针对正交频分线性调频(OFD-LFM)信号MIMO高分辨雷达稀疏成像问题展开研究,在分析了OFD-LFM信号频谱合成原理以及MIMO高分辨雷达一次快拍成像原理的基础上,给出了一种基于频域稀疏OFD-LFM信号和空域稀疏MIMO雷达天线阵列的联合稀疏模型,...针对正交频分线性调频(OFD-LFM)信号MIMO高分辨雷达稀疏成像问题展开研究,在分析了OFD-LFM信号频谱合成原理以及MIMO高分辨雷达一次快拍成像原理的基础上,给出了一种基于频域稀疏OFD-LFM信号和空域稀疏MIMO雷达天线阵列的联合稀疏模型,并结合压缩感知理论,提出了目标高分辨距离像(high-resolution range profile,HRRP)合成方法以及目标二维成像方法。该方法能够在大幅减少OFD-LFM信号子载波个数、大幅减少MIMO高分辨雷达天线阵元个数的条件下,利用一次快拍重构出高质量的目标HRRP和二维像,不仅避免了目标机动带来的运动补偿难题,同时还有利于天线阵列的工程实现。仿真结果表明所提方法是有效的,且具有一定的抗噪性。展开更多
BACKGROUND Oral-facial-digital syndrome type 1(OFD1) is a rare ciliopathy mainly with an Xlinked dominant pattern of inheritance, which is caused by mutations in the OFD1 gene. The OFD1 protein is located within the c...BACKGROUND Oral-facial-digital syndrome type 1(OFD1) is a rare ciliopathy mainly with an Xlinked dominant pattern of inheritance, which is caused by mutations in the OFD1 gene. The OFD1 protein is located within the centrosomes and basal bodies of the primary cilia. It is reported that approximately 15%–50% cases of OFD1 progress to end-stage renal disease(ESRD) following development of polycystic kidney diseases(PKD). Here we report a pair of childhood male twins who presented only renal failure and PKD caused by an OFD1 mutation in China.CASE SUMMARY A pair of 14-year male twins were hospitalized with a complaint of abnormal renal function for nine days. They both complained of ankle pain for 3 mo vs 2 wk, respectively. They denied fever, abdominal pain, daytime or nighttime enuresis, urgency, dysuria, or gross hematuria. Laboratory tests at a local hospital showed renal failure(serum creatinine 485 μmol/L vs 442 μmol/L, blood urea nitrogen 14.7 mol/L vs 14.5 mol/L) and anemia(hemoglobin 88 g/L vs 98 g/L).The twins are monozygotic. There was no abnormal birth, past medical, or family history. Clinical data were analyzed and genetic analysis on PKD was carried out in the twins by next-generation sequencing. The results showed that the twins presented low-molecular-weight proteinuria, hyposthenuria, anemia, renal failure, and renal polycystic changes. Genetic tests showed that the twins both carried a hemizygous mutation in exon 19 c.2524 G>A(p. G842 R) of the OFD1 gene. Their mother heterozygously carried the same mutation as the twins but was without any phenotypes while their father was normal.CONCLUSION We have reported a pair of childhood male twins with an OFD1 mutation who presented ESRD and PKD but without any other phenotypes of OFD1 in China.展开更多
文摘针对正交频分线性调频(OFD-LFM)信号MIMO高分辨雷达稀疏成像问题展开研究,在分析了OFD-LFM信号频谱合成原理以及MIMO高分辨雷达一次快拍成像原理的基础上,给出了一种基于频域稀疏OFD-LFM信号和空域稀疏MIMO雷达天线阵列的联合稀疏模型,并结合压缩感知理论,提出了目标高分辨距离像(high-resolution range profile,HRRP)合成方法以及目标二维成像方法。该方法能够在大幅减少OFD-LFM信号子载波个数、大幅减少MIMO高分辨雷达天线阵元个数的条件下,利用一次快拍重构出高质量的目标HRRP和二维像,不仅避免了目标机动带来的运动补偿难题,同时还有利于天线阵列的工程实现。仿真结果表明所提方法是有效的,且具有一定的抗噪性。
文摘BACKGROUND Oral-facial-digital syndrome type 1(OFD1) is a rare ciliopathy mainly with an Xlinked dominant pattern of inheritance, which is caused by mutations in the OFD1 gene. The OFD1 protein is located within the centrosomes and basal bodies of the primary cilia. It is reported that approximately 15%–50% cases of OFD1 progress to end-stage renal disease(ESRD) following development of polycystic kidney diseases(PKD). Here we report a pair of childhood male twins who presented only renal failure and PKD caused by an OFD1 mutation in China.CASE SUMMARY A pair of 14-year male twins were hospitalized with a complaint of abnormal renal function for nine days. They both complained of ankle pain for 3 mo vs 2 wk, respectively. They denied fever, abdominal pain, daytime or nighttime enuresis, urgency, dysuria, or gross hematuria. Laboratory tests at a local hospital showed renal failure(serum creatinine 485 μmol/L vs 442 μmol/L, blood urea nitrogen 14.7 mol/L vs 14.5 mol/L) and anemia(hemoglobin 88 g/L vs 98 g/L).The twins are monozygotic. There was no abnormal birth, past medical, or family history. Clinical data were analyzed and genetic analysis on PKD was carried out in the twins by next-generation sequencing. The results showed that the twins presented low-molecular-weight proteinuria, hyposthenuria, anemia, renal failure, and renal polycystic changes. Genetic tests showed that the twins both carried a hemizygous mutation in exon 19 c.2524 G>A(p. G842 R) of the OFD1 gene. Their mother heterozygously carried the same mutation as the twins but was without any phenotypes while their father was normal.CONCLUSION We have reported a pair of childhood male twins with an OFD1 mutation who presented ESRD and PKD but without any other phenotypes of OFD1 in China.
