A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. Th...A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses （HRMS, NMR, IR, and CD）.展开更多
Three new compounds(1–3), including a chlorine-containing dihydroisocoumarin pericochlorosin A(1), a chlorinated phenol pericochlorosin B(2) and a decalin derivative pericoannosin G(3), were isolated from endophytic ...Three new compounds(1–3), including a chlorine-containing dihydroisocoumarin pericochlorosin A(1), a chlorinated phenol pericochlorosin B(2) and a decalin derivative pericoannosin G(3), were isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona muricata. The structures and absolute configurations were elucidated by extensive spectroscopic methods and calculated electronic circular dichroism analysis. Compound 2 displayed potent anti-HIV activity with IC50 value of 2.2 μM.展开更多
基金financially supported by the National Natural Science Foundation of China (Nos. 31170041 and 81402835)the National High Technology Research and Development Program of China (No. 2012AA091606)The National Infrastructure of Microbial Resources (No. NIMR-2015-3)
文摘A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses （HRMS, NMR, IR, and CD）.
基金National Natural Science Foundation of China(Grant No.81773607)CAMS Innovation Fund for Medical Sciences(Grant Nos.CIFMS-2018-I2M-3-005 and CIFMS-2016-I2M-2-002)the Drug Inn ovation Major Project(Grant No.2018ZX09711001-001-001)
文摘Three new compounds(1–3), including a chlorine-containing dihydroisocoumarin pericochlorosin A(1), a chlorinated phenol pericochlorosin B(2) and a decalin derivative pericoannosin G(3), were isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona muricata. The structures and absolute configurations were elucidated by extensive spectroscopic methods and calculated electronic circular dichroism analysis. Compound 2 displayed potent anti-HIV activity with IC50 value of 2.2 μM.
