Firstly,an analysis is made from the point of view of sociology on traditional modeling logic of prevention and control of adolescents' deviant behavior in rural community,and maintenance and reproduction of this ...Firstly,an analysis is made from the point of view of sociology on traditional modeling logic of prevention and control of adolescents' deviant behavior in rural community,and maintenance and reproduction of this model.The traditional prevention and control model of adolescents' deviant behavior in rural community is diversity-orderly pattern prevention and control system.This system is based on natural economy,especially on agricultural economy."Supervision by public opinion and moral imitation" is the basic operation logic of this system.It contains a compensation mechanism of "bringing up children for the purpose of being looked after in old age" and "favor returning".Then,deconstruction of traditional prevention and control model for adolescents' deviant behavior in rural community is analyzed.Along with advance in rural modern democratic management and legal construction and growing of rural market economy,function of traditional diversity-orderly pattern of prevention and control of adolescents' deviate behavior in rural community is weak and weak in prevention and control of modern rural adolescents' deviant behavior.Finally,modeling ideas of new(coordinative) prevention and control of rural adolescents' deviant behavior are put forward from four aspects,namely,democracy and legal system,community,family and various rural adolescent admittance organizations.展开更多
目的:探讨κ-阿片受体是否参与缺血后处理的对抗心肌缺血/复灌(I/R)损伤和心肌细胞缺氧/复氧(H/R)损伤的作用及其机制。方法:采用离体大鼠心脏Langendorff灌流模型,全心停灌30 m in、复灌120 m in复制I/R模型,测定心室力学指标和复灌各...目的:探讨κ-阿片受体是否参与缺血后处理的对抗心肌缺血/复灌(I/R)损伤和心肌细胞缺氧/复氧(H/R)损伤的作用及其机制。方法:采用离体大鼠心脏Langendorff灌流模型,全心停灌30 m in、复灌120 m in复制I/R模型,测定心室力学指标和复灌各时点冠脉流出液中乳酸脱氢酶(LDH)含量。实验结束测定心肌组织form azan含量。酶解分离的心肌细胞采用缺氧60 m in、复氧60m in复制H/R模型,测定心肌细胞存活率。结果:在离体心脏模型上,与I/R组相比,缺血后处理组心肌组织的form azan含量明显增高,复灌期间冠脉流出液中LDH含量明显降低,同时缺血后处理明显改善心室力学指标,缓解冠脉流量的减少;在分离心肌细胞模型上,缺氧后处理明显提高心肌细胞存活率。κ-阿片受体阻断剂nor-b inaltorph im ine(nor-BN I)和线粒体ATP敏感性钾通道(m itoKATP)阻断剂5-hydroxydecanoate(5-HD)在离体大鼠心脏模型和分离心肌细胞模型上均能明显减弱缺血后处理的作用。同时在心肌细胞模型上,与H/R组相比,κ-阿片受体激动剂U 50488H明显提高心肌细胞存活率,其作用可被m itoKATP阻断剂5-HD所阻断。结论:缺血后处理具有抗心肌缺血/复灌损伤的作用,这种保护作用可能与其激活κ-阿片受体和m itoKATP有关。展开更多
目的:了解新疆女性性工作者(female sex workers,FSWs)对艾滋病暴露前预防用药(pre-exposure prophylaxis,Pr-EP)的使用意愿,为HIV高危人群Pr-EP的干预奠定基础。方法:对新疆乌鲁木齐市和克拉玛依市娱乐场所自愿参加调查的FSWs进行一对...目的:了解新疆女性性工作者(female sex workers,FSWs)对艾滋病暴露前预防用药(pre-exposure prophylaxis,Pr-EP)的使用意愿,为HIV高危人群Pr-EP的干预奠定基础。方法:对新疆乌鲁木齐市和克拉玛依市娱乐场所自愿参加调查的FSWs进行一对一的匿名问卷调查。结果:本次共调查了762例FSWs,对Pr-EP有673人(88.32%)从未听说过,88人(11.55%)听说过。在高档场所工作的FSWs对艾滋病Pr-EP听说率高于中、低档场所工作的FSWs(P<0.001)。528人(69.29%)表示愿意服用药物,145人(19.03%)不愿意服用药物,89人(11.68%)表示很有可能会使用。高、中、低档场所工作的FSWs对Pr-EP使用意愿未见明显不同(P=0.285)。对于愿意使用Pr-EP者主要关注药物的安全性、效果和费用等;不愿意使用Pr-EP的主要原因依次为:自己没有感染艾滋病的风险、怀疑药物的效果、担心药物的副反应等。结论:新疆FSWs对艾滋病Pr-EP的接受意愿较好,安全性、效果和费用是Pr-EP今后推广应用中的重要影响因素。展开更多
文摘Firstly,an analysis is made from the point of view of sociology on traditional modeling logic of prevention and control of adolescents' deviant behavior in rural community,and maintenance and reproduction of this model.The traditional prevention and control model of adolescents' deviant behavior in rural community is diversity-orderly pattern prevention and control system.This system is based on natural economy,especially on agricultural economy."Supervision by public opinion and moral imitation" is the basic operation logic of this system.It contains a compensation mechanism of "bringing up children for the purpose of being looked after in old age" and "favor returning".Then,deconstruction of traditional prevention and control model for adolescents' deviant behavior in rural community is analyzed.Along with advance in rural modern democratic management and legal construction and growing of rural market economy,function of traditional diversity-orderly pattern of prevention and control of adolescents' deviate behavior in rural community is weak and weak in prevention and control of modern rural adolescents' deviant behavior.Finally,modeling ideas of new(coordinative) prevention and control of rural adolescents' deviant behavior are put forward from four aspects,namely,democracy and legal system,community,family and various rural adolescent admittance organizations.
文摘目的:探讨κ-阿片受体是否参与缺血后处理的对抗心肌缺血/复灌(I/R)损伤和心肌细胞缺氧/复氧(H/R)损伤的作用及其机制。方法:采用离体大鼠心脏Langendorff灌流模型,全心停灌30 m in、复灌120 m in复制I/R模型,测定心室力学指标和复灌各时点冠脉流出液中乳酸脱氢酶(LDH)含量。实验结束测定心肌组织form azan含量。酶解分离的心肌细胞采用缺氧60 m in、复氧60m in复制H/R模型,测定心肌细胞存活率。结果:在离体心脏模型上,与I/R组相比,缺血后处理组心肌组织的form azan含量明显增高,复灌期间冠脉流出液中LDH含量明显降低,同时缺血后处理明显改善心室力学指标,缓解冠脉流量的减少;在分离心肌细胞模型上,缺氧后处理明显提高心肌细胞存活率。κ-阿片受体阻断剂nor-b inaltorph im ine(nor-BN I)和线粒体ATP敏感性钾通道(m itoKATP)阻断剂5-hydroxydecanoate(5-HD)在离体大鼠心脏模型和分离心肌细胞模型上均能明显减弱缺血后处理的作用。同时在心肌细胞模型上,与H/R组相比,κ-阿片受体激动剂U 50488H明显提高心肌细胞存活率,其作用可被m itoKATP阻断剂5-HD所阻断。结论:缺血后处理具有抗心肌缺血/复灌损伤的作用,这种保护作用可能与其激活κ-阿片受体和m itoKATP有关。
文摘目的:了解新疆女性性工作者(female sex workers,FSWs)对艾滋病暴露前预防用药(pre-exposure prophylaxis,Pr-EP)的使用意愿,为HIV高危人群Pr-EP的干预奠定基础。方法:对新疆乌鲁木齐市和克拉玛依市娱乐场所自愿参加调查的FSWs进行一对一的匿名问卷调查。结果:本次共调查了762例FSWs,对Pr-EP有673人(88.32%)从未听说过,88人(11.55%)听说过。在高档场所工作的FSWs对艾滋病Pr-EP听说率高于中、低档场所工作的FSWs(P<0.001)。528人(69.29%)表示愿意服用药物,145人(19.03%)不愿意服用药物,89人(11.68%)表示很有可能会使用。高、中、低档场所工作的FSWs对Pr-EP使用意愿未见明显不同(P=0.285)。对于愿意使用Pr-EP者主要关注药物的安全性、效果和费用等;不愿意使用Pr-EP的主要原因依次为:自己没有感染艾滋病的风险、怀疑药物的效果、担心药物的副反应等。结论:新疆FSWs对艾滋病Pr-EP的接受意愿较好,安全性、效果和费用是Pr-EP今后推广应用中的重要影响因素。
