Endothelial Nitric Oxide Synthase Traffic Inducer in the Umbilical Vessels of the Patients with Pre-eclampsia

The expression of endothelial nitric oxide synthase traffic inducer （NOSTRIN） was examined in the umbilical vessels of the patients with pre-eclampsia （PE） to explore its possible role in the pathogenesis of PE. The NOSTR1N rnRNA in umbilical tissues was determined by RT-PCR. The eNOS activity in umbilical vessels was spectrophotometrically detected. NO2 /NO3, the stable metabolic end products of NO, was measured by using nitrate reductase. RT-PCR showed that the expression level of NOSTRIN was significantly higher in women with PE than in the normal group （P〈0.01）. The activity of eNOS was significantly decreased in PE group [（12.83±3.61） U/mg] than in normal group [（21.72±3.83） U/mg] （P〈0.01）. The level of NO2-/NO3- in PE patients （27.53±7.48） pmol/mg was significantly lower than that of normal group （54.27±9.53） μmol/mg （P〈0.01）. The significant negative correlation existed between the expression of NOSTRIN and the activity of eNOS in umbilical vessels of women with PE （r=-0.58, P〈0.01）. It was concluded that the level of NOSTR1N expression was increased in umbilical vessel of women with PE, indicating that it may be involved in the pathogenesis of PE.

重症急性胰腺炎患者乌司他丁联合奥曲肽治疗的临床效果分析

目的:研究重症急性胰腺炎患者乌司他丁与奥曲肽联合治疗的临床效果。方法:选择2013年1月至2016年1月在我院收治的重症急性胰腺炎患者80例作为此次研究的对象,将这80例患者随机分为对照组和观察组各40例,其中对照组用奥曲肽进行治疗,观察组用乌司他丁与奥曲肽联合进行治疗,观察两组患者的治疗效果以及患者的住院时间、尿淀粉酶的变化。结果:观察组采用乌司他丁联合奥曲肽进行治疗以后,住院时间明显比对照组要少,尿淀粉酶的结果也比对照组要低。结论:重症急性胰腺炎使用乌司他丁联合奥曲肽治疗,取得的治疗效果相对较好,不但可以使患者的血尿淀粉酶达到正常,还可以减少患者的住院时间,从而减轻患者的经济压力。