetric approach, the RMSE value of the derived elevations is found to be less than 2 pixels. The applicability of the DECR method is demonstrated through elevation-based building detection (EBD) in a challenging dense urban area. The quality of the detection result is found to be more than 90%. Additionally, the detected objects were geo-referenced successfully to their correct ground locations to allow direct integration with other maps. In comparison to the original LoS-DSM development algorithm, the DECR algorithm is more efficient by reducing the calculation steps, preserving the co-registration accuracy, and minimizing the need for elevation normalization in dense urban areas.展开更多
The baseline roll and length errors for wide-swath altimeters are major error sources in sea surface measurements that exhibit strong spatial characteristics in the cross-track direction.These errors can be identified...The baseline roll and length errors for wide-swath altimeters are major error sources in sea surface measurements that exhibit strong spatial characteristics in the cross-track direction.These errors can be identified and estimated in accordance with height differences at crossover points generated with nadir altimeters after excluding the interference from other error sources.Most of the wide-swath altimeter baseline estimation methods considered only the roll error in previous studies.A numerical simulation was conducted in this study using nadir altimeters to estimate the roll and length errors simultaneously to provide a selectable scheme for baseline error estimation and correction for future wide-swath altimeters.Results based on the parameters of the surface water and ocean topography mission and Sentinel-3A show that the correlation coefficient of the roll error between the estimated and simulated values is 0.89,while the correlation coefficient of the length error is 0.85.The sea surface height root mean square error(RMSE)can be reduced from 12.18 cm to 6.45 cm based on the two estimated results.The estimation effect can be increased by using multiple nadir altimeters to form an observation constellation.The numerical simulation of the five nadir altimeter constellation shows that the correlation coefficients of the roll and length errors would increase to 0.97,which reduces the sea surface height RMSE to 2.88 cm.In addition,the stability of this method is indicated in simulation experiments,which introduce different degrees of sea state errors.展开更多
We investigated the association of time to prostate-specific antigen nadir (TTPN) and logarithm of prostate-specific antigen velocity after progression Log(PSAVAP) in metastatic prostate cancer with prior primary ...We investigated the association of time to prostate-specific antigen nadir (TTPN) and logarithm of prostate-specific antigen velocity after progression Log(PSAVAP) in metastatic prostate cancer with prior primary androgen deprivation therapy (ADT). All metastatic prostate cancer patients treated with primary ADT from 2000 to 2009 were reviewed. Patients who developed disease progression were included in the subsequent analyses. Patients were categorized into three groups according to their TTPN: TTPN of 〈3 months, 3-17 months, and 〉17 months. We compared the Log(PSAVAP) between the different TTPN groups using Mann-Whitney U-test and Kruskal-Wallis test. Further multiple linear regression analyses on Log(PSAVAP) were performed to adjust for other potential confounding factors. Among 419 patients who were treated with primary ADT, 306 patients developed disease progression with a median follow-up of 28 months, Longer TTPN was associated with lower Log(PSAVAP) (P = 0.008) within all subgroup analyses (TTPN of 〈3 vs 3-17 months, P = 0.020; TTPN of 3-17 vs 〉17 months, P = 0.009; and TTPN of 〈3 vs 〉17 months, P = 0.001). Upon multiple linear regression analyses, baseline PSA (regression coefficient 0.001, P = 0.045), PSA nadir (regression coefficient 0.002, P = 0.040), and TTPN (regression coefficient -0.030, P = 0.001) were the three factors that were significantly associated with Log(PSAVAP). In conclusion, a longer TTPN was associated with lower Log(PSAVAP) in metastatic prostate cancer patients following primary ADT. TTPN cut-offs at 3 months and 17 months appeared to have prognostic significance in predicting Log(PSAVAP). TTPN may serve as a good prognostic indicator in deciding the treatment strategy in patients with disease progression.展开更多
Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these pati...Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these patients are still controversial. In this study, we retrospectively reviewed the data from 71 eligible Chinese patients who received docetaxel chemotherapy from 2009 to 2016 in our hospital and experienced a reduction of prostate-specific antigen (PSA) level 〉50% during the treatment and investigated the potential role of time to nadir (TTN) of PSA. TTN was defined as the time from start of chemotherapy to the nadir of PSA level during the treatment. Multivariable Cox regression models and Kaplan-Meier analysis were used to predict overall survival (OS). In these patients, the median of TTN was 17 weeks. Patients with TTN ≥17 weeks had a longer response time to chemotherapy compared to TTN 〈17 weeks (42.83 vs 21.50 weeks, P 〈 0.001). The time to PSA progression in patients with TTN :〉17 weeks was 11.44 weeks compared to 5.63 weeks when TTN was 〈17 weeks. We found several factors to be associated with OS, including TTN (hazard ratio [HR]. 3.937, 95% confidence interval [CI]: 1.502-10.309, P = 0.005), PSA level at the diagnosis of cancer (HR: 4,337, 95% CI: 1.616-11.645, P= 0.004), duration of initial androgen deprivation therapy (HR: 2.982, 95% CI: 1.104-8.045, P= 0.031), neutrophil-to-lymphocyte ratio (HR: 3.963, 95% CI: 1.380-11.384, P = 0.011), and total PSA response (Class 1 [〈0 response] compared to Class 2 [0-50% response], HR: 3.978, 95% CI: 1.278-12.387, P = 0.017). In conclusion, TTN of PSA remains an important prognostic marker in predicting therapeutic outcome in Chinese population who receive chemotherapy for mCRPC and have 〉50% PSA remission.展开更多
Surface Water and Ocean Topography(SWOT)is a next-generation radar altimeter that offers high resolution,wide swath,imaging capabilities.It has provided free public data worldwide since December 2023.This paper aims t...Surface Water and Ocean Topography(SWOT)is a next-generation radar altimeter that offers high resolution,wide swath,imaging capabilities.It has provided free public data worldwide since December 2023.This paper aims to preliminarily analyze the detection capabilities of the Ka-band radar interferometer(KaRIn)and Nadir altimeter(NALT),which are carried out by SWOT for internal solitary waves(ISWs),and to gather other remote sensing images to validate SWOT observations.KaRIn effectively detects ISW surface features and generates surface height variation maps reflecting the modulations induced by ISWs.However,its swath width does not completely cover the entire wave packet,and the resolution of L2/L3 level products(about 2 km)cannot be used to identify ISWs with smaller wavelengths.Additionally,significant wave height(SWH)images exhibit blocky structures that are not suitable for ISW studies;sea surface height anomaly(SSHA)images display systematic leftright banding.We optimize this imbalance using detrending methods;however,more precise treatment should commence with L1-level data.Quantitative analysis based on L3-level SSHA data indicates that the average SSHA variation induced by ISWs ranges from 10 cm to 20 cm.NALTs disturbed by ISWs record unusually elevated SWH and SSHA values,rendering the data unsuitable for analysis and necessitating targeted corrections in future retracking algorithms.For the normalized radar cross section,Ku-band and four-parameter maximum likelihood estimation retracking demonstrated greater sensitivity to minor changes in the sea surface,making them more suitable for ISW detection.In conclusion,SWOT demonstrates outstanding capabilities in ISW detection,significantly advancing research on the modulation of the sea surface by ISWs and remote sensing imaging mechanisms.展开更多
Background: Most newly diagnosed prostate cancers in Benin are metastatic diseases and patients are reluctant to undergo orchiectomy. Still, chemical androgen deprivation therapy is not always available and not every ...Background: Most newly diagnosed prostate cancers in Benin are metastatic diseases and patients are reluctant to undergo orchiectomy. Still, chemical androgen deprivation therapy is not always available and not every patient can afford it. Thus, it will be interesting to evaluate the results of that therapy in the country. Objective: To analyze the survival rate and factors influencing it in metastatic prostate cancer patients who underwent triptorelin-based androgen deprivation therapy at the former Military Teaching Hospital of Cotonou from January 1, 2012, to December 31, 2022. Patients and Method: Metastatic prostate cancer patients received intragluteal injections of triptorelin 11.25 mg every 3 months. We retrospectively collected follow-up data from the patients’ medical records. By means of the software StataTM version 15, we performed a descriptive analysis of qualitative data. We used Kaplan-Meir method to estimate the overall survival rate in the whole cohort and in specific subgroups of patients. We compared survival rates by using the log-rank test. Results: 68 metastatic prostate cancer patients aged 47-86 years (mean = 69.9) with initial PSA ranging from 24.25 to 6334 ng/mL (mean = 666.1) started triptorelin-based castration. The tumor grade in 21 (33.3%), 14 (22.2%), 15 (23.8), 8 (12.7%), and 5 (7.9%) patients was respectively ISUP grade groups 5, 4, 3, 2, and 1. 15 (22.1%), 4 (5.9%), 2 (2.9%), 1 (1.5%), 11 (16.2%), and 7 (10.3%) patients respectively had hypertension, diabetes mellitus, peptic ulcer, asthma, unilateral or bilateral hydronephrosis, and paralysis. The mean nadir PSA level was 22.5 ng/mL (range: 0.01-220.25). The mean time to nadir PSA level was 8.9 months (range: 3-57). The overall survival rate was 42.6%. There was no significant survival difference between age groups (p = 0.475), relating to the presence of diabetes or hypertension (p = 0.757) or to the presence of paralysis or hydronephrosis (p = 0.090). The initial PSA level exerted no significant impact on patients’ survival (p = 0.461). Neither did the time to PSA nadir (p = 0.263). The PSA nadir less than 4 ng/mL (p = 0.005) and the PSA nadir less than 4 ng/mL achieved in 12 months or less (p = 0.002) were predictive of longer survival rate. The difference in survival rate through the ISUP grade groups was not significant (p = 0.061). Conclusion: The overall survival rate was 42.6% at 5 years. Achieving PSA nadir of less than 4 ng/mL in less than 12 months of castration was predictive of longer survival rate in triptorelin-castrated metastatic prostate cancer patients.展开更多
随着新能源占比的提升,系统惯性降低、调频资源减少,系统频率稳定问题严峻。因此在新型电力系统运行方式多变的背景下,如何快速精准评估大功率扰动下系统频率安全指标显得尤为重要。其中频率最低值指标由于与多种参数存在高度非线性且...随着新能源占比的提升,系统惯性降低、调频资源减少,系统频率稳定问题严峻。因此在新型电力系统运行方式多变的背景下,如何快速精准评估大功率扰动下系统频率安全指标显得尤为重要。其中频率最低值指标由于与多种参数存在高度非线性且无法显式表达的量化关系而难以实现快速准确预测,是频率稳定安全指标评估的研究重点。然而,目前频率最低值快速预测方法难以考虑调频备用的影响。为此,基于系统频差曲线抛物线近似的假设,对平均系统频率(average system frequency,ASF)模型进行开环解耦,进一步得出系统频率最低值时间与调速器输出功率之间的量化关系,最终实现考虑调频备用容量的频率最低值快速预测方法。该方法在小系统和ACTIVSg2000算例上的预测精度分别为99.28%和97.71%,算例结果证明了算法的有效性。该方法对频率安全约束下机组组合、频率稳定控制措施的有效性评估以及频率稳定约束下系统新能源运行承载能力评估等问题具有重要意义。展开更多
电网受扰后频率最低点预测对新型电力系统的频率安全评估非常重要,而目前已有频率动态分析模型较难快速、准确、灵活地预测电网受扰后频率最低点,其中同步发电机调速系统的低阶通用建模以及新能源接入的影响建模是主要挑战。首先提出了...电网受扰后频率最低点预测对新型电力系统的频率安全评估非常重要,而目前已有频率动态分析模型较难快速、准确、灵活地预测电网受扰后频率最低点,其中同步发电机调速系统的低阶通用建模以及新能源接入的影响建模是主要挑战。首先提出了充分考虑频率响应特性的发电机调速系统低阶通用模型,结合新能源场站的通用频率响应模型,建立了新能源接入电网的通用平均系统频率(generic average system frequency,G-ASF)模型,在保证准确度的同时有效降低了模型阶数。然后,基于G-ASF模型直接预测电网在给定功率损失下的频率最低点。最后,在IEEE 3机9节点系统以及含新能源的IEEE 10机39节点系统中进行了仿真,结果表明提出的模型和方法在不同扰动或不同系统结构下均能准确预测频率最低点,且能够用于快速计算频率安全约束下的新能源渗透率极限值,验证了模型的准确性和通用性。展开更多
文摘The integration of optical images and elevation data is of great importance for 3D-assisted mapping applications. Very high resolution (VHR) satellite images provide ideal geo-data for mapping building information. Since buildings are inherently elevated objects, these images need to be co-registered with their elevation data for reliable building detection results. However, accurate co-registration is extremely difficult for off-nadir VHR images acquired over dense urban areas. Therefore, this research proposes a Disparity-Based Elevation Co-Registration (DECR) method for generating a Line-of-Sight Digital Surface Model (LoS-DSM) to efficiently achieve image-elevation data co-registration with pixel-level accuracy. Relative to the traditional photogrammetric approach, the RMSE value of the derived elevations is found to be less than 2 pixels. The applicability of the DECR method is demonstrated through elevation-based building detection (EBD) in a challenging dense urban area. The quality of the detection result is found to be more than 90%. Additionally, the detected objects were geo-referenced successfully to their correct ground locations to allow direct integration with other maps. In comparison to the original LoS-DSM development algorithm, the DECR algorithm is more efficient by reducing the calculation steps, preserving the co-registration accuracy, and minimizing the need for elevation normalization in dense urban areas.
基金the Shandong Provincial Natural Science Foundation(No.ZR2020MD097)the National Key Research and Development Program of China(No.2016YFC1401004)the National Natural Science Foundation of China(No.62031005)。
文摘The baseline roll and length errors for wide-swath altimeters are major error sources in sea surface measurements that exhibit strong spatial characteristics in the cross-track direction.These errors can be identified and estimated in accordance with height differences at crossover points generated with nadir altimeters after excluding the interference from other error sources.Most of the wide-swath altimeter baseline estimation methods considered only the roll error in previous studies.A numerical simulation was conducted in this study using nadir altimeters to estimate the roll and length errors simultaneously to provide a selectable scheme for baseline error estimation and correction for future wide-swath altimeters.Results based on the parameters of the surface water and ocean topography mission and Sentinel-3A show that the correlation coefficient of the roll error between the estimated and simulated values is 0.89,while the correlation coefficient of the length error is 0.85.The sea surface height root mean square error(RMSE)can be reduced from 12.18 cm to 6.45 cm based on the two estimated results.The estimation effect can be increased by using multiple nadir altimeters to form an observation constellation.The numerical simulation of the five nadir altimeter constellation shows that the correlation coefficients of the roll and length errors would increase to 0.97,which reduces the sea surface height RMSE to 2.88 cm.In addition,the stability of this method is indicated in simulation experiments,which introduce different degrees of sea state errors.
文摘We investigated the association of time to prostate-specific antigen nadir (TTPN) and logarithm of prostate-specific antigen velocity after progression Log(PSAVAP) in metastatic prostate cancer with prior primary androgen deprivation therapy (ADT). All metastatic prostate cancer patients treated with primary ADT from 2000 to 2009 were reviewed. Patients who developed disease progression were included in the subsequent analyses. Patients were categorized into three groups according to their TTPN: TTPN of 〈3 months, 3-17 months, and 〉17 months. We compared the Log(PSAVAP) between the different TTPN groups using Mann-Whitney U-test and Kruskal-Wallis test. Further multiple linear regression analyses on Log(PSAVAP) were performed to adjust for other potential confounding factors. Among 419 patients who were treated with primary ADT, 306 patients developed disease progression with a median follow-up of 28 months, Longer TTPN was associated with lower Log(PSAVAP) (P = 0.008) within all subgroup analyses (TTPN of 〈3 vs 3-17 months, P = 0.020; TTPN of 3-17 vs 〉17 months, P = 0.009; and TTPN of 〈3 vs 〉17 months, P = 0.001). Upon multiple linear regression analyses, baseline PSA (regression coefficient 0.001, P = 0.045), PSA nadir (regression coefficient 0.002, P = 0.040), and TTPN (regression coefficient -0.030, P = 0.001) were the three factors that were significantly associated with Log(PSAVAP). In conclusion, a longer TTPN was associated with lower Log(PSAVAP) in metastatic prostate cancer patients following primary ADT. TTPN cut-offs at 3 months and 17 months appeared to have prognostic significance in predicting Log(PSAVAP). TTPN may serve as a good prognostic indicator in deciding the treatment strategy in patients with disease progression.
基金This study was partially supported by the National Natural Science Foundation of China (NSFC 81202014 to KJW, NSFC 81130041 to DLH) and the Fundamental Research Funds for the Central Universities (to KIW).
文摘Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these patients are still controversial. In this study, we retrospectively reviewed the data from 71 eligible Chinese patients who received docetaxel chemotherapy from 2009 to 2016 in our hospital and experienced a reduction of prostate-specific antigen (PSA) level 〉50% during the treatment and investigated the potential role of time to nadir (TTN) of PSA. TTN was defined as the time from start of chemotherapy to the nadir of PSA level during the treatment. Multivariable Cox regression models and Kaplan-Meier analysis were used to predict overall survival (OS). In these patients, the median of TTN was 17 weeks. Patients with TTN ≥17 weeks had a longer response time to chemotherapy compared to TTN 〈17 weeks (42.83 vs 21.50 weeks, P 〈 0.001). The time to PSA progression in patients with TTN :〉17 weeks was 11.44 weeks compared to 5.63 weeks when TTN was 〈17 weeks. We found several factors to be associated with OS, including TTN (hazard ratio [HR]. 3.937, 95% confidence interval [CI]: 1.502-10.309, P = 0.005), PSA level at the diagnosis of cancer (HR: 4,337, 95% CI: 1.616-11.645, P= 0.004), duration of initial androgen deprivation therapy (HR: 2.982, 95% CI: 1.104-8.045, P= 0.031), neutrophil-to-lymphocyte ratio (HR: 3.963, 95% CI: 1.380-11.384, P = 0.011), and total PSA response (Class 1 [〈0 response] compared to Class 2 [0-50% response], HR: 3.978, 95% CI: 1.278-12.387, P = 0.017). In conclusion, TTN of PSA remains an important prognostic marker in predicting therapeutic outcome in Chinese population who receive chemotherapy for mCRPC and have 〉50% PSA remission.
基金The National Natural Science Foundation of China under contract Nos U2006207 and 42006164.
文摘Surface Water and Ocean Topography(SWOT)is a next-generation radar altimeter that offers high resolution,wide swath,imaging capabilities.It has provided free public data worldwide since December 2023.This paper aims to preliminarily analyze the detection capabilities of the Ka-band radar interferometer(KaRIn)and Nadir altimeter(NALT),which are carried out by SWOT for internal solitary waves(ISWs),and to gather other remote sensing images to validate SWOT observations.KaRIn effectively detects ISW surface features and generates surface height variation maps reflecting the modulations induced by ISWs.However,its swath width does not completely cover the entire wave packet,and the resolution of L2/L3 level products(about 2 km)cannot be used to identify ISWs with smaller wavelengths.Additionally,significant wave height(SWH)images exhibit blocky structures that are not suitable for ISW studies;sea surface height anomaly(SSHA)images display systematic leftright banding.We optimize this imbalance using detrending methods;however,more precise treatment should commence with L1-level data.Quantitative analysis based on L3-level SSHA data indicates that the average SSHA variation induced by ISWs ranges from 10 cm to 20 cm.NALTs disturbed by ISWs record unusually elevated SWH and SSHA values,rendering the data unsuitable for analysis and necessitating targeted corrections in future retracking algorithms.For the normalized radar cross section,Ku-band and four-parameter maximum likelihood estimation retracking demonstrated greater sensitivity to minor changes in the sea surface,making them more suitable for ISW detection.In conclusion,SWOT demonstrates outstanding capabilities in ISW detection,significantly advancing research on the modulation of the sea surface by ISWs and remote sensing imaging mechanisms.
文摘Background: Most newly diagnosed prostate cancers in Benin are metastatic diseases and patients are reluctant to undergo orchiectomy. Still, chemical androgen deprivation therapy is not always available and not every patient can afford it. Thus, it will be interesting to evaluate the results of that therapy in the country. Objective: To analyze the survival rate and factors influencing it in metastatic prostate cancer patients who underwent triptorelin-based androgen deprivation therapy at the former Military Teaching Hospital of Cotonou from January 1, 2012, to December 31, 2022. Patients and Method: Metastatic prostate cancer patients received intragluteal injections of triptorelin 11.25 mg every 3 months. We retrospectively collected follow-up data from the patients’ medical records. By means of the software StataTM version 15, we performed a descriptive analysis of qualitative data. We used Kaplan-Meir method to estimate the overall survival rate in the whole cohort and in specific subgroups of patients. We compared survival rates by using the log-rank test. Results: 68 metastatic prostate cancer patients aged 47-86 years (mean = 69.9) with initial PSA ranging from 24.25 to 6334 ng/mL (mean = 666.1) started triptorelin-based castration. The tumor grade in 21 (33.3%), 14 (22.2%), 15 (23.8), 8 (12.7%), and 5 (7.9%) patients was respectively ISUP grade groups 5, 4, 3, 2, and 1. 15 (22.1%), 4 (5.9%), 2 (2.9%), 1 (1.5%), 11 (16.2%), and 7 (10.3%) patients respectively had hypertension, diabetes mellitus, peptic ulcer, asthma, unilateral or bilateral hydronephrosis, and paralysis. The mean nadir PSA level was 22.5 ng/mL (range: 0.01-220.25). The mean time to nadir PSA level was 8.9 months (range: 3-57). The overall survival rate was 42.6%. There was no significant survival difference between age groups (p = 0.475), relating to the presence of diabetes or hypertension (p = 0.757) or to the presence of paralysis or hydronephrosis (p = 0.090). The initial PSA level exerted no significant impact on patients’ survival (p = 0.461). Neither did the time to PSA nadir (p = 0.263). The PSA nadir less than 4 ng/mL (p = 0.005) and the PSA nadir less than 4 ng/mL achieved in 12 months or less (p = 0.002) were predictive of longer survival rate. The difference in survival rate through the ISUP grade groups was not significant (p = 0.061). Conclusion: The overall survival rate was 42.6% at 5 years. Achieving PSA nadir of less than 4 ng/mL in less than 12 months of castration was predictive of longer survival rate in triptorelin-castrated metastatic prostate cancer patients.
文摘随着新能源占比的提升,系统惯性降低、调频资源减少,系统频率稳定问题严峻。因此在新型电力系统运行方式多变的背景下,如何快速精准评估大功率扰动下系统频率安全指标显得尤为重要。其中频率最低值指标由于与多种参数存在高度非线性且无法显式表达的量化关系而难以实现快速准确预测,是频率稳定安全指标评估的研究重点。然而,目前频率最低值快速预测方法难以考虑调频备用的影响。为此,基于系统频差曲线抛物线近似的假设,对平均系统频率(average system frequency,ASF)模型进行开环解耦,进一步得出系统频率最低值时间与调速器输出功率之间的量化关系,最终实现考虑调频备用容量的频率最低值快速预测方法。该方法在小系统和ACTIVSg2000算例上的预测精度分别为99.28%和97.71%,算例结果证明了算法的有效性。该方法对频率安全约束下机组组合、频率稳定控制措施的有效性评估以及频率稳定约束下系统新能源运行承载能力评估等问题具有重要意义。
文摘电网受扰后频率最低点预测对新型电力系统的频率安全评估非常重要,而目前已有频率动态分析模型较难快速、准确、灵活地预测电网受扰后频率最低点,其中同步发电机调速系统的低阶通用建模以及新能源接入的影响建模是主要挑战。首先提出了充分考虑频率响应特性的发电机调速系统低阶通用模型,结合新能源场站的通用频率响应模型,建立了新能源接入电网的通用平均系统频率(generic average system frequency,G-ASF)模型,在保证准确度的同时有效降低了模型阶数。然后,基于G-ASF模型直接预测电网在给定功率损失下的频率最低点。最后,在IEEE 3机9节点系统以及含新能源的IEEE 10机39节点系统中进行了仿真,结果表明提出的模型和方法在不同扰动或不同系统结构下均能准确预测频率最低点,且能够用于快速计算频率安全约束下的新能源渗透率极限值,验证了模型的准确性和通用性。