It is necessary to find a mechanism that generates first-person inner sensation of pleasure to understand what causes addiction and associated behaviour by drugs of abuse.The actual mechanism is expected to explain se...It is necessary to find a mechanism that generates first-person inner sensation of pleasure to understand what causes addiction and associated behaviour by drugs of abuse.The actual mechanism is expected to explain several disparate findings in nucleus accumbens(NAc),a brain region associated with pleasure,in an interconnected manner.Previously,it was possible to derive a mechanism for natural learning and explain:(1)Generation of inner sensation of memory using changes generated by learning;and(2)Long-term potentiation as an experimental delayed scaled-up change by the same mechanism that occur during natural learning.By extending these findings and by using disparate third person observations in NAc from several studies,present work provides a framework of a mechanism that generates internal sensation of pleasure that can provide interconnected explanations for:(1)Ability to induce robust long-term depression(LTD)in NAc from naïve animals;(2)Impaired ability to induce LTD in“addicted”state;(3)Attenuation of postsynaptic potentials by cocaine;and(4)Reduced firing of medium spiny neurons in response to cocaine or dopamine.Findings made by this work are testable.展开更多
Located at the fringe of the western plain in Sichuan Province and the confluence of the Minjiang, Qingyijiang and Daduhe Rivers, Leshan is an historic city of major importance to tourism. As one of the earliest towns...Located at the fringe of the western plain in Sichuan Province and the confluence of the Minjiang, Qingyijiang and Daduhe Rivers, Leshan is an historic city of major importance to tourism. As one of the earliest towns originally under the jurisdiction of Kai Ming Shi, the king of Shu during the Western Zhou Dynasty (B.C. 1066—展开更多
Most people would agree that reading is helpful in acquiring language. I present here a much stronger position:Genuinely interesting and comprehensible reading is not only the main source of literacy and language, but...Most people would agree that reading is helpful in acquiring language. I present here a much stronger position:Genuinely interesting and comprehensible reading is not only the main source of literacy and language, but alsoan important source of knowledge in a wide number of areas, and also contributes to our understanding of others,otherwise known as empathy.展开更多
<span style="font-family:Verdana;">For past deca</span><span style="font-family:Verdana;">des, research of designing </span><span style="font-family:Verdana;"&...<span style="font-family:Verdana;">For past deca</span><span style="font-family:Verdana;">des, research of designing </span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">pleasure</span><span style="font-family:Verdana;">”</span><span style="font-family:Verdana;"> into products</span><span style="font-family:Verdana;"> in the aca</span><span style="font-family:Verdana;">demic community has produced a multitude of evaluation models and fra</span><span style="font-family:Verdana;">mework</span><span style="font-family:Verdana;">s. These models address the critical issues of plea</span><span style="font-family:Verdana;">surable product design </span><span style="font-family:Verdana;">leading to emotional design. This study is intended to explore the change fr</span><span style="font-family:Verdana;">om the need of “usability” for the product design to the need of “pleasure” for the user experience. The questionnaires were used to obtain data from 343 subjects. The four keyboard designs were adopted in the experiment to study the differ</span><span style="font-family:Verdana;">ence and the change from “usability” to</span><span style="font-family:Verdana;"> “pleasure” of users” preference. The results show that the need for pleasure is higher than usability, as well as </span><span style="font-family:Verdana;">attractive things also transmit the feel of work better. Besides, preference is re</span><span style="font-family:Verdana;">lated to gender, age, major, and educational background. Results presented her</span><span style="font-family:Verdana;">ein </span><span style="font-family:Verdana;">provide designers with a valuable reference for examining the</span><span style="font-family:Verdana;"> way how to </span><span style="font-family:Verdana;">design “pleasure” into product and the interactive experience of users in the de</span><span style="font-family:Verdana;">sign process.展开更多
The urban environment affects human behavior and health.Most studies on the feelings of street spaces have not considered a specific kind of realistic scene,such as running.To overcome this limitation,we explored the ...The urban environment affects human behavior and health.Most studies on the feelings of street spaces have not considered a specific kind of realistic scene,such as running.To overcome this limitation,we explored the relationship between the urban environment and the pleasure of running.We collected 8260 street view images from 153 running routes in Beijing and invited more than 400 volunteers of different genders and ages to rate their sense of pleasure in street view images of the urban running environment through an online survey.Then,the proportion of visual elements in street images was extracted based on semantic segmentation,and the landscape was divided.Finally,a linear mixed model was used to predict the pleasure scores of different gender and age groups for different landscapes.The results show significant differences in the pleasure scores for different landscapes and age groups.Middle-aged people’s sense of pleasure was lower than that of the young and the elderly.More greenery was associated with a higher pleasure score,while the proportion of urban elements such as buildings was negatively correlated with the pleasure score.The results indicate that running in a natural landscape is pleasurable and beneficial for mental health.展开更多
A craftsperson makes a celadon bowl at the Fenghuang Mountain Archaeological Site Park in Shangyu District of Shaoxing, east China’s Zhejiang Province, on January 22. As the birthplace of celadon, Shangyu is reviving...A craftsperson makes a celadon bowl at the Fenghuang Mountain Archaeological Site Park in Shangyu District of Shaoxing, east China’s Zhejiang Province, on January 22. As the birthplace of celadon, Shangyu is reviving the local culture by protecting relics, promoting celadon arts and boosting tourism.展开更多
Italian liner Costa Allegra will start its maiden voyage on the northern route this August.China Merchants International Travel,the general agent for Costa Allegra in north China,has made a block booking of the most p...Italian liner Costa Allegra will start its maiden voyage on the northern route this August.China Merchants International Travel,the general agent for Costa Allegra in north China,has made a block booking of the most popu-展开更多
"THE post office will allow the daughters of post and telecommunications staff to become postwomen," said father after he arrived home. That happened one day in early 1951. When I heard the news, I was so ha..."THE post office will allow the daughters of post and telecommunications staff to become postwomen," said father after he arrived home. That happened one day in early 1951. When I heard the news, I was so happy I jumped for joy. My展开更多
ONE of the most outstanding membersof the first women’s team to navigatethe Changjiang River from its glacialsource was known affectionately as "Granny" byher teammates. A septuagenarian retired doctor,and ...ONE of the most outstanding membersof the first women’s team to navigatethe Changjiang River from its glacialsource was known affectionately as "Granny" byher teammates. A septuagenarian retired doctor,and ardent adventure-seeker, Liu Sha has criss-crossed the country by foot, bike and now boatsince her retirement from Sichuan’s MianyangCenter Hospital in 1986.展开更多
It is my great pleasure to introduce you the 19th volume of Neural Regeneration Research(NRR)and the first issue of 2024.The new volume still features a large number of manuscripts reporting on neural regeneration,whi...It is my great pleasure to introduce you the 19th volume of Neural Regeneration Research(NRR)and the first issue of 2024.The new volume still features a large number of manuscripts reporting on neural regeneration,which we hope will be of interest to you.展开更多
文摘It is necessary to find a mechanism that generates first-person inner sensation of pleasure to understand what causes addiction and associated behaviour by drugs of abuse.The actual mechanism is expected to explain several disparate findings in nucleus accumbens(NAc),a brain region associated with pleasure,in an interconnected manner.Previously,it was possible to derive a mechanism for natural learning and explain:(1)Generation of inner sensation of memory using changes generated by learning;and(2)Long-term potentiation as an experimental delayed scaled-up change by the same mechanism that occur during natural learning.By extending these findings and by using disparate third person observations in NAc from several studies,present work provides a framework of a mechanism that generates internal sensation of pleasure that can provide interconnected explanations for:(1)Ability to induce robust long-term depression(LTD)in NAc from naïve animals;(2)Impaired ability to induce LTD in“addicted”state;(3)Attenuation of postsynaptic potentials by cocaine;and(4)Reduced firing of medium spiny neurons in response to cocaine or dopamine.Findings made by this work are testable.
文摘Located at the fringe of the western plain in Sichuan Province and the confluence of the Minjiang, Qingyijiang and Daduhe Rivers, Leshan is an historic city of major importance to tourism. As one of the earliest towns originally under the jurisdiction of Kai Ming Shi, the king of Shu during the Western Zhou Dynasty (B.C. 1066—
文摘Most people would agree that reading is helpful in acquiring language. I present here a much stronger position:Genuinely interesting and comprehensible reading is not only the main source of literacy and language, but alsoan important source of knowledge in a wide number of areas, and also contributes to our understanding of others,otherwise known as empathy.
文摘<span style="font-family:Verdana;">For past deca</span><span style="font-family:Verdana;">des, research of designing </span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">pleasure</span><span style="font-family:Verdana;">”</span><span style="font-family:Verdana;"> into products</span><span style="font-family:Verdana;"> in the aca</span><span style="font-family:Verdana;">demic community has produced a multitude of evaluation models and fra</span><span style="font-family:Verdana;">mework</span><span style="font-family:Verdana;">s. These models address the critical issues of plea</span><span style="font-family:Verdana;">surable product design </span><span style="font-family:Verdana;">leading to emotional design. This study is intended to explore the change fr</span><span style="font-family:Verdana;">om the need of “usability” for the product design to the need of “pleasure” for the user experience. The questionnaires were used to obtain data from 343 subjects. The four keyboard designs were adopted in the experiment to study the differ</span><span style="font-family:Verdana;">ence and the change from “usability” to</span><span style="font-family:Verdana;"> “pleasure” of users” preference. The results show that the need for pleasure is higher than usability, as well as </span><span style="font-family:Verdana;">attractive things also transmit the feel of work better. Besides, preference is re</span><span style="font-family:Verdana;">lated to gender, age, major, and educational background. Results presented her</span><span style="font-family:Verdana;">ein </span><span style="font-family:Verdana;">provide designers with a valuable reference for examining the</span><span style="font-family:Verdana;"> way how to </span><span style="font-family:Verdana;">design “pleasure” into product and the interactive experience of users in the de</span><span style="font-family:Verdana;">sign process.
基金China’s National Key Research and Development Program,No.2017YFB0503500National Natural Science Foundation of China,No.41901321。
文摘The urban environment affects human behavior and health.Most studies on the feelings of street spaces have not considered a specific kind of realistic scene,such as running.To overcome this limitation,we explored the relationship between the urban environment and the pleasure of running.We collected 8260 street view images from 153 running routes in Beijing and invited more than 400 volunteers of different genders and ages to rate their sense of pleasure in street view images of the urban running environment through an online survey.Then,the proportion of visual elements in street images was extracted based on semantic segmentation,and the landscape was divided.Finally,a linear mixed model was used to predict the pleasure scores of different gender and age groups for different landscapes.The results show significant differences in the pleasure scores for different landscapes and age groups.Middle-aged people’s sense of pleasure was lower than that of the young and the elderly.More greenery was associated with a higher pleasure score,while the proportion of urban elements such as buildings was negatively correlated with the pleasure score.The results indicate that running in a natural landscape is pleasurable and beneficial for mental health.
文摘A craftsperson makes a celadon bowl at the Fenghuang Mountain Archaeological Site Park in Shangyu District of Shaoxing, east China’s Zhejiang Province, on January 22. As the birthplace of celadon, Shangyu is reviving the local culture by protecting relics, promoting celadon arts and boosting tourism.
文摘Italian liner Costa Allegra will start its maiden voyage on the northern route this August.China Merchants International Travel,the general agent for Costa Allegra in north China,has made a block booking of the most popu-
文摘"THE post office will allow the daughters of post and telecommunications staff to become postwomen," said father after he arrived home. That happened one day in early 1951. When I heard the news, I was so happy I jumped for joy. My
文摘ONE of the most outstanding membersof the first women’s team to navigatethe Changjiang River from its glacialsource was known affectionately as "Granny" byher teammates. A septuagenarian retired doctor,and ardent adventure-seeker, Liu Sha has criss-crossed the country by foot, bike and now boatsince her retirement from Sichuan’s MianyangCenter Hospital in 1986.
文摘It is my great pleasure to introduce you the 19th volume of Neural Regeneration Research(NRR)and the first issue of 2024.The new volume still features a large number of manuscripts reporting on neural regeneration,which we hope will be of interest to you.