Extramammary Paget’s Disease Manifested by Intraepithelial Adenocarcinoma of the Vulva and Anus Combined with Invasive Adenocarcinoma of the Ampullary Part of the Rectum

The Object of the Study: The author of the given paper describes an unusual combination of two diseases: extramammary Paget’s disease manifested by intraepithelial adenocarcinoma of the vulva and anus combined with invasive adenocarcinoma of the ampullary part of the rectum and describes the atypical manifestations of these diseases. The Content: The content of this research paper includes a description of the patient, an analysis of the clinical picture, diagnostic methods and therapeutic interventions used, a report of the following disease, and the result of the presented case. The Result of the Research Work: The result of the research work is the analysis of a clinical case with two different tumors, where such a combination of tumors is rarely described in the literature. Moreover, no large specific sample with this combination of diseases is available. Patient Characteristics: The given case report describes a patient of the Palliative Care Unit of the Gerontology Clinic with a primary diagnosis of C20-rectal adenocarcinoma in the background of the anal canal, perineal skin Paget’s disease, stage IV. The presented complications of the patient’s primary diagnosis are multiple metastases in the liver;status post palliative chemotherapy;hepatomegaly;metastases to abdominal lymph nodes, inguinal lymph nodes;metastases at Th12, L4 level;pain syndrome. The presented above combination of diagnosed diseases is very rare. Applied Diagnostics: In October 2021, it was performed diagnostic manipulation: biopsy and the pathologist have provided a microscopic description. The first tissue fragment had a pronounced electrothermal lesion and the epithelial structures were not valuable. The second skin tissue fragment was covered with hyperplastic and acanthotic epithelium;its basal and middle layers contained multiple large cells proliferates extending into the medial epidermis, and the cytoplasm of these cells reacted positively with PAS (Periodic Acid Schiff reaction). It needs to be noted that the patient had previously had several years of biopsies from the perineal and anal epidermis, where Paget’s disease had also been diagnosed. The performed immunohistochemistry showed these cells to be CK20 positive, CK7 rare positive and p16 negative. The following pathohistological findings were made: morphological and immunohistochemical picture is consistent with Paget’s disease. According to the ICD-10, the patient was diagnosed with C51 malignant neoplasm of the female external genitalia. Using imaging diagnostics, it became clear that the patient’s rectal adenocarcinoma had progressed to metastatic stage with distant liver metastases in the background of anal canal, perineal skin Paget’s disease. Therapeutic Plan of the Patient: Based on the patient’s main diagnoses, the complications of the principal diagnosis, the patient’s overall severe condition, pain syndrome, age and comorbidities, palliative chemotherapy was approved as a therapeutic option in council of doctors. Monitoring and Outcome of the Patient: The patient’s general condition was becoming worse over time, and she was diagnosed with exitus latalis in December 2022. At that time, the patient was discharged from hospital and was on palliative care at home under the control of her family physician.

锁阳PartⅢ对环磷酰胺致免疫抑制小鼠免疫功能的影响

目的:研究锁阳PartⅢ对环磷酰胺致免疫抑制小鼠免疫功能的影响。方法:用环磷酰胺(CTX,100 mg/kg)腹腔注射制备小鼠免疫低下模型,给药组和阳性对照人参皂苷(TSPG)组剂量均为300 mg/kg.d,空白对照组和缺氧模型组给予同体积的蒸馏水,灌胃给药,共7 d。分别从外周血象、免疫器官指数、巨噬细胞吞噬功能和血清溶血素水平等方面进行评价。结果:锁阳水提物PartⅢ可使CTX免疫抑制小鼠的免疫器官指数、巨噬细胞吞噬功能和血清溶血素水平不同程度的升高。结论:锁阳水提物PartⅢ能够增强CTX免疫抑制小鼠的非特异性和特异性免疫功能,对免疫失衡机体具有一定的保护作用。

存算分离架构下Part元数据的单独管理策略

针对ClickHouse存在的硬件资源无法被充分利用、缺少弹性和节点启动过慢的问题,在存算分离架构下,提出了一套针对描述数据信息的元数据(Part元数据)的管理策略. Part元数据是元数据中最重要的组成成分.为了能够有效管理远程共享存储上的数据,采集了所有Part元数据文件,并将其合并后,经过键值映射、序列化和反序列化,存入分布式键值数据库中.此外,还设计了一套同步策略,以确保远程共享存储上的数据与分布式键值数据库中的元数据的一致性.利用Part元数据管理策略及相关的同步策略,实现了一个针对Part元数据的管理系统,解决了ClickHouse节点启动过慢的问题,并支持高效的节点动态扩缩容.

Part-Whole关系的细分及性质分析

Part-Whole关系的语义差别往往决定了本体是否可以合并或重用。Wiston分类法被用来对医学本体中的Part-Whole关系进行了分类,使每类Part-Whole子关系具有特定的语义并有传递性。利用Mereology理论分析了子关系的性质和子关系之间的相似性,以及子关系之间相似性和逻辑推理正确性的关系。为Part-Whole关系的研究提供了新的方法学。

基于Part-Whole关系的人造物属性分析

知识分析是建立知识库系统过程中的重要一环,其目的就是帮助检查知识库中的知识一致性、完备性和精确性。该文重点讨论了基于Part-Whole关系的人造物属性分析,主要内容是:一是部分和整体的属性之间是否具有继承关系;二是部分的公共属性和整体相同属性的属性值之间的内在约束关系。

汉维语个体量词“张”和part∫ε的认知语义特征比较

"张"的语义经历了引申、扩大、缩小、类化、分化等过程,逐渐发展为"平面"义日益凸显,"动作"义日趋弱化的范畴,这是汉民族认知过程的反映。part∫ε的语义经历了由实渐虚的过程,逐渐发展成为称量"扁平、块状"事物的量词,它的演化展现了维吾尔族的认知过程。

MODAL PART ANALYSIS OF SLOSH OF THE LIQUID IN A CYLINDRICAL CONTAINER IN THE CASE OF SMALL BOND NUMBER

Reconstruction of liquid free slosh modes by curved quiet free surface was investigated in the case of small Bond number by means of modal part analysis method in this paper. It is shown that the curved liquid quiet free surface would couple the modes to form new eigen-modes while the orthogonality of the modes which participate the liquid slosh are given only by their Bessel modal parts and it would change their eigen-frequencies respectively while the orthogonality are given by their triangle function modal parts. By studying the laterally forced slosh of the liquid in a cylindrical container based on the new eigen-modes, a characteristic of modes-choosing was found.

ICCC上STEP part 203前后处理器的设计与实现

STEP（theSTandardfortheExchangeofProductmodeldata）标准是一个服务于CAD。CAM领域的覆盖产品整个生命周期的形式化的产品数据交换标准，其应用协议的研究开发与实现具有广泛的应用价值．本文主要介绍了STEP标准应用协议配置控制设计STEPpart203的前后处理器的设计与实现，包括应用协议的EXPRESS描述编译、几何拓扑映射、面片合成、中性文件交换、在SUNSPARCworkstation上的处理器实现和零件输入输出测试等内容．

基于PartMaker的车铣复合加工技术

车铣复合加工在现代数控加工技术中,发挥着日益重要的作用。针对典型结构件,研究了基于PartMaker的车铣复合加工技术。以典型的轴类零件为例,首先,选择加工机床,进行工艺设计;然后,利用PartMaker软件,编制数控程序并进行后置处理,生成机床加工程序,利用VERICUT软件构建了加工仿真模型,并对机床程序进行了仿真加工;最后,通过实际加工得到了合格的零件,验证了加工方法的可行性。

无线终端产品FCC Part 22/24测试

介绍了无线通信终端产品FCC Part 22/24测试依据的法规、标准及测试项目和方法。给出了频谱分析仪在FCC Part 22/24测试中的应用。

解析美国EMC标准——FCC PART 15

介绍了美国FCC技术法规第15部分所规定的技术要求,包括适用范围、有意/无意发射设备的辐射和传导骚扰测量方法、限值。同时特别针对2007年5月修订版中所涉及的超宽带(UWB)设备、电力线通信设备,以及免执照的国家信息基础设备(U-NII)的特殊要求进行了解析和介绍。

Analysis and Improvement Measures for the Current Situation of Spare Parts Management (SPM)

Based on an investigation on the current situation of SPM in some enterprises, this paper presents the common probletns and poor fields existing in SPM in enterprise; analyzes the reasons which resulted in the situation, and then puts forward some feasible measures to improve it. Lastly, some fields that should be paid more attention in SPM are provided.

INTELLIGENT VIRTUAL CONTROL:MEASURING INSTRUMENT FROM WHOLE TO PART

A new concept called intelligent virtual control (IVC), which can be drivenby measuring functions, is put forward. This small 'intelligent measurement instrument unit (IMIU)',carrying with functions of instrument, consists of different types of intelligent virtualinstrument (IVI) through individual components together as building blocks and can be displayeddirectly on the computer screen. This is a new concept of measuring instrument, and also animportant breakthrough after virtual instrument (VI). Virtual control makes instrument resourcesobtain further exploitation. It brings about a fundamental change to the design and manufacturingmode. The instrument therefore, can not only be produced directly inside a PC, but the product isinvolved in the 'green product' system. So far, all the present digital instruments will grow to bereplaced by intelligent control with green characteristics.

SIMPLE ECOSYSTEM MODEL OF THE CENTRAL PART OF THE EAST CHINA SEA IN SPRING

This paper’s simple ecological model to simulate the ecosystem variation and the vertical carbon flux in the central part of the East China Sea in spring, inter-reated the phytoplankton, zooplankton,autotrophic and heterotrophic bacterioplankton, nitrate, and dissolved organic carbon (DOC) in a run lasting 90 days. Except for DOC, because of poor observation precision,the major seasonal features of the vertical distribution for these components can be simulated by this model. The results show that spring bloom is just a short period of 1-2 weeks and that deposit carbon flux at the bottom interface is about 200 mg /m2 ·d in the first 20 days and then reaches its maximum of 1500mg/m2·d about 2 months later after the spring bloom.

Origin and accumulation of high-maturity oil and gas in deep parts of the Baxian Depression, Bohai Bay Basin, China

Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 ℃ to 201 ℃ in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarbons discovered in the Bohai Bay Basin in eastern China. This discovery suggests favorable exploration prospects for the deep parts of the basin. However, the discovery raises questions regarding the genesis and accumulation of hydrocarbons in deep reservoirs. Based on the geochemical features of the hydrocarbons and characteristics of the source rocks as well as thermal simulation experiments of hydrocarbon generation, we conclude that the oil and gas were generated from the highly mature Sha-4 Member （Es4） source rocks instead of thermal cracking of crude oils in earlier accumulations. The source kitchen with abnormal pressures and karsted carbonate reservoirs control the formation of high-maturity hydrocarbon accumulations in the buried hills （i.e., Niudong-1） in conjunction with several structural-lithologic traps in the ES4 reservoirs since the deposition of the upper Minghuazhen Formation. This means the oil and gas exploration potential in the deep parts of the Baxian Depression is probably high.

基于tree part-based模型的目标识别和定位

提出了一种基于tree part-based模型的目标识别和定位的方法。该方法将tree part-based模型应用于静态图像中单一目标的识别定位,使用可变形模板(Deformable template)处理测试图像,提取与训练模型中的每一部分关联度在一定阈值范围内的特征点,结合外观模型和空间模型实现目标识别和定位。实验结果表明,该方法提高了目标识别和定位的准确率和可靠性。

Research on the Influence of Cutting Condition on the Surface Microstruct ure of Ultra-thin Wall Parts in Ultrasonic Vibration Cutting

In many fields of high-tech industry the ultra-t hi n wall parts are employed. In this paper the experiments were carried out to dis cuss the surface microstructure of the camera’s guided drawtube by applying ult rasonic vibration cutting device to the traditional lathe. The influence rule of the cutting condition on the surface roughness was put forward, which was drawn by comparing the ultrasonic cutting with the common cutting by use of the cemen ted carbide tool and the polycrystalline diamond (PCD) tool. The test results sh owed that the ultrasonic cutting performs better than the common cutting in the same condition. According to the test results analyzing, the surface characteriz ation is influenced clearly by the rigidity of the acoustic system and the machi ne tool, as well the setting height of the tool tip. Otherwise, the dense regula r low frequency vibration ripples will be scraped on the machined surface. When the tool tip is set higher than the rotating center of the work piece by three t imes of the amplitude of ultrasonic vibration, the vibration ripples behave alig ht; they turn light and shade alternatively when the tool tip is lower than the rotating center of the work piece by three times of the amplitude of ultrasonic vibration. According to the test result analyzing, the following conclusions are put forward: 1) The surface roughness in ultrasonic cutting is better than that in common cutting. Under a one third critical cutting velocity, the value of th e surface roughness in ultrasonic cutting rise slightly along with the cutting v elocity, while in common cutting it decreases contrast to the cutting velocity; the curves of the surface roughness in ultrasonic cutting and common cutting see m to be alike, both increase along with the feed rate and the cutting depth, but the value in ultrasonic cutting is smaller in the same condition.2) The influen ce of the coolant on the surface roughness cannot be ignored. The kerosene can b e employed to improve the surface roughness in ultrasonic machining.3) In ultras onic cutting process of aluminum alloy ultra-thin wall work piece, the PCD tool performs better than the cemented carbide tools.4) The vibration ripples result from the not enough rigidity of the acoustic system and the improper setting he ight of the tool tip. The departure of the tool tip from the rotating center of the work piece to some extent causes the vibration ripples on the machined surfa ce.

Orbital-abrasion-assisted Electroforming of Non-rotating Parts

A novel technique of electroforming with orbital moving cathode was carried out for the fabrication of non-rotating thin-walled parts.This technique features a large number of insulating and insoluble hard particles as a real-time polishing to the cathode.When cathode moves,hard particles polish its surface and provide the nickel non-rotating parts with near-mirror finishing.Morphology,microstructure,surface roughness and micro hardness of deposits fabricated by novel method were studied in contrast with the sample produced by traditional electroforming methods.Theoretical analysis and experimental results showed that the novel technique could effectively remove the hydrogen bubbles and nodules,disturb the crystal nucleation,and refine the grains of layer.The mechanical properties were significantly improved over traditional method.The micro-hardness of the layer was in a uniform distribution ranging from 345 HV to 360 HV.It was confirmed that this technique had practical significance to non-rotating thin-walled parts.

Two new saponins from the aerial part of Astragalus membranaceus var. mongholicus

Two new saponins named mongholicoside A （1） and mongholicoside B （2） were isolated from the aerial part of Astragalus membranaceus var mongholicus. Their structures were determined by 1D and 2D NMR, ESI-MS techniques and chemical methods.

Redesigned Surface Based Machining Strategy and Method in Peripheral Milling of Thin-walled Parts

Currently, simultaneously ensuring the machining accuracy and efficiency of thin-walled structures especially high performance parts still remains a challenge. Existing compensating methods are mainly focusing on 3-aixs machining, which sometimes only take one given point as the compensative point at each given cutter location. This paper presents a redesigned surface based machining strategy for peripheral milling of thin-walled parts. Based on an improved cutting force/heat model and finite element method（FEM） simulation environment, a deflection error prediction model, which takes sequence of cutter contact lines as compensation targets, is established. And an iterative algorithm is presented to determine feasible cutter axis positions. The final redesigned surface is subsequently generated by skinning all discrete cutter axis vectors after compensating by using the proposed algorithm. The proposed machining strategy incorporates the thermo-mechanical coupled effect in deflection prediction, and is also validated with flank milling experiment by using five-axis machine tool. At the same time, the deformation error is detected by using three-coordinate measuring machine. Error prediction values and experimental results indicate that they have a good consistency and the proposed approach is able to significantly reduce the dimension error under the same machining conditions compared with conventional methods. The proposed machining strategy has potential in high-efficiency precision machining of thin-walled parts.