Clinical effect of laparoscopic radical resection of colorectal cancer based on propensity score matching

BACKGROUND The incidence of colorectal cancer(CRC)is increasing annually.Laparoscopic radical resection of CRC is a minimally invasive procedure preferred in clinical practice.AIM To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed retrospectively.The control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 PSM.Differences in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were analyzed.RESULTS Thirty patients from both groups were successfully matched.After PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than preoperatively.IL-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before surgery.At 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation group were lower than those in the control group at 24 and 72 h after surgery;and(5)Physical status:One month after surgery,the Karnofsky performance score in the observation group was higher than that in the control group.CONCLUSION Laparoscopic radical resection of CRC has significant benefits,such as reducing postoperative pain and postoperative inflammatory response,avoiding excessive immune inhibition,and contributing to postoperative recovery.

Artificial Self-Recovery Opens up a New Journey of Autonomous Health of Mechanical Equipments

1.Introduction With the implementation of modern production strategies,such as“Industry 4.0”and“Made in China 2025,”the development of high-end mechanical equipment is gradually reaching a high degree of parameterization,digitalization,networking,and intelligence[1].High-end mechanical equipment no longer consists of traditional single devices,but is closely linked to the overall production process;that is,a variety of devices interact with each other and collectively form a complex system.However,faults can lead to production delays throughout the system and even seriously threaten the safety of workers[2].In addition,equipment operating in unmanned air or space vehicles(including space robots)cannot be repaired by humans if they break down[3].Until recently,the typical method of addressing machine faults was primarily the“fault cure”method,which involves manually shutting down,inspecting,and repairing the equipment to restore normal operation.Accordingly,the maintenance cycle of the traditional“fault cure”method is time-consuming,and the quality of the maintenance depends on the skills of the technician[4].

基于Opensim的下肢肌骨运动系统生物力学研究进展

目的近年来,下肢肌骨运动在生物力学领域中占重要地位,但由于实验设备、测量精度等原因不能深入探究。Opensim是一款开源的生物力学模拟工具,具有强大的动力学模拟和可视化能力。因此,本文旨在总结近年来Opensim仿真的下肢肌骨运动系统生物力学研究进展,以期推动相关领域的研究。方法在中国知网、万方和Pub Med数据库进行检索,检索时间为2021~2024年,通过对标题和摘要进行初步筛选后,最终引用18篇文献进行综述,重点关注在运动分析、康复评估以及运动损伤预防等方面的应用。结果Opensim在人体下肢运动生物力学的应用日益广泛。通过Opensim仿真,能够构建个性化的肌骨模型、精确模拟肌肉的激活模式以及骨、关节的运动,从而模拟和分析人体在行走、跑步等运动中的生物力学特性,探究下肢运动的复杂动力学过程。且Opensim还能对模型进行优化设计,以改善运动表现或预防运动损伤,在运动训练、康复治疗和医疗器械设计等领域具有广泛的应用前景。结论通过Opensim的下肢运动生物力学研究,为探究人体运动机制、改善运动表现和预防运动损伤提供了有力支持。未来的研究应继续完善Opensim的模型库、提高模拟的精度,以及加强与临床实践的结合,以推动其在实际应用中的广泛使用。

Malawi Opens Tourism Doors No visa’s needed for Chinese tourists and others,as Malawi makes visits more convenient

When Malawian President Lazarus Chakwera delivered a State of the Nation Address at the 50th Parliamentary Session and Budget Meeting in February,tourism was top of mind.

2023 World Robot Conference Opens in Beijing

The 2023 World Robot Conference was held at Beiren Etrong International Exhibition&Convention Centre of the Economic and Technological Development Zone in Beijing.Themed"Spurring Innovation for the Future",the Conference was hosted by the People's Government of Beijing Municipality,the Ministry of Industry and Information Technology of China and China Association for Science and Technology,organised by Bejing Institute of Electronics.

The Whole-Process People's Democracy Opens Up New Realm of Human Political Civilization

Socialism with Chinese characteristics is a great cause full of vigor and vitality. The democratic politics with Chinese characteristics is a development process of constant exploration and innovation, both in theory and in practice. Since the 18th National Congress of the Communist Party of China(CPC)。

The 14th Beijing Olympic City Sports Culture Festival Opens

The 14th Beijing Olympic City Sports Culture Festival opened in Beijing on August 16th.Thomas Bach,President of the International Olympic Committee,delivered a speech via video.The Festival was hosted by Beijing Olympic City Development Association,and co-organised by Beijing Olympic City Development Centre and Changping District People's Government of Bejing Municipality.The Festival will last until the end of this year,encompassing a wide array of activities.These include major sports events,promotional campaigns for emerging trendy sports.

China-Arab States Tour Operators Conference of the Sixth China-Arab States Expo Opens in Yinchuan,Ningxia

China-Arab States Tour Operators Conference of the Sixth China-Arab States Expo,co-hosted by the Ministry of Culture and Tourism and the People's Government of Ningxia Hui Autonomous Region,and organized by the Network of International Culturalink Entities and the Department of Culture and Tourism of Ningxia Hui Autonomous Region..

The Woodblock Printing Hallof the Palace Museum Opens

Traditional Chinese woodblock printing is the ingenious creation of ancient Chinese laborers,whose invention facilitated cultural dissemination and information sharing,and greatly advanced the progress of world civilization.

红帽OpenShift扩展人工智能平台应用

世界领先的开源解决方案供应商红帽日前宣布为红帽OpenShift AI再添多项新功能。红帽OpenShift AI基于开源技术,以红帽OpenShift和红帽OpenShift数据科学为基础进行构建,并在此基础上进一步扩展后,能够为IT领导者提供一致且可扩展的基础,同时为数据科学家和开发人员创建专业合作伙伴生态系统,帮助他们获取AI领域的创新成果。为实现这一目的,红帽OpenShift AI为IBM watsonx.AI的生成式AI服务提供支撑。

基于OpenStack构建私有云计算平台

云计算是近几年来IT领域非常热门的研究方向,而私有云凭借其安全性、可控性以及有效利用IT设备资源等特性,在云计算领域占据重要位置。本文详细介绍了OpenStack开源云计算平台的架构以及OpenStack的5个功能模块的关系,并重点介绍了一种基于OpenStack构建私有云的方案。此外,本文还分享了私有云平台搭建过程中遇到的问题和解决方法,并分析了此私有云平台的安全性以及弹性计算资源分配能力。

集成Docker容器的OpenStack云平台性能研究

针对Open Stack云平台虚拟机未能较好利用宿主物理机资源的问题,结合基于组件工作的Open Stack在云平台管理中的高效性和Docker容器虚拟化的快速部署优势,搭建基于Docker容器技术的Open Stack云平台。对云平台管理的Docker容器中实际运行的客户机操作系统进行计算、调度、内存访问、文件读写等基础性能测试,做出相关性能的评估与分析,并在多实例运行状态下将其与Open Stack传统虚拟机进行性能比较。分析结果表明,该云平台能够利用Docker容器的轻量级虚拟化优势,优化云计算管理系统的计算性能和文件读写性能。

基于OpenSees摇摆防屈曲支撑钢框架抗震性能分析

为研究摇摆防屈曲支撑钢框架抗震性能,采用Open Sees有限元软件,基于防屈曲支撑钢框架(BRBSF)和摇摆防屈曲支撑钢框架(RBRBSF)拟静力试验建立试验框架数值模型,采用多细分基于刚度法的梁柱单元模拟钢梁与钢柱,梁端削弱截面处用零长度截面单元模拟塑性铰出现,并采用缝(Gap)单元与桁架(Truss)单元模拟摇摆柱脚,对比模拟结果与试验结果,验证模型正确性,并进一步分析RBRBSF响应,结果表明:模型能准确预测BRBSF和RBRBSF抗震性能,摇摆柱脚可减轻主体框架损伤风险。

Laparoscopic vs.open surgery for gastrointestinal stromal tumors of esophagogastric junction:A multicenter,retrospective cohort analysis with propensity score weighting

Objective:Laparoscopic resection is increasingly performed for gastrointestinal stromal tumors(GISTs).However,the laparoscopic approach for GISTs located in the esophagogastric junction(EGJ-GIST)is surgically challenging.This study compares the efficacy of laparoscopic surgery and the open procedure for EGJ-GIST through the propensity score weighting(PSW)method.Methods:Between April 2006 and April 2018,1,824 surgical patients were diagnosed with primary gastric GIST at four medical centers in South China.Of these patients,228 were identified as EGJ-GISTs and retrospectively reviewed clinicopathological characteristics,operative information,and long-term outcomes.PSW was used to create the balanced cohorts.Results:PSW was carried out in laparoscopic and open-surgery cohorts according to year of surgery,sex,age,body mass index(BMI),tumor size,mitotic rates and recurrence risk.After PSW,438 patients consisting of 213 laparoscopic(L group)and 225 open surgery(O group)patients were enrolled.After PSW,the following measures in the L group were superior to those in the O group:median operative time[interquartile range(IQR)]:100.0(64.5-141.5)vs.149.0(104.0-197.5)min,P<0.001;median blood loss(IQR):30.0(10.0-50.0)vs.50.0(20.0-100.0)mL,P=0.002;median time to liquid intake(IQR):3.0(2.0-4.0)vs.4.0(3.0-5.0)d,P<0.001;median hospital stay(IQR):6.0(4.0-8.0)vs.7.0(5.0-12.0)d,P<0.001;and postoperative complications(10.3%vs.22.7%,P=0.001).The median follow-up was 55(range,2-153)months in the entire cohort.No significant differences were detected in either relapse-free survival(RFS)[hazard ratio(HR):0.372,95%confidence interval(95%CI):0.072-1.910,P=0.236]or overall survival(OS)(HR:0.400,95%CI:0.119-1.343,P=0.138)between the two groups.Conclusions:Laparoscopic surgery for EGJ-GIST is associated with the advantages of shorter operative time,reduced blood loss,shorter time to liquid intake,and shorter length of stay,all without compromising postoperative outcomes and long-term survival.

基于OpenSim和SketchUp的虚拟校园技术研究

本文研究了目前虚拟地理环境在虚拟校园方面的应用技术和特点,探讨了基于可快速建三维模型的Google Sketchup软件和开源的Open Simulator虚拟世界平台构建分布式的客户端/服务器的虚拟校园,并以云南师范大学图书馆为应用实例。

Short-term and middle-term evaluation of laparoscopic hepatectomies compared with open hepatectomies: A propensity score matching analysis

AIM To compare short-term results between laparoscopic hepatectomy and open hepatectomy using a propensity score matching. METHODS A patient in the laparoscopic liver resection(LLR) groupwas randomly matched with another patient in the open liver resection(OLR) group using a 1:1 allocated ratio with the nearest estimated propensity score. Patients of the LLR group without matches were excluded. Matching criteria included age, gender, body mass index, American Society of Anesthesiologists score, potential co-morbidities, hepatopathies, size and number of nodules, preoperative chemotherapy, minor or major liver re-sections. Intraoperative and postoperative data were compared in both groups.RESULTS From January 2012 to January 2015, a total of 241 hepa-tectomies were consecutively performed, of which 169 in the OLR group(70.1%) and 72 in the LLR group(29.9%). The conversion rate was 9.7%(n = 7). The mortality rate was 4.2% in the OLR group and 0% in the LLR group. Prior to and after propensity score matching, there was a statistically significant difference favorable to the LLR group regarding shorter operative times(185 min vs 247.5 min; P = 0.002), less blood loss(100 m L vs 300 m L; P = 0.002), a shorter hospital stay(7 d vs 9 d; P = 0.004), and a significantly lower rate of medical complications(4.3% vs 26.4%; P < 0.001). CONCLUSION Laparoscopic liver resections seem to yield better short-term and mid-term results as compared to open hepatectomies and could well be considered a privileged approach and become the gold standard in carefully selected patients.

OpenStack云环境中KVM虚拟机性能测试与优化

目前,虚拟化技术在一定程度上影响着云计算平台的性能,但KVM虚拟机上运行的操作系统(GuestOS)是针对物理机开发的操作系统,因而存在不适合虚拟化环境的因素。文章在OpenStack云环境下,对KVM虚拟机磁盘I/O、网卡I/O和处理器的计算能力进行了测试,对比了KVM虚拟机与物理机的性能差距,并通过将虚拟机的处理器(VCPU)和物理机处理器(CPU)进行绑定,同时将宿主机的扩展页表(EPT)开启,从而实现了对KVM虚拟机性能的优化。

Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy:A propensity score matching analysis

BACKGROUND Laparoscopic total gastrectomy(LTG)has drawn increasing attention over the years.Although LTG has shown surgical benefits compared to open TG(OTG)in early stage gastric cancer(GC),little is known about the surgical and oncological outcomes of LTG for advanced GC following neoadjuvant therapy(NAT).AIM To compare the long-and short-term outcomes of advanced GC patients who underwent LTG vs OTG following NAT.METHODS Advanced GC patients who underwent TG following NAT between April 2011 and May 2018 at the Cancer Hospital of the Chinese Academy of Medical Sciences were enrolled and stratified into two groups:LTG and OTG.Propensity score matching analysis was performed at a 1:1 ratio to overcome possible bias.RESULTS In total,185 patients were enrolled(LTG:78;OTG:109).Of these,138 were paired after propensity score matching.After adjustment for propensity score matching,baseline parameters were similar between the two groups.Compared to OTG,LTG was associated with a significantly shorter length of hospital stay(P=0.012).The rates of R0 resection,lymph node harvest,and postoperative morbidity did not significantly differ between the two groups.Overall survival(OS)outcomes were comparable between the two groups.Pathological T and N stages were found to be independent risk factors for OS.CONCLUSION LTG can be a feasible method for advanced GC patients following NAT,as it appears to be associated with better short-and comparable long-term outcomes compared to OTG.

基于OpenStack平台的云计算系统设置研究

介绍在Open Stack平台下的云计算Iaa S系统的部署方法。结合安徽商贸职业技术学院网络中心私有云应用服务,研究云计算Iaa S系统控制节点和计算节点的部署。

Xinjiang Opens Its Door to the World——An interview with Wang Lequan,Vice-Chairman of the Standing Committee of the Xinjiang Uygur Autonomous Region

Xinjiang is a good place, with pastureland to the north and south of the Tianshan MountainThe Gobi Desert has been changed into fertile fields, irrigated by melting snows.