Background: COVID-19 limitations have hindered the implementation of new technologies by preventing proctors from coming to the site.We share our first experience of magnetic resonance imaging(MRI)-guided focused ultr...Background: COVID-19 limitations have hindered the implementation of new technologies by preventing proctors from coming to the site.We share our first experience of magnetic resonance imaging(MRI)-guided focused ultrasound(MRgFUS)treatment with an international remote online proctorship,and develop and evaluate the methodology of remote MRgFUS proctorship.Methods: This single-center,nonrandomized controlled prospective study included 94 patients:27 with essential tremor(ET)and 67 with tremor-dominant Parkinson's disease(PD).The coming of proctors was impossible,so we arranged for the remote participation of proctors from the United Kingdom,Spain,and Israel.A total of 38 patients(40.4%)received telemedicine-proctored treatment(proctor group)and 56 received their treatment independently(solo group).We used the Clinical Rating Scale for Tremor(CRST)for ET patients and the Unified Parkinson's Disease Rating Scale(UPDRS)Part III for PD patients.Results: In patients with ET,success rates were 81.8%(proctor group)and 100%(solo group)(p=0.22).CRST reduction on the treated side was 71.43%[65.83%;80.56%](proctor group)versus 60.87%[53.99;79.58](solo group)(p=0.19).None of the patients showed worsening of tremors within 1 year.In patients with PD,the success rates were 92.6%(proctor group)and 100%(solo group)(p=0.08).The UPDRS Part III improvement was 30.1%(proctor group)versus 39.9%(solo group)(p=0.003).The 1-year recurrence rate was 40%(proctor group)and 17.5%(solo group)(p=0.04).No complications were observed at 6 months.Conclusions: We developed a feasible and safe methodology for telemedicine remote online-proctored MRgFUS treatment.No significant difference was observed between the solo and developed remote proctor protocols in terms of complication rate,effect,and long-term results;however,UPDRS Part III improvement was better in the PD solo group.This study demonstrated that the MRgFUS international proctorship can be performed successfully remotely.展开更多
The ultrasonic pulse velocity(UPV)correlates significantly with the density and pore size of subgrade filling materials.This research conducts numerous Proctor and UPV tests to examine how moisture and rock content af...The ultrasonic pulse velocity(UPV)correlates significantly with the density and pore size of subgrade filling materials.This research conducts numerous Proctor and UPV tests to examine how moisture and rock content affect compaction quality.The study measures the changes in UPV across dry density and compaction characteristics.The compacted specimens exhibit distinct microstructures and mechanical properties along the dry and wet sides of the compaction curve,primarily influenced by internal water molecules.The maximum dry density exhibits a positive correlation with the rock content,while the optimal moisture content demonstrates an inverse relationship.As the rock content increases,the relative error of UPV measurement rises.The UPV follows a hump-shaped pattern with the initial moisture content.Three intelligent models are established to forecast dry density.The measure of UPV and PSO-BP-NN model quickly assesses compaction quality.展开更多
It had been suggested to use the West African Compaction Test Procedure since the early 1950’s so as to determine the CBR of gravel lateritic soils in West African countries [1]. This test procedure called West Afric...It had been suggested to use the West African Compaction Test Procedure since the early 1950’s so as to determine the CBR of gravel lateritic soils in West African countries [1]. This test procedure called West African Compaction (WAC) [2] is largely used in road construction in West African countries and had the particularity to be long and use a large amount of material. This note is the result of several comparisons between test procedures taken to determine the CBR from the WAC method to the standardized laboratory test commonly used to determine the CBR.展开更多
The presented study dealt with geotechnical investigations on the sub-grade soils along the connector road between the electrical transformer station and the industrial city, New Tiba city, Luxor, to classify these so...The presented study dealt with geotechnical investigations on the sub-grade soils along the connector road between the electrical transformer station and the industrial city, New Tiba city, Luxor, to classify these soils and to examine their geotechnical behavior and their proportionality for constructing the road at the study area. One of the most important aims of this work was to determine the problematic sub-grade soils and to recommend the suitable reclamation. To achieve these goals sixty disturbed samples from six mechanical wash drilling boreholes and three undisturbed samples from three open pits were collected. The studied soils were belonged to Quaternary age. Gradation parameters (coefficient of uniformity, Cu and coefficient of concavity, Cc), plasticity, California bearing ratio (CBR), proctor density and free swelling percent of the studied soils were measured. PH-value, dissolved chloride, dissolved sulfate, calcium carbonate, total carbonate, and total dissolved salts were determined. The results pointed that the studied Quaternary soils along the study road were mainly composed of gravels, sands and clayey sands. The studied gravels were classified as poorly graded gravels (GP) according to Unified Soil Classification System (USCS) and as A-1-b according to American Association of State Highway and Transportation Official (AASHTO). The studied sands were classified as well graded sands (SW) according to USCS and as A-1-a according to AASHTO. The results showed also that the sub-grades at boreholes no. 1, 3, 4, 5, and 6 were excellent to good and the sub-grade at boreholes no. 2 was fair to poor. Free swelling percent of the studied clayey sand soils was ranging from 30% to 80% and they were classified as low to medium grade expansive soil. Replacement and/or chemical stabilization (using lime and/or cement kiln dust) of the problematic clayey sands soils were suggested to reduce their swelling and to prevent the possible heave.展开更多
文摘Background: COVID-19 limitations have hindered the implementation of new technologies by preventing proctors from coming to the site.We share our first experience of magnetic resonance imaging(MRI)-guided focused ultrasound(MRgFUS)treatment with an international remote online proctorship,and develop and evaluate the methodology of remote MRgFUS proctorship.Methods: This single-center,nonrandomized controlled prospective study included 94 patients:27 with essential tremor(ET)and 67 with tremor-dominant Parkinson's disease(PD).The coming of proctors was impossible,so we arranged for the remote participation of proctors from the United Kingdom,Spain,and Israel.A total of 38 patients(40.4%)received telemedicine-proctored treatment(proctor group)and 56 received their treatment independently(solo group).We used the Clinical Rating Scale for Tremor(CRST)for ET patients and the Unified Parkinson's Disease Rating Scale(UPDRS)Part III for PD patients.Results: In patients with ET,success rates were 81.8%(proctor group)and 100%(solo group)(p=0.22).CRST reduction on the treated side was 71.43%[65.83%;80.56%](proctor group)versus 60.87%[53.99;79.58](solo group)(p=0.19).None of the patients showed worsening of tremors within 1 year.In patients with PD,the success rates were 92.6%(proctor group)and 100%(solo group)(p=0.08).The UPDRS Part III improvement was 30.1%(proctor group)versus 39.9%(solo group)(p=0.003).The 1-year recurrence rate was 40%(proctor group)and 17.5%(solo group)(p=0.04).No complications were observed at 6 months.Conclusions: We developed a feasible and safe methodology for telemedicine remote online-proctored MRgFUS treatment.No significant difference was observed between the solo and developed remote proctor protocols in terms of complication rate,effect,and long-term results;however,UPDRS Part III improvement was better in the PD solo group.This study demonstrated that the MRgFUS international proctorship can be performed successfully remotely.
基金supported by the National Natural Science Foundation of China (Grant Nos.52038005 and 52278342)Natural Science Foundation of Tianjin,China (Grant No.23JCJQJC00160).
文摘The ultrasonic pulse velocity(UPV)correlates significantly with the density and pore size of subgrade filling materials.This research conducts numerous Proctor and UPV tests to examine how moisture and rock content affect compaction quality.The study measures the changes in UPV across dry density and compaction characteristics.The compacted specimens exhibit distinct microstructures and mechanical properties along the dry and wet sides of the compaction curve,primarily influenced by internal water molecules.The maximum dry density exhibits a positive correlation with the rock content,while the optimal moisture content demonstrates an inverse relationship.As the rock content increases,the relative error of UPV measurement rises.The UPV follows a hump-shaped pattern with the initial moisture content.Three intelligent models are established to forecast dry density.The measure of UPV and PSO-BP-NN model quickly assesses compaction quality.
文摘It had been suggested to use the West African Compaction Test Procedure since the early 1950’s so as to determine the CBR of gravel lateritic soils in West African countries [1]. This test procedure called West African Compaction (WAC) [2] is largely used in road construction in West African countries and had the particularity to be long and use a large amount of material. This note is the result of several comparisons between test procedures taken to determine the CBR from the WAC method to the standardized laboratory test commonly used to determine the CBR.
文摘The presented study dealt with geotechnical investigations on the sub-grade soils along the connector road between the electrical transformer station and the industrial city, New Tiba city, Luxor, to classify these soils and to examine their geotechnical behavior and their proportionality for constructing the road at the study area. One of the most important aims of this work was to determine the problematic sub-grade soils and to recommend the suitable reclamation. To achieve these goals sixty disturbed samples from six mechanical wash drilling boreholes and three undisturbed samples from three open pits were collected. The studied soils were belonged to Quaternary age. Gradation parameters (coefficient of uniformity, Cu and coefficient of concavity, Cc), plasticity, California bearing ratio (CBR), proctor density and free swelling percent of the studied soils were measured. PH-value, dissolved chloride, dissolved sulfate, calcium carbonate, total carbonate, and total dissolved salts were determined. The results pointed that the studied Quaternary soils along the study road were mainly composed of gravels, sands and clayey sands. The studied gravels were classified as poorly graded gravels (GP) according to Unified Soil Classification System (USCS) and as A-1-b according to American Association of State Highway and Transportation Official (AASHTO). The studied sands were classified as well graded sands (SW) according to USCS and as A-1-a according to AASHTO. The results showed also that the sub-grades at boreholes no. 1, 3, 4, 5, and 6 were excellent to good and the sub-grade at boreholes no. 2 was fair to poor. Free swelling percent of the studied clayey sand soils was ranging from 30% to 80% and they were classified as low to medium grade expansive soil. Replacement and/or chemical stabilization (using lime and/or cement kiln dust) of the problematic clayey sands soils were suggested to reduce their swelling and to prevent the possible heave.
