Introduction: Polyuria is a sign for many disease processes, including diabetes mellitus and diabetes insipidus. Urine osmolarity helps distinguish osmotic diuresis caused by diabetes mellitus from water dieresis indu...Introduction: Polyuria is a sign for many disease processes, including diabetes mellitus and diabetes insipidus. Urine osmolarity helps distinguish osmotic diuresis caused by diabetes mellitus from water dieresis induced by diabetes insipidus. Case Presentation: We report a case of a 48-year-old woman who presented with polyuria, polydipsia, nocturia, and weight loss after a return from a visit to Russia, during which she received a five-day course of antibiotic Demeclocycline, a tetracycline derivative for dental treatment. She recovered from all clinical manifestations by 8 weeks. Conclusion: Manifestation of transient nephrogenic diabetes insipidus is induced by Demeclocycline.展开更多
Dexmedetomidine is anα2 agonist that is frequently used for sedation in intensive care units(ICUs).Hypotension and bradycardia are common adverse effects observed in clinical practice.In perioperative conditions,poly...Dexmedetomidine is anα2 agonist that is frequently used for sedation in intensive care units(ICUs).Hypotension and bradycardia are common adverse effects observed in clinical practice.In perioperative conditions,polyuria is a rare adverse effect with limited case reports after dexmedetomidine infusion.Similar to this situation,in ICU,there are rare cases.We present the case of a 59-year-old man who developed polyuria secondary to high-dose intravenous dexmedetomidine infusion in the medical ICU.展开更多
A male patient with seventy-six years old, frequent urination at night, lassitude, aversion to cold, feeling tired easily on exertion, soreness and weakness in the lumbar region, dark and purplish tongue with white co...A male patient with seventy-six years old, frequent urination at night, lassitude, aversion to cold, feeling tired easily on exertion, soreness and weakness in the lumbar region, dark and purplish tongue with white coating, deep, thread and rapid pulse. Diagnosis: nocturnal polyuria. Syndrome differentiation in traditional Chinese medicine: kidney yang deficiency. In treatment, the Du-moxibustion(moxibustion along the Governor vessel) was adopted in the lumbosacral region. A number of cross marks were marked along Zhōngshū(中枢GV 7) to Yaoshù(腰俞 GV 2). Herbal powder for the Du-moxibustion was put evenly and straightly from GV 7 to GV 2 along the cross marks. The mulberry bark paper was put flatly over the treating region with the folded midline of the paper matching the powder line and the ginger paste was placed on the paper and flatted with the tongue depressor as a trapezium. A groove was pressed on the ginger paste, And moxa was put inside. The upper, middle and lower sites of the moxa were ignited for moxibustion,when the moxa was burnt out then new moxa was replaced. Totally,the moxa was changed 3 times in one treatment. The treatment was given once a week, and 4 treatments as one course. After 2-course Du-moxibustion, the frequency of nocturnal urination was 0-1 time,0-350 mL a night. The patient had lassitude and fatigue occasionally and had no aversion to cold. The treatment was given once every two weeks on the lumbosacral region until the urine frequency was normal at night. The Du-moxibustion improves in kidney yang deficiency, kidney qi deficiency, post-operative body weakness and the deficiency cold of the lower Jiao. This therapy warms the meridian, promotes qi and blood circulation, shortens the recovery time of the normal circulation of the cerebrospinal fluid and nourishes cauda equina as well as alleviates the pressure to cauda equina due to edema. This therapy effectively treats nocturnal polyuria of kidney yang deficiency after lumbar disc herniation surgery.展开更多
Introduction: Nocturia has a multifactorial etiology, and its diagnostic approach involves, in addition to medical history and physical examination, the use of a bladder diary to define the pathophysiological mechanis...Introduction: Nocturia has a multifactorial etiology, and its diagnostic approach involves, in addition to medical history and physical examination, the use of a bladder diary to define the pathophysiological mechanisms present in each case. Methods: This study investigated the prevalence of nocturia, its mechanisms, and associated factors in women with lower urinary tract symptoms attending two urogynecology clinics in the state of Rio de Janeiro, Brazil. Anamnesis, physical examination, and a 24-hour bladder diary were conducted. Two definitions of nocturia were considered: one or more nighttime voids and two or more nighttime voids. Mann-Whitney and Chi-square tests were used, with p-value ≤ 0.05 considered significant. Results: A total of 133 participants were included. The majority were aged 60 years or older (61.4%) and had three or more comorbidities (66.7%), with systemic arterial hypertension being the most prevalent (59.1%). Of the total participants, 54 (41.4%) completed the bladder diary. Among those with one or more nighttime voids (70.7%), the prevalence of nocturnal polyuria was 69.1%, reduced nocturnal bladder capacity was 17.3%, and global polyuria was 12.9%. Among participants with two or more nighttime voids (56.4%), the prevalences were respectively 68.2%, 19.1%, and 13.6%. Among the mechanisms, associations were found only with global polyuria, namely: use of insulin, body mass index and tobacco consumption. An association was also found between recurrent urinary tract infection and global polyuria in participants with two or more nighttime voids. Conclusions: The prevalence of nocturia was higher than that reported in general population studies and specialized services for lower urinary tract symptoms. Nocturnal polyuria was the most prevalent mechanism. Associations were observed between the use of insulin, body mass index, tobacco consumption, and recurrent urinary tract infection with global polyuria. No associations were found between any clinical or demographic variables and nocturnal polyuria or reduced nocturnal bladder capacity.展开更多
【目的】观察自然衰老大鼠膀胱逼尿肌中腺苷酸环化酶(AC)、环磷酸腺苷(cAMP)及蛋白激酶A(PKA)的浓度变化及PKA蛋白表达,探讨缩泉丸"缩尿"的作用机理。【方法】选用老年大鼠(20月龄)50只,分为模型组,金匮肾气丸组,缩泉丸高、...【目的】观察自然衰老大鼠膀胱逼尿肌中腺苷酸环化酶(AC)、环磷酸腺苷(cAMP)及蛋白激酶A(PKA)的浓度变化及PKA蛋白表达,探讨缩泉丸"缩尿"的作用机理。【方法】选用老年大鼠(20月龄)50只,分为模型组,金匮肾气丸组,缩泉丸高、中、低剂量组,每组10只;青年大鼠(3月龄)10只作为空白组。采用酶联免疫吸附(ELISA)法检测逼尿肌中AC活性、cAMP及PKA的浓度变化,采用W estern b lotting检测逼尿肌PKA蛋白的表达。【结果】与模型组比较,缩泉丸组可显著提高自然衰老大鼠逼尿肌中AC活性、cAMP及PKA含量并上调PKA蛋白的表达。【结论】缩泉丸治疗肾虚多尿的作用与其能增加自然衰老大鼠逼尿肌中AC活性、cAMP及PKA含量并增加PKA蛋白的表达有关。展开更多
文摘Introduction: Polyuria is a sign for many disease processes, including diabetes mellitus and diabetes insipidus. Urine osmolarity helps distinguish osmotic diuresis caused by diabetes mellitus from water dieresis induced by diabetes insipidus. Case Presentation: We report a case of a 48-year-old woman who presented with polyuria, polydipsia, nocturia, and weight loss after a return from a visit to Russia, during which she received a five-day course of antibiotic Demeclocycline, a tetracycline derivative for dental treatment. She recovered from all clinical manifestations by 8 weeks. Conclusion: Manifestation of transient nephrogenic diabetes insipidus is induced by Demeclocycline.
文摘Dexmedetomidine is anα2 agonist that is frequently used for sedation in intensive care units(ICUs).Hypotension and bradycardia are common adverse effects observed in clinical practice.In perioperative conditions,polyuria is a rare adverse effect with limited case reports after dexmedetomidine infusion.Similar to this situation,in ICU,there are rare cases.We present the case of a 59-year-old man who developed polyuria secondary to high-dose intravenous dexmedetomidine infusion in the medical ICU.
基金Supported by grant of Shandong Key Research and Development Program:2017GSF19116~~
文摘A male patient with seventy-six years old, frequent urination at night, lassitude, aversion to cold, feeling tired easily on exertion, soreness and weakness in the lumbar region, dark and purplish tongue with white coating, deep, thread and rapid pulse. Diagnosis: nocturnal polyuria. Syndrome differentiation in traditional Chinese medicine: kidney yang deficiency. In treatment, the Du-moxibustion(moxibustion along the Governor vessel) was adopted in the lumbosacral region. A number of cross marks were marked along Zhōngshū(中枢GV 7) to Yaoshù(腰俞 GV 2). Herbal powder for the Du-moxibustion was put evenly and straightly from GV 7 to GV 2 along the cross marks. The mulberry bark paper was put flatly over the treating region with the folded midline of the paper matching the powder line and the ginger paste was placed on the paper and flatted with the tongue depressor as a trapezium. A groove was pressed on the ginger paste, And moxa was put inside. The upper, middle and lower sites of the moxa were ignited for moxibustion,when the moxa was burnt out then new moxa was replaced. Totally,the moxa was changed 3 times in one treatment. The treatment was given once a week, and 4 treatments as one course. After 2-course Du-moxibustion, the frequency of nocturnal urination was 0-1 time,0-350 mL a night. The patient had lassitude and fatigue occasionally and had no aversion to cold. The treatment was given once every two weeks on the lumbosacral region until the urine frequency was normal at night. The Du-moxibustion improves in kidney yang deficiency, kidney qi deficiency, post-operative body weakness and the deficiency cold of the lower Jiao. This therapy warms the meridian, promotes qi and blood circulation, shortens the recovery time of the normal circulation of the cerebrospinal fluid and nourishes cauda equina as well as alleviates the pressure to cauda equina due to edema. This therapy effectively treats nocturnal polyuria of kidney yang deficiency after lumbar disc herniation surgery.
文摘Introduction: Nocturia has a multifactorial etiology, and its diagnostic approach involves, in addition to medical history and physical examination, the use of a bladder diary to define the pathophysiological mechanisms present in each case. Methods: This study investigated the prevalence of nocturia, its mechanisms, and associated factors in women with lower urinary tract symptoms attending two urogynecology clinics in the state of Rio de Janeiro, Brazil. Anamnesis, physical examination, and a 24-hour bladder diary were conducted. Two definitions of nocturia were considered: one or more nighttime voids and two or more nighttime voids. Mann-Whitney and Chi-square tests were used, with p-value ≤ 0.05 considered significant. Results: A total of 133 participants were included. The majority were aged 60 years or older (61.4%) and had three or more comorbidities (66.7%), with systemic arterial hypertension being the most prevalent (59.1%). Of the total participants, 54 (41.4%) completed the bladder diary. Among those with one or more nighttime voids (70.7%), the prevalence of nocturnal polyuria was 69.1%, reduced nocturnal bladder capacity was 17.3%, and global polyuria was 12.9%. Among participants with two or more nighttime voids (56.4%), the prevalences were respectively 68.2%, 19.1%, and 13.6%. Among the mechanisms, associations were found only with global polyuria, namely: use of insulin, body mass index and tobacco consumption. An association was also found between recurrent urinary tract infection and global polyuria in participants with two or more nighttime voids. Conclusions: The prevalence of nocturia was higher than that reported in general population studies and specialized services for lower urinary tract symptoms. Nocturnal polyuria was the most prevalent mechanism. Associations were observed between the use of insulin, body mass index, tobacco consumption, and recurrent urinary tract infection with global polyuria. No associations were found between any clinical or demographic variables and nocturnal polyuria or reduced nocturnal bladder capacity.
文摘【目的】观察自然衰老大鼠膀胱逼尿肌中腺苷酸环化酶(AC)、环磷酸腺苷(cAMP)及蛋白激酶A(PKA)的浓度变化及PKA蛋白表达,探讨缩泉丸"缩尿"的作用机理。【方法】选用老年大鼠(20月龄)50只,分为模型组,金匮肾气丸组,缩泉丸高、中、低剂量组,每组10只;青年大鼠(3月龄)10只作为空白组。采用酶联免疫吸附(ELISA)法检测逼尿肌中AC活性、cAMP及PKA的浓度变化,采用W estern b lotting检测逼尿肌PKA蛋白的表达。【结果】与模型组比较,缩泉丸组可显著提高自然衰老大鼠逼尿肌中AC活性、cAMP及PKA含量并上调PKA蛋白的表达。【结论】缩泉丸治疗肾虚多尿的作用与其能增加自然衰老大鼠逼尿肌中AC活性、cAMP及PKA含量并增加PKA蛋白的表达有关。
